| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in CHP-212 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TLE4 | transducin-like enhancer of split 4 | 0.119343 |
| VMP1 | vacuole membrane protein 1 | 0.0969947 |
| LGR5 | leucine-rich repeat containing G protein-coupled receptor 5 | 0.0899973 |
| DST | dystonin | 0.0720394 |
| HELZ | helicase with zinc finger | 0.0602114 |
| TPST1 | tyrosylprotein sulfotransferase 1 | 0.059977 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.058804 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0481393 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0467107 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0460842 |
| FNBP1 | formin binding protein 1 | 0.0460486 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.044839 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0437882 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0436396 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0415229 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0412851 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0395631 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0381968 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.03811 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0378504 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0376559 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.037056 |
| VEGFA | vascular endothelial growth factor A | 0.0367762 |
| PALLD | palladin, cytoskeletal associated protein | 0.0366145 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0359154 |
| HOMER1 | homer scaffolding protein 1 | 0.0356636 |
| VCL | vinculin | 0.035282 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0352378 |
| PAPOLA | poly(A) polymerase alpha | 0.0347396 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0346316 |
| PCBP3 | poly(rC) binding protein 3 | 0.034619 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.03422 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0339668 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0331919 |
| CD46 | CD46 molecule, complement regulatory protein | 0.0329522 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0327491 |
| OGA | O-GlcNAcase | 0.0326009 |
| ZNF638 | zinc finger protein 638 | 0.0317967 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0316875 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0315543 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0315385 |
| ANO6 | anoctamin 6 | 0.031499 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | 0.0313743 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.030982 |
| SEPTIN9 | septin 9 | 0.0308921 |
| DGKH | diacylglycerol kinase, eta | 0.0307684 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0302506 |
| FOXO3 | forkhead box O3 | 0.0298356 |
| CCNL1 | cyclin L1 | 0.0295056 |
| SPPL3 | signal peptide peptidase like 3 | 0.0284132 |
| COG5 | component of oligomeric golgi complex 5 | 0.0279645 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.027808 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | 0.0267296 |
| TOP1 | topoisomerase (DNA) I | 0.0267072 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0262063 |
| MYO1E | myosin IE | 0.026063 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0258493 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.025827 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0252249 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0250736 |
| JMJD1C | jumonji domain containing 1C | 0.0250385 |
| NEK1 | NIMA-related kinase 1 | 0.024981 |
| DKK2 | dickkopf WNT signaling pathway inhibitor 2 | 0.0248684 |
| SMAD3 | SMAD family member 3 | 0.02461 |
| TRIM9 | tripartite motif containing 9 | 0.0245648 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.0244632 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0243375 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0235325 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0235196 |
| GLCCI1 | glucocorticoid induced 1 | 0.0233013 |
| DPH6 | diphthamine biosynthesis 6 | 0.0232629 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.023245 |
| FAM13A | family with sequence similarity 13, member A | 0.0232386 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | 0.023195 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0231167 |
| FAM107B | family with sequence similarity 107, member B | 0.0230058 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0229914 |
| PPM1D | protein phosphatase, Mg2+/Mn2+ dependent, 1D | 0.0228339 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | 0.0227269 |
| SLITRK6 | SLIT and NTRK-like family, member 6 | 0.0221162 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0221061 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0220954 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.022085 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0220519 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0219728 |
| FBXO11 | F-box protein 11 | 0.0219725 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0218602 |
| GHR | growth hormone receptor | 0.0218336 |
| TOM1L2 | target of myb1-like 2 (chicken) | 0.0218294 |
| TUFT1 | tuftelin 1 | 0.0218071 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0217521 |
| PCBP2 | poly(rC) binding protein 2 | 0.0216601 |
| PDE8A | phosphodiesterase 8A | 0.0216259 |
| UBR1 | ubiquitin protein ligase E3 component n-recognin 1 | 0.0216036 |
| DNMBP | dynamin binding protein | 0.0215789 |
| ZNF148 | zinc finger protein 148 | 0.0215145 |
| USP47 | ubiquitin specific peptidase 47 | 0.0212796 |
