Trifluridine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trifluridine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trifluridine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.295659
LDHA lactate dehydrogenase A 0.140963
GLIS3 GLIS family zinc finger 3 0.131631
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.10561
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0932949
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0856731
VCAN versican 0.0814425
ENO1 enolase 1, (alpha) 0.069481
HLA-E major histocompatibility complex, class I, E 0.0680921
HMGA2 high mobility group AT-hook 2 0.0678976
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0661368
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.061782
CDH13 cadherin 13 0.0571268
HDAC9 histone deacetylase 9 0.0545837
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0518284
TPT1 tumor protein, translationally-controlled 1 0.050217
ASPH aspartate beta-hydroxylase 0.0493461
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0472499
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0471734
PGK1 phosphoglycerate kinase 1 0.0463011
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0425218
EGR1 early growth response 1 0.0410933
PTPRK protein tyrosine phosphatase, receptor type, K 0.0401196
ZBTB38 zinc finger and BTB domain containing 38 0.039759
STC1 stanniocalcin 1 0.0396784
BICC1 BicC family RNA binding protein 1 0.0389657
TGFBI transforming growth factor, beta-induced, 68kDa 0.037249
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0368718
NAP1L1 nucleosome assembly protein 1-like 1 0.0355591
SFRP1 secreted frizzled-related protein 1 0.0343207
MAP1B microtubule-associated protein 1B 0.0342372
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0341571
NAV1 neuron navigator 1 0.0335723
CD44 CD44 molecule (Indian blood group) 0.0328639
INHBA inhibin, beta A 0.0313514
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0309394
DDIT4 DNA-damage-inducible transcript 4 0.0306749
COL6A3 collagen, type VI, alpha 3 0.0305912
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0304154
CREB5 cAMP responsive element binding protein 5 0.0299518
SQSTM1 sequestosome 1 0.0297983
MKI67 marker of proliferation Ki-67 0.0297673
COL1A2 collagen, type I, alpha 2 0.0294914
ZBTB20 zinc finger and BTB domain containing 20 0.0293929
TRIO trio Rho guanine nucleotide exchange factor 0.0291549
CDK6 cyclin-dependent kinase 6 0.0291321
OSBPL8 oxysterol binding protein-like 8 0.0291033
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0289532
PSD3 pleckstrin and Sec7 domain containing 3 0.0289123
RPS12 ribosomal protein S12 0.0289022
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0286308
SYNJ2 synaptojanin 2 0.0285777
PRSS23 protease, serine, 23 0.0285327
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.027959
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.02788
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0275229
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.027497
IGFBP7 insulin-like growth factor binding protein 7 0.0273048
SET SET nuclear proto-oncogene 0.0272744
JUN jun proto-oncogene 0.027184
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0271213
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0270115
RAI14 retinoic acid induced 14 0.0268347
LAMP2 lysosomal-associated membrane protein 2 0.0254341
ZMYND8 zinc finger, MYND-type containing 8 0.0252735
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0248914
WFDC10B WAP four-disulfide core domain 10B 0.0246064
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0245728
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0244039
GADD45B growth arrest and DNA-damage-inducible, beta 0.0243738
F2R coagulation factor II (thrombin) receptor 0.0240042
C6ORF62 chromosome 6 open reading frame 62 0.023793
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0234688
CAVIN1 caveolae associated protein 1 0.0233653
SOX9 SRY (sex determining region Y)-box 9 0.0233599
MBNL1 muscleblind-like splicing regulator 1 0.0231968
ZFP36L1 ZFP36 ring finger protein-like 1 0.023162
KRT19 keratin 19, type I 0.0230574
LGALS12 lectin, galactoside-binding, soluble, 12 0.0228086
BRD2 bromodomain containing 2 0.022658
CALR calreticulin 0.0225464
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0224264
PRRC2C proline-rich coiled-coil 2C 0.0223907
LMNA lamin A/C 0.0222925
CSDE1 cold shock domain containing E1, RNA-binding 0.0221453
IER3 immediate early response 3 0.0220703
FBXL17 F-box and leucine-rich repeat protein 17 0.0218756
SH3KBP1 SH3-domain kinase binding protein 1 0.0217011
ALCAM activated leukocyte cell adhesion molecule 0.0215901
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.021584
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0215563
HLA-A major histocompatibility complex, class I, A 0.0213704
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0213105
EHBP1 EH domain binding protein 1 0.0209235
