| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0983199 |
| VMP1 | vacuole membrane protein 1 | 0.0917604 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0734093 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0710121 |
| ZNF292 | zinc finger protein 292 | 0.0626189 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0598896 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.0594072 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.058568 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0520598 |
| SMAD3 | SMAD family member 3 | 0.0516564 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.0488154 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | 0.0487317 |
| PLSCR2 | phospholipid scramblase 2 | 0.0480712 |
| AREG | amphiregulin | 0.045982 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0442681 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0437899 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0437429 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0428597 |
| LIMA1 | LIM domain and actin binding 1 | 0.0428277 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0421274 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.042049 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0419383 |
| TXNRD1 | thioredoxin reductase 1 | 0.0391087 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0381493 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.035084 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0340819 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0326403 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0324046 |
| FRMD5 | FERM domain containing 5 | 0.0318772 |
| ASPH | aspartate beta-hydroxylase | 0.0315037 |
| EFNB2 | ephrin-B2 | 0.0310891 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0306545 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.02969 |
| RND3 | Rho family GTPase 3 | 0.0294663 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0291119 |
| EHBP1 | EH domain binding protein 1 | 0.0287986 |
| DST | dystonin | 0.0286657 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0285043 |
| DIAPH1 | diaphanous-related formin 1 | 0.028445 |
| JMJD1C | jumonji domain containing 1C | 0.0282862 |
| LCN2 | lipocalin 2 | 0.0274402 |
| VEGFA | vascular endothelial growth factor A | 0.0271311 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0269879 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0267209 |
| PRKCA | protein kinase C, alpha | 0.0259596 |
| LUZP1 | leucine zipper protein 1 | 0.0255455 |
| FTL | ferritin, light polypeptide | 0.0254156 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0253137 |
| SUSD1 | sushi domain containing 1 | 0.0250681 |
| SLK | STE20-like kinase | 0.0250289 |
| PHF3 | PHD finger protein 3 | 0.0245811 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.024534 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0244353 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0240337 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0240173 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0238968 |
| PRSS22 | protease, serine, 22 | 0.0238197 |
| SEPTIN9 | septin 9 | 0.0234717 |
| RPS8 | ribosomal protein S8 | 0.0233677 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0233245 |
| MSI2 | musashi RNA-binding protein 2 | 0.0232591 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0232132 |
| SIK3 | SIK family kinase 3 | 0.0225128 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0214844 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0213214 |
| THOC2 | THO complex 2 | 0.021196 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0209569 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0209519 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0209029 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0209026 |
| RPS6 | ribosomal protein S6 | 0.0207474 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.020617 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.020499 |
| MT2A | metallothionein 2A | 0.0204559 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0204332 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0204058 |
| FAT1 | FAT atypical cadherin 1 | 0.020001 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0199295 |
| MLPH | melanophilin | 0.0198412 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0197959 |
| RPS12 | ribosomal protein S12 | 0.0197082 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0196468 |
| PDZD8 | PDZ domain containing 8 | 0.0195768 |
| PNN | pinin, desmosome associated protein | 0.019544 |
| TNIK | TRAF2 and NCK interacting kinase | 0.019524 |
| DNM2 | dynamin 2 | 0.0194013 |
| ALDH1A2 | aldehyde dehydrogenase 1 family, member A2 | 0.0193537 |
| USP49 | ubiquitin specific peptidase 49 | 0.0190886 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0190641 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0190152 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0189336 |
| KIF5B | kinesin family member 5B | 0.018771 |
| EXOC4 | exocyst complex component 4 | 0.0183246 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0182127 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0181902 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0179311 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.017905 |
| SSH2 | slingshot protein phosphatase 2 | 0.017825 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0177417 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0176706 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.185942 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.176239 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.160383 |
