Trifluridine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trifluridine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Trifluridine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.423481
VIM vimentin 0.106887
MT1E metallothionein 1E 0.0967404
RPS12 ribosomal protein S12 0.0881834
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.078025
RPS3 ribosomal protein S3 0.0603015
ENO1 enolase 1, (alpha) 0.0595431
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0581932
TPT1 tumor protein, translationally-controlled 1 0.0581338
FTL ferritin, light polypeptide 0.0555856
PTMA prothymosin, alpha 0.053286
ANGPTL4 angiopoietin-like 4 0.04965
RPL37A ribosomal protein L37a 0.048741
B2M beta-2-microglobulin 0.048017
FTH1 ferritin, heavy polypeptide 1 0.0451278
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0447958
HLA-B major histocompatibility complex, class I, B 0.0431327
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0410801
RPL26 ribosomal protein L26 0.0403043
SVIL supervillin 0.0401768
RPL36 ribosomal protein L36 0.0395095
RPL12 ribosomal protein L12 0.0390927
RPS8 ribosomal protein S8 0.0388342
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0386924
IFI6 interferon, alpha-inducible protein 6 0.0357845
KMT2E lysine (K)-specific methyltransferase 2E 0.0341648
SQSTM1 sequestosome 1 0.0338389
CXCL8 chemokine (C-X-C motif) ligand 8 0.0325132
RPL37 ribosomal protein L37 0.0297741
BIRC3 baculoviral IAP repeat containing 3 0.0290263
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0283036
RPS17 ribosomal protein S17 0.027691
RPS7 ribosomal protein S7 0.0272544
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0271738
RPLP2 ribosomal protein, large, P2 0.0268599
NAP1L1 nucleosome assembly protein 1-like 1 0.0268341
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0258666
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.02558
AREG amphiregulin 0.0254392
HLA-E major histocompatibility complex, class I, E 0.024859
RPS27 ribosomal protein S27 0.0239571
CAPRIN2 caprin family member 2 0.0239158
EREG epiregulin 0.0238411
KLF6 Kruppel-like factor 6 0.0236764
HDAC9 histone deacetylase 9 0.0236154
BZW1 basic leucine zipper and W2 domains 1 0.0235422
ZSWIM6 zinc finger, SWIM-type containing 6 0.0235389
SDCCAG8 serologically defined colon cancer antigen 8 0.0235205
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0231963
NPAS2 neuronal PAS domain protein 2 0.0223738
KPNB1 karyopherin (importin) beta 1 0.0223644
RPS2 ribosomal protein S2 0.0222511
TPI1 triosephosphate isomerase 1 0.0222464
RACK1 receptor for activated C kinase 1 0.021749
UTRN utrophin 0.0212953
DHRS7 dehydrogenase/reductase (SDR family) member 7 0.0210342
CDK6 cyclin-dependent kinase 6 0.020988
RPS27A ribosomal protein S27a 0.0209221
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0207851
RPL31 ribosomal protein L31 0.0203594
RPL36A ribosomal protein L36a 0.0202967
PRDX1 peroxiredoxin 1 0.0200611
RPL18 ribosomal protein L18 0.0200164
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.0199171
RPS24 ribosomal protein S24 0.0198116
RPS25 ribosomal protein S25 0.0195464
RABGAP1L RAB GTPase activating protein 1-like 0.0193507
TP63 tumor protein p63 0.0192845
TRIM56 tripartite motif containing 56 0.0188874
SRSF11 serine/arginine-rich splicing factor 11 0.0188118
PRELID2 PRELI domain containing 2 0.0187076
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0186034
AKAP9 A kinase (PRKA) anchor protein 9 0.0185358
SLK STE20-like kinase 0.0185127
SPIDR scaffolding protein involved in DNA repair 0.0184439
RPL27 ribosomal protein L27 0.0182996
DIAPH3 diaphanous-related formin 3 0.0182908
CEP290 centrosomal protein 290kDa 0.0182393
PABPN1 poly(A) binding protein, nuclear 1 0.0181484
SRRM2 serine/arginine repetitive matrix 2 0.0180619
IFITM1 interferon induced transmembrane protein 1 0.017998
RPS13 ribosomal protein S13 0.0179194
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0178527
YBX3 Y box binding protein 3 0.0178223
HLA-A major histocompatibility complex, class I, A 0.0177256
TIMP1 TIMP metallopeptidase inhibitor 1 0.017656
CPLANE1 ciliogenesis and planar polarity effector complex subunit 1 0.0175857
PDE4D phosphodiesterase 4D, cAMP-specific 0.0174914
RPLP0 ribosomal protein, large, P0 0.0172502
FAM162A family with sequence similarity 162, member A 0.0169268
TUBA1B tubulin, alpha 1b 0.016919
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0166132
USP11 ubiquitin specific peptidase 11 0.0164024
VMP1 vacuole membrane protein 1 0.0163094
SYAP1 synapse associated protein 1 0.0163007
TUBB4B tubulin, beta 4B class IVb 0.0162942
EIF5B eukaryotic translation initiation factor 5B 0.0160803
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0158732
ATAD2 ATPase family, AAA domain containing 2 0.0158703
HMGB2 high mobility group box 2 0.0158051

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.330824
POTEF POTE ankyrin domain family, member F -0.111283
