Trimetrexate_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trimetrexate perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trimetrexate_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.155746
RPS12 ribosomal protein S12 0.100768
TMSB10 thymosin beta 10 0.0891108
MT2A metallothionein 2A 0.0873878
RPL12 ribosomal protein L12 0.0711138
RPL35A ribosomal protein L35a 0.0686538
RPS8 ribosomal protein S8 0.0638607
EHBP1 EH domain binding protein 1 0.0634421
RUNX1 runt-related transcription factor 1 0.0626879
RPL26 ribosomal protein L26 0.0602178
RPS19 ribosomal protein S19 0.057765
RPL23 ribosomal protein L23 0.0567802
KLF6 Kruppel-like factor 6 0.0542201
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0500878
ZFP36L1 ZFP36 ring finger protein-like 1 0.0493977
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0479469
RPLP1 ribosomal protein, large, P1 0.0463956
WWTR1 WW domain containing transcription regulator 1 0.0451979
RPL36 ribosomal protein L36 0.044731
RPL18 ribosomal protein L18 0.0443802
RPL37A ribosomal protein L37a 0.0430261
RPS2 ribosomal protein S2 0.0429619
RPS17 ribosomal protein S17 0.0419978
MYOF myoferlin 0.0413973
RPS3 ribosomal protein S3 0.0413687
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0413015
TXNIP thioredoxin interacting protein 0.0404171
RACK1 receptor for activated C kinase 1 0.0399554
RTTN rotatin 0.0394952
DST dystonin 0.0393756
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0393142
RPS27 ribosomal protein S27 0.0383627
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0383052
SDK1 sidekick cell adhesion molecule 1 0.0369867
FTL ferritin, light polypeptide 0.0348405
PSD3 pleckstrin and Sec7 domain containing 3 0.0348306
PRELID2 PRELI domain containing 2 0.0347489
RPS14 ribosomal protein S14 0.0346498
RPS23 ribosomal protein S23 0.0338796
CAPRIN2 caprin family member 2 0.0336968
VMP1 vacuole membrane protein 1 0.0330608
RPLP2 ribosomal protein, large, P2 0.0320502
RPS21 ribosomal protein S21 0.0318262
EGR1 early growth response 1 0.0314866
RPL37 ribosomal protein L37 0.0307784
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0306582
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0306055
PYGB phosphorylase, glycogen; brain 0.0298374
RPL28 ribosomal protein L28 0.0293041
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0276712
RPL27 ribosomal protein L27 0.0275075
RPL31 ribosomal protein L31 0.0268549
TSC22D1 TSC22 domain family, member 1 0.0266393
FOSL1 FOS-like antigen 1 0.0259288
RPL35 ribosomal protein L35 0.0258377
RPL19 ribosomal protein L19 0.0257251
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0255809
DSCAM Down syndrome cell adhesion molecule 0.0254361
CXCL8 chemokine (C-X-C motif) ligand 8 0.0252785
RPL32 ribosomal protein L32 0.0251807
CAMTA1 calmodulin binding transcription activator 1 0.0249934
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0249033
NPAS2 neuronal PAS domain protein 2 0.0247514
ZSWIM6 zinc finger, SWIM-type containing 6 0.0244442
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.024202
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0234963
EEF1G eukaryotic translation elongation factor 1 gamma 0.0234257
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0233045
PIAS2 protein inhibitor of activated STAT, 2 0.0231898
CALB2 calbindin 2 0.0230374
SQSTM1 sequestosome 1 0.0227962
BCAR3 breast cancer anti-estrogen resistance 3 0.0222761
RPS28 ribosomal protein S28 0.0219439
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0218302
RPS29 ribosomal protein S29 0.0217745
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0217085
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0211939
AKAP9 A kinase (PRKA) anchor protein 9 0.0210091
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0206874
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0204532
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0203479
CBX3 chromobox homolog 3 0.0201779
RPS26 ribosomal protein S26 0.0201463
FAM177A1 family with sequence similarity 177, member A1 0.0198378
BICD1 bicaudal D homolog 1 (Drosophila) 0.0197853
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.019569
IER2 immediate early response 2 0.0194886
TTC3 tetratricopeptide repeat domain 3 0.0194858
ASTN2 astrotactin 2 0.0194133
EZR ezrin 0.0191825
VCL vinculin 0.0191634
ENO2 enolase 2 (gamma, neuronal) 0.019014
TTC19 tetratricopeptide repeat domain 19 0.0190016
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0188249
BIRC3 baculoviral IAP repeat containing 3 0.0187812
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough 0.0187659
DYNC2I1 dynein 2 intermediate chain 1 0.0185921
BHLHE40 basic helix-loop-helix family, member e40 0.0181042
SIK3 SIK family kinase 3 0.0179887
SLK STE20-like kinase 0.0179114

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.15424
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.128584
TM4SF1 transmembrane 4 L six family member 1 -0.108959
