Triclosan_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ANXA1 annexin A1 0.0447747
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0369801
RIGI RNA sensor RIG-I 0.0351713
ANO6 anoctamin 6 0.0336503
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0329329
NAMPT nicotinamide phosphoribosyltransferase 0.031088
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0305483
RPL31 ribosomal protein L31 0.0301617
B2M beta-2-microglobulin 0.0300605
BASP1 brain abundant, membrane attached signal protein 1 0.0275796
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0273578
MAPK8 mitogen-activated protein kinase 8 0.0265826
IL1RAP interleukin 1 receptor accessory protein 0.0257445
SMAD3 SMAD family member 3 0.0254454
DGKD diacylglycerol kinase, delta 130kDa 0.0246201
PERP PERP, TP53 apoptosis effector 0.0242903
BICD1 bicaudal D homolog 1 (Drosophila) 0.0240654
CREBRF CREB3 regulatory factor 0.0239051
ARHGAP12 Rho GTPase activating protein 12 0.0236317
SQSTM1 sequestosome 1 0.0233232
ZNF638 zinc finger protein 638 0.0227005
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 0.0224486
TM9SF4 transmembrane 9 superfamily protein member 4 0.0222004
DSTN destrin (actin depolymerizing factor) 0.0221989
ESYT2 extended synaptotagmin-like protein 2 0.0220461
CEP290 centrosomal protein 290kDa 0.0216204
PSD3 pleckstrin and Sec7 domain containing 3 0.0214216
PTPRM protein tyrosine phosphatase, receptor type, M 0.0212063
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0211817
CEMIP2 cell migration inducing hyaluronidase 2 0.0210975
SP100 SP100 nuclear antigen 0.0210449
FNDC3A fibronectin type III domain containing 3A 0.0209465
BRWD3 bromodomain and WD repeat domain containing 3 0.0209006
PDE10A phosphodiesterase 10A 0.0207756
TGFBR1 transforming growth factor, beta receptor 1 0.0206293
DSCAM Down syndrome cell adhesion molecule 0.0202566
P3H2 prolyl 3-hydroxylase 2 0.0200271
BIRC3 baculoviral IAP repeat containing 3 0.0200143
RPS27A ribosomal protein S27a 0.0199629
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0196702
PDE4D phosphodiesterase 4D, cAMP-specific 0.0194325
GIGYF2 GRB10 interacting GYF protein 2 0.0193315
CERK ceramide kinase 0.0191655
MBNL2 muscleblind-like splicing regulator 2 0.0187943
STC1 stanniocalcin 1 0.0186748
HLA-A major histocompatibility complex, class I, A 0.0186516
RND3 Rho family GTPase 3 0.0186251
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0185944
JMJD1C jumonji domain containing 1C 0.0183888
KAT6B K(lysine) acetyltransferase 6B 0.0182448
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0180688
LAMC2 laminin, gamma 2 0.0179524
SSBP2 single-stranded DNA binding protein 2 0.0177963
KAT2B K(lysine) acetyltransferase 2B 0.0177171
LAMB3 laminin, beta 3 0.0177014
RPL14 ribosomal protein L14 0.0175729
ZC3H15 zinc finger CCCH-type containing 15 0.0175292
IFRD1 interferon-related developmental regulator 1 0.0175194
DCP2 decapping mRNA 2 0.0174469
SH3KBP1 SH3-domain kinase binding protein 1 0.0174229
TXNIP thioredoxin interacting protein 0.017384
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0173373
AHR aryl hydrocarbon receptor 0.0172356
RPL23 ribosomal protein L23 0.0171598
PDIA3 protein disulfide isomerase family A, member 3 0.0170102
IFI44 interferon-induced protein 44 0.0170004
GADD45A growth arrest and DNA-damage-inducible, alpha 0.0169721
AREG amphiregulin 0.0168723
ANXA5 annexin A5 0.0168708
MPC1 mitochondrial pyruvate carrier 1 0.0167663
EGR1 early growth response 1 0.0167266
LRRC49 leucine rich repeat containing 49 0.0166801
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.016633
ASPH aspartate beta-hydroxylase 0.0165826
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0165126
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 0.0164179
HMBOX1 homeobox containing 1 0.0161407
BRWD1 bromodomain and WD repeat domain containing 1 0.0160817
TMF1 TATA element modulatory factor 1 0.0158864
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1 0.0158051
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0157996
SINHCAF SIN3-HDAC complex associated factor 0.0157466
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0157398
NALF1 NALCN channel auxiliary factor 1 0.015739
FAM3C family with sequence similarity 3, member C 0.0156639
PM20D1 peptidase M20 domain containing 1 0.0156557
SFTPA2 surfactant protein A2 0.0156342
BSDC1 BSD domain containing 1 0.0156209
MACROD2 MACRO domain containing 2 0.0156131
RANBP2 RAN binding protein 2 0.0155883
ISG15 ISG15 ubiquitin-like modifier 0.0155175
COL5A2 collagen, type V, alpha 2 0.0154793
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0154654
ARHGAP21 Rho GTPase activating protein 21 0.0154004
NFE2L1 nuclear factor, erythroid 2-like 1 0.0153733
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 0.0153149
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A 0.0152368
NTN4 netrin 4 0.0151982
CCND1 cyclin D1 0.0151821
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0151599

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.234922