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.105081
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.102574
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0973697
SLC38A2 solute carrier family 38, member 2 -0.0913529
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0713521
TMSB4X thymosin beta 4, X-linked -0.0692319
CD44 CD44 molecule (Indian blood group) -0.0673353
DLG1 discs, large homolog 1 (Drosophila) -0.0653034
AHNAK AHNAK nucleoprotein -0.063014
EEF2 eukaryotic translation elongation factor 2 -0.057542
ACTG1 actin gamma 1 -0.0560912
TNS3 tensin 3 -0.0510411
RPL35A ribosomal protein L35a -0.0494889
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0493085
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0487225
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0485553
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0437293
BRWD1 bromodomain and WD repeat domain containing 1 -0.0435276
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0424409
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0424214
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0423549
EFNA5 ephrin-A5 -0.0419479
CFAP299 cilia and flagella associated protein 299 -0.0419302
FNIP1 folliculin interacting protein 1 -0.041916
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.041341
COL5A2 collagen, type V, alpha 2 -0.0411405
CANX calnexin -0.0399777
LOC112694756 uncharaterized LOC112694756 -0.0396148
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0395513
WARS1 tryptophanyl-tRNA synthetase 1 -0.0395363
EZR ezrin -0.0390251
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0388664
TSC22D1 TSC22 domain family, member 1 -0.0384563
UBC ubiquitin C -0.0378307
CENPF centromere protein F, 350/400kDa -0.0354674
APP amyloid beta (A4) precursor protein -0.0350415
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0349537
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0345003
MBNL2 muscleblind-like splicing regulator 2 -0.0341947
FBXO11 F-box protein 11 -0.0339764
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0337789
EPHA4 EPH receptor A4 -0.0334185
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.033021
FMNL2 formin-like 2 -0.0329054
LMAN1 lectin, mannose-binding, 1 -0.0324995
GSK3B glycogen synthase kinase 3 beta -0.0324744
USP34 ubiquitin specific peptidase 34 -0.0321532
TAOK1 TAO kinase 1 -0.0318944
RPS23 ribosomal protein S23 -0.0316825
EHBP1 EH domain binding protein 1 -0.0316547
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0313785
TXNIP thioredoxin interacting protein -0.0306471
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0301343
RPS6 ribosomal protein S6 -0.0292864
DOCK11 dedicator of cytokinesis 11 -0.0291623
XPO1 exportin 1 -0.0288275
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0287515
MAP4 microtubule-associated protein 4 -0.0287442
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0287289
TMEM123 transmembrane protein 123 -0.0277751
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.027658
BIRC6 baculoviral IAP repeat containing 6 -0.0275837
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.027518
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0275066
FLNB filamin B, beta -0.0271349
ADAR adenosine deaminase, RNA-specific -0.026976
TAPBP TAP binding protein (tapasin) -0.0267903
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0265904
PTK2 protein tyrosine kinase 2 -0.0257445
RPL8 ribosomal protein L8 -0.0255797
ERRFI1 ERBB receptor feedback inhibitor 1 -0.025517
WASF2 WAS protein family, member 2 -0.0254842
PIAS2 protein inhibitor of activated STAT, 2 -0.0254769
PCBP2 poly(rC) binding protein 2 -0.0252996
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0252834
ADAM17 ADAM metallopeptidase domain 17 -0.0252214
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0249744
PDIA6 protein disulfide isomerase family A, member 6 -0.0248678
ZMYND8 zinc finger, MYND-type containing 8 -0.0244697
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0240443
LOXL2 lysyl oxidase-like 2 -0.0236747
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0234041
DENND1A DENN/MADD domain containing 1A -0.0233966
CDK12 cyclin-dependent kinase 12 -0.0233214
TGM2 transglutaminase 2 -0.0231704
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0231297
PSD3 pleckstrin and Sec7 domain containing 3 -0.0228329
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0227018
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0223857
MYOF myoferlin -0.0221339
TTC28 tetratricopeptide repeat domain 28 -0.022129
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.021921
UBE2E3 ubiquitin-conjugating enzyme E2E 3 -0.0218575
GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase -0.0214259
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0212166
BCAR3 breast cancer anti-estrogen resistance 3 -0.0211949
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.021179
MARCHF7 membrane associated ring-CH-type finger 7 -0.021133