Triclosan_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.078546
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0635889
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0630482
GOLGA4 golgin A4 0.0584538
LDHA lactate dehydrogenase A 0.0578492
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0565329
RNF145 ring finger protein 145 0.0561878
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0554255
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0545966
ZNF292 zinc finger protein 292 0.0529372
SMC3 structural maintenance of chromosomes 3 0.0432173
B2M beta-2-microglobulin 0.0396694
NAMPT nicotinamide phosphoribosyltransferase 0.0394121
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0381239
CENPF centromere protein F, 350/400kDa 0.0378522
ENO1 enolase 1, (alpha) 0.037846
RTN4 reticulon 4 0.0371822
PDIA3 protein disulfide isomerase family A, member 3 0.0371721
ZNF608 zinc finger protein 608 0.0358206
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0356426
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0344236
UBA6 ubiquitin-like modifier activating enzyme 6 0.0342467
ADAM10 ADAM metallopeptidase domain 10 0.0338762
EZR ezrin 0.033426
CCNL1 cyclin L1 0.0332784
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0327925
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0324266
RBM25 RNA binding motif protein 25 0.0322827
PLK2 polo-like kinase 2 0.0322597
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0322463
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0316427
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0312939
TXNIP thioredoxin interacting protein 0.0312874
DSTN destrin (actin depolymerizing factor) 0.0308776
TXNRD1 thioredoxin reductase 1 0.0303691
POTEF POTE ankyrin domain family, member F 0.0293851
PRELID2 PRELI domain containing 2 0.029042
GARS1 glycyl-tRNA synthetase 1 0.0288445
ZBTB20 zinc finger and BTB domain containing 20 0.0282784
UBXN4 UBX domain protein 4 0.0279817
YTHDC1 YTH domain containing 1 0.0276692
NUP58 nucleoporin 58 0.0274562
EEF2 eukaryotic translation elongation factor 2 0.0269087
SET SET nuclear proto-oncogene 0.0269086
EML4 echinoderm microtubule associated protein like 4 0.0268634
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0267804
CKAP2 cytoskeleton associated protein 2 0.0265445
TFG TRK-fused gene 0.0264584
MT2A metallothionein 2A 0.0264551
ARRDC3 arrestin domain containing 3 0.0264398
HMGA1 high mobility group AT-hook 1 0.02639
ADAM9 ADAM metallopeptidase domain 9 0.0261552
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0260113
FAM13A family with sequence similarity 13, member A 0.025732
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 0.0254489
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0254168
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0252479
PRRC2C proline-rich coiled-coil 2C 0.0252451
RPS2 ribosomal protein S2 0.0252155
COPB1 coatomer protein complex, subunit beta 1 0.0249186
KDM2A lysine (K)-specific demethylase 2A 0.024667
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0245722
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0243088
TBC1D5 TBC1 domain family, member 5 0.0242772
PFN1 profilin 1 0.024198
TOP2B topoisomerase (DNA) II beta 180kDa 0.0241256
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0241231
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0240617
ECT2 epithelial cell transforming 2 0.0239034
ARHGAP5 Rho GTPase activating protein 5 0.0237895
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0236436
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0236127
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0234068
PIWIL1 piwi-like RNA-mediated gene silencing 1 0.0233712
LNPEP leucyl/cystinyl aminopeptidase 0.0232572
TPR translocated promoter region, nuclear basket protein 0.0232418
SERBP1 SERPINE1 mRNA binding protein 1 0.0232323
SPRED2 sprouty-related, EVH1 domain containing 2 0.0231409
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0231333
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0231047
XRN1 5'-3' exoribonuclease 1 0.0226984
NCKAP1 NCK-associated protein 1 0.0224506
PRDX2 peroxiredoxin 2 0.0223919
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme 0.0223892
SCAF11 SR-related CTD-associated factor 11 0.0223398
ARL4C ADP-ribosylation factor-like 4C 0.0222172
NBAS neuroblastoma amplified sequence 0.0218709
RB1CC1 RB1-inducible coiled-coil 1 0.021738
MXI1 MAX interactor 1, dimerization protein 0.0215313
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 0.021381
USP47 ubiquitin specific peptidase 47 0.0213332
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0212691
MEF2A myocyte enhancer factor 2A 0.021059
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.020974
COG6 component of oligomeric golgi complex 6 0.0208964
BRWD1 bromodomain and WD repeat domain containing 1 0.0206585
PTBP2 polypyrimidine tract binding protein 2 0.0204692
SPRY2 sprouty homolog 2 (Drosophila) 0.0202743
