Triclosan_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.113923
RPS12 ribosomal protein S12 0.073655
PM20D1 peptidase M20 domain containing 1 0.0579009
RPS3 ribosomal protein S3 0.0550306
VCL vinculin 0.0501262
RPS6 ribosomal protein S6 0.0469804
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0462339
RPL26 ribosomal protein L26 0.045868
RPL9 ribosomal protein L9 0.042555
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0407607
ZSWIM6 zinc finger, SWIM-type containing 6 0.0375854
KYNU kynureninase 0.0373336
SMOC1 SPARC related modular calcium binding 1 0.036831
INTS6 integrator complex subunit 6 0.0363682
TPT1 tumor protein, translationally-controlled 1 0.0357644
DST dystonin 0.0355412
MT2A metallothionein 2A 0.0349958
CENPF centromere protein F, 350/400kDa 0.0319247
RPL37A ribosomal protein L37a 0.0316386
SH3KBP1 SH3-domain kinase binding protein 1 0.0260794
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0255358
RPL11 ribosomal protein L11 0.024903
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0246279
PSD3 pleckstrin and Sec7 domain containing 3 0.0244741
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0234073
PRELID2 PRELI domain containing 2 0.0216269
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0212224
PDLIM5 PDZ and LIM domain 5 0.0211432
RPS2 ribosomal protein S2 0.0210242
RACK1 receptor for activated C kinase 1 0.0206184
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0199565
EXT1 exostosin glycosyltransferase 1 0.0193579
NAP1L1 nucleosome assembly protein 1-like 1 0.0189954
RPS8 ribosomal protein S8 0.0188717
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0187095
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0185989
WWTR1 WW domain containing transcription regulator 1 0.0185106
RPL23 ribosomal protein L23 0.0184552
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0183662
SET SET nuclear proto-oncogene 0.0183161
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0181355
FBXL7 F-box and leucine-rich repeat protein 7 0.0178054
GOLGB1 golgin B1 0.017694
NRXN3 neurexin 3 0.0174273
RAD51B RAD51 paralog B 0.0173604
RPS17 ribosomal protein S17 0.017184
CHD1 chromodomain helicase DNA binding protein 1 0.0170913
RBBP6 retinoblastoma binding protein 6 0.0170849
ZMIZ1 zinc finger, MIZ-type containing 1 0.0168143
AADAC arylacetamide deacetylase 0.0167024
BZW1 basic leucine zipper and W2 domains 1 0.0164584
CTIF CBP80/20-dependent translation initiation factor 0.015584
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.0151634
GPC6 glypican 6 0.0151025
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0150014
ATP5F1E ATP synthase F1 subunit epsilon 0.0149167
ACTG1 actin gamma 1 0.0147228
KRT19 keratin 19, type I 0.0146919
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0146875
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0144732
PRKN parkin RBR E3 ubiquitin protein ligase 0.0144138
LAMB4 laminin, beta 4 0.0143581
RPL7A ribosomal protein L7a 0.0142777
IRS2 insulin receptor substrate 2 0.0141271
NTSR1 neurotensin receptor 1 (high affinity) 0.014061
ENO1 enolase 1, (alpha) 0.0138598
TUBB4B tubulin, beta 4B class IVb 0.0137592
NCAPG2 non-SMC condensin II complex, subunit G2 0.0137202
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0133912
ENO2 enolase 2 (gamma, neuronal) 0.0130888
RPL31 ribosomal protein L31 0.0130596
RPL37 ribosomal protein L37 0.0130248
TRAPPC9 trafficking protein particle complex 9 0.0126136
RPL30 ribosomal protein L30 0.0120247
ADARB1 adenosine deaminase, RNA-specific, B1 0.0117199
HSPA8 heat shock 70kDa protein 8 0.0116888
C6ORF62 chromosome 6 open reading frame 62 0.0115931
MRPS35 mitochondrial ribosomal protein S35 0.0115827
NFE2L1 nuclear factor, erythroid 2-like 1 0.0115762
DGKI diacylglycerol kinase, iota 0.0114806
POTEF POTE ankyrin domain family, member F 0.0114522
BBS9 Bardet-Biedl syndrome 9 0.0113881
MACROD2 MACRO domain containing 2 0.0113193
DUSP4 dual specificity phosphatase 4 0.0112063
TLE4 transducin-like enhancer of split 4 0.0111841
NUCB2 nucleobindin 2 0.0111409
CAVIN1 caveolae associated protein 1 0.0109561
GLCCI1 glucocorticoid induced 1 0.0108337
ALCAM activated leukocyte cell adhesion molecule 0.0107877
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0107777
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0107214
FERMT2 fermitin family member 2 0.0107093
RABGAP1L RAB GTPase activating protein 1-like 0.0106199
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0106171
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 0.0106117
SQSTM1 sequestosome 1 0.0105801
ANGPTL4 angiopoietin-like 4 0.010539
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 0.0104927
RPL21 ribosomal protein L21 0.0104919
RPS26 ribosomal protein S26 0.0104876

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.185081
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.160494
FN1 fibronectin 1 -0.136385
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0993572
TXNRD1 thioredoxin reductase 1 -0.0925287