| HLA-B | major histocompatibility complex, class I, B | -0.140723 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.138676 |
| RIGI | RNA sensor RIG-I | -0.135184 |
| RNF213 | ring finger protein 213 | -0.0990229 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0968961 |
| MX1 | MX dynamin-like GTPase 1 | -0.093706 |
| SPATA13 | spermatogenesis associated 13 | -0.0866482 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0852297 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0840094 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.083499 |
| SP100 | SP100 nuclear antigen | -0.0807748 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0801002 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.080055 |
| MX2 | MX dynamin-like GTPase 2 | -0.0791868 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0780351 |
| PLSCR1 | phospholipid scramblase 1 | -0.0771761 |
| B2M | beta-2-microglobulin | -0.0759083 |
| XAF1 | XIAP associated factor 1 | -0.0754093 |
| HLA-C | major histocompatibility complex, class I, C | -0.0702446 |
| EPHB2 | EPH receptor B2 | -0.069896 |
| HLA-E | major histocompatibility complex, class I, E | -0.0694842 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0693005 |
| ATP11A | ATPase, class VI, type 11A | -0.0658393 |
| RRBP1 | ribosome binding protein 1 | -0.0650817 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0642173 |
| H1-0 | H1.0 linker histone | -0.0627303 |
| RABGAP1L | RAB GTPase activating protein 1-like | -0.061754 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0615359 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0610462 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0587581 |
| AHNAK | AHNAK nucleoprotein | -0.0575229 |
| SQSTM1 | sequestosome 1 | -0.0552787 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0549963 |
| RUNX1 | runt-related transcription factor 1 | -0.0548724 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0541109 |
| EGR1 | early growth response 1 | -0.0535396 |
| PTMA | prothymosin, alpha | -0.0533932 |
| IRF1 | interferon regulatory factor 1 | -0.0532055 |
| MKI67 | marker of proliferation Ki-67 | -0.0517784 |
| CALR | calreticulin | -0.051692 |
| HDLBP | high density lipoprotein binding protein | -0.0514578 |
| ANKRD10 | ankyrin repeat domain 10 | -0.050465 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.050321 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0501712 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0499488 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.049487 |
| LYZ | lysozyme | -0.0483661 |
| PMP22 | peripheral myelin protein 22 | -0.0481794 |
| TMEM62 | transmembrane protein 62 | -0.0467829 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0464416 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.0455345 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0453826 |
| CANX | calnexin | -0.0447262 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0437855 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0436313 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0435413 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0432398 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0430696 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0430523 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0428462 |
| SDC4 | syndecan 4 | -0.042046 |
| PARP9 | poly (ADP-ribose) polymerase family, member 9 | -0.0420458 |
| CENPF | centromere protein F, 350/400kDa | -0.0420098 |
| KIAA1217 | KIAA1217 | -0.0419922 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0418768 |
| RBM39 | RNA binding motif protein 39 | -0.0409286 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0408342 |
| WDR45B | WD repeat domain 45B | -0.0401611 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0400593 |
| ARF1 | ADP-ribosylation factor 1 | -0.0396463 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0391579 |
| APOL6 | apolipoprotein L, 6 | -0.0387126 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0378344 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0375581 |
| UBC | ubiquitin C | -0.0374209 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0372672 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.037238 |
| MUC20 | mucin 20, cell surface associated | -0.0370816 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.036994 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0367527 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0362239 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0360839 |
| SAMHD1 | SAM domain and HD domain 1 | -0.0356462 |
| NDRG1 | N-myc downstream regulated 1 | -0.0354901 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0354277 |
| AGR2 | anterior gradient 2 | -0.0353306 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0353143 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0352848 |
| BRCA2 | breast cancer 2, early onset | -0.0351907 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0347486 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0346828 |
| CD164 | CD164 molecule, sialomucin | -0.0344323 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0342498 |
| HLA-A | major histocompatibility complex, class I, A | -0.0341881 |
| NUCB2 | nucleobindin 2 | -0.0336928 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0336757 |
| VPS37B | vacuolar protein sorting 37 homolog B (S. cerevisiae) | -0.0334158 |
