| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trifluridine perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trifluridine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.227469 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.181981 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.114671 |
| FTL | ferritin, light polypeptide | 0.109915 |
| HMGB2 | high mobility group box 2 | 0.109619 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.104674 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102038 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.086367 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0828901 |
| ENO1 | enolase 1, (alpha) | 0.0810681 |
| MT2A | metallothionein 2A | 0.0803984 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0765619 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0654422 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0627893 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0612224 |
| LDHA | lactate dehydrogenase A | 0.0581114 |
| RPS3 | ribosomal protein S3 | 0.0574702 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.054224 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0536315 |
| LAMC2 | laminin, gamma 2 | 0.0521808 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0503591 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0499144 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0483327 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0478207 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0470017 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0451253 |
| RPS12 | ribosomal protein S12 | 0.0443363 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0437032 |
| BRD2 | bromodomain containing 2 | 0.0425716 |
| LAMB3 | laminin, beta 3 | 0.0419839 |
| DUSP6 | dual specificity phosphatase 6 | 0.0419825 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.040682 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0403983 |
| ANXA2 | annexin A2 | 0.0401436 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0399915 |
| SMC4 | structural maintenance of chromosomes 4 | 0.039689 |
| RACK1 | receptor for activated C kinase 1 | 0.0373556 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0362976 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0354036 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0353899 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0348727 |
| MKI67 | marker of proliferation Ki-67 | 0.0345425 |
| ASPH | aspartate beta-hydroxylase | 0.0340491 |
| TXNIP | thioredoxin interacting protein | 0.0323497 |
| CD44 | CD44 molecule (Indian blood group) | 0.0322694 |
| EGR1 | early growth response 1 | 0.0316902 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0316697 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0299021 |
| RPS2 | ribosomal protein S2 | 0.0292735 |
| NCOA7 | nuclear receptor coactivator 7 | 0.0289684 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0288182 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0287637 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0284407 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0273613 |
| KLF6 | Kruppel-like factor 6 | 0.0271704 |
| RPS7 | ribosomal protein S7 | 0.0270444 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0268422 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0268227 |
| RPS17 | ribosomal protein S17 | 0.0267924 |
| HMGA1 | high mobility group AT-hook 1 | 0.0267428 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0257126 |
| FNBP1L | formin binding protein 1-like | 0.025635 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0255418 |
| NDRG1 | N-myc downstream regulated 1 | 0.0253821 |
| ANO6 | anoctamin 6 | 0.0251956 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0246303 |
| RPLP0 | ribosomal protein, large, P0 | 0.0243739 |
| DSPP | dentin sialophosphoprotein | 0.0242604 |
| AHR | aryl hydrocarbon receptor | 0.0234439 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.0231529 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0228298 |
| EZR | ezrin | 0.0223252 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0220729 |
| CENPE | centromere protein E, 312kDa | 0.0220128 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0219936 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0218654 |
| ZNF292 | zinc finger protein 292 | 0.0218467 |
| FLNA | filamin A, alpha | 0.0217081 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0212072 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0211323 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0210293 |
| CTSS | cathepsin S | 0.0210161 |
| SERINC1 | serine incorporator 1 | 0.0207191 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | 0.0207155 |
| SGMS2 | sphingomyelin synthase 2 | 0.0203332 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0201345 |
| RPL9 | ribosomal protein L9 | 0.0201247 |
| HYOU1 | hypoxia up-regulated 1 | 0.0198991 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0198851 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0197314 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0197227 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0195249 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0193904 |
| SMAD3 | SMAD family member 3 | 0.0192425 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0190856 |
| SDC4 | syndecan 4 | 0.0190583 |
| DST | dystonin | 0.0189778 |
| EGFR | epidermal growth factor receptor | 0.0189048 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0187087 |
