| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.160836 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.137305 |
| CDH13 | cadherin 13 | 0.134217 |
| VEGFA | vascular endothelial growth factor A | 0.11974 |
| MT2A | metallothionein 2A | 0.115854 |
| RPS6 | ribosomal protein S6 | 0.11433 |
| EXT1 | exostosin glycosyltransferase 1 | 0.104843 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0850284 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0704841 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0666946 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0649855 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0572542 |
| RUNX1 | runt-related transcription factor 1 | 0.0546881 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0538514 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0521197 |
| RPS12 | ribosomal protein S12 | 0.0508753 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0505504 |
| RPS2 | ribosomal protein S2 | 0.0504635 |
| VMP1 | vacuole membrane protein 1 | 0.0481359 |
| RPS8 | ribosomal protein S8 | 0.0476732 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0473049 |
| ATP13A3 | ATPase type 13A3 | 0.0468996 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0458017 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0433246 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.042543 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0423592 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0421779 |
| RPL5 | ribosomal protein L5 | 0.0419414 |
| CD44 | CD44 molecule (Indian blood group) | 0.0413468 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0407427 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.040126 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0400624 |
| MYO10 | myosin X | 0.0396684 |
| SEC61A1 | Sec61 alpha 1 subunit (S. cerevisiae) | 0.0391194 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0388032 |
| VCAN | versican | 0.0385812 |
| RPL18 | ribosomal protein L18 | 0.0382793 |
| RPS3 | ribosomal protein S3 | 0.0378495 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.037421 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0372553 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0371581 |
| RPL26 | ribosomal protein L26 | 0.0370378 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0368908 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0368839 |
| TMSB10 | thymosin beta 10 | 0.0366766 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0363024 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0359201 |
| HMGA2 | high mobility group AT-hook 2 | 0.0351101 |
| NAV1 | neuron navigator 1 | 0.0349239 |
| COG5 | component of oligomeric golgi complex 5 | 0.0347024 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0342882 |
| GOLGB1 | golgin B1 | 0.0342607 |
| GOLGA4 | golgin A4 | 0.034109 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0339996 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0337607 |
| NAV2 | neuron navigator 2 | 0.0335604 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0333576 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0330817 |
| OGA | O-GlcNAcase | 0.0329169 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0328798 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0327938 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.032499 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0324704 |
| ANXA1 | annexin A1 | 0.0324492 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0320808 |
| EGFR | epidermal growth factor receptor | 0.0314822 |
| PTK2 | protein tyrosine kinase 2 | 0.0313865 |
| RPL36 | ribosomal protein L36 | 0.030733 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | 0.0304739 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0299251 |
| RASA2 | RAS p21 protein activator 2 | 0.0293545 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0291572 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | 0.0290789 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0288519 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0286805 |
| EFNA5 | ephrin-A5 | 0.0286491 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0285111 |
| ANO6 | anoctamin 6 | 0.0283025 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0279384 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0278667 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0277402 |
| MRTFA | myocardin related transcription factor A | 0.0272783 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0269357 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0259021 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0257114 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0256522 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0255322 |
| RPS17 | ribosomal protein S17 | 0.0255102 |
| SMC5 | structural maintenance of chromosomes 5 | 0.0254685 |
| RACK1 | receptor for activated C kinase 1 | 0.025353 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0253363 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0253083 |
| LAMB1 | laminin, beta 1 | 0.0252851 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0250171 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0249758 |
| EXOC6B | exocyst complex component 6B | 0.0249425 |
| RPL37A | ribosomal protein L37a | 0.0247316 |
| NCKAP1 | NCK-associated protein 1 | 0.0245072 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0243568 |
| SMAD3 | SMAD family member 3 | 0.0242652 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.244061 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.15698 |
| VIM | vimentin | -0.148359 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.113163 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.104996 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0985529 |
| STC1 | stanniocalcin 1 | -0.0917904 |
| FN1 | fibronectin 1 | -0.0890546 |
| LDHA | lactate dehydrogenase A | -0.0867817 |
| IER3 | immediate early response 3 | -0.0866289 |
| TPM4 | tropomyosin 4 | -0.0823187 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0791983 |
| COL1A2 | collagen, type I, alpha 2 | -0.0762167 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.0759035 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0758296 |
| NDRG1 | N-myc downstream regulated 1 | -0.0724775 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0722708 |
| CALR | calreticulin | -0.0648402 |
| HLA-B | major histocompatibility complex, class I, B | -0.0638864 |
| LOX | lysyl oxidase | -0.0577788 |
| ACTG1 | actin gamma 1 | -0.0557124 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0509199 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0501171 |
| PTMA | prothymosin, alpha | -0.0477729 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0470254 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0440294 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0407448 |
| PGK1 | phosphoglycerate kinase 1 | -0.0379941 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0377932 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0347393 |
| ADM | adrenomedullin | -0.0347146 |
| CALU | calumenin | -0.03464 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0321374 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0309843 |
| S100A10 | S100 calcium binding protein A10 | -0.0301334 |
| ANXA2 | annexin A2 | -0.0296326 |
| CAVIN1 | caveolae associated protein 1 | -0.029556 |
| IL6 | interleukin 6 | -0.0281605 |
| FBN1 | fibrillin 1 | -0.0274652 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0271039 |
| EGR1 | early growth response 1 | -0.0262566 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0262247 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0255855 |
| CTSB | cathepsin B | -0.0253958 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0253351 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0250164 |
| RPS24 | ribosomal protein S24 | -0.0243008 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0236747 |
| CALD1 | caldesmon 1 | -0.0234398 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0232647 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0226323 |
| PLAUR | plasminogen activator, urokinase receptor | -0.022521 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0224711 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0221712 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0221342 |
| PXDN | peroxidasin | -0.0215297 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0211089 |
| H3-3B | H3.3 histone B | -0.020996 |
| UBC | ubiquitin C | -0.0207394 |
| RIGI | RNA sensor RIG-I | -0.0205316 |
| INHBA | inhibin, beta A | -0.0201232 |
| TUBB | tubulin, beta class I | -0.0200664 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | -0.020044 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0200152 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0200071 |
| SEC24D | SEC24 family member D | -0.0199089 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0196848 |
| RPS15 | ribosomal protein S15 | -0.0196402 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0195693 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0193996 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0192726 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0191658 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0191304 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0191124 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0187351 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0184565 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0183005 |
| CANX | calnexin | -0.018247 |
| CSNK1E | casein kinase 1, epsilon | -0.0178415 |
| SDC4 | syndecan 4 | -0.0176079 |
| HMGA1 | high mobility group AT-hook 1 | -0.0174292 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0172193 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0170728 |
| EHD2 | EH-domain containing 2 | -0.016995 |
| GCLM | glutamate-cysteine ligase, modifier subunit | -0.0168172 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0166594 |
| FKBP10 | FK506 binding protein 10, 65 kDa | -0.016604 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0165319 |
| AHNAK | AHNAK nucleoprotein | -0.01649 |
| RPN2 | ribophorin II | -0.0162738 |
| MTDH | metadherin | -0.0162177 |
| TAGLN2 | transgelin 2 | -0.0161803 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0160916 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.015847 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0157608 |
| CKAP4 | cytoskeleton-associated protein 4 | -0.0156481 |
| RHOC | ras homolog family member C | -0.0156474 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0156102 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0155596 |
| ARF1 | ADP-ribosylation factor 1 | -0.0154463 |
