Triclosan_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.22495
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0911491
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.081206
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0806751
NAMPT nicotinamide phosphoribosyltransferase 0.0682107
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0551282
HMGB2 high mobility group box 2 0.046439
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0419543
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0399964
BRD2 bromodomain containing 2 0.0375845
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0367637
FAM13A family with sequence similarity 13, member A 0.0366259
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0330873
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0324558
HSPA8 heat shock 70kDa protein 8 0.0314583
RPS3 ribosomal protein S3 0.031013
RPS12 ribosomal protein S12 0.0273984
CENPF centromere protein F, 350/400kDa 0.0272087
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0270459
SET SET nuclear proto-oncogene 0.0267959
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0266718
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0262846
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0262574
RPS2 ribosomal protein S2 0.0262465
NAP1L1 nucleosome assembly protein 1-like 1 0.0231191
GOLGA4 golgin A4 0.022242
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.021994
MATR3 matrin 3 0.0219862
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0210406
TMF1 TATA element modulatory factor 1 0.0207468
ANXA5 annexin A5 0.0199338
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0195267
KDM6A lysine (K)-specific demethylase 6A 0.0189261
DDIT4 DNA-damage-inducible transcript 4 0.0183919
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0179886
BZW1 basic leucine zipper and W2 domains 1 0.0179207
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0174875
IFRD1 interferon-related developmental regulator 1 0.0174464
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0173649
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0171755
DIAPH1 diaphanous-related formin 1 0.0171098
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 0.0166652
CENPE centromere protein E, 312kDa 0.0165479
RLF rearranged L-myc fusion 0.0165474
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0163048
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0163001
CKAP5 cytoskeleton associated protein 5 0.016232
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0160097
NEK2 NIMA-related kinase 2 0.0159501
SPAG9 sperm associated antigen 9 0.0158812
RAD21 RAD21 homolog (S. pombe) 0.0158295
CCNL1 cyclin L1 0.0157182
ECT2 epithelial cell transforming 2 0.0155277
RPL14 ribosomal protein L14 0.0154675
BCLAF1 BCL2-associated transcription factor 1 0.015219
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0148097
APLP2 amyloid beta (A4) precursor-like protein 2 0.0147206
SUCO SUN domain containing ossification factor 0.014519
TOP2B topoisomerase (DNA) II beta 180kDa 0.0143176
RPS6 ribosomal protein S6 0.0142683
HILPDA hypoxia inducible lipid droplet-associated 0.0141844
MIER1 mesoderm induction early response 1, transcriptional regulator 0.0141238
NCKAP1 NCK-associated protein 1 0.014097
RNF145 ring finger protein 145 0.0138884
RB1CC1 RB1-inducible coiled-coil 1 0.0138245
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0137647
DSPP dentin sialophosphoprotein 0.01361
ATF3 activating transcription factor 3 0.0134563
IRS2 insulin receptor substrate 2 0.013162
NFE2L1 nuclear factor, erythroid 2-like 1 0.0131529
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0130078
IVNS1ABP influenza virus NS1A binding protein 0.0128252
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0127166
SKP1 S-phase kinase-associated protein 1 0.0126779
STK17B serine/threonine kinase 17b 0.0126528
C6ORF62 chromosome 6 open reading frame 62 0.0124569
PRRC2C proline-rich coiled-coil 2C 0.0124025
CHD1 chromodomain helicase DNA binding protein 1 0.0123624
ANLN anillin, actin binding protein 0.0123571
CRY1 cryptochrome circadian clock 1 0.0122468
KTN1 kinectin 1 (kinesin receptor) 0.0122265
MLF1 myeloid leukemia factor 1 0.0122096
RYBP RING1 and YY1 binding protein 0.0122024
NASP nuclear autoantigenic sperm protein (histone-binding) 0.0121716
SFPQ splicing factor proline/glutamine-rich 0.0121329
RPL7 ribosomal protein L7 0.0121272
CDK1 cyclin-dependent kinase 1 0.0121237
HP1BP3 heterochromatin protein 1, binding protein 3 0.0120822
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0120802
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0118932
MSMO1 methylsterol monooxygenase 1 0.0118674
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0117785
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0116561
SMC4 structural maintenance of chromosomes 4 0.0116191
RPS7 ribosomal protein S7 0.0116137
ADM adrenomedullin 0.0114559
EEF2 eukaryotic translation elongation factor 2 0.0113501
CCDC47 coiled-coil domain containing 47 0.0113428