UBC ubiquitin C -0.107328
HLA-B major histocompatibility complex, class I, B -0.0913501
RIGI RNA sensor RIG-I -0.0890584
APP amyloid beta (A4) precursor protein -0.0847214
PGK1 phosphoglycerate kinase 1 -0.0819212
CD44 CD44 molecule (Indian blood group) -0.0816124
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0772762
VIM vimentin -0.0748216
PTMA prothymosin, alpha -0.0742879
ENO1 enolase 1, (alpha) -0.0738825
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.07342
LDHA lactate dehydrogenase A -0.0727502
AHNAK AHNAK nucleoprotein -0.0718094
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0662424
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0624743
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0613716
EEF2 eukaryotic translation elongation factor 2 -0.0597295
IFIH1 interferon induced with helicase C domain 1 -0.0597076
ZMYND8 zinc finger, MYND-type containing 8 -0.0596637
EREG epiregulin -0.0596402
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0593044
RPS27A ribosomal protein S27a -0.05796
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0564993
CANX calnexin -0.0564403
ACTG1 actin gamma 1 -0.0562436
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0554144
COL5A2 collagen, type V, alpha 2 -0.0536484
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0533801
NAMPT nicotinamide phosphoribosyltransferase -0.0527968
RAI1 retinoic acid induced 1 -0.0521022
LOC112694756 uncharaterized LOC112694756 -0.0514388
CALR calreticulin -0.0506584
PTPRF protein tyrosine phosphatase, receptor type, F -0.0505965
SOD2 superoxide dismutase 2, mitochondrial -0.0500971
RTN4 reticulon 4 -0.0499876
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.047253
WSB1 WD repeat and SOCS box containing 1 -0.0470328
XPO1 exportin 1 -0.0466569
SRGN serglycin -0.0462901
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0461923
TP63 tumor protein p63 -0.0458468
WARS1 tryptophanyl-tRNA synthetase 1 -0.0457569
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0455614
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0438153
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0429334
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0427202
KDM3A lysine (K)-specific demethylase 3A -0.0425153
KPNB1 karyopherin (importin) beta 1 -0.0420037
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0413953
TRIP12 thyroid hormone receptor interactor 12 -0.0403995
WDR45B WD repeat domain 45B -0.0402557
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0398321
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0390676
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0390259
ZFAND3 zinc finger, AN1-type domain 3 -0.0384269
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.038273
SLC38A1 solute carrier family 38, member 1 -0.0381648
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0376647
USP34 ubiquitin specific peptidase 34 -0.0374115
FBXO11 F-box protein 11 -0.0372447
VDAC1 voltage-dependent anion channel 1 -0.0366901
PDIA3 protein disulfide isomerase family A, member 3 -0.0364835
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.035466
PLSCR1 phospholipid scramblase 1 -0.0350745
GLG1 golgi glycoprotein 1 -0.0349975
PDIA4 protein disulfide isomerase family A, member 4 -0.0346842
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0345007
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0343547
PARD3 par-3 family cell polarity regulator -0.0342774
FUS FUS RNA binding protein -0.0341375
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0339547
RNF213 ring finger protein 213 -0.0339439
SP100 SP100 nuclear antigen -0.0337887
SDC4 syndecan 4 -0.0331994
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0328427
ZNFX1 zinc finger, NFX1-type containing 1 -0.0324317
TMEM123 transmembrane protein 123 -0.0322572
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0317661
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0314085
DNER delta/notch-like EGF repeat containing -0.0309299
HOOK2 hook microtubule-tethering protein 2 -0.0308411
DTX3L deltex 3 like, E3 ubiquitin ligase -0.0306934
JUN jun proto-oncogene -0.0306788
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0305849
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0303937
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -0.0299698
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.0298216
WNK1 WNK lysine deficient protein kinase 1 -0.0297466
ANXA1 annexin A1 -0.0293151
TXNRD1 thioredoxin reductase 1 -0.029198
ADAM17 ADAM metallopeptidase domain 17 -0.0290958
SCGB1D1 secretoglobin, family 1D, member 1 -0.0289364
SLC38A2 solute carrier family 38, member 2 -0.0288988
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0286625
HLA-E major histocompatibility complex, class I, E -0.0283464
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0282838
PDIA6 protein disulfide isomerase family A, member 6 -0.0282698