Trifluridine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trifluridine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trifluridine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.203099
CXCL8 chemokine (C-X-C motif) ligand 8 0.146604
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.136512
GRAMD1B GRAM domain containing 1B 0.119304
LDHA lactate dehydrogenase A 0.103209
SLTM SAFB-like, transcription modulator 0.0943026
LAMA4 laminin, alpha 4 0.0909441
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0808031
STC1 stanniocalcin 1 0.0773525
NAMPT nicotinamide phosphoribosyltransferase 0.0743864
ELL2 elongation factor, RNA polymerase II, 2 0.0695798
PM20D1 peptidase M20 domain containing 1 0.0688106
FAM13A family with sequence similarity 13, member A 0.0675648
PDE4D phosphodiesterase 4D, cAMP-specific 0.0674411
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0672937
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0668935
FTH1 ferritin, heavy polypeptide 1 0.0659087
CPE carboxypeptidase E 0.065653
MT2A metallothionein 2A 0.0652092
ENO1 enolase 1, (alpha) 0.0632046
TES testin LIM domain protein 0.0587685
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0566713
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.055736
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0548467
TOP1 topoisomerase (DNA) I 0.0543962
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0543732
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0532988
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0485443
PRRC2C proline-rich coiled-coil 2C 0.0453469
MKI67 marker of proliferation Ki-67 0.0452564
RPS3 ribosomal protein S3 0.0442984
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0441598
AREG amphiregulin 0.0438464
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0428634
SON SON DNA binding protein 0.0411441
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0391236
TPI1 triosephosphate isomerase 1 0.0380033
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0378084
RTN4 reticulon 4 0.0367659
SMYD3 SET and MYND domain containing 3 0.036537
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0358407
IRS2 insulin receptor substrate 2 0.0357574
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0350163
JMJD1C jumonji domain containing 1C 0.0337913
YBX3 Y box binding protein 3 0.033331
RPLP0 ribosomal protein, large, P0 0.0325459
FOXP1 forkhead box P1 0.0320774
CSNK1A1 casein kinase 1, alpha 1 0.031961
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0319289
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0313978
GCLC glutamate-cysteine ligase, catalytic subunit 0.0306698
CEMIP cell migration inducing protein, hyaluronan binding 0.0299178
CHD1 chromodomain helicase DNA binding protein 1 0.0293893
FTL ferritin, light polypeptide 0.0288948
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.028778
LGALS12 lectin, galactoside-binding, soluble, 12 0.0285807
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0285748
EXOC6B exocyst complex component 6B 0.0285595
MBNL1 muscleblind-like splicing regulator 1 0.0284759
PRDX1 peroxiredoxin 1 0.028343
KTN1 kinectin 1 (kinesin receptor) 0.0281577
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0281466
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0278014
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0275168
BLZF1 basic leucine zipper nuclear factor 1 0.0268083
SYAP1 synapse associated protein 1 0.0265103
NAP1L1 nucleosome assembly protein 1-like 1 0.0264861
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0264516
RICTOR RPTOR independent companion of MTOR, complex 2 0.0264172
RUNX1 runt-related transcription factor 1 0.0263107
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.026089
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0260838
B2M beta-2-microglobulin 0.0259853
RIMS2 regulating synaptic membrane exocytosis 2 0.025825
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0245755
YTHDC1 YTH domain containing 1 0.0244571
RAB27B RAB27B, member RAS oncogene family 0.0241487
STAU2 staufen double-stranded RNA binding protein 2 0.0241362
GSTP1 glutathione S-transferase pi 1 0.0235184
RNF145 ring finger protein 145 0.0227785
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0225792
NQO1 NAD(P)H dehydrogenase, quinone 1 0.022523
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0221235
DOCK5 dedicator of cytokinesis 5 0.0221178
SIK3 SIK family kinase 3 0.0221156
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0221135
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0219436
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0219395
LRP1B low density lipoprotein receptor-related protein 1B 0.0219235
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.021895
PFN1 profilin 1 0.0218907
VMP1 vacuole membrane protein 1 0.0218161
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0215331
LPCAT2 lysophosphatidylcholine acyltransferase 2 0.021533
MACC1 metastasis associated in colon cancer 1 0.021098
