| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trifluridine perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trifluridine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.116165 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.111428 |
| TPI1 | triosephosphate isomerase 1 | 0.0962535 |
| YBX3 | Y box binding protein 3 | 0.0817761 |
| RPS3 | ribosomal protein S3 | 0.0586594 |
| MT2A | metallothionein 2A | 0.0565215 |
| TUBA1B | tubulin, alpha 1b | 0.0522891 |
| VIM | vimentin | 0.0507537 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0493347 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0414287 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0391441 |
| PTMA | prothymosin, alpha | 0.0368348 |
| LDHA | lactate dehydrogenase A | 0.036017 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.034119 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0332308 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0329679 |
| TPM3 | tropomyosin 3 | 0.0328841 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0323016 |
| CAVIN1 | caveolae associated protein 1 | 0.0322937 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0314475 |
| TMSB10 | thymosin beta 10 | 0.0301393 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0300685 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0292953 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0292681 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0292572 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.029185 |
| RPS7 | ribosomal protein S7 | 0.0290712 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0280554 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0278681 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0278463 |
| ENO1 | enolase 1, (alpha) | 0.0276479 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0268256 |
| SET | SET nuclear proto-oncogene | 0.0264985 |
| PRDX1 | peroxiredoxin 1 | 0.0263305 |
| KRT18 | keratin 18, type I | 0.0255861 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0253857 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0250339 |
| STC1 | stanniocalcin 1 | 0.02482 |
| S100A11 | S100 calcium binding protein A11 | 0.0245782 |
| KLF6 | Kruppel-like factor 6 | 0.0243521 |
| MYL12B | myosin, light chain 12B, regulatory | 0.023569 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0231406 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0228405 |
| RPS12 | ribosomal protein S12 | 0.0226872 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0226362 |
| RPL9 | ribosomal protein L9 | 0.0217235 |
| RPS2 | ribosomal protein S2 | 0.0204824 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0201237 |
| B2M | beta-2-microglobulin | 0.0198958 |
| CLSPN | claspin | 0.0197594 |
| CIP2A | cellular inhibitor of PP2A | 0.0196472 |
| KIF1A | kinesin family member 1A | 0.0193816 |
| ID3 | inhibitor of DNA binding 3, dominant negative helix-loop-helix protein | 0.0192916 |
| POMP | proteasome maturation protein | 0.0190793 |
| H3-3B | H3.3 histone B | 0.0189098 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0189064 |
| ADRM1 | adhesion regulating molecule 1 | 0.018713 |
| VDAC1 | voltage-dependent anion channel 1 | 0.018413 |
| IER3 | immediate early response 3 | 0.0183882 |
| DNAJC10 | DnaJ (Hsp40) homolog, subfamily C, member 10 | 0.0182732 |
| WWOX | WW domain containing oxidoreductase | 0.0181345 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0177992 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0176923 |
| RACK1 | receptor for activated C kinase 1 | 0.017616 |
| TUBA1C | tubulin, alpha 1c | 0.0175309 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0174026 |
| OLR1 | oxidized low density lipoprotein (lectin-like) receptor 1 | 0.0172466 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0169177 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0167928 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0165739 |
| DHRS7 | dehydrogenase/reductase (SDR family) member 7 | 0.0164988 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0163811 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | 0.0161639 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0160228 |
| SNRPB | small nuclear ribonucleoprotein polypeptides B and B1 | 0.0158691 |
| RRM2 | ribonucleotide reductase M2 | 0.0157444 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0157333 |
| SRP14 | signal recognition particle 14kDa (homologous Alu RNA binding protein) | 0.0155859 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0152066 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0150722 |
| GPX4 | glutathione peroxidase 4 | 0.0148609 |
| RPL26 | ribosomal protein L26 | 0.0147978 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0147564 |
| GLIS3 | GLIS family zinc finger 3 | 0.0146753 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0145752 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | 0.0145375 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0143946 |
| TPM4 | tropomyosin 4 | 0.0143646 |
| CTPS1 | CTP synthase 1 | 0.014312 |
| EBNA1BP2 | EBNA1 binding protein 2 | 0.0140788 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0140343 |
| CENPE | centromere protein E, 312kDa | 0.0140269 |
| TOP1 | topoisomerase (DNA) I | 0.0139995 |
| CIAO1 | cytosolic iron-sulfur assembly component 1 | 0.0138086 |
| HMGB2 | high mobility group box 2 | 0.0137142 |
| ARPC1B | actin related protein 2/3 complex, subunit 1B, 41kDa | 0.013424 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.013389 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0131879 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0131451 |
