| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trifluridine perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trifluridine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| JMJD1C | jumonji domain containing 1C | 0.156209 |
| MT2A | metallothionein 2A | 0.137081 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.133814 |
| PGK1 | phosphoglycerate kinase 1 | 0.115949 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.112463 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.112421 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.110547 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.108057 |
| GPC6 | glypican 6 | 0.106327 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.105688 |
| AFF4 | AF4/FMR2 family, member 4 | 0.104376 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0976175 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0967414 |
| RPL26 | ribosomal protein L26 | 0.0952984 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0888712 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0873035 |
| RPS12 | ribosomal protein S12 | 0.0856908 |
| ENO1 | enolase 1, (alpha) | 0.0823525 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0812805 |
| FMN1 | formin 1 | 0.0811929 |
| FMNL2 | formin-like 2 | 0.0783825 |
| PKM | pyruvate kinase, muscle | 0.0757575 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0738834 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0709537 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0707408 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0702535 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0691321 |
| AOPEP | aminopeptidase O (putative) | 0.0689218 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0677449 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0648566 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0645897 |
| RPS3 | ribosomal protein S3 | 0.0641062 |
| VIM | vimentin | 0.062015 |
| MON2 | MON2 homolog (S. cerevisiae) | 0.059077 |
| FTL | ferritin, light polypeptide | 0.0577961 |
| RPL18 | ribosomal protein L18 | 0.0570784 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0566642 |
| PRKCE | protein kinase C, epsilon | 0.0545994 |
| SBF2 | SET binding factor 2 | 0.0537701 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0528279 |
| RPL37A | ribosomal protein L37a | 0.0526837 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.05173 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0514443 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0476639 |
| SMYD3 | SET and MYND domain containing 3 | 0.0458469 |
| NLGN1 | neuroligin 1 | 0.0452546 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0438587 |
| FRMD4A | FERM domain containing 4A | 0.0436377 |
| UBE2R2 | ubiquitin-conjugating enzyme E2R 2 | 0.043572 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0434549 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0433944 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0404599 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0404454 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0380553 |
| RPS25 | ribosomal protein S25 | 0.0379891 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0378175 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0373228 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0373084 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0371965 |
| B2M | beta-2-microglobulin | 0.0371781 |
| RPS6 | ribosomal protein S6 | 0.0366025 |
| MATR3 | matrin 3 | 0.0360741 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0356165 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0353029 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0353001 |
| USP34 | ubiquitin specific peptidase 34 | 0.0342432 |
| IGF2 | insulin-like growth factor 2 | 0.034152 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0335047 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0334751 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0332884 |
| ERBIN | erbb2 interacting protein | 0.0328942 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0321169 |
| ACTG1 | actin gamma 1 | 0.0318085 |
| RPLP2 | ribosomal protein, large, P2 | 0.0305658 |
| TXNRD1 | thioredoxin reductase 1 | 0.0299693 |
| GOLGB1 | golgin B1 | 0.0296263 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0276508 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0265115 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | 0.0264032 |
| H3-3B | H3.3 histone B | 0.0247609 |
| FRYL | FRY-like | 0.0221754 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0220996 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0217032 |
| PDE10A | phosphodiesterase 10A | 0.0211657 |
| EZR | ezrin | 0.021148 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0209943 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | 0.0178794 |
| ARRDC3 | arrestin domain containing 3 | 0.0175609 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0173191 |
| RPL27A | ribosomal protein L27a | 0.0172634 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0165997 |
| RPL31 | ribosomal protein L31 | 0.015946 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.015772 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0132744 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0131059 |
| PTMA | prothymosin, alpha | 0.0120673 |
| ZNF292 | zinc finger protein 292 | 0.0118365 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0113574 |
| SPAG9 | sperm associated antigen 9 | 0.0106326 |
