| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trifluridine perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trifluridine_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.197234 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.116895 |
| VEGFA | vascular endothelial growth factor A | 0.080025 |
| FN1 | fibronectin 1 | 0.0769717 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0581851 |
| LDHA | lactate dehydrogenase A | 0.0572086 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0547524 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0539046 |
| MAP1B | microtubule-associated protein 1B | 0.0534901 |
| MT2A | metallothionein 2A | 0.0516123 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0505169 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0455202 |
| VIM | vimentin | 0.0443738 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0436445 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0418238 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0416291 |
| ENO1 | enolase 1, (alpha) | 0.040727 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0362246 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0357344 |
| VMP1 | vacuole membrane protein 1 | 0.0346593 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0339291 |
| PKM | pyruvate kinase, muscle | 0.0325662 |
| EGR1 | early growth response 1 | 0.0321959 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0316181 |
| MSN | moesin | 0.0314193 |
| AXL | AXL receptor tyrosine kinase | 0.0309256 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0307353 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0305387 |
| HYOU1 | hypoxia up-regulated 1 | 0.0292989 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0282491 |
| MYADM | myeloid-associated differentiation marker | 0.0269506 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0264565 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.025786 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0252753 |
| ATP13A3 | ATPase type 13A3 | 0.0249467 |
| SON | SON DNA binding protein | 0.0248444 |
| PFN1 | profilin 1 | 0.0247955 |
| HDAC9 | histone deacetylase 9 | 0.024315 |
| HMGA2 | high mobility group AT-hook 2 | 0.0242788 |
| B2M | beta-2-microglobulin | 0.024103 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.0240244 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0235465 |
| VCAN | versican | 0.0235057 |
| PCBP2 | poly(rC) binding protein 2 | 0.0234562 |
| CD44 | CD44 molecule (Indian blood group) | 0.0231558 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0229756 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0226384 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0226036 |
| LOX | lysyl oxidase | 0.0221323 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0218086 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0216025 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0214489 |
| DSTN | destrin (actin depolymerizing factor) | 0.0211081 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0205774 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0205551 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0204446 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0203734 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0199917 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0197682 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0193003 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0192781 |
| TPM3 | tropomyosin 3 | 0.0191537 |
| HMGA1 | high mobility group AT-hook 1 | 0.0190345 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0188572 |
| TPI1 | triosephosphate isomerase 1 | 0.018783 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0186237 |
| FOSL1 | FOS-like antigen 1 | 0.0182749 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0180969 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0180818 |
| SQLE | squalene epoxidase | 0.0179746 |
| BBX | bobby sox homolog (Drosophila) | 0.0177837 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0177316 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.017723 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0175646 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0171073 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0170675 |
| TMF1 | TATA element modulatory factor 1 | 0.0168215 |
| TAGLN2 | transgelin 2 | 0.0167943 |
| FLNA | filamin A, alpha | 0.0167881 |
| TXNRD1 | thioredoxin reductase 1 | 0.0167759 |
| MIER1 | mesoderm induction early response 1, transcriptional regulator | 0.0166169 |
| SPAG9 | sperm associated antigen 9 | 0.016255 |
| POTEF | POTE ankyrin domain family, member F | 0.0161951 |
| PERP | PERP, TP53 apoptosis effector | 0.0161272 |
| PRRC2C | proline-rich coiled-coil 2C | 0.016107 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0158 |
| CCNL1 | cyclin L1 | 0.0156936 |
| MKI67 | marker of proliferation Ki-67 | 0.0155679 |
| PGM3 | phosphoglucomutase 3 | 0.0155581 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0154764 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0152855 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0151958 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0150887 |
| JAG1 | jagged 1 | 0.0150774 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0150561 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0150501 |
| WASF2 | WAS protein family, member 2 | 0.0149767 |
| RPS3 | ribosomal protein S3 | 0.0149424 |
