Trimetrexate_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trimetrexate perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trimetrexate_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.124267
POTEF POTE ankyrin domain family, member F 0.116502
APLP2 amyloid beta (A4) precursor-like protein 2 0.111803
ZSWIM6 zinc finger, SWIM-type containing 6 0.0981517
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.096027
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0873581
MSN moesin 0.081361
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0784331
RPS12 ribosomal protein S12 0.0757665
RPS6 ribosomal protein S6 0.0725887
VEGFA vascular endothelial growth factor A 0.0722485
EEF2 eukaryotic translation elongation factor 2 0.0680584
MYO6 myosin VI 0.0677425
DSPP dentin sialophosphoprotein 0.0650496
SAMD4A sterile alpha motif domain containing 4A 0.05957
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.058714
FTL ferritin, light polypeptide 0.0580945
VMP1 vacuole membrane protein 1 0.0577612
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0553583
RPLP2 ribosomal protein, large, P2 0.05513
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0544389
AKAP13 A kinase (PRKA) anchor protein 13 0.0513593
RPS17 ribosomal protein S17 0.0511249
RACK1 receptor for activated C kinase 1 0.0503639
ANXA1 annexin A1 0.0482851
BRD2 bromodomain containing 2 0.0474082
EXT1 exostosin glycosyltransferase 1 0.0469828
GOLGB1 golgin B1 0.0460846
EZR ezrin 0.0420456
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0395677
EEF1G eukaryotic translation elongation factor 1 gamma 0.0388284
RCOR1 REST corepressor 1 0.0387422
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0383378
RPS27 ribosomal protein S27 0.0371794
RPS2 ribosomal protein S2 0.0370759
HSPA8 heat shock 70kDa protein 8 0.0366699
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0360259
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0359178
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0350907
RPS19 ribosomal protein S19 0.0348127
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0340813
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0337125
GLS2 glutaminase 2 (liver, mitochondrial) 0.0327499
RPLP1 ribosomal protein, large, P1 0.032455
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0322071
MYO5B myosin VB 0.0318097
RPS8 ribosomal protein S8 0.0311155
PCBP2 poly(rC) binding protein 2 0.0308997
PRKCA protein kinase C, alpha 0.0307575
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.030613
PEG10 paternally expressed 10 0.0303543
RPS3 ribosomal protein S3 0.0299812
USP53 ubiquitin specific peptidase 53 0.0299163
RPL18 ribosomal protein L18 0.0298879
CKAP5 cytoskeleton associated protein 5 0.0295513
FBXO32 F-box protein 32 0.0294061
CBX3 chromobox homolog 3 0.029064
TPM3 tropomyosin 3 0.0280113
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0273438
MYO10 myosin X 0.0263406
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0261613
TXNIP thioredoxin interacting protein 0.025942
TIMP2 TIMP metallopeptidase inhibitor 2 0.0259382
SFPQ splicing factor proline/glutamine-rich 0.0244961
TAOK1 TAO kinase 1 0.0243759
RBM25 RNA binding motif protein 25 0.0242074
INTS6 integrator complex subunit 6 0.0239259
RPS14 ribosomal protein S14 0.0238142
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0230201
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0229427
RPS29 ribosomal protein S29 0.0228905
PNN pinin, desmosome associated protein 0.0227419
TUFT1 tuftelin 1 0.0227026
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0221757
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0219449
GPX4 glutathione peroxidase 4 0.0218045
ACAP2 ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 0.0215965
ATXN1 ataxin 1 0.021381
PDCD6IP programmed cell death 6 interacting protein 0.0210673
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0210524
KIF1B kinesin family member 1B 0.0210464
RPL14 ribosomal protein L14 0.0208759
RPL12 ribosomal protein L12 0.0208727
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0208674
RPL5 ribosomal protein L5 0.0205131
MAP1B microtubule-associated protein 1B 0.0204938
ASTN2 astrotactin 2 0.0203848
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0200388
MT2A metallothionein 2A 0.0200332
MAST4 microtubule associated serine/threonine kinase family member 4 0.0200239
SEPTIN11 septin 11 0.0199351
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0199324
SRRM1 serine/arginine repetitive matrix 1 0.019858
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0197881
RPL37A ribosomal protein L37a 0.0197848
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0197713
TTC3 tetratricopeptide repeat domain 3 0.0196506
NFE2L1 nuclear factor, erythroid 2-like 1 0.0194136
CCNL1 cyclin L1 0.0193787
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0193765

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.254679
