| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.232281 |
| PRELID2 | PRELI domain containing 2 | 0.112683 |
| SMAD3 | SMAD family member 3 | 0.105723 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0839126 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0792285 |
| NAV2 | neuron navigator 2 | 0.0732381 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0694264 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0685172 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0643105 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0632223 |
| RARB | retinoic acid receptor, beta | 0.0603074 |
| FAM13A | family with sequence similarity 13, member A | 0.0577923 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0570207 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0562663 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0553623 |
| EFNA5 | ephrin-A5 | 0.0535786 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0518075 |
| ANGPTL4 | angiopoietin-like 4 | 0.049774 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0494599 |
| RPS12 | ribosomal protein S12 | 0.0468663 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0435182 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0434072 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0421539 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0419533 |
| ZNF638 | zinc finger protein 638 | 0.0405632 |
| ASPH | aspartate beta-hydroxylase | 0.0401002 |
| DST | dystonin | 0.0399597 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0391767 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0389445 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0389069 |
| RUNX1 | runt-related transcription factor 1 | 0.0384339 |
| RPS6 | ribosomal protein S6 | 0.0380958 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0377738 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0377583 |
| LOXL2 | lysyl oxidase-like 2 | 0.0376502 |
| SYT1 | synaptotagmin I | 0.0376373 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0372449 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.0365106 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0363173 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0362184 |
| INTS6 | integrator complex subunit 6 | 0.0362122 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | 0.0362003 |
| FBXO32 | F-box protein 32 | 0.0359832 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0354947 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0352433 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.0350904 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0348846 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0346555 |
| RPL37A | ribosomal protein L37a | 0.0344387 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0344151 |
| ADD3 | adducin 3 (gamma) | 0.0338632 |
| RPLP1 | ribosomal protein, large, P1 | 0.0338336 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0337454 |
| RPS8 | ribosomal protein S8 | 0.0335242 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0327197 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0326378 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.032279 |
| SQSTM1 | sequestosome 1 | 0.0319648 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0317602 |
| ZNF292 | zinc finger protein 292 | 0.0316962 |
| RAD51B | RAD51 paralog B | 0.0316287 |
| HMGA2 | high mobility group AT-hook 2 | 0.0315797 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0313496 |
| CA12 | carbonic anhydrase XII | 0.0310173 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0306838 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0297502 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0295229 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0293175 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.029284 |
| SEPTIN9 | septin 9 | 0.0292716 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0289826 |
| PARP8 | poly (ADP-ribose) polymerase family, member 8 | 0.0287383 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0284586 |
| PRKCA | protein kinase C, alpha | 0.0283757 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0283442 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0282958 |
| PDK3 | pyruvate dehydrogenase kinase, isozyme 3 | 0.0282275 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0279433 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0275607 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0274838 |
| SMYD3 | SET and MYND domain containing 3 | 0.0273232 |
| RPS17 | ribosomal protein S17 | 0.0272742 |
| WWOX | WW domain containing oxidoreductase | 0.0272329 |
| ATXN1 | ataxin 1 | 0.0269709 |
| RAI14 | retinoic acid induced 14 | 0.0268794 |
| FAM3C | family with sequence similarity 3, member C | 0.0268148 |
| CTBP2 | C-terminal binding protein 2 | 0.0266358 |
| IFI44L | interferon-induced protein 44-like | 0.0264848 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0259376 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0254333 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0253903 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0250988 |
| RPL31 | ribosomal protein L31 | 0.0246118 |
| RPL11 | ribosomal protein L11 | 0.0245336 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0242662 |
| RPL37 | ribosomal protein L37 | 0.024219 |
| SVIL | supervillin | 0.0241353 |
| RUNX2 | runt-related transcription factor 2 | 0.0239659 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0237306 |
| RPS19 | ribosomal protein S19 | 0.0236038 |
| Symbol | Name | Standardized Value |
|---|---|---|
| OSMR | oncostatin M receptor | -0.119152 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.117985 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0982401 |
| LOX | lysyl oxidase | -0.0968907 |
| CD44 | CD44 molecule (Indian blood group) | -0.090233 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0819743 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0782957 |
| GOLGA4 | golgin A4 | -0.0780343 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0736614 |
| FN1 | fibronectin 1 | -0.0644014 |
| EGR1 | early growth response 1 | -0.0635274 |
| SETD5 | SET domain containing 5 | -0.0590837 |
| GLCCI1 | glucocorticoid induced 1 | -0.0588943 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0583712 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0570842 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.055518 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0547601 |
| COPA | coatomer protein complex, subunit alpha | -0.0504244 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0494559 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0491494 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0457487 |
| RBM39 | RNA binding motif protein 39 | -0.0448037 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0444274 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0444117 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0434509 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0431604 |
| USP34 | ubiquitin specific peptidase 34 | -0.0427242 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0410423 |
| TNNC1 | troponin C type 1 (slow) | -0.0410398 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | -0.0403071 |
| S100A6 | S100 calcium binding protein A6 | -0.0393304 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0390787 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0388935 |
| VRK2 | vaccinia related kinase 2 | -0.0379993 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0379229 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.037484 |
| IL1R1 | interleukin 1 receptor, type I | -0.0373284 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0358234 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0356204 |
| POTEF | POTE ankyrin domain family, member F | -0.0352086 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0348802 |
| CALU | calumenin | -0.0334548 |
| NF1 | neurofibromin 1 | -0.0329398 |
| FTL | ferritin, light polypeptide | -0.0326943 |
| PID1 | phosphotyrosine interaction domain containing 1 | -0.0317949 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0316468 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0312643 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0312251 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0310419 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0310117 |
| HM13 | histocompatibility (minor) 13 | -0.0310048 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0308512 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0301568 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0301344 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0300466 |
| OXSR1 | oxidative stress responsive 1 | -0.0299031 |
| SRP54 | signal recognition particle 54kDa | -0.0295891 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0295223 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0294617 |
| MORF4L2 | mortality factor 4 like 2 | -0.0291703 |
| STC1 | stanniocalcin 1 | -0.0290518 |
| HDLBP | high density lipoprotein binding protein | -0.0288277 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0287685 |
| SLC30A7 | solute carrier family 30 (zinc transporter), member 7 | -0.0286959 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.028461 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0284538 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0283919 |
| TPM4 | tropomyosin 4 | -0.028373 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0281736 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0278318 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.027064 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0269381 |
| RNF24 | ring finger protein 24 | -0.0265269 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0264157 |
| GOLGA3 | golgin A3 | -0.0263791 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0261931 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0261828 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0261368 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0260527 |
| USP15 | ubiquitin specific peptidase 15 | -0.0258792 |
| SYAP1 | synapse associated protein 1 | -0.0257825 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0256196 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0255662 |
| ADAM28 | ADAM metallopeptidase domain 28 | -0.0251591 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0250078 |
| ARID3B | AT rich interactive domain 3B (BRIGHT-like) | -0.0246227 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.0246124 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.0245279 |
| ITGB3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | -0.0245235 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0241844 |
| SEC24A | SEC24 family member A | -0.02405 |
| GNA12 | guanine nucleotide binding protein (G protein) alpha 12 | -0.0239522 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0236778 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0234572 |
| PRRX1 | paired related homeobox 1 | -0.0234566 |
| ZNF407 | zinc finger protein 407 | -0.0228341 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0227463 |
| TMSB10 | thymosin beta 10 | -0.0225934 |
| DENND4A | DENN/MADD domain containing 4A | -0.0223284 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0222785 |
