| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.154648 |
| RPS6 | ribosomal protein S6 | 0.152403 |
| RPS12 | ribosomal protein S12 | 0.10076 |
| MYO1E | myosin IE | 0.0945314 |
| TMSB10 | thymosin beta 10 | 0.0811882 |
| RPS2 | ribosomal protein S2 | 0.062845 |
| RPS26 | ribosomal protein S26 | 0.0582244 |
| LGR4 | leucine-rich repeat containing G protein-coupled receptor 4 | 0.0561063 |
| ONECUT3 | one cut homeobox 3 | 0.0551833 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0531483 |
| RPS8 | ribosomal protein S8 | 0.0522308 |
| RPL26 | ribosomal protein L26 | 0.048095 |
| RPS19 | ribosomal protein S19 | 0.0480826 |
| FTL | ferritin, light polypeptide | 0.0475067 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | 0.0466907 |
| AREG | amphiregulin | 0.0464304 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.045235 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0444346 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0435429 |
| RPS17 | ribosomal protein S17 | 0.0422739 |
| VEGFA | vascular endothelial growth factor A | 0.0422233 |
| RPLP2 | ribosomal protein, large, P2 | 0.0414969 |
| RPS21 | ribosomal protein S21 | 0.038579 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0383038 |
| LMO7 | LIM domain 7 | 0.0356835 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0353004 |
| RPL12 | ribosomal protein L12 | 0.0350814 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0348352 |
| EGFR | epidermal growth factor receptor | 0.0346752 |
| MUC13 | mucin 13, cell surface associated | 0.0343977 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.034277 |
| RPL36 | ribosomal protein L36 | 0.0341712 |
| RPS3 | ribosomal protein S3 | 0.0322634 |
| RPL18 | ribosomal protein L18 | 0.0318334 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0313847 |
| ABHD2 | abhydrolase domain containing 2 | 0.0307518 |
| RPS27 | ribosomal protein S27 | 0.0303424 |
| FAT1 | FAT atypical cadherin 1 | 0.0284193 |
| TXNIP | thioredoxin interacting protein | 0.0282602 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0281513 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0276661 |
| DIAPH3 | diaphanous-related formin 3 | 0.0272596 |
| ASTN2 | astrotactin 2 | 0.0268462 |
| POTEF | POTE ankyrin domain family, member F | 0.0263219 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0262263 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0256276 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0249026 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0245508 |
| RRM2 | ribonucleotide reductase M2 | 0.0238418 |
| NRXN3 | neurexin 3 | 0.023833 |
| MAGI3 | membrane associated guanylate kinase, WW and PDZ domain containing 3 | 0.0235376 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | 0.023362 |
| SIK3 | SIK family kinase 3 | 0.023276 |
| CD47 | CD47 molecule | 0.0231802 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0223478 |
| ATAD2 | ATPase family, AAA domain containing 2 | 0.0221715 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0220875 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0217274 |
| TGFBR3 | transforming growth factor, beta receptor III | 0.0213408 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0212466 |
| VMP1 | vacuole membrane protein 1 | 0.0212327 |
| RPL23 | ribosomal protein L23 | 0.0206629 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0206053 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0204824 |
| OGDH | oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) | 0.0204806 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0203464 |
| PCDH9 | protocadherin 9 | 0.0200385 |
| SMYD3 | SET and MYND domain containing 3 | 0.0198423 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0195839 |
| CLCN3 | chloride channel, voltage-sensitive 3 | 0.0192234 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0192113 |
| RPL32 | ribosomal protein L32 | 0.0192083 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0191997 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | 0.0191847 |
| RPL37A | ribosomal protein L37a | 0.0191507 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 0.0189583 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.018873 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0187406 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0185634 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0185505 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0185042 |
| SON | SON DNA binding protein | 0.0183194 |
| RPL28 | ribosomal protein L28 | 0.0183005 |
| SLC1A1 | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 | 0.0182313 |
| PNN | pinin, desmosome associated protein | 0.0182012 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0180496 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | 0.0178762 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0178294 |
| GPX4 | glutathione peroxidase 4 | 0.0176836 |
| ZFP36 | ZFP36 ring finger protein | 0.0176251 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0174826 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.017292 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0172628 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0172149 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0171819 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0169341 |
| RPL37 | ribosomal protein L37 | 0.0168286 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0165362 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0163955 |
