Triclosan_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.100373
PDE4D phosphodiesterase 4D, cAMP-specific 0.0897656
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0679548
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0605146
MTSS1 metastasis suppressor 1 0.0570439
MEF2A myocyte enhancer factor 2A 0.0567339
ANXA1 annexin A1 0.0485243
TGM2 transglutaminase 2 0.0477601
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0452955
ENO1 enolase 1, (alpha) 0.0444982
SAMD9 sterile alpha motif domain containing 9 0.0365943
IFI44L interferon-induced protein 44-like 0.0344714
KLF5 Kruppel-like factor 5 (intestinal) 0.0339158
GBP2 guanylate binding protein 2, interferon-inducible 0.0334975
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0310492
ASPH aspartate beta-hydroxylase 0.030587
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0303852
TPM3 tropomyosin 3 0.0299295
DIAPH1 diaphanous-related formin 1 0.0293232
FNDC3B fibronectin type III domain containing 3B 0.0292371
DSPP dentin sialophosphoprotein 0.0291177
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0290036
CLU clusterin 0.0289862
SOD2 superoxide dismutase 2, mitochondrial 0.0278348
UBA6 ubiquitin-like modifier activating enzyme 6 0.0273605
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0271094
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0266853
APLP2 amyloid beta (A4) precursor-like protein 2 0.0264601
HLA-E major histocompatibility complex, class I, E 0.0263137
FAM13A family with sequence similarity 13, member A 0.0262968
PCDH1 protocadherin 1 0.0262898
MSN moesin 0.0258478
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0256126
ZSWIM6 zinc finger, SWIM-type containing 6 0.025087
PSD3 pleckstrin and Sec7 domain containing 3 0.0249792
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.024506
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0244537
KDM2A lysine (K)-specific demethylase 2A 0.0241041
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0231022
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0229888
MATR3 matrin 3 0.0227457
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0223676
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0223211
LRP1B low density lipoprotein receptor-related protein 1B 0.0218343
HSPH1 heat shock 105kDa/110kDa protein 1 0.0216882
SLK STE20-like kinase 0.0215999
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0214268
EXT1 exostosin glycosyltransferase 1 0.0213316
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0211428
SIK3 SIK family kinase 3 0.0208814
SET SET nuclear proto-oncogene 0.0206425
IFI44 interferon-induced protein 44 0.0206326
EFNA5 ephrin-A5 0.0204457
IFITM1 interferon induced transmembrane protein 1 0.0201322
GMDS GDP-mannose 4,6-dehydratase 0.0195141
IPO7 importin 7 0.0194209
UBC ubiquitin C 0.0194021
PEAK1 pseudopodium-enriched atypical kinase 1 0.0193077
SNX3 sorting nexin 3 0.0191168
RND3 Rho family GTPase 3 0.0191078
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0190899
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0190642
SESTD1 SEC14 and spectrin domains 1 0.0189027
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187582
MED13L mediator complex subunit 13-like 0.018629
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0185946
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0182361
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0181639
EXOC4 exocyst complex component 4 0.0181322
VEGFA vascular endothelial growth factor A 0.018062
LRRC8C leucine rich repeat containing 8 family, member C 0.0180217
AKAP12 A kinase (PRKA) anchor protein 12 0.0179208
BZW1 basic leucine zipper and W2 domains 1 0.0178699
SKAP2 src kinase associated phosphoprotein 2 0.0178408
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0177779
IFI6 interferon, alpha-inducible protein 6 0.0176691
CSNK1A1 casein kinase 1, alpha 1 0.0175883
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0175658
INTS6 integrator complex subunit 6 0.0172139
MBNL2 muscleblind-like splicing regulator 2 0.0169202
ATAD2 ATPase family, AAA domain containing 2 0.0168458
NRDC nardilysin convertase 0.0167824
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0167812
ERRFI1 ERBB receptor feedback inhibitor 1 0.0167771
RPL3 ribosomal protein L3 0.0167335
BTBD9 BTB (POZ) domain containing 9 0.0165332
ECPAS Ecm29 proteasome adaptor and scaffold 0.0165236
TMOD3 tropomodulin 3 (ubiquitous) 0.0164515
FNIP1 folliculin interacting protein 1 0.0162601
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0161021
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0160735
KCTD12 potassium channel tetramerization domain containing 12 0.0159647
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group) 0.0159577
RSAD2 radical S-adenosyl methionine domain containing 2 0.0158924
AHR aryl hydrocarbon receptor 0.0156447
DPY19L1 dpy-19-like 1 (C. elegans) 0.015588
