Triclosan_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.200024
NAMPT nicotinamide phosphoribosyltransferase 0.0782396
ERRFI1 ERBB receptor feedback inhibitor 1 0.073885
FAM13A family with sequence similarity 13, member A 0.0692963
HILPDA hypoxia inducible lipid droplet-associated 0.0687559
AKAP12 A kinase (PRKA) anchor protein 12 0.0671805
STC1 stanniocalcin 1 0.0586714
PDIA3 protein disulfide isomerase family A, member 3 0.0461467
ARRDC3 arrestin domain containing 3 0.0456764
SEC31A SEC31 homolog A (S. cerevisiae) 0.0420571
CDH13 cadherin 13 0.0418401
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0397639
GPBP1 GC-rich promoter binding protein 1 0.0380463
MTDH metadherin 0.0363978
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0362504
DSCAM Down syndrome cell adhesion molecule 0.0361917
COPA coatomer protein complex, subunit alpha 0.0358166
RAB1A RAB1A, member RAS oncogene family 0.035619
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0334534
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0310582
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0303953
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0299052
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0292057
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0291714
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0291008
ADM adrenomedullin 0.0285854
ESYT2 extended synaptotagmin-like protein 2 0.0279237
PDIA4 protein disulfide isomerase family A, member 4 0.0276031
YME1L1 YME1-like 1 ATPase 0.0270189
NSD3 nuclear receptor binding SET domain protein 3 0.0267584
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0257982
YTHDC1 YTH domain containing 1 0.02563
HM13 histocompatibility (minor) 13 0.0251373
UGCG UDP-glucose ceramide glucosyltransferase 0.0251191
AFF3 AF4/FMR2 family, member 3 0.0246805
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0244807
RND3 Rho family GTPase 3 0.0244765
ZNF395 zinc finger protein 395 0.0238086
PTGES2 prostaglandin E synthase 2 0.0237343
RINT1 RAD50 interactor 1 0.0232637
SERINC3 serine incorporator 3 0.0229579
LIMS1 LIM and senescent cell antigen-like domains 1 0.0228994
VIRMA vir like m6A methyltransferase associated 0.0227821
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0227038
PNPLA8 patatin-like phospholipase domain containing 8 0.0226993
GOLGA4 golgin A4 0.0226363
BRWD3 bromodomain and WD repeat domain containing 3 0.0225905
SH3GLB1 SH3-domain GRB2-like endophilin B1 0.0225476
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0225344
OPTN optineurin 0.0224964
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0223494
ENO1 enolase 1, (alpha) 0.0221291
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0219843
GMCL1 germ cell-less, spermatogenesis associated 1 0.0219156
VDAC1 voltage-dependent anion channel 1 0.0214941
COG5 component of oligomeric golgi complex 5 0.0213852
IGFBP3 insulin-like growth factor binding protein 3 0.021183
TMEM87A transmembrane protein 87A 0.0211372
BTBD9 BTB (POZ) domain containing 9 0.0209282
CHIC2 cysteine-rich hydrophobic domain 2 0.0207728
SEC13 SEC13 homolog (S. cerevisiae) 0.0207641
TFG TRK-fused gene 0.02074
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0205036
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0204795
MLEC malectin 0.020469
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0203063
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0202063
INSIG2 insulin induced gene 2 0.0201538
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.0200826
TP53BP1 tumor protein p53 binding protein 1 0.0199987
ASXL1 additional sex combs like transcriptional regulator 1 0.0198345
CCNT2 cyclin T2 0.0196938
BZW1 basic leucine zipper and W2 domains 1 0.0196026
RLF rearranged L-myc fusion 0.0192681
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0190891
RIPK2 receptor-interacting serine-threonine kinase 2 0.0190681
SRP72 signal recognition particle 72kDa 0.018986
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0189317
GOLGB1 golgin B1 0.0189149
WDR43 WD repeat domain 43 0.0188138
PMM2 phosphomannomutase 2 0.0187853
SEC24A SEC24 family member A 0.0186318
USP37 ubiquitin specific peptidase 37 0.0185472
RTCB RNA 2',3'-cyclic phosphate and 5'-OH ligase 0.0180713
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0180703
MMP12 matrix metallopeptidase 12 0.0180408
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0180261
DDIT4 DNA-damage-inducible transcript 4 0.017955
PPIL4 peptidylprolyl isomerase (cyclophilin)-like 4 0.0179212
MYADM myeloid-associated differentiation marker 0.0176196
CSMD2 CUB and Sushi multiple domains 2 0.0176074
IL1RAP interleukin 1 receptor accessory protein 0.0173874
MXI1 MAX interactor 1, dimerization protein 0.0172196
TTC17 tetratricopeptide repeat domain 17 0.0172006
CRYZL1 crystallin, zeta (quinone reductase)-like 1 0.017193
COQ10B coenzyme Q10 homolog B (S. cerevisiae) 0.017119
ANTXR2 anthrax toxin receptor 2 0.0171013
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0170855