CEP112 centrosomal protein 112kDa 0.0208344
EXT1 exostosin glycosyltransferase 1 0.0208273
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 0.0207236
GPBP1 GC-rich promoter binding protein 1 0.0201298
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0199986
TRIM55 tripartite motif containing 55 0.0197357

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.256235
SOD2 superoxide dismutase 2, mitochondrial -0.178562
RPS6 ribosomal protein S6 -0.127044
NAMPT nicotinamide phosphoribosyltransferase -0.112113
RPL35A ribosomal protein L35a -0.0776375
FNDC3B fibronectin type III domain containing 3B -0.0685155
RPS19 ribosomal protein S19 -0.0586281
RPS23 ribosomal protein S23 -0.0572556
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0557638
RPLP1 ribosomal protein, large, P1 -0.0553495
ELL2 elongation factor, RNA polymerase II, 2 -0.0538151
TMSB10 thymosin beta 10 -0.0537372
FN1 fibronectin 1 -0.0530102
HLA-B major histocompatibility complex, class I, B -0.0496735
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0489941
RPL23 ribosomal protein L23 -0.0477762
PPARD peroxisome proliferator-activated receptor delta -0.0475732
EIF1 eukaryotic translation initiation factor 1 -0.046427
MT2A metallothionein 2A -0.0455312
MYH9 myosin, heavy chain 9, non-muscle -0.0451103
EEF2 eukaryotic translation elongation factor 2 -0.0445673
PCBP2 poly(rC) binding protein 2 -0.0438077
WTAP Wilms tumor 1 associated protein -0.0432921
ACTG1 actin gamma 1 -0.0431895
RPLP2 ribosomal protein, large, P2 -0.0423655
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.042058
NT5C2 5'-nucleotidase, cytosolic II -0.0410252
LOC112694756 uncharaterized LOC112694756 -0.0405201
UGCG UDP-glucose ceramide glucosyltransferase -0.040334
NAV2 neuron navigator 2 -0.0399738
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 -0.0391413
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0389017
RPL32 ribosomal protein L32 -0.0388852
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0388257
UBC ubiquitin C -0.0386111
SDK1 sidekick cell adhesion molecule 1 -0.0381535
RPL11 ribosomal protein L11 -0.0380721
PHIP pleckstrin homology domain interacting protein -0.0359612
YBX1 Y box binding protein 1 -0.0355906
OGA O-GlcNAcase -0.0351317
SPAG9 sperm associated antigen 9 -0.0349074
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0344835
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.034131
EPAS1 endothelial PAS domain protein 1 -0.0331109
GOLGA4 golgin A4 -0.0329899
TSC22D2 TSC22 domain family, member 2 -0.0328808
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0328477
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0326878
CCNL1 cyclin L1 -0.0323361
RPL28 ribosomal protein L28 -0.032196
SNX14 sorting nexin 14 -0.0318486
TAPBP TAP binding protein (tapasin) -0.0317517
HELZ helicase with zinc finger -0.0316323
RPL19 ribosomal protein L19 -0.0314537
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0313695
MYOF myoferlin -0.0306851
FNIP1 folliculin interacting protein 1 -0.0301933
RPL35 ribosomal protein L35 -0.0290913
OPTN optineurin -0.0283362
ARRDC3 arrestin domain containing 3 -0.027951
RPS11 ribosomal protein S11 -0.0278866
FLNB filamin B, beta -0.0278447
TNS3 tensin 3 -0.0277702
RPS10 ribosomal protein S10 -0.0276563
FOXO3 forkhead box O3 -0.0275076
NABP1 nucleic acid binding protein 1 -0.027445
RPS4X ribosomal protein S4, X-linked -0.0273707
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0273381
RPS21 ribosomal protein S21 -0.0272276
DEK DEK proto-oncogene -0.0269951
RPS29 ribosomal protein S29 -0.0267222
NAP1L4 nucleosome assembly protein 1-like 4 -0.0266027
RPL34 ribosomal protein L34 -0.0265739
RPL8 ribosomal protein L8 -0.0259469
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0254472
RPL36 ribosomal protein L36 -0.0248854
RPS27 ribosomal protein S27 -0.0247139
FMNL2 formin-like 2 -0.0245805
CANX calnexin -0.0239325
CLIC4 chloride intracellular channel 4 -0.0236483
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0236332
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0235931
DUSP5 dual specificity phosphatase 5 -0.023304
PRELID2 PRELI domain containing 2 -0.0232266
RPS14 ribosomal protein S14 -0.0231514
MSN moesin -0.0227098
RPL5 ribosomal protein L5 -0.0226281
ARF4 ADP-ribosylation factor 4 -0.0224998
MARCHF6 membrane associated ring-CH-type finger 6 -0.0223287
TRA2A transformer 2 alpha homolog (Drosophila) -0.0221662
GGNBP2 gametogenetin binding protein 2 -0.0219398
IGFBP3 insulin-like growth factor binding protein 3 -0.0219014
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0218981
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0217222
STAG2 stromal antigen 2 -0.021691
TENT5A terminal nucleotidyltransferase 5A -0.0216661
ZNF451 zinc finger protein 451 -0.0215991
RIGI RNA sensor RIG-I -0.0214716
RPS20 ribosomal protein S20 -0.0213122
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.020916