| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trimetrexate_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.171266 |
| MYOF | myoferlin | 0.110602 |
| GRAMD1B | GRAM domain containing 1B | 0.0934896 |
| TOP1 | topoisomerase (DNA) I | 0.0719713 |
| RUNX1 | runt-related transcription factor 1 | 0.0668068 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.062147 |
| FAM13A | family with sequence similarity 13, member A | 0.062136 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.058998 |
| VMP1 | vacuole membrane protein 1 | 0.0582193 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0535832 |
| SPAG9 | sperm associated antigen 9 | 0.0517345 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0504184 |
| MT2A | metallothionein 2A | 0.0482854 |
| ZNF638 | zinc finger protein 638 | 0.0475786 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0475378 |
| SIK3 | SIK family kinase 3 | 0.0457186 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0456401 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0446183 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0444809 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0435924 |
| GPHN | gephyrin | 0.0431791 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0426814 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0422331 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0421961 |
| RPS6 | ribosomal protein S6 | 0.0420714 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0420105 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0419098 |
| USP34 | ubiquitin specific peptidase 34 | 0.0419021 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0417919 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0417499 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0413242 |
| DTNA | dystrobrevin, alpha | 0.0412403 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0403946 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0389254 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0388877 |
| STRN3 | striatin, calmodulin binding protein 3 | 0.0388731 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0385067 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.03791 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0377901 |
| ANKRD11 | ankyrin repeat domain 11 | 0.036709 |
| JMJD1C | jumonji domain containing 1C | 0.0366798 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0352285 |
| TBC1D22A | TBC1 domain family, member 22A | 0.034952 |
| SMYD3 | SET and MYND domain containing 3 | 0.0347017 |
| SMAD3 | SMAD family member 3 | 0.034653 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0346134 |
| SON | SON DNA binding protein | 0.0345542 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | 0.0343153 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0337904 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0335749 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0333468 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0325431 |
| OGA | O-GlcNAcase | 0.0322957 |
| TES | testin LIM domain protein | 0.0321183 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0317061 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0314801 |
| SNX9 | sorting nexin 9 | 0.0313905 |
| GOLGB1 | golgin B1 | 0.0305675 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0303739 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0303273 |
| EXOC6B | exocyst complex component 6B | 0.0301488 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0296036 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.02953 |
| RBM25 | RNA binding motif protein 25 | 0.0293675 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0292948 |
| SYAP1 | synapse associated protein 1 | 0.0287135 |
| PRELID2 | PRELI domain containing 2 | 0.0286725 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0284769 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0284076 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.027934 |
| PCBP2 | poly(rC) binding protein 2 | 0.0279028 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 0.0275187 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0272209 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0271635 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0271281 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.02707 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0269821 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0269039 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0268433 |
| ZNF292 | zinc finger protein 292 | 0.0267536 |
| WWOX | WW domain containing oxidoreductase | 0.02654 |
| CUL4A | cullin 4A | 0.0264065 |
| GOLGA4 | golgin A4 | 0.0259713 |
| ZFR | zinc finger RNA binding protein | 0.0258104 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0257554 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0256297 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0255951 |
| THOC2 | THO complex 2 | 0.0255581 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0250108 |
| PTEN | phosphatase and tensin homolog | 0.02486 |
| PTK2 | protein tyrosine kinase 2 | 0.024748 |
| BPTF | bromodomain PHD finger transcription factor | 0.0246155 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0244403 |
| SLK | STE20-like kinase | 0.0242028 |
| RNF149 | ring finger protein 149 | 0.0241762 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0239798 |
| NBAS | neuroblastoma amplified sequence | 0.0238777 |
| USP47 | ubiquitin specific peptidase 47 | 0.0237192 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0236452 |