| RPL7 | ribosomal protein L7 | 0.0186767 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.213395 |
| POTEF | POTE ankyrin domain family, member F | -0.20517 |
| ACTG1 | actin gamma 1 | -0.146585 |
| RPL35A | ribosomal protein L35a | -0.14133 |
| TMSB10 | thymosin beta 10 | -0.139816 |
| UBC | ubiquitin C | -0.115085 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.113015 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0996696 |
| TMSB4X | thymosin beta 4, X-linked | -0.0872771 |
| FNDC3B | fibronectin type III domain containing 3B | -0.080687 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0785229 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0731507 |
| S100A10 | S100 calcium binding protein A10 | -0.0719948 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0699046 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0649066 |
| KRT7 | keratin 7, type II | -0.0640605 |
| RPL34 | ribosomal protein L34 | -0.0637528 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0623028 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0608534 |
| RPL8 | ribosomal protein L8 | -0.0600543 |
| RPS23 | ribosomal protein S23 | -0.0584879 |
| CCND1 | cyclin D1 | -0.057858 |
| VEGFA | vascular endothelial growth factor A | -0.0576717 |
| FN1 | fibronectin 1 | -0.0562815 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0561743 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0556816 |
| CD2AP | CD2-associated protein | -0.0553259 |
| FAM3C | family with sequence similarity 3, member C | -0.0552565 |
| PDLIM5 | PDZ and LIM domain 5 | -0.054063 |
| PTMA | prothymosin, alpha | -0.0539586 |
| MCU | mitochondrial calcium uniporter | -0.0535792 |
| GOLGA4 | golgin A4 | -0.0524082 |
| HLA-B | major histocompatibility complex, class I, B | -0.0506766 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0500996 |
| RCOR1 | REST corepressor 1 | -0.050003 |
| FBXO32 | F-box protein 32 | -0.0498701 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0495948 |
| PTK2 | protein tyrosine kinase 2 | -0.0489177 |
| FBXO34 | F-box protein 34 | -0.0482659 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0472698 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.045747 |
| GNAS | GNAS complex locus | -0.0453081 |
| WASF2 | WAS protein family, member 2 | -0.0451248 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0439125 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0433847 |
| ARHGAP20 | Rho GTPase activating protein 20 | -0.0422909 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0421248 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.041536 |
| RPS6 | ribosomal protein S6 | -0.0413473 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0412772 |
| CD63 | CD63 molecule | -0.0408483 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.040067 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.03993 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0392855 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0391791 |
| RPS15 | ribosomal protein S15 | -0.0385896 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0384143 |
| ARF4 | ADP-ribosylation factor 4 | -0.0383437 |
| RPS19 | ribosomal protein S19 | -0.0377108 |
| KRT8 | keratin 8, type II | -0.0369936 |
| TMEM263 | transmembrane protein 263 | -0.0368067 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0364619 |
| SRPK2 | SRSF protein kinase 2 | -0.0356209 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0353021 |
| COPA | coatomer protein complex, subunit alpha | -0.0352928 |
| ERBIN | erbb2 interacting protein | -0.0352855 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0350904 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0349082 |
| RPL32 | ribosomal protein L32 | -0.0345614 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0342803 |
| AHNAK | AHNAK nucleoprotein | -0.034236 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0340882 |
| RRBP1 | ribosome binding protein 1 | -0.0338685 |
| RHOA | ras homolog family member A | -0.0338071 |
| RPS11 | ribosomal protein S11 | -0.0334129 |
| FNIP1 | folliculin interacting protein 1 | -0.0333741 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0333258 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0332481 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0328886 |
| BBX | bobby sox homolog (Drosophila) | -0.03262 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.031797 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.0308355 |
| RPS29 | ribosomal protein S29 | -0.0307615 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0305112 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0305087 |
| MYO6 | myosin VI | -0.030229 |
| RPS21 | ribosomal protein S21 | -0.0298022 |
| TMEM165 | transmembrane protein 165 | -0.0297734 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0294437 |
| RPL23 | ribosomal protein L23 | -0.0294425 |
| CTSD | cathepsin D | -0.0292463 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0287125 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0286604 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0285565 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0279164 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0278839 |
| VCL | vinculin | -0.0273672 |
| RSF1 | remodeling and spacing factor 1 | -0.0271388 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.026688 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | -0.0264712 |