| ZFP36 | ZFP36 ring finger protein | 0.0212094 |
| SCAF11 | SR-related CTD-associated factor 11 | 0.0211553 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0211003 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LSAMP | limbic system-associated membrane protein | -0.194438 |
| NRG1 | neuregulin 1 | -0.147168 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0997887 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | -0.0986132 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0845019 |
| GPC5 | glypican 5 | -0.0790917 |
| IGF2 | insulin-like growth factor 2 | -0.0788105 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.078609 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.070421 |
| RNF213 | ring finger protein 213 | -0.0688033 |
| CADM2 | cell adhesion molecule 2 | -0.0639448 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.0546651 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.0497694 |
| RPL23 | ribosomal protein L23 | -0.0483401 |
| PTMA | prothymosin, alpha | -0.0474768 |
| ACTG1 | actin gamma 1 | -0.0473765 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0469709 |
| COL3A1 | collagen, type III, alpha 1 | -0.0467894 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0460528 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0451812 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.043344 |
| CNTN4 | contactin 4 | -0.041178 |
| SPAG9 | sperm associated antigen 9 | -0.0409708 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0389206 |
| PCDH9 | protocadherin 9 | -0.0388768 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0383919 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0375724 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0373223 |
| RPL38 | ribosomal protein L38 | -0.0371622 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0371351 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | -0.0369828 |
| RPS12 | ribosomal protein S12 | -0.0367652 |
| AUTS2 | autism susceptibility candidate 2 | -0.0365381 |
| FRMD4A | FERM domain containing 4A | -0.0363505 |
| MX2 | MX dynamin-like GTPase 2 | -0.036313 |
| TRIB2 | tribbles pseudokinase 2 | -0.0356857 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0350766 |
| CENPF | centromere protein F, 350/400kDa | -0.0348367 |
| RPL34 | ribosomal protein L34 | -0.034234 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0336977 |
| RPL19 | ribosomal protein L19 | -0.0332852 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0328267 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0328025 |
| EGR1 | early growth response 1 | -0.0325794 |
| ENAH | enabled homolog (Drosophila) | -0.0324067 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0322723 |
| COL1A1 | collagen, type I, alpha 1 | -0.031677 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0307746 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0304697 |
| RPL35A | ribosomal protein L35a | -0.0302567 |
| AHNAK | AHNAK nucleoprotein | -0.0294855 |
| MAPK10 | mitogen-activated protein kinase 10 | -0.029445 |
| RIGI | RNA sensor RIG-I | -0.0286081 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0285242 |
| RPL37 | ribosomal protein L37 | -0.0276017 |
| RPS3 | ribosomal protein S3 | -0.0274634 |
| LPIN1 | lipin 1 | -0.0273042 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0272515 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0272264 |
| RPS24 | ribosomal protein S24 | -0.0272109 |
| DIAPH2 | diaphanous-related formin 2 | -0.027185 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0269503 |
| CCDC91 | coiled-coil domain containing 91 | -0.0268205 |
| RPS8 | ribosomal protein S8 | -0.0266553 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0265829 |
| TMSB10 | thymosin beta 10 | -0.0265172 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0262378 |
| CUX1 | cut-like homeobox 1 | -0.0258704 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0257037 |
| GREM2 | gremlin 2, DAN family BMP antagonist | -0.0256555 |
| PRKCA | protein kinase C, alpha | -0.0255434 |
| NCAM2 | neural cell adhesion molecule 2 | -0.0254056 |
| BPTF | bromodomain PHD finger transcription factor | -0.0253163 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0250308 |
| RPLP0 | ribosomal protein, large, P0 | -0.0246267 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0245048 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0244562 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0244355 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0243233 |
| SYT1 | synaptotagmin I | -0.0242832 |
| KIF5B | kinesin family member 5B | -0.0239112 |
| MTAP | methylthioadenosine phosphorylase | -0.0237803 |
| ZNF804A | zinc finger protein 804A | -0.0235763 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.023419 |
| ZNF124 | zinc finger protein 124 | -0.0232845 |
| RALYL | RALY RNA binding protein-like | -0.0232428 |
| RPL7 | ribosomal protein L7 | -0.0231825 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0230513 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0228358 |
| MT2A | metallothionein 2A | -0.0226732 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.02267 |
| CALD1 | caldesmon 1 | -0.0226684 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0225787 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0225738 |
| OSMR | oncostatin M receptor | -0.0225234 |
| KIAA1958 | KIAA1958 | -0.0224041 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0223771 |
| PTPN13 | protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) | -0.022279 |
| RPL26 | ribosomal protein L26 | -0.0222419 |
| TPM4 | tropomyosin 4 | -0.0221969 |
