| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trifluridine perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trifluridine_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.149412 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.139313 |
| KYNU | kynureninase | 0.126309 |
| LMO7 | LIM domain 7 | 0.111132 |
| MT2A | metallothionein 2A | 0.098244 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0956349 |
| EGFR | epidermal growth factor receptor | 0.091208 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0832524 |
| FTL | ferritin, light polypeptide | 0.0784884 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0766345 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0746742 |
| RAD51B | RAD51 paralog B | 0.0738827 |
| RIGI | RNA sensor RIG-I | 0.0705776 |
| MYO10 | myosin X | 0.0698601 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0689852 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0688675 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0680668 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0648403 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0600968 |
| VIM | vimentin | 0.0593389 |
| ANO6 | anoctamin 6 | 0.0593056 |
| USP53 | ubiquitin specific peptidase 53 | 0.0592462 |
| RPS12 | ribosomal protein S12 | 0.0577171 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0576516 |
| VGLL3 | vestigial-like family member 3 | 0.0574425 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0573808 |
| RPS17 | ribosomal protein S17 | 0.0571401 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0567222 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.055809 |
| NDRG1 | N-myc downstream regulated 1 | 0.0556429 |
| AREG | amphiregulin | 0.0506245 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0499195 |
| ENO1 | enolase 1, (alpha) | 0.0475772 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0469769 |
| B2M | beta-2-microglobulin | 0.0468039 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0465802 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0463481 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0458852 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0452698 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0451589 |
| MCL1 | myeloid cell leukemia 1 | 0.0436806 |
| STK17A | serine/threonine kinase 17a | 0.0436263 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0432958 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0431064 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0426247 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0424246 |
| IGF2 | insulin-like growth factor 2 | 0.0421393 |
| S100P | S100 calcium binding protein P | 0.0418786 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0418238 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0417557 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 0.0410255 |
| RPS24 | ribosomal protein S24 | 0.0409466 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0408807 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0408486 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0403807 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0400211 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0392935 |
| C6ORF132 | chromosome 6 open reading frame 132 | 0.0392001 |
| STC1 | stanniocalcin 1 | 0.0388012 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0387783 |
| RPL5 | ribosomal protein L5 | 0.0384815 |
| ARMH4 | armadillo like helical domain containing 4 | 0.0383228 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0381299 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0378704 |
| RNF213 | ring finger protein 213 | 0.0377069 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0371528 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0371046 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0368583 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0362148 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0361008 |
| LAMA4 | laminin, alpha 4 | 0.036062 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0359971 |
| RND3 | Rho family GTPase 3 | 0.0359758 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0358242 |
| RPL37 | ribosomal protein L37 | 0.0357082 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | 0.0355958 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.035213 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0348761 |
| PERP | PERP, TP53 apoptosis effector | 0.0347483 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0344998 |
| AEBP2 | AE binding protein 2 | 0.0344709 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0341861 |
| WWC1 | WW and C2 domain containing 1 | 0.033738 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0333045 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0332798 |
| PHF3 | PHD finger protein 3 | 0.0330293 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0326679 |
| NPAS2 | neuronal PAS domain protein 2 | 0.03251 |
| FMN1 | formin 1 | 0.0324119 |
| TJP1 | tight junction protein 1 | 0.0322166 |
| ZNF654 | zinc finger protein 654 | 0.0320482 |
| ASPH | aspartate beta-hydroxylase | 0.031822 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0317447 |
| RPS16 | ribosomal protein S16 | 0.0317015 |
| TMSB10 | thymosin beta 10 | 0.0314824 |
| RPL28 | ribosomal protein L28 | 0.0314063 |
| R3HDM2 | R3H domain containing 2 | 0.0312782 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0311245 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0311012 |