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0912525
EFNA5 ephrin-A5 -0.0857425
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0841141
PDE4D phosphodiesterase 4D, cAMP-specific -0.0832663
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0766548
GDA guanine deaminase -0.0762206
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0742729
SMYD3 SET and MYND domain containing 3 -0.073515
NALF1 NALCN channel auxiliary factor 1 -0.0699204
ELL2 elongation factor, RNA polymerase II, 2 -0.0690236
VIM vimentin -0.0661459
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0648162
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0629444
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0628209
PDE10A phosphodiesterase 10A -0.0612388
IGFBP3 insulin-like growth factor binding protein 3 -0.0606621
TFPI2 tissue factor pathway inhibitor 2 -0.0600682
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0595584
TRIO trio Rho guanine nucleotide exchange factor -0.0594792
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0593154
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0581324
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0568537
CANX calnexin -0.056724
FTH1 ferritin, heavy polypeptide 1 -0.0565409
RTN4 reticulon 4 -0.0559241
DGKD diacylglycerol kinase, delta 130kDa -0.0544559
ESYT2 extended synaptotagmin-like protein 2 -0.0538869
SPAG9 sperm associated antigen 9 -0.0537903
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0516958
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0510914
FNDC3B fibronectin type III domain containing 3B -0.0487235
LIMCH1 LIM and calponin homology domains 1 -0.0480821
TGFBI transforming growth factor, beta-induced, 68kDa -0.0472731
RPL35A ribosomal protein L35a -0.0456702
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0449148
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0441527
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0440768
TMSB10 thymosin beta 10 -0.043932
FTL ferritin, light polypeptide -0.0432636
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0421497
S100A6 S100 calcium binding protein A6 -0.0421119
MFF mitochondrial fission factor -0.0419712
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0417173
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0413655
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0410071
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0409328
TTC28 tetratricopeptide repeat domain 28 -0.0407778
PTGR1 prostaglandin reductase 1 -0.0407172
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0403251
RPS23 ribosomal protein S23 -0.040042
TMX4 thioredoxin-related transmembrane protein 4 -0.03951
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.039482
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0384026
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0381162
PDIA3 protein disulfide isomerase family A, member 3 -0.0380816
RPLP1 ribosomal protein, large, P1 -0.0378934
COL5A2 collagen, type V, alpha 2 -0.0374176
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0371539
SOD2 superoxide dismutase 2, mitochondrial -0.0370951
USP3 ubiquitin specific peptidase 3 -0.0366449
PGK1 phosphoglycerate kinase 1 -0.0363089
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0356623
SOX4 SRY (sex determining region Y)-box 4 -0.0355926
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0353303
BIRC6 baculoviral IAP repeat containing 6 -0.0351834
NPEPPS aminopeptidase puromycin sensitive -0.035161
TBXT T-box transcription factor T -0.0350667
IL6 interleukin 6 -0.0350094
FAM13A family with sequence similarity 13, member A -0.0340946
ZEB2 zinc finger E-box binding homeobox 2 -0.0338666
TPD52 tumor protein D52 -0.0335105
HLA-B major histocompatibility complex, class I, B -0.0333803
ZBTB38 zinc finger and BTB domain containing 38 -0.0332384
MXI1 MAX interactor 1, dimerization protein -0.032864
SRPK2 SRSF protein kinase 2 -0.0325378
CTSL cathepsin L -0.0324098
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0322686
AVL9 AVL9 homolog (S. cerevisiase) -0.0316587
WDR45B WD repeat domain 45B -0.0314153
PDIA6 protein disulfide isomerase family A, member 6 -0.0311559
NBAS neuroblastoma amplified sequence -0.0311501
BCAS3 breast carcinoma amplified sequence 3 -0.0311337
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0309714
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0302492
ZMYND8 zinc finger, MYND-type containing 8 -0.03017
OGA O-GlcNAcase -0.0301557
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0300951
RBM39 RNA binding motif protein 39 -0.0299261
IGF1R insulin-like growth factor 1 receptor -0.0298301
ADGRD1 adhesion G protein-coupled receptor D1 -0.0298147
CHD1L chromodomain helicase DNA binding protein 1-like -0.0296786
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0295967
PBX1 pre-B-cell leukemia homeobox 1 -0.0290351
ABLIM1 actin binding LIM protein 1 -0.0289572
TM4SF1 transmembrane 4 L six family member 1 -0.0289526