| TUBA1B | tubulin, alpha 1b | 0.0149264 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0149058 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.407268 |
| COL1A1 | collagen, type I, alpha 1 | -0.326217 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.235123 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.171094 |
| IER3 | immediate early response 3 | -0.144278 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.11933 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.100003 |
| CDH13 | cadherin 13 | -0.0990944 |
| RPL35A | ribosomal protein L35a | -0.0795708 |
| COL5A1 | collagen, type V, alpha 1 | -0.0789772 |
| AHNAK | AHNAK nucleoprotein | -0.0727575 |
| LOXL2 | lysyl oxidase-like 2 | -0.0717641 |
| ACTG1 | actin gamma 1 | -0.0646154 |
| CADM1 | cell adhesion molecule 1 | -0.0587328 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.054359 |
| NDRG1 | N-myc downstream regulated 1 | -0.0501282 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0497967 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0480965 |
| FBN1 | fibrillin 1 | -0.0478862 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0467545 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0455751 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0453275 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0423733 |
| RRBP1 | ribosome binding protein 1 | -0.0400531 |
| HLA-B | major histocompatibility complex, class I, B | -0.0394848 |
| S100A10 | S100 calcium binding protein A10 | -0.0388931 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.038019 |
| UBC | ubiquitin C | -0.0374114 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0372418 |
| CAVIN1 | caveolae associated protein 1 | -0.0369949 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0369319 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0367353 |
| RPS8 | ribosomal protein S8 | -0.0361109 |
| TPM4 | tropomyosin 4 | -0.0342456 |
| RPL34 | ribosomal protein L34 | -0.0340253 |
| GNAS | GNAS complex locus | -0.0339757 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0334268 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0330557 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0326352 |
| TMSB4X | thymosin beta 4, X-linked | -0.0319317 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0307131 |
| COL7A1 | collagen, type VII, alpha 1 | -0.030685 |
| RPS6 | ribosomal protein S6 | -0.0305953 |
| CANX | calnexin | -0.0300606 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0298239 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0293461 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0290876 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0290274 |
| COL3A1 | collagen, type III, alpha 1 | -0.0283196 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0269861 |
| COL1A2 | collagen, type I, alpha 2 | -0.0266253 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0265615 |
| RPL8 | ribosomal protein L8 | -0.0263129 |
| CALU | calumenin | -0.026301 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0262152 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0260227 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0251956 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0250744 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.024508 |
| RPL23 | ribosomal protein L23 | -0.0244136 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0243118 |
| PTMA | prothymosin, alpha | -0.02389 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0238791 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0234911 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0233912 |
| RPL38 | ribosomal protein L38 | -0.0233407 |
| RPS24 | ribosomal protein S24 | -0.0232296 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0226678 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0221537 |
| ADM | adrenomedullin | -0.0221382 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0221197 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0216734 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0215002 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0214261 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0214212 |
| MTSS1 | metastasis suppressor 1 | -0.02114 |
| RPS11 | ribosomal protein S11 | -0.021118 |
| RPL28 | ribosomal protein L28 | -0.0209453 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0209155 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0208841 |
| RPL11 | ribosomal protein L11 | -0.020822 |
| LAMB3 | laminin, beta 3 | -0.0203759 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.0200984 |
| RPLP1 | ribosomal protein, large, P1 | -0.0192813 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0192012 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0191736 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0190069 |
| RPS15 | ribosomal protein S15 | -0.0189609 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0187157 |
| CD99 | CD99 molecule | -0.0186259 |
| RPS20 | ribosomal protein S20 | -0.0185252 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0183834 |
| PDE10A | phosphodiesterase 10A | -0.0183089 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0182003 |
| MAP4 | microtubule-associated protein 4 | -0.0181418 |
| CD63 | CD63 molecule | -0.0181345 |
| RPL19 | ribosomal protein L19 | -0.0180748 |
| RPS27A | ribosomal protein S27a | -0.0180281 |
| EFNA5 | ephrin-A5 | -0.0176748 |
| OAZ1 | ornithine decarboxylase antizyme 1 | -0.0172638 |