| UBB | ubiquitin B | 0.0131387 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.316703 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.107256 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0909993 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0746109 |
| MCL1 | myeloid cell leukemia 1 | -0.0738497 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0646362 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0622289 |
| FBXO11 | F-box protein 11 | -0.0598756 |
| RPL35A | ribosomal protein L35a | -0.0586511 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0564153 |
| RAD51B | RAD51 paralog B | -0.0551193 |
| COPA | coatomer protein complex, subunit alpha | -0.0536972 |
| RBM39 | RNA binding motif protein 39 | -0.0535729 |
| TPM2 | tropomyosin 2 (beta) | -0.0532984 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0531854 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0476058 |
| USP34 | ubiquitin specific peptidase 34 | -0.0460963 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0452316 |
| RSF1 | remodeling and spacing factor 1 | -0.0420061 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0415779 |
| PTK2 | protein tyrosine kinase 2 | -0.041195 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0409935 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0406833 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0405118 |
| ZNF638 | zinc finger protein 638 | -0.0394521 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0386685 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0373478 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0373198 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0367079 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0367023 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0361612 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0358477 |
| SBF2 | SET binding factor 2 | -0.0353633 |
| UBC | ubiquitin C | -0.0352152 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.034611 |
| SETD5 | SET domain containing 5 | -0.0344196 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0343374 |
| OSMR | oncostatin M receptor | -0.0342723 |
| PCBP2 | poly(rC) binding protein 2 | -0.0324732 |
| FMNL2 | formin-like 2 | -0.0322643 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0319048 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0317353 |
| GOLGA4 | golgin A4 | -0.0316389 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.03108 |
| NABP1 | nucleic acid binding protein 1 | -0.031041 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.030315 |
| WASF2 | WAS protein family, member 2 | -0.0302306 |
| AHNAK | AHNAK nucleoprotein | -0.0301782 |
| MED13 | mediator complex subunit 13 | -0.0300943 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0300622 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0298454 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0296294 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0295567 |
| CANX | calnexin | -0.0294972 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0294342 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0293439 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0292845 |
| RPS19 | ribosomal protein S19 | -0.0291653 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0291065 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0286578 |
| EGR1 | early growth response 1 | -0.0285478 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.028415 |
| CCNL1 | cyclin L1 | -0.0284034 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0282176 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.028212 |
| BBX | bobby sox homolog (Drosophila) | -0.0281081 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.02807 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0280675 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0278284 |
| RPL8 | ribosomal protein L8 | -0.0275849 |
| KMT2A | lysine (K)-specific methyltransferase 2A | -0.0274787 |
| RPS6 | ribosomal protein S6 | -0.027395 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0272718 |
| COG5 | component of oligomeric golgi complex 5 | -0.027186 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0270539 |
| NF1 | neurofibromin 1 | -0.026717 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0267055 |
| DENND5B | DENN/MADD domain containing 5B | -0.0263019 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0262311 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0262182 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0259957 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0258081 |
| CTTN | cortactin | -0.0258032 |
| ATXN2 | ataxin 2 | -0.0257415 |
| ATXN1 | ataxin 1 | -0.0257188 |
| OGA | O-GlcNAcase | -0.0256569 |
| ATF6 | activating transcription factor 6 | -0.0250908 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0248958 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0248006 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0246591 |
| RPL23 | ribosomal protein L23 | -0.0246457 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0244993 |
| WNK1 | WNK lysine deficient protein kinase 1 | -0.0243483 |
| RAB10 | RAB10, member RAS oncogene family | -0.0242939 |
| MED13L | mediator complex subunit 13-like | -0.0242144 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0242032 |
| BAZ2A | bromodomain adjacent to zinc finger domain, 2A | -0.0242022 |
| RAB1A | RAB1A, member RAS oncogene family | -0.024089 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0240408 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0239938 |
