| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.357658 |
| RPS3 | ribosomal protein S3 | 0.0793412 |
| TXNRD1 | thioredoxin reductase 1 | 0.0631782 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | 0.0559044 |
| RPS12 | ribosomal protein S12 | 0.0551245 |
| RPS21 | ribosomal protein S21 | 0.0546669 |
| TMSB10 | thymosin beta 10 | 0.0541049 |
| HOMER1 | homer scaffolding protein 1 | 0.0528564 |
| RPS17 | ribosomal protein S17 | 0.0465152 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0438617 |
| MT2A | metallothionein 2A | 0.0435509 |
| TPI1 | triosephosphate isomerase 1 | 0.0433362 |
| RPS2 | ribosomal protein S2 | 0.0426793 |
| RPS8 | ribosomal protein S8 | 0.0418336 |
| RPS6 | ribosomal protein S6 | 0.0377607 |
| KLF6 | Kruppel-like factor 6 | 0.0352058 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0349062 |
| RPL37A | ribosomal protein L37a | 0.0344319 |
| GPHN | gephyrin | 0.0335818 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0331419 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0319856 |
| VMP1 | vacuole membrane protein 1 | 0.0319387 |
| RPS26 | ribosomal protein S26 | 0.0310598 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0306773 |
| RPL9 | ribosomal protein L9 | 0.0306157 |
| RPL36 | ribosomal protein L36 | 0.0301325 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0299631 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0286452 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0280777 |
| YBX3 | Y box binding protein 3 | 0.027548 |
| KIAA1328 | KIAA1328 | 0.0274174 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.027273 |
| GPX4 | glutathione peroxidase 4 | 0.0271222 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0268462 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0260117 |
| RPL26 | ribosomal protein L26 | 0.0259125 |
| CDCP1 | CUB domain containing protein 1 | 0.0252647 |
| TMEM41B | transmembrane protein 41B | 0.0251517 |
| RPL18 | ribosomal protein L18 | 0.0250914 |
| RACK1 | receptor for activated C kinase 1 | 0.0250367 |
| MACROD2 | MACRO domain containing 2 | 0.0246966 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0246895 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0242776 |
| NCAPG2 | non-SMC condensin II complex, subunit G2 | 0.0241655 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0240322 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 0.0240285 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0237762 |
| USP15 | ubiquitin specific peptidase 15 | 0.0230429 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0226589 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0225811 |
| RRM2 | ribonucleotide reductase M2 | 0.0224257 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0223386 |
| WWOX | WW domain containing oxidoreductase | 0.0223073 |
| AEBP2 | AE binding protein 2 | 0.0222696 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.0221661 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.02213 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0219799 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0217868 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0217528 |
| INTS6 | integrator complex subunit 6 | 0.0215609 |
| CEP290 | centrosomal protein 290kDa | 0.0215517 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0214026 |
| MAPK8 | mitogen-activated protein kinase 8 | 0.02131 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0211015 |
| RALGAPB | Ral GTPase activating protein, beta subunit (non-catalytic) | 0.0209865 |
| MELK | maternal embryonic leucine zipper kinase | 0.0209126 |
| CBX3 | chromobox homolog 3 | 0.0207045 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0206228 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0204862 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0204182 |
| TOP1 | topoisomerase (DNA) I | 0.02018 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0201202 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0200603 |
| TRIM59 | tripartite motif containing 59 | 0.0198631 |
| PNN | pinin, desmosome associated protein | 0.0198517 |
| BRD4 | bromodomain containing 4 | 0.0194397 |
| RCOR1 | REST corepressor 1 | 0.0193954 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.019228 |
| HELLS | helicase, lymphoid-specific | 0.0191314 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0189907 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0189309 |
| ATP13A3 | ATPase type 13A3 | 0.0188917 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.018649 |
| STMN1 | stathmin 1 | 0.0185751 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0182562 |
| WDR70 | WD repeat domain 70 | 0.0181344 |
| RPS7 | ribosomal protein S7 | 0.0180551 |
| U2SURP | U2 snRNP-associated SURP domain containing | 0.0180295 |
| WNT2B | wingless-type MMTV integration site family, member 2B | 0.0180169 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0179099 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0178778 |
| CKAP5 | cytoskeleton associated protein 5 | 0.0177424 |
| ANKRD36C | ankyrin repeat domain 36C | 0.017616 |
| RPLP1 | ribosomal protein, large, P1 | 0.0175554 |
| RPS27 | ribosomal protein S27 | 0.0174508 |
| IER2 | immediate early response 2 | 0.0173874 |
| RPL12 | ribosomal protein L12 | 0.0172741 |