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0155863
MAML3 mastermind-like 3 (Drosophila) 0.0153649
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0153551
RPL21 ribosomal protein L21 0.0152542

decreased expression

Symbol Name Standardized Value
FLNB filamin B, beta -0.257021
NDRG1 N-myc downstream regulated 1 -0.17404
RBM39 RNA binding motif protein 39 -0.105489
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.10197
TMSB10 thymosin beta 10 -0.0986351
AHNAK AHNAK nucleoprotein -0.0965656
FOXO1 forkhead box O1 -0.088308
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0878863
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0852552
LOC112694756 uncharaterized LOC112694756 -0.0814492
BCL2L1 BCL2-like 1 -0.0770998
IGF2 insulin-like growth factor 2 -0.0694345
SULF1 sulfatase 1 -0.0641522
PTMA prothymosin, alpha -0.0630069
ANKRD33B ankyrin repeat domain 33B -0.0616561
GNAS GNAS complex locus -0.0600807
H1-0 H1.0 linker histone -0.0574537
LMNA lamin A/C -0.0574011
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0572459
PLEC plectin -0.0571458
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0565894
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0550132
ACTN4 actinin, alpha 4 -0.0539361
NRG1 neuregulin 1 -0.0538853
TRIO trio Rho guanine nucleotide exchange factor -0.0530225
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0523284
NEK7 NIMA-related kinase 7 -0.0523066
OSMR oncostatin M receptor -0.0515957
LAMA5 laminin, alpha 5 -0.0514909
NCOA3 nuclear receptor coactivator 3 -0.0481855
PALLD palladin, cytoskeletal associated protein -0.0470263
VCL vinculin -0.0466804
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0454143
FSCN1 fascin actin-bundling protein 1 -0.0452535
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) -0.044086
ITCH itchy E3 ubiquitin protein ligase -0.0439135
S100A10 S100 calcium binding protein A10 -0.0432656
BMAL2 basic helix-loop-helix ARNT like 2 -0.0431981
ANLN anillin, actin binding protein -0.0431976
CANX calnexin -0.0428903
HSPG2 heparan sulfate proteoglycan 2 -0.0426446
EFHD2 EF-hand domain family, member D2 -0.0421825
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0419916
AOPEP aminopeptidase O (putative) -0.0414431
PGK1 phosphoglycerate kinase 1 -0.0408487
ITSN1 intersectin 1 (SH3 domain protein) -0.0405389
ANXA2 annexin A2 -0.0404882
SEC31A SEC31 homolog A (S. cerevisiae) -0.0403336
DLG1 discs, large homolog 1 (Drosophila) -0.0396839
SLC45A4 solute carrier family 45, member 4 -0.0390795
S100A2 S100 calcium binding protein A2 -0.0382382
DUSP6 dual specificity phosphatase 6 -0.0374867
NAV2 neuron navigator 2 -0.0372862
COPA coatomer protein complex, subunit alpha -0.0372017
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0369981
DOCK5 dedicator of cytokinesis 5 -0.0368476
GARS1 glycyl-tRNA synthetase 1 -0.0368034
CAVIN1 caveolae associated protein 1 -0.0363569
WASF2 WAS protein family, member 2 -0.0351759
NAMPT nicotinamide phosphoribosyltransferase -0.0349703
MARCHF6 membrane associated ring-CH-type finger 6 -0.0348497
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0344896
MYO10 myosin X -0.0344481
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0338463
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0335663
HM13 histocompatibility (minor) 13 -0.0334381
RAB6A RAB6A, member RAS oncogene family -0.0332737
EMP1 epithelial membrane protein 1 -0.0331083
MYH9 myosin, heavy chain 9, non-muscle -0.0330588
RPS21 ribosomal protein S21 -0.0328787
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0327445
CD99 CD99 molecule -0.0325666
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0324009
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0322257
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0321874
NPEPPS aminopeptidase puromycin sensitive -0.0320924
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0317765
LMAN1 lectin, mannose-binding, 1 -0.0316733
BLCAP bladder cancer associated protein -0.0312584
BCAR3 breast cancer anti-estrogen resistance 3 -0.0312056
THBD thrombomodulin -0.0311961
RRBP1 ribosome binding protein 1 -0.0307467
MT1X metallothionein 1X -0.0305418
FLNA filamin A, alpha -0.0304429
CAPRIN2 caprin family member 2 -0.0304306
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0304058
ITGA6 integrin, alpha 6 -0.0303458
LOXL2 lysyl oxidase-like 2 -0.0302114
CALU calumenin -0.0301965
YBX3 Y box binding protein 3 -0.0300847
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.030057
MORF4L2 mortality factor 4 like 2 -0.0299634
RIN2 Ras and Rab interactor 2 -0.0294701
GLG1 golgi glycoprotein 1 -0.0293239
SPAG9 sperm associated antigen 9 -0.0292696
IER3 immediate early response 3 -0.0290711
CD59 CD59 molecule, complement regulatory protein -0.028793
AMOTL1 angiomotin like 1 -0.0287477
HDLBP high density lipoprotein binding protein -0.0287069
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.0285795