Triclosan_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Triclosan perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Triclosan_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HILPDA hypoxia inducible lipid droplet-associated 0.046206
INTS6 integrator complex subunit 6 0.0381473
MRPS6 mitochondrial ribosomal protein S6 0.0365743
NDRG1 N-myc downstream regulated 1 0.0359886
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0352914
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0336076
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0297706
IGFBP3 insulin-like growth factor binding protein 3 0.0296605
PLIN2 perilipin 2 0.0276316
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0275744
FAM13A family with sequence similarity 13, member A 0.0269689
ESYT2 extended synaptotagmin-like protein 2 0.0259509
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0258448
GRB10 growth factor receptor-bound protein 10 0.0255373
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0249506
ERRFI1 ERBB receptor feedback inhibitor 1 0.0243472
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0234273
ZFP36L1 ZFP36 ring finger protein-like 1 0.0230203
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.021823
ZSWIM6 zinc finger, SWIM-type containing 6 0.0217488
VEGFA vascular endothelial growth factor A 0.01999
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0199071
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0189704
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0184766
UBA6 ubiquitin-like modifier activating enzyme 6 0.0168518
STC1 stanniocalcin 1 0.0165581
QKI QKI, KH domain containing, RNA binding 0.0164126
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0163817
EPAS1 endothelial PAS domain protein 1 0.0157212
SIRT1 sirtuin 1 0.0153438
DDIT4 DNA-damage-inducible transcript 4 0.0151922
CADM1 cell adhesion molecule 1 0.0151766
LIMCH1 LIM and calponin homology domains 1 0.0151749
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0148002
UBAP2 ubiquitin associated protein 2 0.0146811
SDK1 sidekick cell adhesion molecule 1 0.0145698
TTC19 tetratricopeptide repeat domain 19 0.0142903
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0142811
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0142429
FERMT2 fermitin family member 2 0.0137877
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0136323
ZCCHC7 zinc finger, CCHC domain containing 7 0.0135225
CLIC4 chloride intracellular channel 4 0.0130805
PALLD palladin, cytoskeletal associated protein 0.012961
RNF145 ring finger protein 145 0.0125828
RYBP RING1 and YY1 binding protein 0.0125313
SOD2 superoxide dismutase 2, mitochondrial 0.0124692
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0122023
LRRC23 leucine rich repeat containing 23 0.0121998
TSC22D2 TSC22 domain family, member 2 0.0121877
DENND4A DENN/MADD domain containing 4A 0.0118684
FOSL1 FOS-like antigen 1 0.0118626
TGFB1 transforming growth factor, beta 1 0.0117437
ADM adrenomedullin 0.0117212
STC2 stanniocalcin 2 0.0115624
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0115192
ABLIM1 actin binding LIM protein 1 0.01151
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0114398
SSBP2 single-stranded DNA binding protein 2 0.0114076
GMCL1 germ cell-less, spermatogenesis associated 1 0.0114062
INSIG2 insulin induced gene 2 0.0113875
RCOR1 REST corepressor 1 0.0113374
SLC38A2 solute carrier family 38, member 2 0.0112833
POU2F2 POU class 2 homeobox 2 0.0112609
TTC3 tetratricopeptide repeat domain 3 0.0111016
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0109128
SMOC1 SPARC related modular calcium binding 1 0.0108541
IGF2 insulin-like growth factor 2 0.0108271
PDIA3 protein disulfide isomerase family A, member 3 0.0107898
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0106603
CEMIP2 cell migration inducing hyaluronidase 2 0.0105478
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0102604
MXD1 MAX dimerization protein 1 0.0101993
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0101136
CTBP2 C-terminal binding protein 2 0.0100773
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.010066
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0100454
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 0.00999108
CCDC88A coiled-coil domain containing 88A 0.00994207
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00970784
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.00963545
DDIT3 DNA-damage-inducible transcript 3 0.00961746
RTN3 reticulon 3 0.00943725
MYOF myoferlin 0.00935105
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.00931957
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.00931128
TRA2A transformer 2 alpha homolog (Drosophila) 0.00921439
CLIP4 CAP-GLY domain containing linker protein family, member 4 0.00921056
BRD2 bromodomain containing 2 0.00915965
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00914592
CDH13 cadherin 13 0.00912822
USP37 ubiquitin specific peptidase 37 0.00907115
MTSS1 metastasis suppressor 1 0.00907113
