Triclosan_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.0927294
AKAP12 A kinase (PRKA) anchor protein 12 0.0863491
MEIS2 Meis homeobox 2 0.0832445
FNBP1 formin binding protein 1 0.0601057
THSD4 thrombospondin, type I, domain containing 4 0.0593091
SLITRK6 SLIT and NTRK-like family, member 6 0.0581541
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0568645
NRG1 neuregulin 1 0.0538701
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0536277
FAM13A family with sequence similarity 13, member A 0.0511547
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0510223
TRIO trio Rho guanine nucleotide exchange factor 0.0489748
FHIT fragile histidine triad 0.0477248
CENPF centromere protein F, 350/400kDa 0.0472204
ANTXR1 anthrax toxin receptor 1 0.0457331
BCAS3 breast carcinoma amplified sequence 3 0.043776
KMT2E lysine (K)-specific methyltransferase 2E 0.0422016
PTPRE protein tyrosine phosphatase, receptor type, E 0.0419676
PTPRD protein tyrosine phosphatase, receptor type, D 0.0410179
NALF1 NALCN channel auxiliary factor 1 0.0396061
SET SET nuclear proto-oncogene 0.039573
ERRFI1 ERBB receptor feedback inhibitor 1 0.0390963
FNDC3B fibronectin type III domain containing 3B 0.0364612
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0352964
ZFP36L1 ZFP36 ring finger protein-like 1 0.0346749
PTPRK protein tyrosine phosphatase, receptor type, K 0.0333662
ARHGAP9 Rho GTPase activating protein 9 0.0330755
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0329087
ADGRB3 adhesion G protein-coupled receptor B3 0.0325684
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0324444
INSIG2 insulin induced gene 2 0.0318974
PCBP3 poly(rC) binding protein 3 0.03184
CADM1 cell adhesion molecule 1 0.0311992
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0310036
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0294342
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0293191
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.028995
NAMPT nicotinamide phosphoribosyltransferase 0.0288659
ELL2 elongation factor, RNA polymerase II, 2 0.0285476
THOC2 THO complex 2 0.0275581
VEGFA vascular endothelial growth factor A 0.0274839
SERBP1 SERPINE1 mRNA binding protein 1 0.0273177
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0268425
UBE3A ubiquitin protein ligase E3A 0.0267796
SCAF11 SR-related CTD-associated factor 11 0.0265229
PTPRM protein tyrosine phosphatase, receptor type, M 0.0264445
CNTN4 contactin 4 0.0263156
NKTR natural killer cell triggering receptor 0.0260698
SLFN5 schlafen family member 5 0.0258475
LAMB1 laminin, beta 1 0.0257896
SPATS2L spermatogenesis associated, serine-rich 2-like 0.025444
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0252729
YEATS2 YEATS domain containing 2 0.0247421
SKIL SKI-like proto-oncogene 0.0247203
ERCC6L2 excision repair cross-complementation group 6-like 2 0.024691
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0245353
MYO6 myosin VI 0.024405
FAT1 FAT atypical cadherin 1 0.0243882
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0239608
IFI44L interferon-induced protein 44-like 0.0238589
RSF1 remodeling and spacing factor 1 0.0237697
MIMS1 mitochondrial inner membrane scaffold 1 0.0237132
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0236399
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0235648
PARD3 par-3 family cell polarity regulator 0.0232309
BRWD3 bromodomain and WD repeat domain containing 3 0.0231294
PDE8A phosphodiesterase 8A 0.0231251
LRRC7 leucine rich repeat containing 7 0.0228434
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.0228025
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0227889
BTBD9 BTB (POZ) domain containing 9 0.0227329
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0227322
ATM ATM serine/threonine kinase 0.0226669
EVL Enah/Vasp-like 0.0226502
RBM39 RNA binding motif protein 39 0.0224337
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0222776
KAT6B K(lysine) acetyltransferase 6B 0.0220162
CEP350 centrosomal protein 350kDa 0.0216478
VCAN versican 0.0216429
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 0.0216392
SREBF2 sterol regulatory element binding transcription factor 2 0.0215469
ITGAV integrin, alpha V 0.0214249
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0214146
TRIM44 tripartite motif containing 44 0.0213956
IL6ST interleukin 6 signal transducer 0.0211925
IFI44 interferon-induced protein 44 0.0210745
FNIP1 folliculin interacting protein 1 0.0209702
CDH13 cadherin 13 0.0209365
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.0208108
IWS1 IWS1 homolog (S. cerevisiae) 0.0205755
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0205386
BPTF bromodomain PHD finger transcription factor 0.0205104
DDIT4 DNA-damage-inducible transcript 4 0.0204845
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0204252
BIRC6 baculoviral IAP repeat containing 6 0.0204121
CCNL1 cyclin L1 0.0203236
MMP16 matrix metallopeptidase 16 (membrane-inserted) 0.020303