| DYNC2I1 | dynein 2 intermediate chain 1 | 0.0236245 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | -0.274449 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.258093 |
| LAMC2 | laminin, gamma 2 | -0.141635 |
| ASPH | aspartate beta-hydroxylase | -0.127101 |
| LRP1B | low density lipoprotein receptor-related protein 1B | -0.124491 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.113837 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.111575 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.103013 |
| AHNAK | AHNAK nucleoprotein | -0.102405 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0874989 |
| NDRG1 | N-myc downstream regulated 1 | -0.0855184 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0833842 |
| EFNA5 | ephrin-A5 | -0.0696582 |
| TMSB10 | thymosin beta 10 | -0.0643209 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0632451 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0613988 |
| ACTG1 | actin gamma 1 | -0.0595737 |
| HLA-B | major histocompatibility complex, class I, B | -0.0581682 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.057958 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0560733 |
| GM2A | GM2 ganglioside activator | -0.0557063 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0552889 |
| RNF213 | ring finger protein 213 | -0.053321 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.052924 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0528279 |
| INTS6 | integrator complex subunit 6 | -0.0522352 |
| ANXA2 | annexin A2 | -0.0512429 |
| TNS3 | tensin 3 | -0.0485453 |
| EGR1 | early growth response 1 | -0.047974 |
| SP100 | SP100 nuclear antigen | -0.0475805 |
| LDHA | lactate dehydrogenase A | -0.0473215 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0462285 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0457999 |
| PLEC | plectin | -0.04292 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0427395 |
| TRIM56 | tripartite motif containing 56 | -0.041488 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0404098 |
| FRY | furry homolog (Drosophila) | -0.0394869 |
| S100A10 | S100 calcium binding protein A10 | -0.0394861 |
| NABP1 | nucleic acid binding protein 1 | -0.0386983 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0375228 |
| HDLBP | high density lipoprotein binding protein | -0.0372042 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0360587 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0357422 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0355005 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0349908 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0348897 |
| RIGI | RNA sensor RIG-I | -0.0348626 |
| MX1 | MX dynamin-like GTPase 1 | -0.0348488 |
| SDC4 | syndecan 4 | -0.0344415 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0344031 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0331277 |
| CP | ceruloplasmin (ferroxidase) | -0.0329687 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0328476 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0327052 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0318519 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0312548 |
| STC1 | stanniocalcin 1 | -0.0311597 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | -0.0310683 |
| IFI44L | interferon-induced protein 44-like | -0.0308018 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.030581 |
| KRT18 | keratin 18, type I | -0.0304299 |
| KRT8 | keratin 8, type II | -0.0303288 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0302084 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.030076 |
| KRT86 | keratin 86, type II | -0.0294958 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0293881 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0292254 |
| LAMB3 | laminin, beta 3 | -0.0290862 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0290787 |
| KRT7 | keratin 7, type II | -0.0288253 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0287806 |
| GNAS | GNAS complex locus | -0.0287513 |
| AGR2 | anterior gradient 2 | -0.0280818 |
| ARF1 | ADP-ribosylation factor 1 | -0.0276618 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | -0.0271164 |
| PGK1 | phosphoglycerate kinase 1 | -0.0263172 |
| CCND1 | cyclin D1 | -0.0262907 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0262655 |
| S100A6 | S100 calcium binding protein A6 | -0.0259986 |
| UBC | ubiquitin C | -0.0259292 |
| SPTSSA | serine palmitoyltransferase, small subunit A | -0.025903 |
| IRF1 | interferon regulatory factor 1 | -0.0258651 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0257812 |
| ADAR | adenosine deaminase, RNA-specific | -0.025552 |
| PLSCR1 | phospholipid scramblase 1 | -0.0255302 |
| H1-0 | H1.0 linker histone | -0.0255112 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0249419 |
| ARCN1 | archain 1 | -0.0246518 |
| RPS24 | ribosomal protein S24 | -0.024088 |
| CDR2 | cerebellar degeneration-related protein 2, 62kDa | -0.0236412 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0235867 |
| ATG7 | autophagy related 7 | -0.0229397 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0229394 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0229334 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0228991 |
| B2M | beta-2-microglobulin | -0.0228039 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0227878 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0224678 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | -0.0220583 |
