| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.148327 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.120948 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.102155 |
| INHBA | inhibin, beta A | 0.0849426 |
| GPC6 | glypican 6 | 0.0811547 |
| MT2A | metallothionein 2A | 0.0801217 |
| FRMD4A | FERM domain containing 4A | 0.0796966 |
| VIM | vimentin | 0.0764998 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.07417 |
| VMP1 | vacuole membrane protein 1 | 0.071378 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0696606 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0685737 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0680763 |
| NAV1 | neuron navigator 1 | 0.0670543 |
| FN1 | fibronectin 1 | 0.0654027 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0637572 |
| NHSL1 | NHS-like 1 | 0.0615 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0612802 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0601196 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0597473 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0585978 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0584691 |
| HMGA2 | high mobility group AT-hook 2 | 0.0571493 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0567302 |
| SMAD3 | SMAD family member 3 | 0.056237 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0535206 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0533621 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0490192 |
| FRMD5 | FERM domain containing 5 | 0.0483346 |
| CALD1 | caldesmon 1 | 0.048153 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.0476583 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0476038 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0473729 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | 0.0465636 |
| MYO10 | myosin X | 0.0464818 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0462265 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0459076 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0458539 |
| EGFR | epidermal growth factor receptor | 0.0455127 |
| OXR1 | oxidation resistance 1 | 0.0454853 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0454533 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0453907 |
| MYOF | myoferlin | 0.0452162 |
| GLIS3 | GLIS family zinc finger 3 | 0.0451906 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0447154 |
| ATM | ATM serine/threonine kinase | 0.0442069 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0436159 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0423732 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0420695 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0420564 |
| NKTR | natural killer cell triggering receptor | 0.0419463 |
| GPHN | gephyrin | 0.0418391 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0416047 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0410271 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0409461 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0402006 |
| MAP1B | microtubule-associated protein 1B | 0.0398582 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | 0.039677 |
| FBN1 | fibrillin 1 | 0.0396753 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.0390668 |
| DST | dystonin | 0.0385455 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0382924 |
| INTS6 | integrator complex subunit 6 | 0.0377951 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0376238 |
| PDE10A | phosphodiesterase 10A | 0.0374338 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0373847 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0371444 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0370921 |
| CNKSR3 | CNKSR family member 3 | 0.0366973 |
| NRP1 | neuropilin 1 | 0.0364617 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0362659 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0362484 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0361304 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0357688 |
| NAV2 | neuron navigator 2 | 0.0352618 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0351903 |
| SGIP1 | SH3-domain GRB2-like (endophilin) interacting protein 1 | 0.0349368 |
| EXOC4 | exocyst complex component 4 | 0.034729 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0342978 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0342207 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0341766 |
| RNF103-CHMP3 | RNF103-CHMP3 readthrough | 0.0341701 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0341192 |
| PRKCA | protein kinase C, alpha | 0.0340794 |
| NRG1 | neuregulin 1 | 0.0339292 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0337085 |
| ACER3 | alkaline ceramidase 3 | 0.0335537 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0331977 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0330221 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | 0.03285 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.032759 |
| SMYD3 | SET and MYND domain containing 3 | 0.032731 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0327141 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0326975 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0323171 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0323078 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0322557 |
| MMP1 | matrix metallopeptidase 1 | 0.0322451 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.0322084 |
| IFI44 | interferon-induced protein 44 | 0.032036 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GRB10 | growth factor receptor-bound protein 10 | -0.132256 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.130244 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.11519 |
| NDRG1 | N-myc downstream regulated 1 | -0.114057 |
| KRT17 | keratin 17, type I | -0.113948 |
| LAMB3 | laminin, beta 3 | -0.111086 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.107779 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.104798 |
| ANXA2 | annexin A2 | -0.0976461 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0958399 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0941681 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0872977 |
| ATOSA | atos homolog A | -0.0845593 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | -0.0829851 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0816062 |
| MYO1E | myosin IE | -0.0788399 |
| IGF2 | insulin-like growth factor 2 | -0.0783106 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0758826 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0756937 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0730237 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0715861 |
| KYNU | kynureninase | -0.0708811 |
| PARD3 | par-3 family cell polarity regulator | -0.0660309 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0642089 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0637185 |
| MXD1 | MAX dimerization protein 1 | -0.0610778 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0603386 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0597959 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0574566 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0564286 |
| EGR1 | early growth response 1 | -0.0557398 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0554663 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0553214 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | -0.0551416 |
| FTL | ferritin, light polypeptide | -0.0525591 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0523991 |
| RND3 | Rho family GTPase 3 | -0.0509838 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0502632 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0502567 |
| NPTN | neuroplastin | -0.0500918 |
| PGK1 | phosphoglycerate kinase 1 | -0.0497648 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0493108 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0491161 |
| TMEM165 | transmembrane protein 165 | -0.0491107 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0485407 |
| LSAMP | limbic system-associated membrane protein | -0.0477305 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0470932 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0462576 |
| SDC4 | syndecan 4 | -0.0461036 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0459255 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0456949 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0455049 |
| PKM | pyruvate kinase, muscle | -0.0450328 |
| PTMA | prothymosin, alpha | -0.0444995 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0442968 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0441044 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | -0.0433324 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0430292 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0430013 |
| DTNA | dystrobrevin, alpha | -0.042973 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0422054 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0421486 |
| SVIL | supervillin | -0.0412408 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0408211 |
| RNF149 | ring finger protein 149 | -0.0407785 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0406762 |
| SPAG9 | sperm associated antigen 9 | -0.0396557 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | -0.0396277 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0393155 |
| ABHD17C | abhydrolase domain containing 17C | -0.0390409 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0388029 |
| UBAP1 | ubiquitin associated protein 1 | -0.0381356 |
| ETS2 | v-ets avian erythroblastosis virus E26 oncogene homolog 2 | -0.038077 |
| RIGI | RNA sensor RIG-I | -0.0380423 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0375275 |
| TMOD3 | tropomodulin 3 (ubiquitous) | -0.037466 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0374559 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0371794 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0371774 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0368618 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0365376 |
| PARD6B | par-6 family cell polarity regulator beta | -0.0362709 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0362539 |
| SLMAP | sarcolemma associated protein | -0.0361683 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0361432 |
| TLK1 | tousled-like kinase 1 | -0.0360807 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0358547 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0355057 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0354524 |
| ZNF207 | zinc finger protein 207 | -0.0354264 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0351824 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0349344 |
| GLCCI1 | glucocorticoid induced 1 | -0.0348908 |
| ZNF638 | zinc finger protein 638 | -0.0348558 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0341518 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0340162 |
| SACK1A | scaffolding CK1 anchoring protein A | -0.033888 |
| MUC16 | mucin 16, cell surface associated | -0.033656 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.03365 |
| CTDSPL2 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 | -0.0333058 |
