Triclosan_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.0687676
PSD3 pleckstrin and Sec7 domain containing 3 0.0468278
FN1 fibronectin 1 0.0357151
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0331394
ASPH aspartate beta-hydroxylase 0.0318498
HMGA2 high mobility group AT-hook 2 0.0317251
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0292805
SAMD9 sterile alpha motif domain containing 9 0.0289406
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0282807
NTN4 netrin 4 0.0274486
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0270132
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0259966
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0258952
FAM20C family with sequence similarity 20, member C 0.025748
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0246257
EXT1 exostosin glycosyltransferase 1 0.0237997
PRELID2 PRELI domain containing 2 0.0231924
ARHGAP5 Rho GTPase activating protein 5 0.0225633
LOX lysyl oxidase 0.0222739
ALCAM activated leukocyte cell adhesion molecule 0.0206945
STAT1 signal transducer and activator of transcription 1, 91kDa 0.020636
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0201143
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0200855
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0195744
RIMS2 regulating synaptic membrane exocytosis 2 0.0193513
NAV2 neuron navigator 2 0.0190365
ZSWIM6 zinc finger, SWIM-type containing 6 0.0189263
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 0.0188457
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0186025
AADAC arylacetamide deacetylase 0.018485
INTS6 integrator complex subunit 6 0.0180257
SYT1 synaptotagmin I 0.017979
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0168976
ENO1 enolase 1, (alpha) 0.0163206
LOXL2 lysyl oxidase-like 2 0.0161261
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0160823
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0158438
JUN jun proto-oncogene 0.0152544
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.015021
ERRFI1 ERBB receptor feedback inhibitor 1 0.0149731
BZW1 basic leucine zipper and W2 domains 1 0.0149203
WWOX WW domain containing oxidoreductase 0.0149006
MAST4 microtubule associated serine/threonine kinase family member 4 0.0148469
RASAL2 RAS protein activator like 2 0.0147333
DST dystonin 0.0147162
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0145519
PALM2AKAP2 PALM2 and AKAP2 fusion 0.014447
MLPH melanophilin 0.0144016
STK38L serine/threonine kinase 38 like 0.0143358
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.014328
RIGI RNA sensor RIG-I 0.0142389
WWTR1 WW domain containing transcription regulator 1 0.0141282
FLRT2 fibronectin leucine rich transmembrane protein 2 0.0139248
ARHGAP22 Rho GTPase activating protein 22 0.0137409
GLS2 glutaminase 2 (liver, mitochondrial) 0.0137189
ANKRD36 ankyrin repeat domain 36 0.0131322
PEAK1 pseudopodium-enriched atypical kinase 1 0.0130621
ANXA2 annexin A2 0.0128796
THBS1 thrombospondin 1 0.0128551
ZNF804A zinc finger protein 804A 0.0128117
IFI44L interferon-induced protein 44-like 0.0127192
AHNAK2 AHNAK nucleoprotein 2 0.0126146
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0123862
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0120064
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0119273
UTRN utrophin 0.0118575
GPR39 G protein-coupled receptor 39 0.0118054
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0117666
PHF3 PHD finger protein 3 0.0116835
EREG epiregulin 0.0113716
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0113064
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0112997
FBN1 fibrillin 1 0.0112199
ZNF185 zinc finger protein 185 (LIM domain) 0.0109789
SLIT2 slit homolog 2 (Drosophila) 0.0109431
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.010923
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0107679
SAMD4A sterile alpha motif domain containing 4A 0.010674
FNIP2 folliculin interacting protein 2 0.0106415
TPST1 tyrosylprotein sulfotransferase 1 0.0106372
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0106271
AUTS2 autism susceptibility candidate 2 0.0104713
TMOD1 tropomodulin 1 0.0104461
CCSER1 coiled-coil serine-rich protein 1 0.0104045
CD44 CD44 molecule (Indian blood group) 0.0102374
MACF1 microtubule-actin crosslinking factor 1 0.0102329
FAM13A family with sequence similarity 13, member A 0.0102096
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0101367
TUT7 terminal uridylyl transferase 7 0.00999295
EFCAB13 EF-hand calcium binding domain 13 0.00998932
BBS9 Bardet-Biedl syndrome 9 0.00997019
ANO6 anoctamin 6 0.00996854
ITSN2 intersectin 2 0.00979899
AFDN afadin, adherens junction formation factor 0.00975115
ANXA1 annexin A1 0.00974137
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.00969576
KLF5 Kruppel-like factor 5 (intestinal) 0.0096345
ANGPTL4 angiopoietin-like 4 0.00962879
CORO1C coronin, actin binding protein, 1C 0.00962127
CAPRIN2 caprin family member 2 0.00952872

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.192687