HILPDA hypoxia inducible lipid droplet-associated 0.0200529
NGLY1 N-glycanase 1 0.0200271
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0199975

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.296927
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.249774
IGF2 insulin-like growth factor 2 -0.202959
SYT1 synaptotagmin I -0.120918
ACTG1 actin gamma 1 -0.0888893
PTMA prothymosin, alpha -0.0880169
VIM vimentin -0.0864111
LPIN1 lipin 1 -0.0594709
COL1A1 collagen, type I, alpha 1 -0.0575762
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0565897
RPL38 ribosomal protein L38 -0.0562242
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0550104
FMN1 formin 1 -0.0549952
TMSB10 thymosin beta 10 -0.0524686
RPL35A ribosomal protein L35a -0.0510644
RPL19 ribosomal protein L19 -0.0508379
PKM pyruvate kinase, muscle -0.0495859
CLTC clathrin, heavy chain (Hc) -0.0487281
TBX2 T-box 2 -0.0468193
DPH6 diphthamine biosynthesis 6 -0.0452779
RPLP1 ribosomal protein, large, P1 -0.0447809
RPL23 ribosomal protein L23 -0.0429571
HELZ helicase with zinc finger -0.0428053
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0421307
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0416271
SOS1 son of sevenless homolog 1 (Drosophila) -0.0390584
RPL37A ribosomal protein L37a -0.038603
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0385131
LOC112694756 uncharaterized LOC112694756 -0.0380515
SMYD3 SET and MYND domain containing 3 -0.0380491
RPS24 ribosomal protein S24 -0.0377952
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 -0.0358297
RPL34 ribosomal protein L34 -0.0346446
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0344926
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 -0.0335568
NREP neuronal regeneration related protein -0.0331344
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.032692
FBXL20 F-box and leucine-rich repeat protein 20 -0.0324444
NPEPPS aminopeptidase puromycin sensitive -0.0323597
RPL32 ribosomal protein L32 -0.0320845
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0314118
RPLP0 ribosomal protein, large, P0 -0.0311904
EIF1 eukaryotic translation initiation factor 1 -0.0304791
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0298802
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0294824
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0289443
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0287805
MED13 mediator complex subunit 13 -0.0285439
PRKCA protein kinase C, alpha -0.0281667
RPS23 ribosomal protein S23 -0.0280154
MBNL2 muscleblind-like splicing regulator 2 -0.0278501
KCNIP4 Kv channel interacting protein 4 -0.0278093
RPS27 ribosomal protein S27 -0.0276785
RPL8 ribosomal protein L8 -0.0274077
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0272937
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0269688
TRPS1 trichorhinophalangeal syndrome I -0.0264134
RPS6 ribosomal protein S6 -0.0263987
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0263664
TPT1 tumor protein, translationally-controlled 1 -0.0261243
S100A6 S100 calcium binding protein A6 -0.0260023
HMGA1 high mobility group AT-hook 1 -0.0259902
MED13L mediator complex subunit 13-like -0.0259132
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0258205
VCL vinculin -0.0257612
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0255963
BRD4 bromodomain containing 4 -0.0254164
RPL27 ribosomal protein L27 -0.0250319
UNC5C unc-5 homolog C (C. elegans) -0.0249713
LARP4B La ribonucleoprotein domain family, member 4B -0.0247757
CUX1 cut-like homeobox 1 -0.0247132
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0245855
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0245001
PALLD palladin, cytoskeletal associated protein -0.0244976
RPL36 ribosomal protein L36 -0.024477
CDK12 cyclin-dependent kinase 12 -0.0244427
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0243654
RPL12 ribosomal protein L12 -0.0242736
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0241739
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0240378
TIMP3 TIMP metallopeptidase inhibitor 3 -0.024028
RPL28 ribosomal protein L28 -0.023859
ACTN1 actinin, alpha 1 -0.0238079
ATRNL1 attractin-like 1 -0.0236134
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0234534
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0234365
WSB1 WD repeat and SOCS box containing 1 -0.0231483
TCERG1 transcription elongation regulator 1 -0.0230928
FTL ferritin, light polypeptide -0.0228243
NPR2 natriuretic peptide receptor 2 -0.0227183
CCDC47 coiled-coil domain containing 47 -0.0227082
VDAC1 voltage-dependent anion channel 1 -0.0223111
GNAS GNAS complex locus -0.0222603
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0222593
CALR calreticulin -0.0221669
EXT1 exostosin glycosyltransferase 1 -0.0220234
DST dystonin -0.0220124
RAD21 RAD21 homolog (S. pombe) -0.0219701
CFDP1 craniofacial development protein 1 -0.0218674
SCLT1 sodium channel and clathrin linker 1 -0.0217858