| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.122949 |
| LMO7 | LIM domain 7 | 0.118106 |
| MT2A | metallothionein 2A | 0.108701 |
| MYOF | myoferlin | 0.0879025 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0839704 |
| RPS8 | ribosomal protein S8 | 0.0730826 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0678142 |
| CD44 | CD44 molecule (Indian blood group) | 0.0666909 |
| RAI14 | retinoic acid induced 14 | 0.0648242 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0631606 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0601052 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0559158 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0557894 |
| RASAL2 | RAS protein activator like 2 | 0.0530494 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0522018 |
| INTS6 | integrator complex subunit 6 | 0.0497938 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0493349 |
| RPS12 | ribosomal protein S12 | 0.0491446 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0477954 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0462 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0460813 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0458865 |
| DST | dystonin | 0.0458636 |
| SMAD3 | SMAD family member 3 | 0.0454925 |
| SQSTM1 | sequestosome 1 | 0.0451289 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.044659 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0425788 |
| EFNA5 | ephrin-A5 | 0.0424107 |
| DOK5 | docking protein 5 | 0.0423618 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0423138 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | 0.0421338 |
| ATXN1 | ataxin 1 | 0.0419282 |
| CDKN2A | cyclin-dependent kinase inhibitor 2A | 0.0418072 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0416395 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0415689 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0391231 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0390722 |
| SIK3 | SIK family kinase 3 | 0.0387663 |
| JMJD1C | jumonji domain containing 1C | 0.0380782 |
| TGM2 | transglutaminase 2 | 0.0378628 |
| RNF217 | ring finger protein 217 | 0.0378187 |
| RPS2 | ribosomal protein S2 | 0.0369807 |
| SLK | STE20-like kinase | 0.0368202 |
| LYST | lysosomal trafficking regulator | 0.0367946 |
| RPL37 | ribosomal protein L37 | 0.0366198 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0359356 |
| SEPTIN9 | septin 9 | 0.0358781 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0351551 |
| VMP1 | vacuole membrane protein 1 | 0.0348303 |
| EZR | ezrin | 0.0347781 |
| PTK2 | protein tyrosine kinase 2 | 0.0346417 |
| MT1E | metallothionein 1E | 0.0341696 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0340341 |
| MSN | moesin | 0.0333307 |
| IRS2 | insulin receptor substrate 2 | 0.0329535 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0327534 |
| RPS3 | ribosomal protein S3 | 0.0325822 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0323137 |
| ANO6 | anoctamin 6 | 0.0318823 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0316731 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0312479 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0312167 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0304927 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0300215 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0299946 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0299162 |
| EGFR | epidermal growth factor receptor | 0.0299067 |
| DIAPH1 | diaphanous-related formin 1 | 0.0292406 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0287555 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0284293 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0284228 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0283853 |
| MEGF6 | multiple EGF-like-domains 6 | 0.0282423 |
| TJP1 | tight junction protein 1 | 0.0280803 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0280249 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0279929 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0279653 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0277593 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0276209 |
| RPL37A | ribosomal protein L37a | 0.0275948 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0275902 |
| LUZP1 | leucine zipper protein 1 | 0.0274359 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0272004 |
| CNTNAP3 | contactin associated protein-like 3 | 0.0269545 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0268634 |
| UTRN | utrophin | 0.0268082 |
| VEGFA | vascular endothelial growth factor A | 0.0266824 |
| VCL | vinculin | 0.0264663 |
| SLTM | SAFB-like, transcription modulator | 0.0262942 |
| BARX2 | BARX homeobox 2 | 0.0261749 |
| SVIL | supervillin | 0.0260343 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0255836 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0253716 |
| PRELID2 | PRELI domain containing 2 | 0.0248684 |
| OSMR | oncostatin M receptor | 0.0246329 |
| GOLGB1 | golgin B1 | 0.0246134 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | 0.0244245 |
| RACK1 | receptor for activated C kinase 1 | 0.0239582 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0239534 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0238495 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.182402 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.109388 |