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162795
VIM vimentin -0.131399
NAMPT nicotinamide phosphoribosyltransferase -0.112644
IGFBP3 insulin-like growth factor binding protein 3 -0.110601
PDE4D phosphodiesterase 4D, cAMP-specific -0.0862336
FNDC3B fibronectin type III domain containing 3B -0.0775366
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0762672
FTH1 ferritin, heavy polypeptide 1 -0.0735387
SDK1 sidekick cell adhesion molecule 1 -0.0720507
FTL ferritin, light polypeptide -0.0701118
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0700752
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0700493
USP34 ubiquitin specific peptidase 34 -0.065181
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0628255
NRG1 neuregulin 1 -0.060294
ZMYND8 zinc finger, MYND-type containing 8 -0.0595556
PTMA prothymosin, alpha -0.0592704
DPYD dihydropyrimidine dehydrogenase -0.0590454
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0580075
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0574658
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0566294
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0558947
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0551893
RPL35A ribosomal protein L35a -0.0550285
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0546597
KDM2A lysine (K)-specific demethylase 2A -0.0541003
TFPI2 tissue factor pathway inhibitor 2 -0.0515306
RPLP1 ribosomal protein, large, P1 -0.050825
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0498062
S100A6 S100 calcium binding protein A6 -0.0488746
TMEM165 transmembrane protein 165 -0.0481297
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0456141
BASP1 brain abundant, membrane attached signal protein 1 -0.0451429
OSMR oncostatin M receptor -0.0450123
GPC6 glypican 6 -0.0445882
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0444635
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0439776
NRP1 neuropilin 1 -0.0437596
RPS19 ribosomal protein S19 -0.0420326
SETD5 SET domain containing 5 -0.0411337
ETV6 ets variant 6 -0.0399575
AKAP13 A kinase (PRKA) anchor protein 13 -0.0392277
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0392016
LMAN1 lectin, mannose-binding, 1 -0.0388803
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0386471
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0380302
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0379127
ATG7 autophagy related 7 -0.0371673
RPS21 ribosomal protein S21 -0.0360923
C15ORF48 chromosome 15 open reading frame 48 -0.0360066
KYNU kynureninase -0.0359585
EFNA5 ephrin-A5 -0.0359084
ITCH itchy E3 ubiquitin protein ligase -0.03583
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.035772
GOLGA4 golgin A4 -0.035546
SREBF2 sterol regulatory element binding transcription factor 2 -0.0350807
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0349302
VEGFA vascular endothelial growth factor A -0.0348344
WSB1 WD repeat and SOCS box containing 1 -0.0347903
CDH2 cadherin 2, type 1, N-cadherin (neuronal) -0.0347874
FRMD4A FERM domain containing 4A -0.0343628
RPL36 ribosomal protein L36 -0.034238
MTSS1 metastasis suppressor 1 -0.0341898
VRK2 vaccinia related kinase 2 -0.0341789
RBM39 RNA binding motif protein 39 -0.0341589
EIF1 eukaryotic translation initiation factor 1 -0.0338879
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0338822
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0337143
RAP1B RAP1B, member of RAS oncogene family -0.0331689
RAB1A RAB1A, member RAS oncogene family -0.0329645
CDH13 cadherin 13 -0.0329639
PCBP2 poly(rC) binding protein 2 -0.0326373
PID1 phosphotyrosine interaction domain containing 1 -0.0322425
NUMB numb homolog (Drosophila) -0.0319268
EGR1 early growth response 1 -0.0318419
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0317262
STC1 stanniocalcin 1 -0.0317069
PTK2 protein tyrosine kinase 2 -0.0315545
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0313899
MRPS6 mitochondrial ribosomal protein S6 -0.0313423
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0304741
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0303938
PDIA3 protein disulfide isomerase family A, member 3 -0.0303056
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0302585
MEF2A myocyte enhancer factor 2A -0.0300569
HMGA1 high mobility group AT-hook 1 -0.0296433
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0291613
ZBTB20 zinc finger and BTB domain containing 20 -0.0290986
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.028964
WASF2 WAS protein family, member 2 -0.0289375
RPLP2 ribosomal protein, large, P2 -0.0288321
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0285842
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0284059
TGM2 transglutaminase 2 -0.0282978
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0281876
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0281654
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0276332
ADAM28 ADAM metallopeptidase domain 28 -0.0273622
RPL28 ribosomal protein L28 -0.0271193