Trifluridine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trifluridine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trifluridine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CEMIP cell migration inducing protein, hyaluronan binding 0.0640076
NALF1 NALCN channel auxiliary factor 1 0.0584171
VMP1 vacuole membrane protein 1 0.0546169
VCL vinculin 0.0458626
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0442659
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0442205
IGFBP3 insulin-like growth factor binding protein 3 0.0381408
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0381314
TIMP3 TIMP metallopeptidase inhibitor 3 0.0368919
NPAS2 neuronal PAS domain protein 2 0.0346062
PRKCA protein kinase C, alpha 0.0331784
R3HDM2 R3H domain containing 2 0.0331591
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.032991
RNF213 ring finger protein 213 0.0324854
PLPP1 phospholipid phosphatase 1 0.0316364
ANTXR1 anthrax toxin receptor 1 0.0312012
PTPRD protein tyrosine phosphatase, receptor type, D 0.0310746
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0307596
FTH1 ferritin, heavy polypeptide 1 0.0304579
BPTF bromodomain PHD finger transcription factor 0.0304081
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0287049
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0282136
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0281189
TLE4 transducin-like enhancer of split 4 0.028099
EFNA5 ephrin-A5 0.0278407
GPBP1 GC-rich promoter binding protein 1 0.0274091
SRSF11 serine/arginine-rich splicing factor 11 0.0273121
ARHGAP9 Rho GTPase activating protein 9 0.0270897
HILPDA hypoxia inducible lipid droplet-associated 0.0269641
DACH2 dachshund family transcription factor 2 0.0259886
ARHGAP42 Rho GTPase activating protein 42 0.0257632
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0251563
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0247236
CADM2 cell adhesion molecule 2 0.024442
RPS27 ribosomal protein S27 0.0243837
SYT1 synaptotagmin I 0.0243245
GSE1 Gse1 coiled-coil protein 0.0241958
RNASEH2A ribonuclease H2, subunit A 0.0236543
ZBTB20 zinc finger and BTB domain containing 20 0.0236141
EGR1 early growth response 1 0.0236037
CNTN4 contactin 4 0.0232711
BCAS3 breast carcinoma amplified sequence 3 0.0230977
MYO9A myosin IXA 0.023082
RPS3 ribosomal protein S3 0.0229166
PCDH15 protocadherin-related 15 0.0226846
TPST1 tyrosylprotein sulfotransferase 1 0.02268
ADARB1 adenosine deaminase, RNA-specific, B1 0.0226634
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0224595
RGS4 regulator of G-protein signaling 4 0.0224277
FN1 fibronectin 1 0.0224038
PTPRE protein tyrosine phosphatase, receptor type, E 0.0223973
VCAN versican 0.0215214
ZSWIM6 zinc finger, SWIM-type containing 6 0.0214759
PTEN phosphatase and tensin homolog 0.0207971
MCL1 myeloid cell leukemia 1 0.0205695
TPM4 tropomyosin 4 0.0205564
RABGAP1L RAB GTPase activating protein 1-like 0.0204247
EXOC4 exocyst complex component 4 0.0203308
GREB1L growth regulation by estrogen in breast cancer-like 0.0200102
LINGO2 leucine rich repeat and Ig domain containing 2 0.0199424
RPS7 ribosomal protein S7 0.0198858
MYO6 myosin VI 0.0198312
CXXC5 CXXC finger protein 5 0.0197066
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0196941
PMP22 peripheral myelin protein 22 0.0196709
DLC1 DLC1 Rho GTPase activating protein 0.0195144
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0195133
TENM4 teneurin transmembrane protein 4 0.0193548
YBX3 Y box binding protein 3 0.0193202
AFF3 AF4/FMR2 family, member 3 0.0188191
DNM3 dynamin 3 0.0188122
RACK1 receptor for activated C kinase 1 0.0185214
SYTL3 synaptotagmin-like 3 0.0184348
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 0.0182266
KIF26B kinesin family member 26B 0.0182121
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.018212
ITGAV integrin, alpha V 0.0180612
SOD2 superoxide dismutase 2, mitochondrial 0.0180514
CAMKMT calmodulin-lysine N-methyltransferase 0.0178993
ADGRB3 adhesion G protein-coupled receptor B3 0.0176887
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0176641
ARB2A ARB2 cotranscriptional regulator A 0.0176257
KLF6 Kruppel-like factor 6 0.0174422
PALLD palladin, cytoskeletal associated protein 0.0174292
PRRC2B proline-rich coiled-coil 2B 0.0173311
SIK2 salt-inducible kinase 2 0.016624
RAP1B RAP1B, member of RAS oncogene family 0.0166091
SOX4 SRY (sex determining region Y)-box 4 0.0165529
PHF14 PHD finger protein 14 0.0164703
IRAK2 interleukin-1 receptor-associated kinase 2 0.0164503
TBX2 T-box 2 0.0164349
RAB11FIP3 RAB11 family interacting protein 3 (class II) 0.0163483
GATA3 GATA binding protein 3 0.0163332
ALG11 ALG11, alpha-1,2-mannosyltransferase 0.0162891
SDCCAG8 serologically defined colon cancer antigen 8 0.0161682
RAD51B RAD51 paralog B 0.0160281
FTL ferritin, light polypeptide 0.0159431
PACS1 phosphofurin acidic cluster sorting protein 1 0.015934
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0157848
