| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.285847 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.201099 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0921647 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.080157 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.075639 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0718885 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0713213 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0622322 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0552105 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.053613 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0509378 |
| RPS12 | ribosomal protein S12 | 0.0508082 |
| WWOX | WW domain containing oxidoreductase | 0.0496436 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0483039 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.047682 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0472247 |
| ATXN1 | ataxin 1 | 0.0468484 |
| BRD2 | bromodomain containing 2 | 0.0458877 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0451683 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0439716 |
| PRRC2C | proline-rich coiled-coil 2C | 0.043461 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.040314 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0400375 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0397499 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0394367 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0388393 |
| RPS17 | ribosomal protein S17 | 0.0378382 |
| BMP6 | bone morphogenetic protein 6 | 0.0377087 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0373698 |
| PUM1 | pumilio RNA-binding family member 1 | 0.0363056 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0362811 |
| TOP1 | topoisomerase (DNA) I | 0.0362295 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0352358 |
| VMP1 | vacuole membrane protein 1 | 0.0351602 |
| MT1X | metallothionein 1X | 0.0349644 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0349109 |
| CCNL1 | cyclin L1 | 0.0346442 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0345315 |
| FMNL2 | formin-like 2 | 0.0344799 |
| FAM107B | family with sequence similarity 107, member B | 0.0341937 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0340652 |
| PRELID2 | PRELI domain containing 2 | 0.033964 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0337618 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0333986 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0327769 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0323766 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0322579 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0320296 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.0315588 |
| JMJD1C | jumonji domain containing 1C | 0.0314814 |
| NEGR1 | neuronal growth regulator 1 | 0.0312587 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0310626 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0302424 |
| COPA | coatomer protein complex, subunit alpha | 0.0299393 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.029739 |
| RCOR1 | REST corepressor 1 | 0.0296653 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0295184 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.02912 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | 0.0290644 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.028498 |
| CUL3 | cullin 3 | 0.0284673 |
| MRTFA | myocardin related transcription factor A | 0.0283916 |
| RPS21 | ribosomal protein S21 | 0.0283239 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0283132 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.0282964 |
| NLK | nemo-like kinase | 0.0277608 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0276016 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0275801 |
| TMSB10 | thymosin beta 10 | 0.0274947 |
| GPHN | gephyrin | 0.0273204 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0270874 |
| RRM2 | ribonucleotide reductase M2 | 0.026925 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0269225 |
| RANBP9 | RAN binding protein 9 | 0.0264604 |
| FTO | fat mass and obesity associated | 0.0264229 |
| SIK3 | SIK family kinase 3 | 0.0258349 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0254619 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.025117 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0250347 |
| NUP98 | nucleoporin 98kDa | 0.0247573 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0245623 |
| HELZ | helicase with zinc finger | 0.0243908 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.024378 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0243566 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0241836 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0241028 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0239209 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0238995 |
| RPS2 | ribosomal protein S2 | 0.023886 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0237908 |
| PCBP2 | poly(rC) binding protein 2 | 0.0237621 |
| CTBP2 | C-terminal binding protein 2 | 0.0235357 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0234373 |
| MSN | moesin | 0.0233225 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.022967 |
| INTS6 | integrator complex subunit 6 | 0.0228159 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0225687 |
| YLPM1 | YLP motif containing 1 | 0.0223834 |
| FOXO3 | forkhead box O3 | 0.0222754 |
| EPG5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 0.0222293 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.204504 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.171632 |
| VIM | vimentin | -0.166236 |
| TXNRD1 | thioredoxin reductase 1 | -0.15664 |
| ACTG1 | actin gamma 1 | -0.124818 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.118481 |
| GRAMD1B | GRAM domain containing 1B | -0.106723 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.102329 |
| IGF2 | insulin-like growth factor 2 | -0.10213 |
| TPM4 | tropomyosin 4 | -0.0864233 |
| LDHA | lactate dehydrogenase A | -0.0802501 |
| PTMA | prothymosin, alpha | -0.0737419 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0720625 |
| IER3 | immediate early response 3 | -0.0681804 |
| AHNAK | AHNAK nucleoprotein | -0.0570002 |
| ANXA2 | annexin A2 | -0.0566623 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0554471 |
| FTL | ferritin, light polypeptide | -0.054343 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0537653 |
| HDAC9 | histone deacetylase 9 | -0.053147 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0526878 |
| CAVIN1 | caveolae associated protein 1 | -0.0524504 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0508518 |
| FGB | fibrinogen beta chain | -0.0495094 |
| S100A6 | S100 calcium binding protein A6 | -0.0493915 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0488959 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0483735 |
| PYGL | phosphorylase, glycogen, liver | -0.0480767 |
| OSMR | oncostatin M receptor | -0.0475156 |
| PKM | pyruvate kinase, muscle | -0.0458531 |
| RPL19 | ribosomal protein L19 | -0.0457755 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0445864 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0441994 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0441728 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0440041 |
| STC1 | stanniocalcin 1 | -0.0429333 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0428244 |
| S100A10 | S100 calcium binding protein A10 | -0.0420093 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0388305 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0382791 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0382663 |
| HLA-B | major histocompatibility complex, class I, B | -0.0362797 |
| ENO1 | enolase 1, (alpha) | -0.0361924 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0359295 |
| EGR1 | early growth response 1 | -0.034201 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0335556 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0333861 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0330678 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0328024 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0320791 |
| CANX | calnexin | -0.0317492 |
| RPL35A | ribosomal protein L35a | -0.0307 |
| ERBIN | erbb2 interacting protein | -0.0304864 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0302832 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0301235 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0294946 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0291059 |
| ZFHX3 | zinc finger homeobox 3 | -0.0290328 |
| GNAS | GNAS complex locus | -0.0281286 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0280187 |
| RHOA | ras homolog family member A | -0.027475 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0270238 |
| RPS27A | ribosomal protein S27a | -0.0269776 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0266161 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0264529 |
| CD99 | CD99 molecule | -0.0263525 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0262498 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0259933 |
| BICC1 | BicC family RNA binding protein 1 | -0.0259782 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0259602 |
| TMEM123 | transmembrane protein 123 | -0.0259258 |
| CALR | calreticulin | -0.0257347 |
| JUN | jun proto-oncogene | -0.025501 |
| SQSTM1 | sequestosome 1 | -0.0253345 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0249823 |
| PGK1 | phosphoglycerate kinase 1 | -0.0248251 |
| CTSL | cathepsin L | -0.0246102 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0245737 |
| APP | amyloid beta (A4) precursor protein | -0.0243146 |
| HLA-E | major histocompatibility complex, class I, E | -0.0240271 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0239523 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0239141 |
| HMGB1 | high mobility group box 1 | -0.0238591 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0238139 |
| RAN | RAN, member RAS oncogene family | -0.0237522 |
| TCIM | transcriptional and immune response regulator | -0.0234103 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0228574 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0220451 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0220002 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0219347 |
| HMGA1 | high mobility group AT-hook 1 | -0.0218307 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0216119 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0215433 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0215112 |
| C15ORF48 | chromosome 15 open reading frame 48 | -0.021478 |
| RPL8 | ribosomal protein L8 | -0.0214053 |
| CFDP1 | craniofacial development protein 1 | -0.0213919 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0211951 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0211695 |
| TMSB4X | thymosin beta 4, X-linked | -0.0208412 |