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.17377
FNDC3B fibronectin type III domain containing 3B -0.122853
ASPH aspartate beta-hydroxylase -0.116836
LPP LIM domain containing preferred translocation partner in lipoma -0.111912
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.105331
NAMPT nicotinamide phosphoribosyltransferase -0.103606
TM4SF1 transmembrane 4 L six family member 1 -0.0984277
PGK1 phosphoglycerate kinase 1 -0.0954406
ANXA2 annexin A2 -0.0835559
NPEPPS aminopeptidase puromycin sensitive -0.0828697
GRB10 growth factor receptor-bound protein 10 -0.0813338
TPT1 tumor protein, translationally-controlled 1 -0.0798805
CCND1 cyclin D1 -0.0755476
MARCHF6 membrane associated ring-CH-type finger 6 -0.0734512
ACTG1 actin gamma 1 -0.0712652
HLA-B major histocompatibility complex, class I, B -0.0700058
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0677465
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.066568
CD2AP CD2-associated protein -0.0636661
LAMB3 laminin, beta 3 -0.0603518
WSB1 WD repeat and SOCS box containing 1 -0.0598163
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.059731
F3 coagulation factor III (thromboplastin, tissue factor) -0.0568613
KDM3A lysine (K)-specific demethylase 3A -0.0562073
TMEM123 transmembrane protein 123 -0.0560991
TFG TRK-fused gene -0.0558894
RPL35A ribosomal protein L35a -0.0538414
PTMA prothymosin, alpha -0.0536181
S100A10 S100 calcium binding protein A10 -0.0536069
TSC22D2 TSC22 domain family, member 2 -0.0534818
S100A6 S100 calcium binding protein A6 -0.0531346
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.052988
ZNF292 zinc finger protein 292 -0.0524049
RAB1A RAB1A, member RAS oncogene family -0.0519199
AHNAK AHNAK nucleoprotein -0.0512407
OSBPL3 oxysterol binding protein-like 3 -0.0484807
RBM39 RNA binding motif protein 39 -0.0481494
PLAU plasminogen activator, urokinase -0.0478073
TPM4 tropomyosin 4 -0.046821
ZFAND3 zinc finger, AN1-type domain 3 -0.0462909
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0458936
CTSB cathepsin B -0.045262
ARF1 ADP-ribosylation factor 1 -0.0452558
ERBIN erbb2 interacting protein -0.0450847
KRT8 keratin 8, type II -0.0444173
CAB39 calcium binding protein 39 -0.043919
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0434802
LIMCH1 LIM and calponin homology domains 1 -0.0434165
BASP1 brain abundant, membrane attached signal protein 1 -0.0433574
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0425896
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0423045
HMGA1 high mobility group AT-hook 1 -0.0411037
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0404761
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0404038
SLMAP sarcolemma associated protein -0.0398173
IFI6 interferon, alpha-inducible protein 6 -0.0393358
IFITM3 interferon induced transmembrane protein 3 -0.0392929
RLF rearranged L-myc fusion -0.0391879
SETD5 SET domain containing 5 -0.0390762
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0390682
FAM162A family with sequence similarity 162, member A -0.0390018
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0388909
GNAS GNAS complex locus -0.0387425
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0386374
CALU calumenin -0.0376407
PLEC plectin -0.0371366
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0360713
TMEM263 transmembrane protein 263 -0.0357202
RPS24 ribosomal protein S24 -0.0356603
KMT2E lysine (K)-specific methyltransferase 2E -0.035616
IFITM1 interferon induced transmembrane protein 1 -0.0354237
ARHGAP29 Rho GTPase activating protein 29 -0.0354221
CDK17 cyclin-dependent kinase 17 -0.0350984
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0350852
CCNY cyclin Y -0.0348203
KRT7 keratin 7, type II -0.034739
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0343099
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0339527
IFI16 interferon, gamma-inducible protein 16 -0.0339035
STAG2 stromal antigen 2 -0.0338895
RAD21 RAD21 homolog (S. pombe) -0.0338801
RNF145 ring finger protein 145 -0.0333901
WTAP Wilms tumor 1 associated protein -0.0331932
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0331086
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0330909
HLA-A major histocompatibility complex, class I, A -0.0330359
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0329043
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0324632
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0323957
NIPBL Nipped-B homolog (Drosophila) -0.0323152
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0321805
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0321177
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0320265
CAPN2 calpain 2, (m/II) large subunit -0.0319468
TRA2A transformer 2 alpha homolog (Drosophila) -0.0318578
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0318034
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0315353
EFNA5 ephrin-A5 -0.0314809
LMAN1 lectin, mannose-binding, 1 -0.031471