VIM vimentin -0.156169
FNDC3B fibronectin type III domain containing 3B -0.0858709
CD44 CD44 molecule (Indian blood group) -0.0817118
TMSB10 thymosin beta 10 -0.0724798
LDHA lactate dehydrogenase A -0.0707237
TAS2R14 taste receptor, type 2, member 14 -0.0685909
ERBIN erbb2 interacting protein -0.0680084
LOC112694756 uncharaterized LOC112694756 -0.0646588
RBM39 RNA binding motif protein 39 -0.0606124
ITCH itchy E3 ubiquitin protein ligase -0.0578462
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0575937
AHNAK AHNAK nucleoprotein -0.0566409
POTEF POTE ankyrin domain family, member F -0.0566297
PKM pyruvate kinase, muscle -0.0564346
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0550192
WAC WW domain containing adaptor with coiled-coil -0.0525919
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0501941
SVIL supervillin -0.0481546
ZBTB20 zinc finger and BTB domain containing 20 -0.0478998
ANKRD11 ankyrin repeat domain 11 -0.0478122
AKAP12 A kinase (PRKA) anchor protein 12 -0.0477521
CENPF centromere protein F, 350/400kDa -0.0475178
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0466771
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0465229
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0459673
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0439381
PARD3 par-3 family cell polarity regulator -0.0438303
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0436681
GOLGA4 golgin A4 -0.0436064
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0433659
PHF20 PHD finger protein 20 -0.043079
VDAC1 voltage-dependent anion channel 1 -0.042816
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0423101
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0421043
FMNL2 formin-like 2 -0.0417855
NKTR natural killer cell triggering receptor -0.0414528
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0411988
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0408418
DST dystonin -0.040779
VMP1 vacuole membrane protein 1 -0.0402676
ASXL1 additional sex combs like transcriptional regulator 1 -0.0400789
RALY RALY heterogeneous nuclear ribonucleoprotein -0.039877
MYH9 myosin, heavy chain 9, non-muscle -0.0397741
PUM2 pumilio RNA-binding family member 2 -0.0397228
SPAG9 sperm associated antigen 9 -0.0392433
CSNK1A1 casein kinase 1, alpha 1 -0.0390459
LMO7 LIM domain 7 -0.0383818
TRIP12 thyroid hormone receptor interactor 12 -0.0380986
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0380876
TPM4 tropomyosin 4 -0.0380373
NCAPD2 non-SMC condensin I complex, subunit D2 -0.0378496
SNX14 sorting nexin 14 -0.0376919
MBNL1 muscleblind-like splicing regulator 1 -0.0373273
TPX2 TPX2, microtubule-associated -0.0373131
AKAP13 A kinase (PRKA) anchor protein 13 -0.0371849
FMN1 formin 1 -0.0371661
FUS FUS RNA binding protein -0.0366348
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0366052
ACTN1 actinin, alpha 1 -0.0361413
STK24 serine/threonine kinase 24 -0.0360458
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0353105
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0342646
MACF1 microtubule-actin crosslinking factor 1 -0.0341477
GSK3B glycogen synthase kinase 3 beta -0.0341001
INTS6 integrator complex subunit 6 -0.0340669
SEPTIN9 septin 9 -0.033895
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0338558
THSD4 thrombospondin, type I, domain containing 4 -0.0335059
PRRC2C proline-rich coiled-coil 2C -0.03316
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0330409
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0330312
PTMA prothymosin, alpha -0.0328961
MCL1 myeloid cell leukemia 1 -0.0326879
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0325704
BIRC6 baculoviral IAP repeat containing 6 -0.0323446
MAPKAP1 mitogen-activated protein kinase associated protein 1 -0.0322946
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0321477
DOCK4 dedicator of cytokinesis 4 -0.0320996
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0319964
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0319561
AFF4 AF4/FMR2 family, member 4 -0.0317091
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0315099
SETD5 SET domain containing 5 -0.0315068
GLS2 glutaminase 2 (liver, mitochondrial) -0.0313792
ANKRD28 ankyrin repeat domain 28 -0.0312834
UBE2K ubiquitin-conjugating enzyme E2K -0.0312328
TM4SF1 transmembrane 4 L six family member 1 -0.0312324
CCDC50 coiled-coil domain containing 50 -0.031203
AKAP10 A kinase (PRKA) anchor protein 10 -0.0308573
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0305776
CLTC clathrin, heavy chain (Hc) -0.030398
GPATCH2L G patch domain containing 2-like -0.0303259
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0300543
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0299831
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0299785
RB1CC1 RB1-inducible coiled-coil 1 -0.0298614
RRBP1 ribosome binding protein 1 -0.0298447
ATM ATM serine/threonine kinase -0.0297475
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0295809