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0209365
RPS12 ribosomal protein S12 0.0208535
LRP12 low density lipoprotein receptor-related protein 12 0.0208333
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.020809
PKM pyruvate kinase, muscle 0.0206773

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.226698
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107042
TMSB10 thymosin beta 10 -0.0918073
PTPRM protein tyrosine phosphatase, receptor type, M -0.0908281
ACTG1 actin gamma 1 -0.0861183
NDRG1 N-myc downstream regulated 1 -0.084564
INTS6 integrator complex subunit 6 -0.0710716
AHNAK AHNAK nucleoprotein -0.0708432
S100A10 S100 calcium binding protein A10 -0.0658187
RPL35A ribosomal protein L35a -0.0608489
IGFBP3 insulin-like growth factor binding protein 3 -0.0555345
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0547309
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0496855
TPT1 tumor protein, translationally-controlled 1 -0.0461199
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0444117
PTMA prothymosin, alpha -0.0429488
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0418119
PATJ PATJ crumbs cell polarity complex component -0.04153
NABP1 nucleic acid binding protein 1 -0.0404717
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0383998
ZMYND8 zinc finger, MYND-type containing 8 -0.0374626
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0368273
FBXO11 F-box protein 11 -0.0366895
PDLIM5 PDZ and LIM domain 5 -0.0359965
MCL1 myeloid cell leukemia 1 -0.034615
CAMTA1 calmodulin binding transcription activator 1 -0.0342705
KRT8 keratin 8, type II -0.0335045
MYO1D myosin ID -0.0332167
AGR2 anterior gradient 2 -0.032484
CUX1 cut-like homeobox 1 -0.0313504
KRT7 keratin 7, type II -0.0300066
HDLBP high density lipoprotein binding protein -0.0299148
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0298575
TRAF3 TNF receptor-associated factor 3 -0.029709
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0294933
WASF2 WAS protein family, member 2 -0.0288757
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0285555
PLEC plectin -0.0282192
H1-0 H1.0 linker histone -0.0279799
FLNB filamin B, beta -0.0274497
RPL34 ribosomal protein L34 -0.0269408
KDM3B lysine (K)-specific demethylase 3B -0.0267995
ASPH aspartate beta-hydroxylase -0.0265361
RPS6 ribosomal protein S6 -0.0256372
RPS29 ribosomal protein S29 -0.0255015
SPIRE1 spire-type actin nucleation factor 1 -0.0254941
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0251262
TNS3 tensin 3 -0.0249062
RPS23 ribosomal protein S23 -0.0248807
LAMC2 laminin, gamma 2 -0.0240031
HLA-B major histocompatibility complex, class I, B -0.0239984
MAML2 mastermind-like 2 (Drosophila) -0.0238984
ANKRD10 ankyrin repeat domain 10 -0.0238363
UBC ubiquitin C -0.023735
RAB1A RAB1A, member RAS oncogene family -0.0233888
EIF1 eukaryotic translation initiation factor 1 -0.023359
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.023117
RPL31 ribosomal protein L31 -0.0227345
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 -0.022636
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0226075
SEC31A SEC31 homolog A (S. cerevisiae) -0.0225966
FUS FUS RNA binding protein -0.0225892
GOLGB1 golgin B1 -0.02237
CTBP2 C-terminal binding protein 2 -0.0215903
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0215338
RPLP1 ribosomal protein, large, P1 -0.0215158
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0214312
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0212771
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0208914
ATG7 autophagy related 7 -0.0208288
ADAM32 ADAM metallopeptidase domain 32 -0.0207171
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0203828
RIN2 Ras and Rab interactor 2 -0.0202116
SEC24D SEC24 family member D -0.0197358
MYH9 myosin, heavy chain 9, non-muscle -0.0196481
RPL38 ribosomal protein L38 -0.0196469
CANX calnexin -0.0195934
AEBP2 AE binding protein 2 -0.0195523
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.019468
VCL vinculin -0.0193073
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0190506
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0189535
ENO2 enolase 2 (gamma, neuronal) -0.0189071
RPS25 ribosomal protein S25 -0.0186951
FNIP1 folliculin interacting protein 1 -0.0186716
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0186014
AKAP13 A kinase (PRKA) anchor protein 13 -0.018493
CATSPERB catsper channel auxiliary subunit beta -0.0184764
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0184038
GOLGA3 golgin A3 -0.0182724
ARHGAP26 Rho GTPase activating protein 26 -0.0182451
GOSR2 golgi SNAP receptor complex member 2 -0.0182229
AHNAK2 AHNAK nucleoprotein 2 -0.0181966
VEGFA vascular endothelial growth factor A -0.0180474
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0180104
RPS27 ribosomal protein S27 -0.0177542
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0172485
KRT86 keratin 86, type II -0.0172073
N4BP2L2 NEDD4 binding protein 2-like 2 -0.017149
SCEL sciellin -0.017104