Triclosan_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0975491
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0784876
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0494247
IGFBP3 insulin-like growth factor binding protein 3 0.0436053
STC1 stanniocalcin 1 0.0388106
GOLGA4 golgin A4 0.0364681
CADM1 cell adhesion molecule 1 0.0343428
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0301722
GOLGB1 golgin B1 0.0266472
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0256181
TMEM158 transmembrane protein 158 (gene/pseudogene) 0.0253452
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.024725
ASPH aspartate beta-hydroxylase 0.0237186
TPR translocated promoter region, nuclear basket protein 0.0235307
CANX calnexin 0.0229095
JARID2 jumonji, AT rich interactive domain 2 0.0221431
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.022103
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0219253
NUCB2 nucleobindin 2 0.021164
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0209392
TMF1 TATA element modulatory factor 1 0.0205814
TTC3 tetratricopeptide repeat domain 3 0.0198905
ANXA1 annexin A1 0.0182846
CXCL8 chemokine (C-X-C motif) ligand 8 0.01795
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.017851
PSD3 pleckstrin and Sec7 domain containing 3 0.0177744
AKAP9 A kinase (PRKA) anchor protein 9 0.0177267
BZW1 basic leucine zipper and W2 domains 1 0.0176651
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0172699
GARS1 glycyl-tRNA synthetase 1 0.0170008
SEC63 SEC63 homolog (S. cerevisiae) 0.0163846
CSDE1 cold shock domain containing E1, RNA-binding 0.0163573
PDIA3 protein disulfide isomerase family A, member 3 0.0163348
PDIA6 protein disulfide isomerase family A, member 6 0.0160419
AKAP12 A kinase (PRKA) anchor protein 12 0.0159719
PGM3 phosphoglucomutase 3 0.015431
HYOU1 hypoxia up-regulated 1 0.0153044
HILPDA hypoxia inducible lipid droplet-associated 0.0152896
MTDH metadherin 0.0152564
PICALM phosphatidylinositol binding clathrin assembly protein 0.0151823
CLTC clathrin, heavy chain (Hc) 0.0149092
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0148667
COPA coatomer protein complex, subunit alpha 0.0147132
SFPQ splicing factor proline/glutamine-rich 0.0146838
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0145676
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0142216
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0141696
ATM ATM serine/threonine kinase 0.0141659
SIK3 SIK family kinase 3 0.014137
FBN1 fibrillin 1 0.0140585
GNL2 guanine nucleotide binding protein-like 2 (nucleolar) 0.0139891
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0137988
COPB1 coatomer protein complex, subunit beta 1 0.0137846
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) 0.0134234
DSTN destrin (actin depolymerizing factor) 0.0134182
TMEM41B transmembrane protein 41B 0.0133167
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0133016
XRN2 5'-3' exoribonuclease 2 0.0131832
C6ORF62 chromosome 6 open reading frame 62 0.0131423
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0131294
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0131075
OSBPL8 oxysterol binding protein-like 8 0.0129086
NAP1L1 nucleosome assembly protein 1-like 1 0.0127659
CHD1 chromodomain helicase DNA binding protein 1 0.0126157
MLEC malectin 0.012563
LIMS1 LIM and senescent cell antigen-like domains 1 0.0125389
MSN moesin 0.0125214
RND3 Rho family GTPase 3 0.0125104
ENO1 enolase 1, (alpha) 0.0124872
NAMPT nicotinamide phosphoribosyltransferase 0.0123554
ANKHD1 ankyrin repeat and KH domain containing 1 0.0123481
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0122411
TPM3 tropomyosin 3 0.0122355
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0121596
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0121554
KDM2A lysine (K)-specific demethylase 2A 0.0121493
ZSWIM6 zinc finger, SWIM-type containing 6 0.0120988
ATF4 activating transcription factor 4 0.0119247
KIF5B kinesin family member 5B 0.0117999
SP100 SP100 nuclear antigen 0.0116734
SUCO SUN domain containing ossification factor 0.0116727
PDIA5 protein disulfide isomerase family A, member 5 0.0116718
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0116472
TTC28 tetratricopeptide repeat domain 28 0.0116403
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0114865
MYADM myeloid-associated differentiation marker 0.0114279
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.011336
BIRC6 baculoviral IAP repeat containing 6 0.0113311
YME1L1 YME1-like 1 ATPase 0.0112897
TLN1 talin 1 0.0112383
DST dystonin 0.0112075
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0110616
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0109533
GNL3 guanine nucleotide binding protein-like 3 (nucleolar) 0.0108862
MBNL1 muscleblind-like splicing regulator 1 0.0107896