| GIGYF2 | GRB10 interacting GYF protein 2 | 0.0163877 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTMA | prothymosin, alpha | -0.205194 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.136195 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.118547 |
| ANXA2 | annexin A2 | -0.115907 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.112373 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.106525 |
| NALF1 | NALCN channel auxiliary factor 1 | -0.0996399 |
| GOLGA4 | golgin A4 | -0.0912571 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0827645 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0811704 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0808313 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0781549 |
| AHNAK | AHNAK nucleoprotein | -0.0775549 |
| KRT8 | keratin 8, type II | -0.0712294 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0708282 |
| ITGA6 | integrin, alpha 6 | -0.0662251 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0634711 |
| KRT18 | keratin 18, type I | -0.0612965 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0612479 |
| RBM39 | RNA binding motif protein 39 | -0.0605915 |
| CCNY | cyclin Y | -0.060502 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0593987 |
| NDRG1 | N-myc downstream regulated 1 | -0.0578048 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0553652 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -0.0551576 |
| NPSR1 | neuropeptide S receptor 1 | -0.0547797 |
| PGK1 | phosphoglycerate kinase 1 | -0.0547625 |
| WDR45B | WD repeat domain 45B | -0.054377 |
| OGA | O-GlcNAcase | -0.0512374 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0510345 |
| SBF2 | SET binding factor 2 | -0.0503226 |
| CANX | calnexin | -0.0472812 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0472131 |
| AGR2 | anterior gradient 2 | -0.0465689 |
| DSG2 | desmoglein 2 | -0.0454413 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0451185 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0450389 |
| FAM13A | family with sequence similarity 13, member A | -0.0439673 |
| EPCAM | epithelial cell adhesion molecule | -0.0436296 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0426806 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0418671 |
| CLTC | clathrin, heavy chain (Hc) | -0.0408833 |
| LDHA | lactate dehydrogenase A | -0.0406953 |
| NF1 | neurofibromin 1 | -0.0405679 |
| TMEM123 | transmembrane protein 123 | -0.0398833 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0397545 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0392653 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0390671 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0390525 |
| PERP | PERP, TP53 apoptosis effector | -0.0378016 |
| H1-0 | H1.0 linker histone | -0.0375518 |
| RPS24 | ribosomal protein S24 | -0.0373795 |
| RPL35A | ribosomal protein L35a | -0.0372486 |
| EREG | epiregulin | -0.0371195 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0370986 |
| RAB1A | RAB1A, member RAS oncogene family | -0.037037 |
| CD2AP | CD2-associated protein | -0.0369281 |
| RRBP1 | ribosome binding protein 1 | -0.0366681 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0359957 |
| USP3 | ubiquitin specific peptidase 3 | -0.0354734 |
| SETD5 | SET domain containing 5 | -0.0354082 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0351658 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0350908 |
| LAMB3 | laminin, beta 3 | -0.035076 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0350523 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0348977 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0345626 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0342096 |
| PIGR | polymeric immunoglobulin receptor | -0.0338899 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0338469 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0337914 |
| MUC5AC | mucin 5AC, oligomeric mucus/gel-forming | -0.0337116 |
| RTN4 | reticulon 4 | -0.0334354 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0333884 |
| KIAA1217 | KIAA1217 | -0.0333199 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.0332598 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0324698 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0324261 |
| GPHN | gephyrin | -0.0322921 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0321668 |
| MAP4 | microtubule-associated protein 4 | -0.0319329 |
| INSIG1 | insulin induced gene 1 | -0.0314748 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0314279 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0313451 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0313397 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0313372 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0313237 |
| FERMT1 | fermitin family member 1 | -0.0311935 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0311493 |
| HMGB1 | high mobility group box 1 | -0.0310869 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0310179 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0308871 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0307437 |
| CENPF | centromere protein F, 350/400kDa | -0.0305897 |
| TFRC | transferrin receptor | -0.030579 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0303383 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0303036 |
| SSH2 | slingshot protein phosphatase 2 | -0.0302658 |
| PPARG | peroxisome proliferator-activated receptor gamma | -0.030102 |
| TFF3 | trefoil factor 3 (intestinal) | -0.0299744 |