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0113159
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0113142

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.225659
TMSB10 thymosin beta 10 -0.216701
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.167492
PTMA prothymosin, alpha -0.14225
ACTG1 actin gamma 1 -0.12809
LPP LIM domain containing preferred translocation partner in lipoma -0.11976
FTL ferritin, light polypeptide -0.114576
RPL35A ribosomal protein L35a -0.103657
KRT7 keratin 7, type II -0.101007
EXT1 exostosin glycosyltransferase 1 -0.0934253
FN1 fibronectin 1 -0.0901148
IFI27 interferon, alpha-inducible protein 27 -0.0884076
FBXO32 F-box protein 32 -0.0851273
S100A6 S100 calcium binding protein A6 -0.0790533
MYO6 myosin VI -0.0751703
POTEF POTE ankyrin domain family, member F -0.0732459
GNAS GNAS complex locus -0.0701623
S100A10 S100 calcium binding protein A10 -0.0693741
TPM4 tropomyosin 4 -0.068991
UBC ubiquitin C -0.0684012
CCND1 cyclin D1 -0.0659891
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.065772
UBE2H ubiquitin-conjugating enzyme E2H -0.0652929
ERBIN erbb2 interacting protein -0.0642419
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0637909
AHNAK AHNAK nucleoprotein -0.058805
HSPB1 heat shock 27kDa protein 1 -0.0581086
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0577889
TRIO trio Rho guanine nucleotide exchange factor -0.0566446
RPL8 ribosomal protein L8 -0.0554534
LIMCH1 LIM and calponin homology domains 1 -0.0551362
HLA-B major histocompatibility complex, class I, B -0.0548741
FNDC3B fibronectin type III domain containing 3B -0.0545679
MDK midkine (neurite growth-promoting factor 2) -0.053767
WSB1 WD repeat and SOCS box containing 1 -0.0536111
PKM pyruvate kinase, muscle -0.0518749
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0515078
RPLP1 ribosomal protein, large, P1 -0.0508858
IFI6 interferon, alpha-inducible protein 6 -0.0506421
CSTB cystatin B (stefin B) -0.0504087
KRT8 keratin 8, type II -0.0500789
RPS23 ribosomal protein S23 -0.0493338
SOX4 SRY (sex determining region Y)-box 4 -0.0486582
HMGA1 high mobility group AT-hook 1 -0.0483925
MAP1B microtubule-associated protein 1B -0.0474946
FTH1 ferritin, heavy polypeptide 1 -0.0471418
F3 coagulation factor III (thromboplastin, tissue factor) -0.0469607
NPEPPS aminopeptidase puromycin sensitive -0.0467795
LOC112694756 uncharaterized LOC112694756 -0.0465125
KRT18 keratin 18, type I -0.0462145
PDLIM5 PDZ and LIM domain 5 -0.0461146
IFI16 interferon, gamma-inducible protein 16 -0.0460876
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0449472
LDHA lactate dehydrogenase A -0.044906
PGK1 phosphoglycerate kinase 1 -0.0447664
FAM3C family with sequence similarity 3, member C -0.0443939
LAMB3 laminin, beta 3 -0.0436106
LY6E lymphocyte antigen 6 complex, locus E -0.043387
IFITM3 interferon induced transmembrane protein 3 -0.0428961
PLEC plectin -0.042297
LMO7 LIM domain 7 -0.0421179
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0417012
ISG15 ISG15 ubiquitin-like modifier -0.0412114
IGFBP3 insulin-like growth factor binding protein 3 -0.0409757
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0409658
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0403054
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0402804
WASF2 WAS protein family, member 2 -0.0402501
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0399498
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0399168
CD2AP CD2-associated protein -0.0395251
LMNA lamin A/C -0.0390259
HLA-A major histocompatibility complex, class I, A -0.0389758
VEGFA vascular endothelial growth factor A -0.0387255
TMEM165 transmembrane protein 165 -0.0385546
GRB10 growth factor receptor-bound protein 10 -0.0384182
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0381136
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0379102
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0378203
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0376758
TMEM123 transmembrane protein 123 -0.0374361
KRT19 keratin 19, type I -0.0374102
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0371726
ITCH itchy E3 ubiquitin protein ligase -0.0369079
S100A9 S100 calcium binding protein A9 -0.0367607
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0355158
FBXO34 F-box protein 34 -0.0351239
DSG2 desmoglein 2 -0.0350523
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0348971
RPL34 ribosomal protein L34 -0.0347809
RASAL2 RAS protein activator like 2 -0.0347211
RRBP1 ribosome binding protein 1 -0.0344873
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0344425
BASP1 brain abundant, membrane attached signal protein 1 -0.0344153
RAB7A RAB7A, member RAS oncogene family -0.0341198
EPCAM epithelial cell adhesion molecule -0.0331463
TM4SF1 transmembrane 4 L six family member 1 -0.032804
TPT1 tumor protein, translationally-controlled 1 -0.0327201
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.032506
KDM5B lysine (K)-specific demethylase 5B -0.0323297