KDM6A lysine (K)-specific demethylase 6A 0.017076
SMARCA5 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 0.0169344

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.146386
TGFBI transforming growth factor, beta-induced, 68kDa -0.133902
VIM vimentin -0.123267
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.119509
HLA-B major histocompatibility complex, class I, B -0.101403
COL1A2 collagen, type I, alpha 2 -0.0919962
COL1A1 collagen, type I, alpha 1 -0.0739883
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.071473
CALD1 caldesmon 1 -0.0662321
ANXA2 annexin A2 -0.063359
COL6A1 collagen, type VI, alpha 1 -0.0621645
PSD3 pleckstrin and Sec7 domain containing 3 -0.0584521
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0581758
MYH9 myosin, heavy chain 9, non-muscle -0.0552779
CD44 CD44 molecule (Indian blood group) -0.0534185
COL6A3 collagen, type VI, alpha 3 -0.0509459
PKM pyruvate kinase, muscle -0.0488356
EXT1 exostosin glycosyltransferase 1 -0.048359
NAV1 neuron navigator 1 -0.0467506
GLIS3 GLIS family zinc finger 3 -0.0453817
PRSS23 protease, serine, 23 -0.045094
DST dystonin -0.0437747
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0436864
TRIO trio Rho guanine nucleotide exchange factor -0.0404057
MARCHF6 membrane associated ring-CH-type finger 6 -0.0403902
UBE2H ubiquitin-conjugating enzyme E2H -0.0382584
MED13L mediator complex subunit 13-like -0.0380849
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0371951
HLA-C major histocompatibility complex, class I, C -0.0370519
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.036753
FRMD4A FERM domain containing 4A -0.0356482
TPM4 tropomyosin 4 -0.0343701
VCL vinculin -0.0343639
FTL ferritin, light polypeptide -0.0340687
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0339896
UBC ubiquitin C -0.0338694
COL6A2 collagen, type VI, alpha 2 -0.0335584
PGK1 phosphoglycerate kinase 1 -0.033203
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0322283
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0321986
S100A9 S100 calcium binding protein A9 -0.032162
MAPK8 mitogen-activated protein kinase 8 -0.0320972
ANKRD12 ankyrin repeat domain 12 -0.0320362
H3-3B H3.3 histone B -0.0319099
STC2 stanniocalcin 2 -0.0313072
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0309323
TENT5A terminal nucleotidyltransferase 5A -0.0307984
TPT1 tumor protein, translationally-controlled 1 -0.0305969
TBCA tubulin folding cofactor A -0.0301019
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0300096
S100A6 S100 calcium binding protein A6 -0.0298683
KMT2C lysine (K)-specific methyltransferase 2C -0.029668
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0296571
FAT1 FAT atypical cadherin 1 -0.0291373
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0288239
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0286787
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.028484
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0283868
PRELID2 PRELI domain containing 2 -0.0282266
FN1 fibronectin 1 -0.0281733
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0281635
RPL11 ribosomal protein L11 -0.0279203
TNPO1 transportin 1 -0.027737
NIPBL Nipped-B homolog (Drosophila) -0.0275861
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.027488
LAMC1 laminin, gamma 1 (formerly LAMB2) -0.0271655
SOD2 superoxide dismutase 2, mitochondrial -0.0269667
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0264824
HPCAL1 hippocalcin-like 1 -0.0264602
ANKRD11 ankyrin repeat domain 11 -0.0262691
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0262444
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0262113
ZFC3H1 zinc finger, C3H1-type containing -0.0261324
CLIP2 CAP-GLY domain containing linker protein 2 -0.0259445
CSNK1A1 casein kinase 1, alpha 1 -0.0255966
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0255813
COL7A1 collagen, type VII, alpha 1 -0.0255578
EPAS1 endothelial PAS domain protein 1 -0.0254886
PRKCA protein kinase C, alpha -0.0254831
RPS24 ribosomal protein S24 -0.0252149
RASAL2 RAS protein activator like 2 -0.0249014
RPS6 ribosomal protein S6 -0.0248171
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0247734
ZBTB20 zinc finger and BTB domain containing 20 -0.0246735
ERBIN erbb2 interacting protein -0.0244809
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0244116
TRIP12 thyroid hormone receptor interactor 12 -0.0241447
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0239822
EGR1 early growth response 1 -0.0238843
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0238624
ACTN4 actinin, alpha 4 -0.0238407
TPM1 tropomyosin 1 (alpha) -0.0237784
LCOR ligand dependent nuclear receptor corepressor -0.0237119
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0236629
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0236294
COL5A1 collagen, type V, alpha 1 -0.0236102
SDC4 syndecan 4 -0.023445
NRP1 neuropilin 1 -0.0233771
MT1X metallothionein 1X -0.0232533
SOCS5 suppressor of cytokine signaling 5 -0.0230056