| IGF2 | insulin-like growth factor 2 | -0.0969902 |
| PTMA | prothymosin, alpha | -0.0882127 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0869294 |
| S100A10 | S100 calcium binding protein A10 | -0.077084 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0747777 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0733795 |
| NDRG1 | N-myc downstream regulated 1 | -0.0696184 |
| ITGA6 | integrin, alpha 6 | -0.0622927 |
| CLU | clusterin | -0.0613764 |
| AHNAK | AHNAK nucleoprotein | -0.0588584 |
| KRT17 | keratin 17, type I | -0.0587126 |
| LDHA | lactate dehydrogenase A | -0.0567017 |
| PGK1 | phosphoglycerate kinase 1 | -0.0532406 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0520654 |
| B2M | beta-2-microglobulin | -0.0498833 |
| ANLN | anillin, actin binding protein | -0.0492986 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0474493 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.0468901 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0468798 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0466567 |
| HLA-B | major histocompatibility complex, class I, B | -0.045295 |
| TMSB4X | thymosin beta 4, X-linked | -0.044818 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0447112 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0440682 |
| EMP1 | epithelial membrane protein 1 | -0.0420255 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0419576 |
| KRT6A | keratin 6A, type II | -0.0418815 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0417331 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0395071 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.038441 |
| ANXA2 | annexin A2 | -0.0383012 |
| FLNB | filamin B, beta | -0.0376041 |
| POTEF | POTE ankyrin domain family, member F | -0.0370295 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0361507 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0360735 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0359255 |
| IFI44 | interferon-induced protein 44 | -0.0347457 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0337075 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0328322 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.032081 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0319312 |
| RIGI | RNA sensor RIG-I | -0.0318815 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.031557 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0313448 |
| TAGLN2 | transgelin 2 | -0.0312536 |
| S100A2 | S100 calcium binding protein A2 | -0.03125 |
| LMNA | lamin A/C | -0.0309371 |
| RBM39 | RNA binding motif protein 39 | -0.0304459 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0303365 |
| H1-0 | H1.0 linker histone | -0.0298752 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0292673 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0291876 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0287233 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0283024 |
| CD99 | CD99 molecule | -0.0282381 |
| PLEC | plectin | -0.0281907 |
| DSG2 | desmoglein 2 | -0.0281186 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0275106 |
| UBE2V1 | ubiquitin-conjugating enzyme E2 variant 1 | -0.0274937 |
| ARPC5 | actin related protein 2/3 complex, subunit 5, 16kDa | -0.0273392 |
| SH3BGRL3 | SH3 domain binding glutamate-rich protein like 3 | -0.026931 |
| ACTG1 | actin gamma 1 | -0.0268749 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0267973 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.026786 |
| RPL27A | ribosomal protein L27a | -0.026687 |
| PLS3 | plastin 3 | -0.0266227 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0265224 |
| CANX | calnexin | -0.0258368 |
| HMGA1 | high mobility group AT-hook 1 | -0.0255904 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0252975 |
| MTPN | myotrophin | -0.0252118 |
| PKM | pyruvate kinase, muscle | -0.0249611 |
| SP100 | SP100 nuclear antigen | -0.0248332 |
| CALR | calreticulin | -0.0248169 |
| FLNA | filamin A, alpha | -0.0243239 |
| GNAS | GNAS complex locus | -0.0243221 |
| UBC | ubiquitin C | -0.0242259 |
| C4BPB | complement component 4 binding protein, beta | -0.0240209 |
| PFN1 | profilin 1 | -0.0237953 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.023678 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0234721 |
| FOSL1 | FOS-like antigen 1 | -0.0233659 |
| RPS24 | ribosomal protein S24 | -0.0233029 |
| MYO10 | myosin X | -0.0233017 |
| CLINT1 | clathrin interactor 1 | -0.0232973 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0231289 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0227904 |
| MKI67 | marker of proliferation Ki-67 | -0.0226912 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0226888 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0226462 |
| CSNK1E | casein kinase 1, epsilon | -0.022557 |
| ARF1 | ADP-ribosylation factor 1 | -0.0224577 |
| SDCBP | syndecan binding protein (syntenin) | -0.0223665 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.022336 |
| HELZ2 | helicase with zinc finger 2, transcriptional coactivator | -0.0222678 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0218956 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0217281 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0215448 |
