Triclosan_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MACC1 metastasis associated in colon cancer 1 0.0786956
SYNE2 spectrin repeat containing, nuclear envelope 2 0.077791
LMO7 LIM domain 7 0.0713467
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0648829
MYO1E myosin IE 0.0645657
GMDS GDP-mannose 4,6-dehydratase 0.063187
MBNL2 muscleblind-like splicing regulator 2 0.0630424
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0623371
TMC5 transmembrane channel-like 5 0.0598836
VCL vinculin 0.0483663
PLSCR1 phospholipid scramblase 1 0.0463368
NAMPT nicotinamide phosphoribosyltransferase 0.0444878
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0443469
CANX calnexin 0.0441258
PATJ PATJ crumbs cell polarity complex component 0.0426865
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0423903
ENO1 enolase 1, (alpha) 0.0395388
SAMD4A sterile alpha motif domain containing 4A 0.0394156
GOLGB1 golgin B1 0.0391993
IGF1R insulin-like growth factor 1 receptor 0.0391469
FNDC3A fibronectin type III domain containing 3A 0.0376676
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0373806
TJP1 tight junction protein 1 0.0369224
BTBD9 BTB (POZ) domain containing 9 0.0366445
PHF3 PHD finger protein 3 0.0366396
RIGI RNA sensor RIG-I 0.0345072
NCEH1 neutral cholesterol ester hydrolase 1 0.0337064
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0336796
FOXP1 forkhead box P1 0.033659
ITGA6 integrin, alpha 6 0.0325345
LCN2 lipocalin 2 0.0322219
STK24 serine/threonine kinase 24 0.0319858
EHBP1 EH domain binding protein 1 0.0312516
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0309205
MECOM MDS1 and EVI1 complex locus 0.0307274
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0303148
PRKG1 protein kinase, cGMP-dependent, type I 0.0301913
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0301751
LPP LIM domain containing preferred translocation partner in lipoma 0.0298527
FHIT fragile histidine triad 0.0296971
CEMIP cell migration inducing protein, hyaluronan binding 0.0294069
RAD51B RAD51 paralog B 0.0293714
KTN1 kinectin 1 (kinesin receptor) 0.029112
ATXN1 ataxin 1 0.0289846
ANXA3 annexin A3 0.0288303
NCKAP5 NCK-associated protein 5 0.0283181
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0274904
TMED2 transmembrane emp24 domain trafficking protein 2 0.0274809
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 0.0274186
LDLRAD4 low density lipoprotein receptor class A domain containing 4 0.0272778
RABGAP1L RAB GTPase activating protein 1-like 0.0271461
TRIO trio Rho guanine nucleotide exchange factor 0.0271086
CDHR2 cadherin-related family member 2 0.0271047
MCU mitochondrial calcium uniporter 0.0270605
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0268144
PLCH1 phospholipase C, eta 1 0.0257806
SPIDR scaffolding protein involved in DNA repair 0.0246458
AOPEP aminopeptidase O (putative) 0.024052
DSTN destrin (actin depolymerizing factor) 0.0234933
XRRA1 X-ray radiation resistance associated 1 0.0233931
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0231494
SMYD3 SET and MYND domain containing 3 0.0231406
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0231251
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) 0.0229566
DSPP dentin sialophosphoprotein 0.0227911
YAP1 Yes-associated protein 1 0.0226787
VWA8 von Willebrand factor A domain containing 8 0.0226065
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0224079
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0224047
SPATA13 spermatogenesis associated 13 0.0222325
EREG epiregulin 0.0221878
ARL15 ADP-ribosylation factor-like 15 0.0215272
CDK6 cyclin-dependent kinase 6 0.0215053
ADAM10 ADAM metallopeptidase domain 10 0.0214746
RBM26 RNA binding motif protein 26 0.0211412
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0210799
UTRN utrophin 0.0210309
JMJD1C jumonji domain containing 1C 0.0208696
EIF4B eukaryotic translation initiation factor 4B 0.0208649
CHD1 chromodomain helicase DNA binding protein 1 0.0207319
DTX3L deltex 3 like, E3 ubiquitin ligase 0.0207296
AATF apoptosis antagonizing transcription factor 0.0207035
NEBL nebulette 0.0206001
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0205604
TBC1D22A TBC1 domain family, member 22A 0.0205571
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0201605
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0200717
ETV6 ets variant 6 0.0200583
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0200395
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0200247
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0199747
CD44 CD44 molecule (Indian blood group) 0.0196181
PTPN4 protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte) 0.0193979
SET SET nuclear proto-oncogene 0.0193696
WWOX WW domain containing oxidoreductase 0.0193302
SKAP1 src kinase associated phosphoprotein 1 0.019305
MEIS2 Meis homeobox 2 0.0192269
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.019215