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.00904925
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.00903317
SRP54 signal recognition particle 54kDa 0.00897332
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.00896747
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.00895534
TUBA1B tubulin, alpha 1b 0.00894911
COL6A3 collagen, type VI, alpha 3 0.00894288

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.348548
FN1 fibronectin 1 -0.18844
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.17846
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139795
SQSTM1 sequestosome 1 -0.133582
TMEM156 transmembrane protein 156 -0.117339
CANX calnexin -0.11164
ITGA1 integrin, alpha 1 -0.110347
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.105268
ASPH aspartate beta-hydroxylase -0.104502
NAMPT nicotinamide phosphoribosyltransferase -0.103869
OSMR oncostatin M receptor -0.095339
GLIS3 GLIS family zinc finger 3 -0.0924608
EXT1 exostosin glycosyltransferase 1 -0.0858833
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0848259
NRG1 neuregulin 1 -0.0757478
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0743006
NRP1 neuropilin 1 -0.0691449
HLA-B major histocompatibility complex, class I, B -0.0636916
TMSB10 thymosin beta 10 -0.0617605
FNDC3B fibronectin type III domain containing 3B -0.061339
SYT1 synaptotagmin I -0.0607321
ETV6 ets variant 6 -0.0591833
CD44 CD44 molecule (Indian blood group) -0.0584706
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0581901
PRRC2C proline-rich coiled-coil 2C -0.0575474
MCTP2 multiple C2 domains, transmembrane 2 -0.0573342
KLHL5 kelch-like family member 5 -0.057046
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0567529
PTMA prothymosin, alpha -0.0558295
TRIO trio Rho guanine nucleotide exchange factor -0.0554662
RPS27A ribosomal protein S27a -0.0544189
SMAD3 SMAD family member 3 -0.054075
CAB39 calcium binding protein 39 -0.0506208
ETV1 ets variant 1 -0.0497263
FNBP1 formin binding protein 1 -0.0497108
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0494601
HMGA2 high mobility group AT-hook 2 -0.0493693
FOXP1 forkhead box P1 -0.048439
IFI16 interferon, gamma-inducible protein 16 -0.047106
S100A6 S100 calcium binding protein A6 -0.0469888
AHR aryl hydrocarbon receptor -0.0468383
PELO pelota homolog (Drosophila) -0.0465951
TXNRD1 thioredoxin reductase 1 -0.0463988
IFI27 interferon, alpha-inducible protein 27 -0.0448855
HIPK2 homeodomain interacting protein kinase 2 -0.0440994
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0436414
UBC ubiquitin C -0.0436304
ACTN4 actinin, alpha 4 -0.0418791
SMYD3 SET and MYND domain containing 3 -0.0416709
SVIL supervillin -0.04144
RUNX2 runt-related transcription factor 2 -0.0412795
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0412327
EREG epiregulin -0.0410765
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.03912
LOC112694756 uncharaterized LOC112694756 -0.0384383
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0383995
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0383417
MYH9 myosin, heavy chain 9, non-muscle -0.0376168
VIM vimentin -0.0368801
MT2A metallothionein 2A -0.0367694
CDCP1 CUB domain containing protein 1 -0.0366658
NAP1L1 nucleosome assembly protein 1-like 1 -0.036653
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0365282
ENO1 enolase 1, (alpha) -0.0364589
VCL vinculin -0.0360359
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0359852
MKI67 marker of proliferation Ki-67 -0.0359553
PTK2 protein tyrosine kinase 2 -0.0359324
NRIP1 nuclear receptor interacting protein 1 -0.0348796
UBE2K ubiquitin-conjugating enzyme E2K -0.0348163
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0345663
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0343419
DST dystonin -0.0340421
PKM pyruvate kinase, muscle -0.0337828
NPC1 Niemann-Pick disease, type C1 -0.0336998
RPS12 ribosomal protein S12 -0.033683
RAD21 RAD21 homolog (S. pombe) -0.0335367
SYNJ2 synaptojanin 2 -0.033373
RPL26 ribosomal protein L26 -0.0327303
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0326149
RRBP1 ribosome binding protein 1 -0.0325098
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0323935
RACK1 receptor for activated C kinase 1 -0.0322088
SMOX spermine oxidase -0.0321935
TPT1 tumor protein, translationally-controlled 1 -0.0320573
MAP1B microtubule-associated protein 1B -0.0320179
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0316699
ETNK1 ethanolamine kinase 1 -0.0315906
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.031169
APP amyloid beta (A4) precursor protein -0.0311341
NFE2L2 nuclear factor, erythroid 2-like 2 -0.031026
ITGB5 integrin, beta 5 -0.0305916
ADAR adenosine deaminase, RNA-specific -0.0297591
LRMDA leucine rich melanocyte differentiation associated -0.0294861
RPL23 ribosomal protein L23 -0.029417
ANKRD11 ankyrin repeat domain 11 -0.0293724
TAS2R14 taste receptor, type 2, member 14 -0.0292477
SFTPA2 surfactant protein A2 -0.0291477
PTBP3 polypyrimidine tract binding protein 3 -0.0291272