PPP1R13B protein phosphatase 1, regulatory subunit 13B 0.0157755

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.235867
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.235064
PTMA prothymosin, alpha -0.106049
COL1A1 collagen, type I, alpha 1 -0.0967086
HELZ helicase with zinc finger -0.0834813
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0827402
ACTG1 actin gamma 1 -0.0786405
COL3A1 collagen, type III, alpha 1 -0.0669465
RPL35A ribosomal protein L35a -0.0635744
LPIN1 lipin 1 -0.0540792
SPAG9 sperm associated antigen 9 -0.0528768
EIF1 eukaryotic translation initiation factor 1 -0.0519894
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0513136
IGF2 insulin-like growth factor 2 -0.0512973
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0508069
FAM13A family with sequence similarity 13, member A -0.0477269
KDM3A lysine (K)-specific demethylase 3A -0.0468125
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0467269
CENPF centromere protein F, 350/400kDa -0.0462917
RPL38 ribosomal protein L38 -0.0462763
MEIS2 Meis homeobox 2 -0.0462045
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0456447
NPEPPS aminopeptidase puromycin sensitive -0.0450887
AHNAK AHNAK nucleoprotein -0.0445814
NF1 neurofibromin 1 -0.0442404
VIM vimentin -0.0434667
CLTC clathrin, heavy chain (Hc) -0.0427462
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0422064
RPL19 ribosomal protein L19 -0.0419328
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0412249
SOS1 son of sevenless homolog 1 (Drosophila) -0.0401756
HAND2 heart and neural crest derivatives expressed 2 -0.0392679
RSL1D1 ribosomal L1 domain containing 1 -0.0391411
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0378057
DST dystonin -0.0368788
RAD21 RAD21 homolog (S. pombe) -0.0362923
SETD5 SET domain containing 5 -0.0358438
APP amyloid beta (A4) precursor protein -0.0353503
CANX calnexin -0.03515
RAB1A RAB1A, member RAS oncogene family -0.0351422
RPLP1 ribosomal protein, large, P1 -0.0351205
UBC ubiquitin C -0.035096
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0350753
CCDC47 coiled-coil domain containing 47 -0.034683
ADAR adenosine deaminase, RNA-specific -0.0345121
ZC3H11A zinc finger CCCH-type containing 11A -0.0341372
ZMYM2 zinc finger, MYM-type 2 -0.0334921
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0334449
TMSB10 thymosin beta 10 -0.0329583
NAMPT nicotinamide phosphoribosyltransferase -0.0328195
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0327293
GLG1 golgi glycoprotein 1 -0.0323869
MED13 mediator complex subunit 13 -0.0323121
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0321358
RPS6 ribosomal protein S6 -0.0320527
TPR translocated promoter region, nuclear basket protein -0.0314783
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.031238
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.031217
PHIP pleckstrin homology domain interacting protein -0.0308587
RBMX RNA binding motif protein, X-linked -0.0306161
PGK1 phosphoglycerate kinase 1 -0.0305571
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0302239
CCND1 cyclin D1 -0.0301796
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.029763
ZNF292 zinc finger protein 292 -0.0297185
UBE2D2 ubiquitin-conjugating enzyme E2D 2 -0.0297091
RPL34 ribosomal protein L34 -0.0296876
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0293376
TENT5A terminal nucleotidyltransferase 5A -0.0293252
NRG1 neuregulin 1 -0.0291273
NCOR1 nuclear receptor corepressor 1 -0.028908
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.028851
RO60 Ro60, Y RNA binding protein -0.0288441
MARCHF6 membrane associated ring-CH-type finger 6 -0.0288364
WDR45B WD repeat domain 45B -0.0287117
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha -0.0285596
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0282888
SEC31A SEC31 homolog A (S. cerevisiae) -0.0280577
DSCAM Down syndrome cell adhesion molecule -0.0278715
KLHL13 kelch-like family member 13 -0.0278094
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0277678
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0277127
THSD4 thrombospondin, type I, domain containing 4 -0.0273497
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0272982
NAP1L1 nucleosome assembly protein 1-like 1 -0.0270202
TENT2 terminal nucleotidyltransferase 2 -0.0268895
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0266198
AKAP12 A kinase (PRKA) anchor protein 12 -0.0266014
AOPEP aminopeptidase O (putative) -0.0265551
CASC3 cancer susceptibility candidate 3 -0.0262468
RPL7A ribosomal protein L7a -0.0261461
GNAS GNAS complex locus -0.0261419
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0259729
FNBP1 formin binding protein 1 -0.0259469
TULP4 tubby like protein 4 -0.0259267
RPL32 ribosomal protein L32 -0.0257982
MKI67 marker of proliferation Ki-67 -0.0257017
ITPRID2 ITPR interacting domain containing 2 -0.0256697
KAT6A K(lysine) acetyltransferase 6A -0.0252991
NIPBL Nipped-B homolog (Drosophila) -0.0252508