| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | 0.15032 |
| CDH13 | cadherin 13 | 0.087619 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0818109 |
| CENPF | centromere protein F, 350/400kDa | 0.0766865 |
| POTEF | POTE ankyrin domain family, member F | 0.0765799 |
| DST | dystonin | 0.0742314 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0717527 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0709145 |
| GLIS3 | GLIS family zinc finger 3 | 0.0678098 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0658774 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0615908 |
| MT2A | metallothionein 2A | 0.0607648 |
| CYTH3 | cytohesin 3 | 0.0590122 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0583003 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0580626 |
| COPA | coatomer protein complex, subunit alpha | 0.0573389 |
| PBX3 | pre-B-cell leukemia homeobox 3 | 0.0559777 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0532428 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.053032 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0527766 |
| FNDC3B | fibronectin type III domain containing 3B | 0.049394 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0492293 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0487051 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0483701 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0467412 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0457049 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0456962 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0444507 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0439131 |
| NAV2 | neuron navigator 2 | 0.0436372 |
| CD44 | CD44 molecule (Indian blood group) | 0.0432663 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0429196 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0428481 |
| NEK7 | NIMA-related kinase 7 | 0.0415529 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0413558 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0412527 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0406102 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0398918 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.039093 |
| MB21D2 | Mab-21 domain containing 2 | 0.0390535 |
| RASAL2 | RAS protein activator like 2 | 0.0389509 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0386327 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0385922 |
| ASPH | aspartate beta-hydroxylase | 0.0373934 |
| PODXL | podocalyxin-like | 0.0372496 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.037055 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0369589 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | 0.0368221 |
| SMC4 | structural maintenance of chromosomes 4 | 0.0357901 |
| CEP55 | centrosomal protein 55kDa | 0.0357692 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0348712 |
| BCL2L1 | BCL2-like 1 | 0.0346424 |
| VCL | vinculin | 0.0345998 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.033946 |
| JMJD1C | jumonji domain containing 1C | 0.0338907 |
| ERBIN | erbb2 interacting protein | 0.0338288 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0337382 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0336555 |
| ZNF148 | zinc finger protein 148 | 0.0330672 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0329873 |
| CSTB | cystatin B (stefin B) | 0.0322414 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0322169 |
| OGA | O-GlcNAcase | 0.032141 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0318569 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0316237 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0314862 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0308634 |
| PFN1 | profilin 1 | 0.030496 |
| HELZ | helicase with zinc finger | 0.030374 |
| TMSB4X | thymosin beta 4, X-linked | 0.0298973 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0298744 |
| SUCO | SUN domain containing ossification factor | 0.0296551 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0295919 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0295625 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0291833 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0289331 |
| MSN | moesin | 0.0288933 |
| SMAD3 | SMAD family member 3 | 0.0280563 |
| FSD1L | fibronectin type III and SPRY domain containing 1-like | 0.0277959 |
| MAP1B | microtubule-associated protein 1B | 0.027771 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0274124 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0273485 |
| SETD5 | SET domain containing 5 | 0.0272646 |
| SLC39A11 | solute carrier family 39, member 11 | 0.0272444 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.027221 |
| EZR | ezrin | 0.0271554 |
| PTK2 | protein tyrosine kinase 2 | 0.0269708 |
| CAMSAP2 | calmodulin regulated spectrin-associated protein family, member 2 | 0.0267592 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0267525 |
| RPS24 | ribosomal protein S24 | 0.0267521 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0267215 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0263433 |
| NF1 | neurofibromin 1 | 0.0262539 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0261428 |
| INTS6 | integrator complex subunit 6 | 0.026084 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0259908 |
| DIAPH3 | diaphanous-related formin 3 | 0.0259769 |
| FNIP2 | folliculin interacting protein 2 | 0.0255302 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0254259 |