| PRKCA | protein kinase C, alpha | 0.0310814 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | -0.191589 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.185942 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.128856 |
| AHNAK | AHNAK nucleoprotein | -0.115062 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.101559 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.073323 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0707396 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0696213 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0666881 |
| ATOSA | atos homolog A | -0.0654244 |
| FDPS | farnesyl diphosphate synthase | -0.0614216 |
| ABCG1 | ATP-binding cassette, sub-family G (WHITE), member 1 | -0.0608242 |
| SHB | Src homology 2 domain containing adaptor protein B | -0.0598198 |
| CD2AP | CD2-associated protein | -0.0564278 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0564138 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0556515 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0550277 |
| RIOK3 | RIO kinase 3 | -0.0548915 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0529128 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0525465 |
| FAM13A | family with sequence similarity 13, member A | -0.051792 |
| MMP1 | matrix metallopeptidase 1 | -0.0491868 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0491391 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0487871 |
| ADGRB3 | adhesion G protein-coupled receptor B3 | -0.0487312 |
| MYOF | myoferlin | -0.0485304 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0477999 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.0474696 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0474412 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0466518 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0463571 |
| SETD5 | SET domain containing 5 | -0.0462442 |
| HELZ | helicase with zinc finger | -0.0459646 |
| MIDN | midnolin | -0.0458658 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.045214 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0451 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0450645 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0448552 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0443363 |
| MXD1 | MAX dimerization protein 1 | -0.0440382 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0440347 |
| S100A8 | S100 calcium binding protein A8 | -0.0440302 |
| GRB7 | growth factor receptor-bound protein 7 | -0.0438994 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0438854 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0433755 |
| TC2N | tandem C2 domains, nuclear | -0.0428707 |
| TMEM41B | transmembrane protein 41B | -0.0427809 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0426464 |
| HOMER1 | homer scaffolding protein 1 | -0.0415976 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0406032 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0405413 |
| ANXA1 | annexin A1 | -0.0396665 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0396215 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | -0.0394934 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0391365 |
| FRMD5 | FERM domain containing 5 | -0.039119 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0391103 |
| SRPK2 | SRSF protein kinase 2 | -0.0390252 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0384683 |
| ITGB4 | integrin, beta 4 | -0.0376893 |
| THOC2 | THO complex 2 | -0.0375189 |
| USP3 | ubiquitin specific peptidase 3 | -0.0368757 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0367235 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0363665 |
| ZNF609 | zinc finger protein 609 | -0.0362332 |
| CA12 | carbonic anhydrase XII | -0.036214 |
| RREB1 | ras responsive element binding protein 1 | -0.0357372 |
| CDYL | chromodomain protein, Y-like | -0.03571 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0347633 |
| DIAPH2 | diaphanous-related formin 2 | -0.0347345 |
| NCOA3 | nuclear receptor coactivator 3 | -0.034642 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | -0.0345639 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0342551 |
| ATP13A3 | ATPase type 13A3 | -0.0341202 |
| FBXO34 | F-box protein 34 | -0.0341068 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0336985 |
| RBM39 | RNA binding motif protein 39 | -0.0335845 |
| WASF2 | WAS protein family, member 2 | -0.0334076 |
| PAIP2 | poly(A) binding protein interacting protein 2 | -0.0331769 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0327689 |
| CLINT1 | clathrin interactor 1 | -0.0327572 |
| PAPOLA | poly(A) polymerase alpha | -0.0327477 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0326589 |
| PDS5A | PDS5 cohesin associated factor A | -0.0324792 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0319741 |
| CDH13 | cadherin 13 | -0.0317763 |
| USP15 | ubiquitin specific peptidase 15 | -0.0313927 |
| PCBP2 | poly(rC) binding protein 2 | -0.0311581 |
| HPCAL1 | hippocalcin-like 1 | -0.0310122 |
| CD44 | CD44 molecule (Indian blood group) | -0.0309249 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | -0.0307621 |
| ARFGEF1 | ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) | -0.0306752 |
| TMEM123 | transmembrane protein 123 | -0.0306632 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0306238 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0303284 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0302848 |
| JUP | junction plakoglobin | -0.0300155 |
| TMEM263 | transmembrane protein 263 | -0.0297134 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0296896 |
| ZNF638 | zinc finger protein 638 | -0.0296383 |
