Trifluridine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trifluridine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trifluridine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.231346
RPS12 ribosomal protein S12 0.149947
FTL ferritin, light polypeptide 0.108163
FTH1 ferritin, heavy polypeptide 1 0.107278
RPS3 ribosomal protein S3 0.10146
MT2A metallothionein 2A 0.0893733
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0830598
RPS8 ribosomal protein S8 0.0760845
BZW1 basic leucine zipper and W2 domains 1 0.0738074
COL8A1 collagen, type VIII, alpha 1 0.0694454
RPL26 ribosomal protein L26 0.0692026
RPS2 ribosomal protein S2 0.0686227
RPLP0 ribosomal protein, large, P0 0.0685609
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0653172
RPS17 ribosomal protein S17 0.0649807
VIM vimentin 0.063875
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0620304
RACK1 receptor for activated C kinase 1 0.0603318
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0594864
MKI67 marker of proliferation Ki-67 0.0592404
PM20D1 peptidase M20 domain containing 1 0.0589775
RPL37A ribosomal protein L37a 0.0589657
RPLP1 ribosomal protein, large, P1 0.0574828
RPS27 ribosomal protein S27 0.0560415
RPL9 ribosomal protein L9 0.0560352
RPS6 ribosomal protein S6 0.05589
RAB3B RAB3B, member RAS oncogene family 0.0546468
LDHA lactate dehydrogenase A 0.0544785
RPL31 ribosomal protein L31 0.0543443
TPT1 tumor protein, translationally-controlled 1 0.0522024
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.049822
RPS7 ribosomal protein S7 0.04707
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0457221
RPL12 ribosomal protein L12 0.0456016
SH3KBP1 SH3-domain kinase binding protein 1 0.0451384
TOP2A topoisomerase (DNA) II alpha 170kDa 0.044493
RPL36 ribosomal protein L36 0.0439662
KYNU kynureninase 0.0436983
DGKD diacylglycerol kinase, delta 130kDa 0.0414625
RGS2 regulator of G-protein signaling 2 0.0403142
CENPF centromere protein F, 350/400kDa 0.0395134
RPL13A ribosomal protein L13a 0.0386387
ANTXR1 anthrax toxin receptor 1 0.0380219
RPL35 ribosomal protein L35 0.0378885
TPI1 triosephosphate isomerase 1 0.037531
RPL7 ribosomal protein L7 0.0373922
RPLP2 ribosomal protein, large, P2 0.0368347
SLF1 SMC5-SMC6 complex localization factor 1 0.0366638
TMX4 thioredoxin-related transmembrane protein 4 0.0364653
SMC4 structural maintenance of chromosomes 4 0.0362055
RPL37 ribosomal protein L37 0.0361169
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0360178
B2M beta-2-microglobulin 0.0329968
PDE4D phosphodiesterase 4D, cAMP-specific 0.0329403
RPL19 ribosomal protein L19 0.0328042
DISP1 dispatched homolog 1 (Drosophila) 0.0326703
ESYT2 extended synaptotagmin-like protein 2 0.0325605
PRKN parkin RBR E3 ubiquitin protein ligase 0.0325588
PYGL phosphorylase, glycogen, liver 0.0325521
RPL27 ribosomal protein L27 0.0322661
CDK6 cyclin-dependent kinase 6 0.0321605
CXCL8 chemokine (C-X-C motif) ligand 8 0.0307212
RPS4X ribosomal protein S4, X-linked 0.0302009
TIMP1 TIMP metallopeptidase inhibitor 1 0.0297607
ANXA2 annexin A2 0.029581
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0292783
SRRM2 serine/arginine repetitive matrix 2 0.0291207
ALCAM activated leukocyte cell adhesion molecule 0.029016
RPL36A ribosomal protein L36a 0.02877
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0286476
YBX3 Y box binding protein 3 0.0285979
RPL11 ribosomal protein L11 0.0284152
P3H2 prolyl 3-hydroxylase 2 0.0282762
PDIA3 protein disulfide isomerase family A, member 3 0.0282564
RPL18 ribosomal protein L18 0.028136
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0280378
TUBB4B tubulin, beta 4B class IVb 0.0271179
TPR translocated promoter region, nuclear basket protein 0.0269899
SYNE2 spectrin repeat containing, nuclear envelope 2 0.026911
ENO1 enolase 1, (alpha) 0.0265357
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0264891
NCOA7 nuclear receptor coactivator 7 0.0262608
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0262475
NAP1L1 nucleosome assembly protein 1-like 1 0.0259569
GNAS GNAS complex locus 0.0258208
RPL21 ribosomal protein L21 0.0257918
ITGA6 integrin, alpha 6 0.0256618
PA2G4 proliferation-associated 2G4, 38kDa 0.0255956
ISG15 ISG15 ubiquitin-like modifier 0.0253238
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0253093
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0252068
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0250606
TPM3 tropomyosin 3 0.0249936
MAP7 microtubule-associated protein 7 0.0248054
KRT19 keratin 19, type I 0.0246305
CLU clusterin 0.0242641
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 0.0240448
PDE7B phosphodiesterase 7B 0.0238877
WWTR1 WW domain containing transcription regulator 1 0.0238676
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0235882

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.253978
UBC ubiquitin C -0.154664
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.143379
