| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.371205 |
| RPS6 | ribosomal protein S6 | 0.1391 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0961336 |
| RPS12 | ribosomal protein S12 | 0.0866997 |
| DSPP | dentin sialophosphoprotein | 0.0862984 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0861633 |
| EHBP1 | EH domain binding protein 1 | 0.0860009 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0763057 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0750082 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0740323 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0733051 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0708748 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0651131 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0633749 |
| FRMD5 | FERM domain containing 5 | 0.0625761 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0610079 |
| KLF6 | Kruppel-like factor 6 | 0.0512299 |
| TF | transferrin | 0.0510704 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0509713 |
| RPS8 | ribosomal protein S8 | 0.0506804 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0506448 |
| DLC1 | DLC1 Rho GTPase activating protein | 0.0479656 |
| RPL37A | ribosomal protein L37a | 0.0475158 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0461623 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.044462 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0438248 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0423935 |
| RACK1 | receptor for activated C kinase 1 | 0.0420024 |
| FAM107B | family with sequence similarity 107, member B | 0.0413513 |
| RPS2 | ribosomal protein S2 | 0.0412474 |
| VMP1 | vacuole membrane protein 1 | 0.0406979 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0363674 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0359572 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0357433 |
| RPL26 | ribosomal protein L26 | 0.0350533 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0341685 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0336955 |
| RPS21 | ribosomal protein S21 | 0.0330909 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0321772 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0321228 |
| FOXP1 | forkhead box P1 | 0.0305927 |
| RASA2 | RAS p21 protein activator 2 | 0.0304535 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0302752 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0302358 |
| FAM13A | family with sequence similarity 13, member A | 0.0299276 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0295956 |
| SVIL | supervillin | 0.0295321 |
| VEGFA | vascular endothelial growth factor A | 0.0293153 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0287748 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0285086 |
| MT2A | metallothionein 2A | 0.0282851 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0282775 |
| RNASET2 | ribonuclease T2 | 0.0281189 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.028106 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0280208 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0279564 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0275645 |
| RPS17 | ribosomal protein S17 | 0.0271966 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0271466 |
| RPL31 | ribosomal protein L31 | 0.0265113 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0263366 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0262763 |
| ITGA6 | integrin, alpha 6 | 0.0262288 |
| DTNA | dystrobrevin, alpha | 0.0261061 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | 0.0256355 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0254963 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0254312 |
| TNS1 | tensin 1 | 0.0253899 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0252736 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0252371 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0251798 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0251363 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0249896 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0247286 |
| SMAD3 | SMAD family member 3 | 0.0245977 |
| RPS3 | ribosomal protein S3 | 0.0242725 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | 0.024034 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0236397 |
| EPC2 | enhancer of polycomb homolog 2 (Drosophila) | 0.0234714 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0231914 |
| DUSP6 | dual specificity phosphatase 6 | 0.0227619 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0226111 |
| FKTN | fukutin | 0.0225742 |
| LPIN2 | lipin 2 | 0.0225092 |
| KIF5B | kinesin family member 5B | 0.0224864 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0224131 |
| LMCD1 | LIM and cysteine-rich domains 1 | 0.0222223 |
| GOLGA4 | golgin A4 | 0.0221628 |
| RBBP6 | retinoblastoma binding protein 6 | 0.0221367 |
| MYO6 | myosin VI | 0.0220707 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0216997 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0216336 |
| FAT1 | FAT atypical cadherin 1 | 0.0216069 |
| THOC2 | THO complex 2 | 0.0214096 |
| ATP10A | ATPase, class V, type 10A | 0.0212686 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0212387 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0211659 |
| TLE4 | transducin-like enhancer of split 4 | 0.0210041 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0209598 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0208462 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.194442 |
| FN1 | fibronectin 1 | -0.154466 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.14913 |
| C3 | complement component 3 | -0.138771 |
| APOA2 | apolipoprotein A-II | -0.12133 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0922805 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0873596 |
| GPC3 | glypican 3 | -0.0805854 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0759841 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0712166 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.070782 |
| HMGA1 | high mobility group AT-hook 1 | -0.0660718 |
| SDC4 | syndecan 4 | -0.0644621 |
| PERP | PERP, TP53 apoptosis effector | -0.0631587 |
| UBC | ubiquitin C | -0.0619684 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0601416 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0592992 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0583322 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.058185 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0569026 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0564341 |
| TMEM123 | transmembrane protein 123 | -0.0554102 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.055103 |
| KRT8 | keratin 8, type II | -0.0506877 |
| EGR1 | early growth response 1 | -0.0486645 |
| A2M | alpha-2-macroglobulin | -0.0484572 |
| RIGI | RNA sensor RIG-I | -0.0482358 |
| CALR | calreticulin | -0.0439622 |
| LYZ | lysozyme | -0.0408297 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0407779 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0406012 |
| RPS24 | ribosomal protein S24 | -0.0391169 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0388696 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0387736 |
| CP | ceruloplasmin (ferroxidase) | -0.0382468 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0372792 |
| FTL | ferritin, light polypeptide | -0.0368003 |
| PEG3 | paternally expressed 3 | -0.0365485 |
| RNF213 | ring finger protein 213 | -0.0359892 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0344215 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0342202 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0337574 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0334678 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0333695 |
| PARD3 | par-3 family cell polarity regulator | -0.0331688 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0331026 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0329123 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0323171 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0313715 |
| LDHA | lactate dehydrogenase A | -0.0309675 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0307923 |
| PGK1 | phosphoglycerate kinase 1 | -0.0297358 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0280408 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0271282 |
| MX2 | MX dynamin-like GTPase 2 | -0.0270176 |
| CFB | complement factor B | -0.0269254 |
| HDLBP | high density lipoprotein binding protein | -0.0269044 |
| GLRX | glutaredoxin (thioltransferase) | -0.0268812 |
| RPS27A | ribosomal protein S27a | -0.0266995 |
| TPM4 | tropomyosin 4 | -0.0266433 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0260685 |
| H3-3B | H3.3 histone B | -0.025846 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0258071 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0257327 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.025346 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0253239 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0252016 |
| EFNA1 | ephrin-A1 | -0.0251279 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.024972 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0246749 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.024523 |
| TRAM1 | translocation associated membrane protein 1 | -0.0245129 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0241237 |
| PKM | pyruvate kinase, muscle | -0.0239667 |
| APOC1 | apolipoprotein C-I | -0.0237737 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0233553 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0231916 |
| CALD1 | caldesmon 1 | -0.0231528 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0230826 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0230405 |
| YAP1 | Yes-associated protein 1 | -0.0230058 |
| PTCHD4 | patched domain containing 4 | -0.0228932 |
| RPL8 | ribosomal protein L8 | -0.0228594 |
| RTN4 | reticulon 4 | -0.0226938 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.0225936 |
| MED13L | mediator complex subunit 13-like | -0.0224307 |
| HLA-B | major histocompatibility complex, class I, B | -0.0221335 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.022102 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0220876 |
| DEK | DEK proto-oncogene | -0.0218908 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0217531 |
| PHF21A | PHD finger protein 21A | -0.0217275 |
| ASGR2 | asialoglycoprotein receptor 2 | -0.0216139 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0214706 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0214483 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0212639 |
| SLF2 | SMC5-SMC6 complex localization factor 2 | -0.0210841 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0210731 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0208511 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0206688 |
