Trihydroxyisoflavone Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/54736541
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Genes

200 proteins with high or low expression in Trihydroxyisoflavone relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
DNAH1 dynein, axonemal, heavy chain 1 1.25
OTUD3 OTU deubiquitinase 3 0.66
CACUL1 CDK2-associated, cullin domain 1 0.61
IREB2 iron-responsive element binding protein 2 0.52
PKP2 plakophilin 2 0.48
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) 0.46
SNTA1 syntrophin, alpha 1 0.45
ALKBH7 alkB, alkylation repair homolog 7 (E. coli) 0.44
TPM1 tropomyosin 1 (alpha) 0.43
GUK1 guanylate kinase 1 0.42
IRF2 interferon regulatory factor 2 0.42
MYT1 myelin transcription factor 1 0.42
KMT2E lysine (K)-specific methyltransferase 2E 0.42
ATG4A autophagy related 4A, cysteine peptidase 0.41
CNPY3 canopy FGF signaling regulator 3 0.41
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa 0.4
COL18A1 collagen, type XVIII, alpha 1 0.39
NDST1 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1 0.39
TMC7 transmembrane channel-like 7 0.38
RGP1 RGP1 retrograde golgi transport homolog (S. cerevisiae) 0.37
NMRAL1 NmrA-like family domain containing 1 0.36
KRT222 keratin 222, type II 0.35
GABPB2 GA binding protein transcription factor, beta subunit 2 0.35
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.34
ADAM19 ADAM metallopeptidase domain 19 0.34
PARD6G par-6 family cell polarity regulator gamma 0.34
CADPS2 Ca++-dependent secretion activator 2 0.34
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) 0.33
ZNF654 zinc finger protein 654 0.33
MLH3 mutL homolog 3 0.33
RBM23 RNA binding motif protein 23 0.32
PLK2 polo-like kinase 2 0.32
USP45 ubiquitin specific peptidase 45 0.31
GREB1 growth regulation by estrogen in breast cancer 1 0.31
MRPL52 mitochondrial ribosomal protein L52 0.3
ABHD18 abhydrolase domain containing 18 0.3
ZNF428 zinc finger protein 428 0.3
CDCA4 cell division cycle associated 4 0.3
IL17RB interleukin 17 receptor B 0.29
TMEM134 transmembrane protein 134 0.29
EWSR1 EWS RNA-binding protein 1 0.29
ELK1 ELK1, member of ETS oncogene family 0.28
LRRC45 leucine rich repeat containing 45 0.28
COX18 COX18 cytochrome c oxidase assembly factor 0.28
HSPA12B heat shock 70kD protein 12B 0.28
RNASEH2A ribonuclease H2, subunit A 0.28
HAUS4 HAUS augmin-like complex, subunit 4 0.28
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 0.28
C19ORF25 chromosome 19 open reading frame 25 0.27
OTULINL OTU deubiquitinase with linear linkage specificity like 0.27
FAT3 FAT atypical cadherin 3 0.27
NEIL3 nei endonuclease VIII-like 3 (E. coli) 0.27
TMEM109 transmembrane protein 109 0.27
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 0.26
COL12A1 collagen, type XII, alpha 1 0.26
PGS1 phosphatidylglycerophosphate synthase 1 0.26
FRY furry homolog (Drosophila) 0.25
SOX12 SRY (sex determining region Y)-box 12 0.25
MRPL34 mitochondrial ribosomal protein L34 0.25
ZNF729 zinc finger protein 729 0.25
SYN2 synapsin II 0.25
SENP8 SUMO/sentrin specific peptidase family member 8 0.25
GAMT guanidinoacetate N-methyltransferase 0.25
TUBGCP6 tubulin, gamma complex associated protein 6 0.25
TMEM67 transmembrane protein 67 0.25
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.25
BORCS6 BLOC-1 related complex subunit 6 0.25
R3HDM1 R3H domain containing 1 0.25
F8A1 coagulation factor VIII-associated 1 0.25
CDC25A cell division cycle 25A 0.24
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) 0.24
COX5B cytochrome c oxidase subunit Vb 0.24
IMMT inner membrane protein, mitochondrial 0.24
ACP6 acid phosphatase 6, lysophosphatidic 0.24
RETREG3 reticulophagy regulator family member 3 0.24
F8 coagulation factor VIII, procoagulant component 0.24
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha 0.24
NCS1 neuronal calcium sensor 1 0.24
SPIRE1 spire-type actin nucleation factor 1 0.24
CCM2 cerebral cavernous malformation 2 0.24
S100PBP S100P binding protein 0.24
PEX5 peroxisomal biogenesis factor 5 0.23
NCOR1 nuclear receptor corepressor 1 0.23
TMEM259 transmembrane protein 259 0.23
CDC42SE2 CDC42 small effector 2 0.23
CEP57 centrosomal protein 57kDa 0.23
GEN1 GEN1 Holliday junction 5' flap endonuclease 0.23
MB21D2 Mab-21 domain containing 2 0.23
HYLS1 hydrolethalus syndrome 1 0.23
NFIC nuclear factor I/C (CCAAT-binding transcription factor) 0.23
ICOSLG inducible T-cell co-stimulator ligand 0.23
CPA4 carboxypeptidase A4 0.23
RELT RELT tumor necrosis factor receptor 0.23
PLCL2 phospholipase C-like 2 0.23
PPARD peroxisome proliferator-activated receptor delta 0.23
BTBD11 BTB (POZ) domain containing 11 0.22
EPHA1 EPH receptor A1 0.22
BACE2 beta-site APP-cleaving enzyme 2 0.22
HEXD hexosaminidase D 0.22
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.22