| RPLP1 | ribosomal protein, large, P1 | 0.0104622 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.36187 |
| NDRG1 | N-myc downstream regulated 1 | -0.15831 |
| EGFR | epidermal growth factor receptor | -0.152391 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.134495 |
| MYOF | myoferlin | -0.132174 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.121702 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.109016 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.104345 |
| FN1 | fibronectin 1 | -0.102935 |
| MYO1E | myosin IE | -0.101904 |
| YAP1 | Yes-associated protein 1 | -0.0963077 |
| HMGA2 | high mobility group AT-hook 2 | -0.0893753 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0883729 |
| PRKCA | protein kinase C, alpha | -0.0868345 |
| SLTM | SAFB-like, transcription modulator | -0.0862954 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0818127 |
| FHIT | fragile histidine triad | -0.0801857 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0792985 |
| EFNA5 | ephrin-A5 | -0.0787161 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0784206 |
| CANX | calnexin | -0.0770153 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0729556 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0707382 |
| CD44 | CD44 molecule (Indian blood group) | -0.0682415 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0682117 |
| HDAC9 | histone deacetylase 9 | -0.0667931 |
| MYO6 | myosin VI | -0.0661892 |
| TMSB10 | thymosin beta 10 | -0.0655581 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0644381 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0614462 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.061384 |
| PARD3 | par-3 family cell polarity regulator | -0.0570114 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0562711 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.053628 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | -0.0524745 |
| RPS13 | ribosomal protein S13 | -0.0501839 |
| RAD51B | RAD51 paralog B | -0.050168 |
| CUL3 | cullin 3 | -0.0496229 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0478149 |
| RUNX1 | runt-related transcription factor 1 | -0.0476496 |
| LAMA4 | laminin, alpha 4 | -0.0464942 |
| TPM4 | tropomyosin 4 | -0.0434865 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0404874 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0398057 |
| FLNB | filamin B, beta | -0.0396174 |
| MAP4 | microtubule-associated protein 4 | -0.0392067 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0380286 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0365454 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0346663 |
| MCL1 | myeloid cell leukemia 1 | -0.0346594 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0337425 |
| PIAS1 | protein inhibitor of activated STAT, 1 | -0.0332587 |
| PRELID2 | PRELI domain containing 2 | -0.0331945 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0328055 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0320297 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0320059 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0315284 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0304759 |
| PDE8A | phosphodiesterase 8A | -0.030291 |
| EGR1 | early growth response 1 | -0.0295115 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0281109 |
| RPL37 | ribosomal protein L37 | -0.0276092 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0275793 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0253134 |
| RPS19 | ribosomal protein S19 | -0.024608 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0229335 |
| RPS8 | ribosomal protein S8 | -0.0227774 |
| FNIP1 | folliculin interacting protein 1 | -0.0218656 |
| ASPH | aspartate beta-hydroxylase | -0.021857 |
| DST | dystonin | -0.0203671 |
| MYO10 | myosin X | -0.0192681 |
| INHBA | inhibin, beta A | -0.0179411 |
| RSF1 | remodeling and spacing factor 1 | -0.017871 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0178545 |
| FBXO11 | F-box protein 11 | -0.0177115 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0176567 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.017538 |
| LMO7 | LIM domain 7 | -0.0165156 |
| BBX | bobby sox homolog (Drosophila) | -0.0156927 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0154151 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0150578 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0147789 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0147373 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0143809 |
| SLIT2 | slit homolog 2 (Drosophila) | -0.0136515 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0133449 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0127259 |
| COPA | coatomer protein complex, subunit alpha | -0.0124092 |
| RTN4 | reticulon 4 | -0.011983 |
| YBX3 | Y box binding protein 3 | -0.0102475 |
| TBC1D22A | TBC1 domain family, member 22A | -0.00986425 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0094736 |
| ADNP | activity-dependent neuroprotector homeobox | -0.0079123 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.00773801 |
| GOLGA4 | golgin A4 | -0.007284 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.00652189 |
| HLA-B | major histocompatibility complex, class I, B | -0.00643739 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.00633336 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.00527621 |
| LDHA | lactate dehydrogenase A | -0.0045476 |
