Triclosan_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.104812
H1-0 H1.0 linker histone 0.103621
GMDS GDP-mannose 4,6-dehydratase 0.103251
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0657349
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0639764
EMP1 epithelial membrane protein 1 0.0596031
ANLN anillin, actin binding protein 0.0592144
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0573522
CEMIP cell migration inducing protein, hyaluronan binding 0.0562911
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0552458
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0551179
IFI6 interferon, alpha-inducible protein 6 0.0529034
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0512694
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0507762
RNF213 ring finger protein 213 0.0488936
EZR ezrin 0.0487486
IFI27 interferon, alpha-inducible protein 27 0.0486055
MKI67 marker of proliferation Ki-67 0.0476796
MTUS1 microtubule associated tumor suppressor 1 0.0473446
AHR aryl hydrocarbon receptor 0.044126
ASPH aspartate beta-hydroxylase 0.0434159
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0425815
AKAP13 A kinase (PRKA) anchor protein 13 0.0424072
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0423289
MBNL1 muscleblind-like splicing regulator 1 0.0421838
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0414352
DSPP dentin sialophosphoprotein 0.0412701
ECT2 epithelial cell transforming 2 0.040852
TM4SF1 transmembrane 4 L six family member 1 0.038422
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0383951
NCEH1 neutral cholesterol ester hydrolase 1 0.0375189
CAPN8 calpain 8 0.0374887
IQGAP1 IQ motif containing GTPase activating protein 1 0.0372687
FAT1 FAT atypical cadherin 1 0.0370396
MACC1 metastasis associated in colon cancer 1 0.0369276
CD2AP CD2-associated protein 0.0365407
KRT8 keratin 8, type II 0.0363254
LMO7 LIM domain 7 0.0362969
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0359674
PLSCR1 phospholipid scramblase 1 0.0357296
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0346761
XAF1 XIAP associated factor 1 0.034503
AFDN afadin, adherens junction formation factor 0.0343783
AHNAK AHNAK nucleoprotein 0.0343285
HMGB2 high mobility group box 2 0.034108
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0339703
MX2 MX dynamin-like GTPase 2 0.033581
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0335592
PRKCA protein kinase C, alpha 0.0333213
LOC102724023 ES1 protein homolog, mitochondrial 0.0330507
LPP LIM domain containing preferred translocation partner in lipoma 0.03304
TMC5 transmembrane channel-like 5 0.0327583
LCOR ligand dependent nuclear receptor corepressor 0.0324167
CDCP1 CUB domain containing protein 1 0.0323396
FRMD5 FERM domain containing 5 0.0318622
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0308296
USP6NL USP6 N-terminal like 0.0307991
FLNB filamin B, beta 0.0295673
ANXA2 annexin A2 0.0283674
TCF12 transcription factor 12 0.0282167
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0281905
RAD21 RAD21 homolog (S. pombe) 0.0281244
ENO1 enolase 1, (alpha) 0.028124
UBB ubiquitin B 0.0281046
DIAPH3 diaphanous-related formin 3 0.0274828
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0274502
SP100 SP100 nuclear antigen 0.027399
SEPTIN9 septin 9 0.0272881
MTAP methylthioadenosine phosphorylase 0.0270272
LAMA4 laminin, alpha 4 0.0269797
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0266153
ETV6 ets variant 6 0.0265841
CSNK1A1 casein kinase 1, alpha 1 0.026541
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.026323
RSRC1 arginine/serine-rich coiled-coil 1 0.0261971
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 0.0261686
WWOX WW domain containing oxidoreductase 0.0259576
XRN1 5'-3' exoribonuclease 1 0.0259502
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0258794
SAMHD1 SAM domain and HD domain 1 0.025599
BZW1 basic leucine zipper and W2 domains 1 0.0255544
MYO5B myosin VB 0.0252831
CENPF centromere protein F, 350/400kDa 0.02518
SHROOM3 shroom family member 3 0.0251021
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.025071
NPEPPS aminopeptidase puromycin sensitive 0.0247847
ATAD2 ATPase family, AAA domain containing 2 0.0247463
MECOM MDS1 and EVI1 complex locus 0.0246621
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.024541
RIGI RNA sensor RIG-I 0.0240703
NF1 neurofibromin 1 0.0239439
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0239281
KLF5 Kruppel-like factor 5 (intestinal) 0.0238179
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0237942
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0237204
ZC3H12B zinc finger CCCH-type containing 12B 0.0233678
TPR translocated promoter region, nuclear basket protein 0.0232421
MSI2 musashi RNA-binding protein 2 0.0231975
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0231569
EHBP1 EH domain binding protein 1 0.0227823

