| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AREG | amphiregulin | 0.226323 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.130088 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.114053 |
| VMP1 | vacuole membrane protein 1 | 0.100114 |
| TMSB10 | thymosin beta 10 | 0.0858085 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0810592 |
| RPS12 | ribosomal protein S12 | 0.0640589 |
| JMJD1C | jumonji domain containing 1C | 0.0592797 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0578241 |
| FTL | ferritin, light polypeptide | 0.0497961 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0494005 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0469732 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0462588 |
| RPS6 | ribosomal protein S6 | 0.0457535 |
| RPS2 | ribosomal protein S2 | 0.0434383 |
| EPHA6 | EPH receptor A6 | 0.0416432 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0412529 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.040794 |
| CCNL1 | cyclin L1 | 0.0398777 |
| EFNA5 | ephrin-A5 | 0.0397269 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0396586 |
| HMGA2 | high mobility group AT-hook 2 | 0.0395725 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0393279 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0391912 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0374025 |
| PCBP2 | poly(rC) binding protein 2 | 0.0370662 |
| EXOC6B | exocyst complex component 6B | 0.0364648 |
| RCOR1 | REST corepressor 1 | 0.0363539 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | 0.0361925 |
| POTEF | POTE ankyrin domain family, member F | 0.0359665 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | 0.0338928 |
| RPS26 | ribosomal protein S26 | 0.0336451 |
| TXNRD1 | thioredoxin reductase 1 | 0.0333436 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0324419 |
| CELF2 | CUGBP, Elav-like family member 2 | 0.0320185 |
| ELP4 | elongator acetyltransferase complex subunit 4 | 0.0315364 |
| PDGFC | platelet derived growth factor C | 0.0315341 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.031489 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | 0.0305746 |
| HDAC9 | histone deacetylase 9 | 0.0302492 |
| GTDC1 | glycosyltransferase-like domain containing 1 | 0.0301441 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.029906 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0297749 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0296349 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0294495 |
| CAMKMT | calmodulin-lysine N-methyltransferase | 0.0294396 |
| TPI1 | triosephosphate isomerase 1 | 0.0292053 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0291291 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0284111 |
| RNF128 | ring finger protein 128, E3 ubiquitin protein ligase | 0.0282577 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0281639 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.0280531 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0280316 |
| YAP1 | Yes-associated protein 1 | 0.0279251 |
| CDK19 | cyclin-dependent kinase 19 | 0.0278767 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0276552 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.027642 |
| MPG | N-methylpurine-DNA glycosylase | 0.0276388 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0273615 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0271028 |
| OXR1 | oxidation resistance 1 | 0.0267908 |
| MED13L | mediator complex subunit 13-like | 0.0267681 |
| DENND5A | DENN/MADD domain containing 5A | 0.026711 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0266172 |
| WWOX | WW domain containing oxidoreductase | 0.0264359 |
| GPHN | gephyrin | 0.0264019 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.026329 |
| ATP11A | ATPase, class VI, type 11A | 0.026172 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0260479 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0257877 |
| PEG10 | paternally expressed 10 | 0.0257173 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | 0.0255575 |
| BRD2 | bromodomain containing 2 | 0.0252026 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0248551 |
| RPS21 | ribosomal protein S21 | 0.0248505 |
| MAP3K14 | mitogen-activated protein kinase kinase kinase 14 | 0.0247152 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0245414 |
| ETNK1 | ethanolamine kinase 1 | 0.0245348 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0244444 |
| INTS6 | integrator complex subunit 6 | 0.0243383 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0241989 |
| UMAD1 | UBAP1-MVB12-associated (UMA) domain containing 1 | 0.0241437 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0240825 |
| PNN | pinin, desmosome associated protein | 0.0240166 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0240007 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0239753 |
| RPLP2 | ribosomal protein, large, P2 | 0.0237897 |
| MYPN | myopalladin | 0.0234665 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0234317 |
| USP34 | ubiquitin specific peptidase 34 | 0.0232286 |
| MIPOL1 | mirror-image polydactyly 1 | 0.0232157 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.023038 |
| QKI | QKI, KH domain containing, RNA binding | 0.0229378 |
| RPS19 | ribosomal protein S19 | 0.0228079 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0227745 |
| METTL15 | methyltransferase like 15 | 0.0226979 |
| RPL12 | ribosomal protein L12 | 0.022689 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0226534 |