GALK2 galactokinase 2 0.0191154
ZNF841 zinc finger protein 841 0.0190603

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.158023
TPT1 tumor protein, translationally-controlled 1 -0.123012
NDRG1 N-myc downstream regulated 1 -0.102086
HLA-B major histocompatibility complex, class I, B -0.0974731
PTMA prothymosin, alpha -0.0970857
EGR1 early growth response 1 -0.0869248
C6ORF132 chromosome 6 open reading frame 132 -0.0858959
PKM pyruvate kinase, muscle -0.0846181
TXNIP thioredoxin interacting protein -0.0817675
B2M beta-2-microglobulin -0.0767372
RHOBTB3 Rho-related BTB domain containing 3 -0.0728594
FTH1 ferritin, heavy polypeptide 1 -0.066828
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0633714
RPL35A ribosomal protein L35a -0.0633572
LOC112694756 uncharaterized LOC112694756 -0.0613608
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0609321
TSC22D2 TSC22 domain family, member 2 -0.0581845
FTL ferritin, light polypeptide -0.056205
RNF213 ring finger protein 213 -0.0557741
MT2A metallothionein 2A -0.0542615
TSC22D1 TSC22 domain family, member 1 -0.0529539
IFI6 interferon, alpha-inducible protein 6 -0.0511922
PGK1 phosphoglycerate kinase 1 -0.0501534
HLA-A major histocompatibility complex, class I, A -0.0494119
ZMYND8 zinc finger, MYND-type containing 8 -0.0491682
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.048636
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0480617
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0480003
FNDC3B fibronectin type III domain containing 3B -0.0475097
HLA-C major histocompatibility complex, class I, C -0.0459372
TMSB10 thymosin beta 10 -0.0448949
GNAS GNAS complex locus -0.0436476
RPL23 ribosomal protein L23 -0.0425173
INTS6 integrator complex subunit 6 -0.0420083
PERP PERP, TP53 apoptosis effector -0.0416097
SREBF2 sterol regulatory element binding transcription factor 2 -0.04137
KRT19 keratin 19, type I -0.0411657
ABLIM1 actin binding LIM protein 1 -0.038312
NPEPPS aminopeptidase puromycin sensitive -0.0382287
S100A6 S100 calcium binding protein A6 -0.0381595
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0379064
TMPRSS4 transmembrane protease, serine 4 -0.0371577
SRRM2 serine/arginine repetitive matrix 2 -0.0360612
HLA-E major histocompatibility complex, class I, E -0.0360112
RBM39 RNA binding motif protein 39 -0.0355329
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.035462
FOXO3 forkhead box O3 -0.0353451
ACTG1 actin gamma 1 -0.0350178
SLC38A1 solute carrier family 38, member 1 -0.0349319
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0348328
SQSTM1 sequestosome 1 -0.0346716
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.034175
FNIP1 folliculin interacting protein 1 -0.0338632
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0331567
MSI2 musashi RNA-binding protein 2 -0.0329922
BAIAP2L1 BAI1-associated protein 2-like 1 -0.032918
H1-0 H1.0 linker histone -0.032219
RNF149 ring finger protein 149 -0.0321731
PRKCA protein kinase C, alpha -0.0321402
SORBS1 sorbin and SH3 domain containing 1 -0.0319281
RPL19 ribosomal protein L19 -0.0318766
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0318435
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0312258
USP53 ubiquitin specific peptidase 53 -0.0306971
RPLP1 ribosomal protein, large, P1 -0.0306606
UBC ubiquitin C -0.0305031
VDAC1 voltage-dependent anion channel 1 -0.0304759
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0303389
KIAA1217 KIAA1217 -0.0301994
IFI27 interferon, alpha-inducible protein 27 -0.030196
DNM2 dynamin 2 -0.0301492
STAU1 staufen double-stranded RNA binding protein 1 -0.0300879
H3-3B H3.3 histone B -0.0299637
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0298635
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0298047
ANXA4 annexin A4 -0.0297929
S100A10 S100 calcium binding protein A10 -0.0296951
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0296102
ACBD3 acyl-CoA binding domain containing 3 -0.0294384
HMGB1 high mobility group box 1 -0.0294173
RPS6 ribosomal protein S6 -0.0293827
APOL1 apolipoprotein L, 1 -0.0290762
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.028965
RNF43 ring finger protein 43 -0.0288296
RPL7L1 ribosomal protein L7-like 1 -0.0288118
KPNB1 karyopherin (importin) beta 1 -0.0285664
HBS1L HBS1-like translational GTPase -0.0281946
FOSL2 FOS-like antigen 2 -0.0279191
TM4SF19 transmembrane 4 L six family member 19 -0.0278014
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0276737
PTPRF protein tyrosine phosphatase, receptor type, F -0.0268476
ITGB4 integrin, beta 4 -0.0267367
GLO1 glyoxalase I -0.02667
TFF3 trefoil factor 3 (intestinal) -0.0265722
NT5C2 5'-nucleotidase, cytosolic II -0.0264998
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0263225
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0262589
MXD1 MAX dimerization protein 1 -0.0262233
RAB10 RAB10, member RAS oncogene family -0.0262058
DCAF7 DDB1 and CUL4 associated factor 7 -0.0260292