low expression

Symbol Name Standardized Value
AZGP1 alpha-2-glycoprotein 1, zinc-binding -1.32
ELL2 elongation factor, RNA polymerase II, 2 -1.28
TTLL4 tubulin tyrosine ligase-like family member 4 -1.22
SERGEF secretion regulating guanine nucleotide exchange factor -0.72
ZBTB17 zinc finger and BTB domain containing 17 -0.68
NR1D2 nuclear receptor subfamily 1, group D, member 2 -0.67
MRC2 mannose receptor, C type 2 -0.64
CLASP2 cytoplasmic linker associated protein 2 -0.63
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.63
NTHL1 nth endonuclease III-like 1 (E. coli) -0.61
ANKRD22 ankyrin repeat domain 22 -0.58
SGSM1 small G protein signaling modulator 1 -0.57
SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 -0.57
CRLF1 cytokine receptor-like factor 1 -0.56
FAM177A1 family with sequence similarity 177, member A1 -0.55
AGRN agrin -0.53
KLHDC3 kelch domain containing 3 -0.52
RNF19B ring finger protein 19B -0.51
DNAJC25 DnaJ (Hsp40) homolog, subfamily C , member 25 -0.5
SLC35B3 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 -0.5
ARHGEF35 Rho guanine nucleotide exchange factor (GEF) 35 -0.5
STYK1 serine/threonine/tyrosine kinase 1 -0.49
FADS1 fatty acid desaturase 1 -0.49
FURIN furin (paired basic amino acid cleaving enzyme) -0.48
UBL7 ubiquitin-like 7 -0.47
FAM126B family with sequence similarity 126, member B -0.47
ACVR1B activin A receptor, type IB -0.46
VEZT vezatin, adherens junctions transmembrane protein -0.45
PRXL2A peroxiredoxin like 2A -0.45
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.45
CIC capicua transcriptional repressor -0.44
TBC1D14 TBC1 domain family, member 14 -0.44
MUTYH mutY homolog -0.44
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.43
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) -0.42
CYHR1 cysteine/histidine-rich 1 -0.41
COA6 cytochrome c oxidase assembly factor 6 -0.41
CEP295 centrosomal protein 295kDa -0.4
ARSB arylsulfatase B -0.4
CIAO3 cytosolic iron-sulfur assembly component 3 -0.39
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -0.39
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.38
GLRX glutaredoxin (thioltransferase) -0.37
FUNDC1 FUN14 domain containing 1 -0.36
CST3 cystatin C -0.36
MMACHC methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria -0.36
GAB1 GRB2-associated binding protein 1 -0.35
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -0.35
BTBD9 BTB (POZ) domain containing 9 -0.35
S100A14 S100 calcium binding protein A14 -0.35
OPHN1 oligophrenin 1 -0.34
ZNF581 zinc finger protein 581 -0.34
RNASE4 ribonuclease, RNase A family, 4 -0.34
BAHCC1 BAH domain and coiled-coil containing 1 -0.33
NAV2 neuron navigator 2 -0.33
FBXL2 F-box and leucine-rich repeat protein 2 -0.33
PTOV1 prostate tumor overexpressed 1 -0.33
TPST2 tyrosylprotein sulfotransferase 2 -0.33
PLAUR plasminogen activator, urokinase receptor -0.33
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -0.33
TRIM38 tripartite motif containing 38 -0.32
ZNF827 zinc finger protein 827 -0.32
SDE2 SDE2 telomere maintenance homolog (S. pombe) -0.32
FTH1 ferritin, heavy polypeptide 1 -0.32
IRAK2 interleukin-1 receptor-associated kinase 2 -0.32
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -0.32
TGFBR1 transforming growth factor, beta receptor 1 -0.32
HSP90AA4P heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene -0.31
ZNF446 zinc finger protein 446 -0.31
STYX serine/threonine/tyrosine interacting protein -0.31
TSTD2 thiosulfate sulfurtransferase (rhodanese)-like domain containing 2 -0.31
PARP8 poly (ADP-ribose) polymerase family, member 8 -0.31
NHEJ1 nonhomologous end-joining factor 1 -0.31
CMC2 C-x(9)-C motif containing 2 -0.3
SNX19 sorting nexin 19 -0.3
VIM vimentin -0.3
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.3
TRAF3IP2 TRAF3 interacting protein 2 -0.3
WDFY3 WD repeat and FYVE domain containing 3 -0.29
DTD2 D-tyrosyl-tRNA deacylase 2 (putative) -0.29
FOXJ2 forkhead box J2 -0.29
FLYWCH1 FLYWCH-type zinc finger 1 -0.29
EVI5L ecotropic viral integration site 5-like -0.29
ZNF888 zinc finger protein 888 -0.29
TAF11 TAF11 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 28kDa -0.29
SLC43A2 solute carrier family 43 (amino acid system L transporter), member 2 -0.29
RAB24 RAB24, member RAS oncogene family -0.29
FAM117B family with sequence similarity 117, member B -0.28
NKTR natural killer cell triggering receptor -0.28
TANGO2 transport and golgi organization 2 homolog (Drosophila) -0.28
ADAT3 adenosine deaminase, tRNA-specific 3 -0.28
LTBP1 latent transforming growth factor beta binding protein 1 -0.28
MVB12B multivesicular body subunit 12B -0.28
TPK1 thiamin pyrophosphokinase 1 -0.28
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.28
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -0.27
ELOVL6 ELOVL fatty acid elongase 6 -0.27
ATG14 autophagy related 14 -0.27
HLA-E major histocompatibility complex, class I, E -0.27
C6ORF47 chromosome 6 open reading frame 47 -0.27