decreased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 -0.21127
NPSR1 neuropeptide S receptor 1 -0.161872
TMSB10 thymosin beta 10 -0.149311
RPL35A ribosomal protein L35a -0.141032
MAML2 mastermind-like 2 (Drosophila) -0.125396
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116342
TPT1 tumor protein, translationally-controlled 1 -0.0983116
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0937621
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0879389
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0841567
RPS6 ribosomal protein S6 -0.0832695
FTH1 ferritin, heavy polypeptide 1 -0.080167
PTMA prothymosin, alpha -0.0788237
RPL23 ribosomal protein L23 -0.0761065
FTL ferritin, light polypeptide -0.0745327
VEGFA vascular endothelial growth factor A -0.0729027
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0682077
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0644325
S100A6 S100 calcium binding protein A6 -0.0552856
GARS1 glycyl-tRNA synthetase 1 -0.0551719
GOLGA4 golgin A4 -0.0548676
RPS25 ribosomal protein S25 -0.0539373
WDR45B WD repeat domain 45B -0.0538134
NDRG1 N-myc downstream regulated 1 -0.0525683
RPS19 ribosomal protein S19 -0.0506736
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0502324
LOC112694756 uncharaterized LOC112694756 -0.0482122
RPS21 ribosomal protein S21 -0.0480379
S100A9 S100 calcium binding protein A9 -0.0480342
IARS1 isoleucyl-tRNA synthetase 1 -0.0461455
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0449232
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0446606
C6ORF132 chromosome 6 open reading frame 132 -0.0442236
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0438493
AGR2 anterior gradient 2 -0.0437765
KLHL29 kelch-like family member 29 -0.0434268
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0432995
HM13 histocompatibility (minor) 13 -0.0431543
MBNL2 muscleblind-like splicing regulator 2 -0.0429379
HLA-B major histocompatibility complex, class I, B -0.0403879
RPS16 ribosomal protein S16 -0.0400164
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0399372
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0395731
TNIK TRAF2 and NCK interacting kinase -0.0392691
ATXN1 ataxin 1 -0.0382417
ITGA6 integrin, alpha 6 -0.0370615
RPLP1 ribosomal protein, large, P1 -0.0366602
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.036127
RPS5 ribosomal protein S5 -0.035948
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0358303
RPL30 ribosomal protein L30 -0.0355202
RPL8 ribosomal protein L8 -0.0353774
EIF1 eukaryotic translation initiation factor 1 -0.0351111
PGK1 phosphoglycerate kinase 1 -0.034843
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0346103
PCBP2 poly(rC) binding protein 2 -0.0344879
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0341524
TES testin LIM domain protein -0.0339717
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0334011
ITGB4 integrin, beta 4 -0.0332421
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0331999
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0329913
RPL34 ribosomal protein L34 -0.032791
RPL7A ribosomal protein L7a -0.0327756
TTC3 tetratricopeptide repeat domain 3 -0.0326715
SLC38A1 solute carrier family 38, member 1 -0.0324175
RPS10 ribosomal protein S10 -0.0323852
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.032281
EIF4A2 eukaryotic translation initiation factor 4A2 -0.032096
BTG1 B-cell translocation gene 1, anti-proliferative -0.0313982
RPL5 ribosomal protein L5 -0.0313322
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0311225
SETD5 SET domain containing 5 -0.0311052
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -0.0310601
KRT7 keratin 7, type II -0.0300042
NUPR1 nuclear protein, transcriptional regulator, 1 -0.0295717
FBXO11 F-box protein 11 -0.0293917
RPS8 ribosomal protein S8 -0.0291658
PFN1 profilin 1 -0.0291371
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0289049
SLC38A2 solute carrier family 38, member 2 -0.0288225
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0287619
DLC1 DLC1 Rho GTPase activating protein -0.0282568
PKM pyruvate kinase, muscle -0.028165
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.028152
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0278516
RPS11 ribosomal protein S11 -0.027674
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0274822
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0271853
AKAP9 A kinase (PRKA) anchor protein 9 -0.0271154
MUC1 mucin 1, cell surface associated -0.0268853
RPL19 ribosomal protein L19 -0.0267423
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0266133
S100A11 S100 calcium binding protein A11 -0.0265419
RPS29 ribosomal protein S29 -0.026461
ACTG1 actin gamma 1 -0.026359
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0263199
SREBF2 sterol regulatory element binding transcription factor 2 -0.0258771
USP34 ubiquitin specific peptidase 34 -0.0257966
CCNL1 cyclin L1 -0.0257545