CALR calreticulin 0.0107857
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0107843
IARS1 isoleucyl-tRNA synthetase 1 0.0107236
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0106512
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.010605

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.295264
MT2A metallothionein 2A -0.265639
FN1 fibronectin 1 -0.157879
COL1A1 collagen, type I, alpha 1 -0.140504
TMSB10 thymosin beta 10 -0.109509
FTL ferritin, light polypeptide -0.0729011
CD44 CD44 molecule (Indian blood group) -0.0673868
VIM vimentin -0.0670971
RPL35A ribosomal protein L35a -0.0664108
MT1X metallothionein 1X -0.0541421
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0514751
COL6A3 collagen, type VI, alpha 3 -0.0484669
RPS19 ribosomal protein S19 -0.0458006
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0452881
TPM4 tropomyosin 4 -0.0438276
EXT1 exostosin glycosyltransferase 1 -0.0435417
LOC112694756 uncharaterized LOC112694756 -0.0417535
TRIO trio Rho guanine nucleotide exchange factor -0.0411775
PKM pyruvate kinase, muscle -0.0373122
COL5A1 collagen, type V, alpha 1 -0.0367239
RPLP1 ribosomal protein, large, P1 -0.0363545
LTBP1 latent transforming growth factor beta binding protein 1 -0.0361846
SMAD3 SMAD family member 3 -0.0358598
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0356347
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0355652
S100A9 S100 calcium binding protein A9 -0.035409
RPL19 ribosomal protein L19 -0.0344524
ECE1 endothelin converting enzyme 1 -0.0337756
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0332999
ACTG1 actin gamma 1 -0.0314596
RPL28 ribosomal protein L28 -0.0313448
CSF1 colony stimulating factor 1 (macrophage) -0.0313339
IER3 immediate early response 3 -0.0301066
ZBTB20 zinc finger and BTB domain containing 20 -0.0300086
RPL8 ribosomal protein L8 -0.0293418
RPS8 ribosomal protein S8 -0.0291339
HLA-B major histocompatibility complex, class I, B -0.0283604
TAPBP TAP binding protein (tapasin) -0.0273383
RUNX1 runt-related transcription factor 1 -0.026674
FTH1 ferritin, heavy polypeptide 1 -0.0266305
RPS20 ribosomal protein S20 -0.0265652
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0261138
AHNAK AHNAK nucleoprotein -0.0260094
RPLP2 ribosomal protein, large, P2 -0.0256546
RPS15 ribosomal protein S15 -0.0254689
RPL32 ribosomal protein L32 -0.0253765
S100A10 S100 calcium binding protein A10 -0.0252463
CYB5R3 cytochrome b5 reductase 3 -0.0251631
DLG1 discs, large homolog 1 (Drosophila) -0.0250028
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0235672
MTSS1 metastasis suppressor 1 -0.0231431
LOXL2 lysyl oxidase-like 2 -0.0223794
PXDN peroxidasin -0.0223617
ICAM1 intercellular adhesion molecule 1 -0.0223209
TRPS1 trichorhinophalangeal syndrome I -0.0223017
PRELID2 PRELI domain containing 2 -0.022288
GLIS3 GLIS family zinc finger 3 -0.021959
RPS14 ribosomal protein S14 -0.0212592
RPL23 ribosomal protein L23 -0.0212404
RPS23 ribosomal protein S23 -0.0212387
EGR1 early growth response 1 -0.0211844
RPL12 ribosomal protein L12 -0.0211396
FNDC3B fibronectin type III domain containing 3B -0.0210891
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0210887
MYO10 myosin X -0.021043
RPS5 ribosomal protein S5 -0.0206979
RPL34 ribosomal protein L34 -0.0206195
ALCAM activated leukocyte cell adhesion molecule -0.0206024
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0205302
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0204426
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0203932
RPS16 ribosomal protein S16 -0.0203239
RPS21 ribosomal protein S21 -0.0202327
RPL36 ribosomal protein L36 -0.0197078
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0197026
BHLHE40 basic helix-loop-helix family, member e40 -0.0195994
WWTR1 WW domain containing transcription regulator 1 -0.0195317
RPS11 ribosomal protein S11 -0.0193899
PTMA prothymosin, alpha -0.0193442
COL1A2 collagen, type I, alpha 2 -0.0192835
PLEC plectin -0.0192727
MAP4 microtubule-associated protein 4 -0.0192436
ADAM12 ADAM metallopeptidase domain 12 -0.0191032
PFN1 profilin 1 -0.0190262
MAML2 mastermind-like 2 (Drosophila) -0.0189278
TPM1 tropomyosin 1 (alpha) -0.0188412
ZBTB38 zinc finger and BTB domain containing 38 -0.0186231
MYH9 myosin, heavy chain 9, non-muscle -0.0185345
RPL5 ribosomal protein L5 -0.0185311
ANXA2 annexin A2 -0.0183939
RPS13 ribosomal protein S13 -0.018299
SH3PXD2B SH3 and PX domains 2B -0.0182542
HMGA2 high mobility group AT-hook 2 -0.0181685
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.018159
MYO9B myosin IXB -0.0180953
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.018032
IFITM3 interferon induced transmembrane protein 3 -0.017422
YBX1 Y box binding protein 1 -0.0173308
F3 coagulation factor III (thromboplastin, tissue factor) -0.0170806
ANTXR2 anthrax toxin receptor 2 -0.0170211