| NEGR1 | neuronal growth regulator 1 | 0.0224333 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0224254 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.216288 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.151188 |
| NLGN1 | neuroligin 1 | -0.128328 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.117371 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.102009 |
| ACTG1 | actin gamma 1 | -0.101712 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0921319 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0867559 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0855949 |
| AHNAK | AHNAK nucleoprotein | -0.0831428 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0796713 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0790782 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0753317 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0744575 |
| PTMA | prothymosin, alpha | -0.0616085 |
| CANX | calnexin | -0.0602748 |
| CCND1 | cyclin D1 | -0.0587974 |
| TMEM123 | transmembrane protein 123 | -0.05871 |
| MKI67 | marker of proliferation Ki-67 | -0.0579388 |
| ASPH | aspartate beta-hydroxylase | -0.0525095 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0516396 |
| CALR | calreticulin | -0.0491022 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0490635 |
| TPM4 | tropomyosin 4 | -0.0480853 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0463678 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0463142 |
| PGK1 | phosphoglycerate kinase 1 | -0.0462483 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0455019 |
| CENPF | centromere protein F, 350/400kDa | -0.0414221 |
| CLDN1 | claudin 1 | -0.0398931 |
| HMGA1 | high mobility group AT-hook 1 | -0.0391926 |
| LDHA | lactate dehydrogenase A | -0.0384642 |
| WDR45B | WD repeat domain 45B | -0.0362958 |
| S100A10 | S100 calcium binding protein A10 | -0.0360435 |
| BRI3BP | BRI3 binding protein | -0.0352891 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0352335 |
| RPS27A | ribosomal protein S27a | -0.0340504 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0340091 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0339291 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0338589 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0335053 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0331886 |
| ZNF804A | zinc finger protein 804A | -0.0318582 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0317316 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0314487 |
| PRR11 | proline rich 11 | -0.0311399 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0293453 |
| CAVIN1 | caveolae associated protein 1 | -0.0292935 |
| TUBA1C | tubulin, alpha 1c | -0.0290032 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0288357 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0285461 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0282402 |
| HNRNPD | heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) | -0.0278749 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0274976 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0274717 |
| RPL35A | ribosomal protein L35a | -0.027135 |
| FAM110C | family with sequence similarity 110, member C | -0.0270093 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0266094 |
| ENO1 | enolase 1, (alpha) | -0.0265938 |
| ANXA2 | annexin A2 | -0.0259748 |
| HMGB1 | high mobility group box 1 | -0.0258963 |
| NHSL1 | NHS-like 1 | -0.0253392 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0253348 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0251795 |
| STIP1 | stress-induced phosphoprotein 1 | -0.0249055 |
| LMAN1 | lectin, mannose-binding, 1 | -0.024863 |
| RPL19 | ribosomal protein L19 | -0.0246832 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0246804 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0244425 |
| RPL38 | ribosomal protein L38 | -0.0242101 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0240838 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.0239869 |
| G3BP1 | GTPase activating protein (SH3 domain) binding protein 1 | -0.0237171 |
| RAN | RAN, member RAS oncogene family | -0.0235935 |
| RAI14 | retinoic acid induced 14 | -0.0228641 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0228284 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0228244 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0227843 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0226787 |
| RPS24 | ribosomal protein S24 | -0.0226599 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.0225148 |
| RSL1D1 | ribosomal L1 domain containing 1 | -0.0223363 |
| DEK | DEK proto-oncogene | -0.0220819 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0220681 |
| EPCAM | epithelial cell adhesion molecule | -0.021816 |
| CHD4 | chromodomain helicase DNA binding protein 4 | -0.0216407 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0214927 |
| FUS | FUS RNA binding protein | -0.0213548 |
| ICAM1 | intercellular adhesion molecule 1 | -0.0208643 |
| HNRNPAB | heterogeneous nuclear ribonucleoprotein A/B | -0.0206384 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0206254 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | -0.0206212 |
| OSMR | oncostatin M receptor | -0.0206081 |
| MAP1B | microtubule-associated protein 1B | -0.0206063 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0206012 |
| RNF213 | ring finger protein 213 | -0.0205156 |
| TUBB | tubulin, beta class I | -0.0202918 |
| LARS1 | leucyl-tRNA synthetase 1 | -0.0202628 |
| RHOQ | ras homolog family member Q | -0.020221 |
| CTTN | cortactin | -0.0197771 |