RNMT RNA (guanine-7-) methyltransferase 0.0202221
GOLM2 golgi membrane protein 2 0.0201331

decreased expression

Symbol Name Standardized Value
CPED1 cadherin-like and PC-esterase domain containing 1 -0.205894
PTMA prothymosin, alpha -0.187487
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.14762
PDE4B phosphodiesterase 4B, cAMP-specific -0.125874
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.103187
AHNAK AHNAK nucleoprotein -0.103164
FOXP1 forkhead box P1 -0.101794
VCL vinculin -0.0860374
RPL35A ribosomal protein L35a -0.0780943
BMP10 bone morphogenetic protein 10 -0.0740624
EGFR epidermal growth factor receptor -0.0639099
NBEA neurobeachin -0.0635958
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0623164
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0610911
RPL34 ribosomal protein L34 -0.0609758
DLG1 discs, large homolog 1 (Drosophila) -0.0539761
RPS25 ribosomal protein S25 -0.0517074
RPS23 ribosomal protein S23 -0.0503039
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0494904
RPLP1 ribosomal protein, large, P1 -0.0489459
EFNA5 ephrin-A5 -0.0487166
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0466252
ZMYND8 zinc finger, MYND-type containing 8 -0.0442368
TM4SF1 transmembrane 4 L six family member 1 -0.0432599
TPT1 tumor protein, translationally-controlled 1 -0.043056
RPL31 ribosomal protein L31 -0.0415767
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0405602
RPLP2 ribosomal protein, large, P2 -0.0399542
RPS13 ribosomal protein S13 -0.0396937
NFIA nuclear factor I/A -0.0391759
CAMTA1 calmodulin binding transcription activator 1 -0.038284
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0379542
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0370138
CRPPA CDP-L-ribitol pyrophosphorylase A -0.0368127
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0366123
NEBL nebulette -0.0365712
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.0359199
RPS19 ribosomal protein S19 -0.0354483
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0353483
PDE7B phosphodiesterase 7B -0.0340863
NPAS2 neuronal PAS domain protein 2 -0.0338653
RPL23 ribosomal protein L23 -0.0337816
UNC13A unc-13 homolog A (C. elegans) -0.0336452
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0331556
RPS27A ribosomal protein S27a -0.0320136
TAOK1 TAO kinase 1 -0.0318506
RPL37A ribosomal protein L37a -0.0316699
RPL13A ribosomal protein L13a -0.0314128
GPHN gephyrin -0.0313103
CUX1 cut-like homeobox 1 -0.0312394
LPP LIM domain containing preferred translocation partner in lipoma -0.0309491
INTS6 integrator complex subunit 6 -0.0306526
RPS29 ribosomal protein S29 -0.0306355
CLIP1 CAP-GLY domain containing linker protein 1 -0.0302193
GPATCH8 G patch domain containing 8 -0.0302054
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0299294
GLI2 GLI family zinc finger 2 -0.0298795
ENO2 enolase 2 (gamma, neuronal) -0.0295275
AEBP2 AE binding protein 2 -0.0292762
RPL19 ribosomal protein L19 -0.0291092
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0288323
RPS24 ribosomal protein S24 -0.0284231
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.028405
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.027923
TTC28 tetratricopeptide repeat domain 28 -0.0274867
BCL2 B-cell CLL/lymphoma 2 -0.0271259
NT5C2 5'-nucleotidase, cytosolic II -0.0270271
RPL10A ribosomal protein L10a -0.0268905
RPS27 ribosomal protein S27 -0.0266202
BCOR BCL6 corepressor -0.0265412
SMYD3 SET and MYND domain containing 3 -0.0265206
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0265177
DENND1A DENN/MADD domain containing 1A -0.0263485
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0263311
RBM6 RNA binding motif protein 6 -0.0261773
RPL8 ribosomal protein L8 -0.0256365
NCOA3 nuclear receptor coactivator 3 -0.0255414
RFC3 replication factor C (activator 1) 3, 38kDa -0.0255011
ACTN4 actinin, alpha 4 -0.025441
TAS2R14 taste receptor, type 2, member 14 -0.0250219
RPL4 ribosomal protein L4 -0.0249754
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0247054
RPL38 ribosomal protein L38 -0.0245643
S100A10 S100 calcium binding protein A10 -0.0245098
KANK1 KN motif and ankyrin repeat domains 1 -0.0240447
GSE1 Gse1 coiled-coil protein -0.0237925
NOP56 NOP56 ribonucleoprotein -0.0237336
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.0236728
MSRB3 methionine sulfoxide reductase B3 -0.0236504
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.023603
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0231942
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0231733
SDK1 sidekick cell adhesion molecule 1 -0.0231017
ZEB1 zinc finger E-box binding homeobox 1 -0.0230679
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.022763
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0225405
PRUNE2 prune homolog 2 (Drosophila) -0.0223386
INO80 INO80 complex subunit -0.0223289
S100A9 S100 calcium binding protein A9 -0.0222029
SBF2 SET binding factor 2 -0.0221341