| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trifluridine perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trifluridine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.133306 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.11112 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0888415 |
| APOB | apolipoprotein B | 0.0681367 |
| C3 | complement component 3 | 0.0653319 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0595917 |
| RPS12 | ribosomal protein S12 | 0.0564928 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.053646 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0530266 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0515684 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0500813 |
| JMJD1C | jumonji domain containing 1C | 0.0497794 |
| SVIL | supervillin | 0.0488005 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.048523 |
| CFB | complement factor B | 0.0469373 |
| ITGAV | integrin, alpha V | 0.0441712 |
| VCL | vinculin | 0.0440064 |
| MRTFA | myocardin related transcription factor A | 0.0437187 |
| EML4 | echinoderm microtubule associated protein like 4 | 0.0425653 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0425118 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0422788 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | 0.0417559 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | 0.0414966 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0413652 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0403155 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0388983 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0388588 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0386383 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0382892 |
| MT2A | metallothionein 2A | 0.037479 |
| CRY1 | cryptochrome circadian clock 1 | 0.0355656 |
| PCBP2 | poly(rC) binding protein 2 | 0.0348223 |
| SRSF11 | serine/arginine-rich splicing factor 11 | 0.034307 |
| CPE | carboxypeptidase E | 0.0337956 |
| TF | transferrin | 0.0337268 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0336242 |
| FOXO1 | forkhead box O1 | 0.0323968 |
| WDR43 | WD repeat domain 43 | 0.0322219 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0320329 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0318695 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0311852 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0305527 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0304797 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0303859 |
| AHR | aryl hydrocarbon receptor | 0.0303723 |
| RBM39 | RNA binding motif protein 39 | 0.0299449 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | 0.0291489 |
| NUP58 | nucleoporin 58 | 0.0288613 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0287293 |
| PRRC2C | proline-rich coiled-coil 2C | 0.028713 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0286444 |
| FOXP1 | forkhead box P1 | 0.0286014 |
| MYO6 | myosin VI | 0.0285256 |
| RTN4 | reticulon 4 | 0.028232 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0279212 |
| YAP1 | Yes-associated protein 1 | 0.0276775 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.027328 |
| AFDN | afadin, adherens junction formation factor | 0.0270062 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0268565 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0267878 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | 0.0267479 |
| RPS7 | ribosomal protein S7 | 0.0262082 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0261054 |
| TMEM41B | transmembrane protein 41B | 0.0257912 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0253599 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.025299 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0251314 |
| SERINC1 | serine incorporator 1 | 0.0251128 |
| KIF5B | kinesin family member 5B | 0.0244725 |
| FERMT1 | fermitin family member 1 | 0.024018 |
| RPL9 | ribosomal protein L9 | 0.0236989 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0232403 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0232115 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.023027 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0228895 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0227348 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0226459 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0223605 |
| PPP1R9A | protein phosphatase 1, regulatory subunit 9A | 0.0221301 |
| SON | SON DNA binding protein | 0.0218509 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0217541 |
| TMEM87A | transmembrane protein 87A | 0.0217162 |
| YTHDC1 | YTH domain containing 1 | 0.0217132 |
| FNBP1L | formin binding protein 1-like | 0.0215237 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0214195 |
| DIAPH1 | diaphanous-related formin 1 | 0.0213499 |
| ITGB5 | integrin, beta 5 | 0.0213341 |
| CCNY | cyclin Y | 0.0213037 |
| GCC2 | GRIP and coiled-coil domain containing 2 | 0.0211446 |
| TCF12 | transcription factor 12 | 0.0210074 |
| DSTN | destrin (actin depolymerizing factor) | 0.0209539 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | 0.0209191 |
| TMF1 | TATA element modulatory factor 1 | 0.0208573 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0208143 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0208072 |
| UBE2E3 | ubiquitin-conjugating enzyme E2E 3 | 0.020797 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0207549 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0206917 |