| BRD2 | bromodomain containing 2 | 0.0172631 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | 0.0170807 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.017036 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.179832 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.126748 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0722636 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0706929 |
| PTMA | prothymosin, alpha | -0.0672616 |
| UBC | ubiquitin C | -0.066121 |
| PDE10A | phosphodiesterase 10A | -0.0655266 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0638351 |
| HLA-B | major histocompatibility complex, class I, B | -0.0626886 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0620828 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0610189 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | -0.0605717 |
| AHNAK | AHNAK nucleoprotein | -0.059265 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0577938 |
| TPM4 | tropomyosin 4 | -0.0576852 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0568577 |
| ADAR | adenosine deaminase, RNA-specific | -0.0553882 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0524126 |
| PGK1 | phosphoglycerate kinase 1 | -0.0515074 |
| RNF213 | ring finger protein 213 | -0.0511598 |
| TPM3 | tropomyosin 3 | -0.050192 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0497509 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0486642 |
| ENO1 | enolase 1, (alpha) | -0.0476062 |
| GRAMD1B | GRAM domain containing 1B | -0.047394 |
| TLK1 | tousled-like kinase 1 | -0.0471048 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0458327 |
| RAD51B | RAD51 paralog B | -0.0449181 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0445585 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0445246 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0428894 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0428535 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0421751 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0413914 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0401715 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0395968 |
| NCAPD2 | non-SMC condensin I complex, subunit D2 | -0.0395375 |
| CTTN | cortactin | -0.0392911 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | -0.0386581 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0382346 |
| VIM | vimentin | -0.0369778 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0369459 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | -0.0367687 |
| CANX | calnexin | -0.0367675 |
| OSMR | oncostatin M receptor | -0.0364424 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0362046 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0360811 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0358968 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0356838 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0355763 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0347717 |
| IGF2 | insulin-like growth factor 2 | -0.0346081 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0337987 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0330586 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0328761 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0325711 |
| CCT8 | chaperonin containing TCP1, subunit 8 (theta) | -0.0323976 |
| TFG | TRK-fused gene | -0.0323274 |
| PTK2 | protein tyrosine kinase 2 | -0.0320843 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0315879 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0312338 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.031089 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0308799 |
| CCND1 | cyclin D1 | -0.0302895 |
| USP34 | ubiquitin specific peptidase 34 | -0.0302444 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0300892 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0297668 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0295848 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0288054 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0285852 |
| LDHA | lactate dehydrogenase A | -0.0285777 |
| DARS1 | aspartyl-tRNA synthetase 1 | -0.0283942 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0280131 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0277963 |
| RPS15 | ribosomal protein S15 | -0.02774 |
| RPL19 | ribosomal protein L19 | -0.0270087 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0268547 |
| ZNF148 | zinc finger protein 148 | -0.0268446 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0268188 |
| THADA | thyroid adenoma associated | -0.0263455 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0262377 |
| YBX1 | Y box binding protein 1 | -0.0261347 |
| ATXN1 | ataxin 1 | -0.0257955 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0254249 |
| EHBP1 | EH domain binding protein 1 | -0.025153 |
| SRP72 | signal recognition particle 72kDa | -0.0251206 |
| ZNF207 | zinc finger protein 207 | -0.025083 |
| PHACTR4 | phosphatase and actin regulator 4 | -0.0250822 |
| HMGA1 | high mobility group AT-hook 1 | -0.0250387 |
| RPS27A | ribosomal protein S27a | -0.0250275 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0248913 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0246325 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0245603 |
| TRIM56 | tripartite motif containing 56 | -0.0245431 |
| PHF21A | PHD finger protein 21A | -0.0245309 |
| CALR | calreticulin | -0.0243517 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0243056 |
| PKM | pyruvate kinase, muscle | -0.0242301 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.0242116 |
| RPL7A | ribosomal protein L7a | -0.0242063 |