| KLF12 | Kruppel-like factor 12 | 0.0253538 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.344452 |
| AHNAK | AHNAK nucleoprotein | -0.156074 |
| LOX | lysyl oxidase | -0.117658 |
| THBS2 | thrombospondin 2 | -0.109277 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.107808 |
| COL5A1 | collagen, type V, alpha 1 | -0.10657 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0970571 |
| FN1 | fibronectin 1 | -0.0962704 |
| MX2 | MX dynamin-like GTPase 2 | -0.0947839 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0888286 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0872546 |
| FBN1 | fibrillin 1 | -0.0857013 |
| RIGI | RNA sensor RIG-I | -0.0758682 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0738173 |
| HLA-B | major histocompatibility complex, class I, B | -0.0724031 |
| NDRG1 | N-myc downstream regulated 1 | -0.0712964 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0712863 |
| LOXL2 | lysyl oxidase-like 2 | -0.0642368 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0620519 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0609548 |
| FLNA | filamin A, alpha | -0.0550153 |
| ANXA2 | annexin A2 | -0.0469027 |
| FLNB | filamin B, beta | -0.0467655 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0428214 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0423607 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0421865 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0418013 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0408646 |
| TPM4 | tropomyosin 4 | -0.0396705 |
| VIM | vimentin | -0.0395699 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0395053 |
| COL5A2 | collagen, type V, alpha 2 | -0.0394724 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0391633 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0389316 |
| JUN | jun proto-oncogene | -0.0384314 |
| STC1 | stanniocalcin 1 | -0.0374512 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0370503 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0367604 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0363345 |
| RNF213 | ring finger protein 213 | -0.0358059 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0354937 |
| ADAR | adenosine deaminase, RNA-specific | -0.0347024 |
| CCND1 | cyclin D1 | -0.0336707 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0335388 |
| CD109 | CD109 molecule | -0.0319211 |
| TNIP1 | TNFAIP3 interacting protein 1 | -0.0317611 |
| COL1A2 | collagen, type I, alpha 2 | -0.0314545 |
| NAV1 | neuron navigator 1 | -0.0314526 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0312488 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0308506 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.030818 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0302667 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0301578 |
| SP100 | SP100 nuclear antigen | -0.0299406 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0298547 |
| INSIG1 | insulin induced gene 1 | -0.0295101 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0291689 |
| SEPTIN9 | septin 9 | -0.0285582 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0283497 |
| TNS3 | tensin 3 | -0.0282262 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0276772 |
| HLA-C | major histocompatibility complex, class I, C | -0.0268345 |
| SLFN5 | schlafen family member 5 | -0.0264549 |
| TPM1 | tropomyosin 1 (alpha) | -0.0263578 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0263016 |
| SQSTM1 | sequestosome 1 | -0.0261865 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0257434 |
| DEPP1 | DEPP autophagy regulator 1 | -0.0249471 |
| PGK1 | phosphoglycerate kinase 1 | -0.0249062 |
| AFAP1 | actin filament associated protein 1 | -0.0248328 |
| MXRA5 | matrix-remodelling associated 5 | -0.0246 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0245073 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.0243 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0242906 |
| LMAN1 | lectin, mannose-binding, 1 | -0.024115 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0240227 |
| TAGLN2 | transgelin 2 | -0.0240018 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0239144 |
| TRIM22 | tripartite motif containing 22 | -0.0238325 |
| MYADM | myeloid-associated differentiation marker | -0.0235742 |
| SMIM44 | small integral membrane protein 44 | -0.0234272 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0233727 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0230132 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0228152 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0227696 |
| CAVIN1 | caveolae associated protein 1 | -0.0225964 |
| LMNA | lamin A/C | -0.0220831 |
| PLAUR | plasminogen activator, urokinase receptor | -0.0220758 |
| SUCNR1 | succinate receptor 1 | -0.0219311 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0219238 |
| ACTG1 | actin gamma 1 | -0.0218194 |
| SDC4 | syndecan 4 | -0.0212261 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.020945 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.02089 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0208043 |
| TENM3 | teneurin transmembrane protein 3 | -0.0205612 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0202656 |
| AUTS2 | autism susceptibility candidate 2 | -0.0200218 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0198967 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0196873 |