TM4SF1 transmembrane 4 L six family member 1 -0.13551
FN1 fibronectin 1 -0.104268
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.102019
MCL1 myeloid cell leukemia 1 -0.0770601
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0725292
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0696693
GDA guanine deaminase -0.069625
LIMCH1 LIM and calponin homology domains 1 -0.0683707
ACTG1 actin gamma 1 -0.0674159
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0661704
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0639508
CDH13 cadherin 13 -0.0637944
AHNAK AHNAK nucleoprotein -0.0610319
RPL35A ribosomal protein L35a -0.0582885
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0577228
SMYD3 SET and MYND domain containing 3 -0.0568753
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0558876
DOCK4 dedicator of cytokinesis 4 -0.05437
CANX calnexin -0.0473808
S100A10 S100 calcium binding protein A10 -0.0466234
IGFBP3 insulin-like growth factor binding protein 3 -0.0454265
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.043605
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0428339
PCBP3 poly(rC) binding protein 3 -0.0425165
TBXT T-box transcription factor T -0.0412396
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0411963
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0410732
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0396058
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0387689
SLC38A2 solute carrier family 38, member 2 -0.0387462
WARS1 tryptophanyl-tRNA synthetase 1 -0.0386297
NALF1 NALCN channel auxiliary factor 1 -0.0382648
RBM39 RNA binding motif protein 39 -0.0381206
FNDC3B fibronectin type III domain containing 3B -0.0376704
USP34 ubiquitin specific peptidase 34 -0.0358933
PCBP2 poly(rC) binding protein 2 -0.0358501
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0354245
RPS27A ribosomal protein S27a -0.0341364
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.034087
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0337403
ASPH aspartate beta-hydroxylase -0.0337319
OGA O-GlcNAcase -0.0335651
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0323881
RPS23 ribosomal protein S23 -0.0322897
AKAP13 A kinase (PRKA) anchor protein 13 -0.0317411
ADGRD1 adhesion G protein-coupled receptor D1 -0.0313624
AUTS2 autism susceptibility candidate 2 -0.0310136
CTSL cathepsin L -0.0309815
CALU calumenin -0.0296996
STC1 stanniocalcin 1 -0.0295395
PDIA4 protein disulfide isomerase family A, member 4 -0.0283844
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0281906
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0279944
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0279104
PDIA6 protein disulfide isomerase family A, member 6 -0.0278157
CD44 CD44 molecule (Indian blood group) -0.0276968
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0276636
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.027323
GRB10 growth factor receptor-bound protein 10 -0.0270953
NCKAP5 NCK-associated protein 5 -0.0268616
ATP5F1B ATP synthase F1 subunit beta -0.026677
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0266614
EXT1 exostosin glycosyltransferase 1 -0.0264279
FLNB filamin B, beta -0.0258897
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0258279
SRPK2 SRSF protein kinase 2 -0.0256891
CDK12 cyclin-dependent kinase 12 -0.0254557
COL5A2 collagen, type V, alpha 2 -0.0254485
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0254099
RPL34 ribosomal protein L34 -0.0251625
SEC31A SEC31 homolog A (S. cerevisiae) -0.0250927
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0247667
GSK3B glycogen synthase kinase 3 beta -0.0246651
TMSB4X thymosin beta 4, X-linked -0.0245093
NAMPT nicotinamide phosphoribosyltransferase -0.0244699
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.024377
N4BP2L2 NEDD4 binding protein 2-like 2 -0.024346
EIF4A2 eukaryotic translation initiation factor 4A2 -0.024037
ZC3H11A zinc finger CCCH-type containing 11A -0.0240173
VCL vinculin -0.0239076
HLA-B major histocompatibility complex, class I, B -0.0238012
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0237675
TFPI2 tissue factor pathway inhibitor 2 -0.023732
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0234584
MGST1 microsomal glutathione S-transferase 1 -0.0233633
SPAG9 sperm associated antigen 9 -0.0232698
RPS15 ribosomal protein S15 -0.0232243
COPA coatomer protein complex, subunit alpha -0.0231905
RICTOR RPTOR independent companion of MTOR, complex 2 -0.023101
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0230482
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0225014
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0222905
RPS11 ribosomal protein S11 -0.0222835
ZNF638 zinc finger protein 638 -0.0222533
TENM3 teneurin transmembrane protein 3 -0.022016
SDK1 sidekick cell adhesion molecule 1 -0.0218277
RBMX RNA binding motif protein, X-linked -0.021643