| TXNRD1 | thioredoxin reductase 1 | 0.0206696 |
| ARPP19 | cAMP-regulated phosphoprotein, 19kDa | 0.0205953 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.141499 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.139811 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.127684 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.126561 |
| GPC6 | glypican 6 | -0.105664 |
| IGF2 | insulin-like growth factor 2 | -0.0947489 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0908482 |
| ASPH | aspartate beta-hydroxylase | -0.0862654 |
| PEG3 | paternally expressed 3 | -0.0846908 |
| FN1 | fibronectin 1 | -0.082837 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0799903 |
| APOA2 | apolipoprotein A-II | -0.0772858 |
| H1-0 | H1.0 linker histone | -0.0739907 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0679898 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0675517 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0662718 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0652841 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | -0.0648507 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0615776 |
| CP | ceruloplasmin (ferroxidase) | -0.0604961 |
| ATXN1 | ataxin 1 | -0.0598909 |
| NPAS2 | neuronal PAS domain protein 2 | -0.057826 |
| ACTG1 | actin gamma 1 | -0.0572962 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0569724 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0560058 |
| AHNAK | AHNAK nucleoprotein | -0.0554235 |
| RNF213 | ring finger protein 213 | -0.0553526 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0550117 |
| KIAA1217 | KIAA1217 | -0.0547366 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0533698 |
| SDC4 | syndecan 4 | -0.0519477 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.051551 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0470838 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0456695 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0448554 |
| RPL35A | ribosomal protein L35a | -0.0448342 |
| UGP2 | UDP-glucose pyrophosphorylase 2 | -0.044267 |
| INTS6 | integrator complex subunit 6 | -0.0427814 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0413339 |
| GNAS | GNAS complex locus | -0.0408981 |
| NDRG1 | N-myc downstream regulated 1 | -0.0408624 |
| TNS3 | tensin 3 | -0.0405491 |
| ATP10A | ATPase, class V, type 10A | -0.0404782 |
| PRELID2 | PRELI domain containing 2 | -0.0393869 |
| GK | glycerol kinase | -0.0391865 |
| ZNF638 | zinc finger protein 638 | -0.0386938 |
| RPS19 | ribosomal protein S19 | -0.0383995 |
| RPL34 | ribosomal protein L34 | -0.0374592 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0362099 |
| UBC | ubiquitin C | -0.0358446 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0355917 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0353986 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0347844 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0346689 |
| HPCAL1 | hippocalcin-like 1 | -0.0345695 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0341784 |
| FMNL2 | formin-like 2 | -0.033387 |
| ZHX2 | zinc fingers and homeoboxes 2 | -0.0333439 |
| RIGI | RNA sensor RIG-I | -0.0330411 |
| SMAD3 | SMAD family member 3 | -0.0324648 |
| RPLP1 | ribosomal protein, large, P1 | -0.0322233 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0317098 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0316657 |
| PHF3 | PHD finger protein 3 | -0.0314725 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0311072 |
| GPC3 | glypican 3 | -0.0309519 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0308381 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0306694 |
| RPL11 | ribosomal protein L11 | -0.0305049 |
| CANX | calnexin | -0.0301925 |
| FUS | FUS RNA binding protein | -0.0297489 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | -0.0295498 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.029373 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0289287 |
| SLC9A1 | solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 | -0.0289202 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.028611 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0285322 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.0285258 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0284245 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.028393 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0281559 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0275549 |
| ITGA1 | integrin, alpha 1 | -0.0272301 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | -0.0270707 |
| PLXDC2 | plexin domain containing 2 | -0.026983 |
| RPS21 | ribosomal protein S21 | -0.0266001 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.025798 |
| RPS5 | ribosomal protein S5 | -0.0257528 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.025692 |
| RPS24 | ribosomal protein S24 | -0.0256553 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0255815 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0255644 |
| COL7A1 | collagen, type VII, alpha 1 | -0.0255205 |
| A1CF | APOBEC1 complementation factor | -0.0254695 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0254458 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.025423 |
| IQSEC1 | IQ motif and Sec7 domain 1 | -0.0252628 |
| HMGA1 | high mobility group AT-hook 1 | -0.0248647 |
| PLEC | plectin | -0.024714 |
| STK39 | serine threonine kinase 39 | -0.0242671 |
