Trimetrexate_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trimetrexate perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trimetrexate_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.124248
PDLIM5 PDZ and LIM domain 5 0.119429
RPS12 ribosomal protein S12 0.104563
KYNU kynureninase 0.101183
DST dystonin 0.089663
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0756501
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0730464
ZSWIM6 zinc finger, SWIM-type containing 6 0.0727525
COL8A1 collagen, type VIII, alpha 1 0.0726823
FMNL2 formin-like 2 0.0704673
VCL vinculin 0.0686067
COL4A6 collagen, type IV, alpha 6 0.0659788
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0645084
TRIO trio Rho guanine nucleotide exchange factor 0.0638306
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0627391
AKAP13 A kinase (PRKA) anchor protein 13 0.0583278
FNDC3B fibronectin type III domain containing 3B 0.0546168
BASP1 brain abundant, membrane attached signal protein 1 0.0533193
RPS2 ribosomal protein S2 0.0532144
SMOC1 SPARC related modular calcium binding 1 0.0524731
RPS8 ribosomal protein S8 0.0487896
RPL26 ribosomal protein L26 0.0484174
RPS17 ribosomal protein S17 0.0473308
PTEN phosphatase and tensin homolog 0.0461873
SH3KBP1 SH3-domain kinase binding protein 1 0.0454726
TMSB10 thymosin beta 10 0.0453527
VMP1 vacuole membrane protein 1 0.0417749
FNDC3A fibronectin type III domain containing 3A 0.0405849
RPS19 ribosomal protein S19 0.0400586
INTS6 integrator complex subunit 6 0.0399657
RPL9 ribosomal protein L9 0.0390122
RPL37A ribosomal protein L37a 0.0373161
CTBP2 C-terminal binding protein 2 0.0370517
ZEB2 zinc finger E-box binding homeobox 2 0.0368753
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0361822
CTSC cathepsin C 0.0356713
CTIF CBP80/20-dependent translation initiation factor 0.0355728
DNER delta/notch-like EGF repeat containing 0.0354585
MYOF myoferlin 0.0353089
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0337803
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0337634
RAD51B RAD51 paralog B 0.0335883
RGS2 regulator of G-protein signaling 2 0.0334905
SMAD2 SMAD family member 2 0.0333538
GLCCI1 glucocorticoid induced 1 0.0322843
RPS21 ribosomal protein S21 0.031727
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0312914
BMP6 bone morphogenetic protein 6 0.0311689
ESYT2 extended synaptotagmin-like protein 2 0.0306674
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0297541
POTEF POTE ankyrin domain family, member F 0.0295572
PCBP2 poly(rC) binding protein 2 0.0285742
GPHN gephyrin 0.0282473
IRS2 insulin receptor substrate 2 0.0281431
TOP1 topoisomerase (DNA) I 0.0280482
CBX3 chromobox homolog 3 0.027471
ASTN2 astrotactin 2 0.0266615
MBD5 methyl-CpG binding domain protein 5 0.0264102
PUM2 pumilio RNA-binding family member 2 0.0263446
RACK1 receptor for activated C kinase 1 0.0260977
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0260785
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0260263
EPHA4 EPH receptor A4 0.0256139
SAMD4A sterile alpha motif domain containing 4A 0.0252341
MCTP1 multiple C2 domains, transmembrane 1 0.0252203
NAP1L1 nucleosome assembly protein 1-like 1 0.0250639
NT5C2 5'-nucleotidase, cytosolic II 0.0249352
ARHGAP5 Rho GTPase activating protein 5 0.0249249
BIRC6 baculoviral IAP repeat containing 6 0.0249201
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0248512
ATXN1 ataxin 1 0.0247825
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0244825
RPS14 ribosomal protein S14 0.0242743
MSN moesin 0.0240294
TGFBR1 transforming growth factor, beta receptor 1 0.0237881
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0237036
USP9X ubiquitin specific peptidase 9, X-linked 0.0236594
SLF1 SMC5-SMC6 complex localization factor 1 0.0234194
NCOR2 nuclear receptor corepressor 2 0.0234059
LAMA5 laminin, alpha 5 0.0233776
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0232499
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0232247
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0231967
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0230848
CXCL8 chemokine (C-X-C motif) ligand 8 0.0230592
COL4A5 collagen, type IV, alpha 5 0.0228899
ZNF638 zinc finger protein 638 0.0228189
CHD1 chromodomain helicase DNA binding protein 1 0.0224842
MYO10 myosin X 0.022453
COPA coatomer protein complex, subunit alpha 0.0223711
RPS26 ribosomal protein S26 0.0222392
MBNL1 muscleblind-like splicing regulator 1 0.0218679
PUM1 pumilio RNA-binding family member 1 0.0218631
CAMTA1 calmodulin binding transcription activator 1 0.0218459
RASAL2 RAS protein activator like 2 0.0218339
RPL37 ribosomal protein L37 0.0217216
USP53 ubiquitin specific peptidase 53 0.0216126
CHSY3 chondroitin sulfate synthase 3 0.0215227
SFPQ splicing factor proline/glutamine-rich 0.0213055
ATP13A3 ATPase type 13A3 0.0211145

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.323972
NAMPT nicotinamide phosphoribosyltransferase -0.107977
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0737071
IGFBP3 insulin-like growth factor binding protein 3 -0.0690677
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0662185
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0660349
TBXT T-box transcription factor T -0.0608012
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0595355
HLA-B major histocompatibility complex, class I, B -0.0581276
PDE4D phosphodiesterase 4D, cAMP-specific -0.0577512
PGK1 phosphoglycerate kinase 1 -0.0571122
SMYD3 SET and MYND domain containing 3 -0.0550886
WARS1 tryptophanyl-tRNA synthetase 1 -0.0533867
TFPI2 tissue factor pathway inhibitor 2 -0.0527819
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0516634
TMX4 thioredoxin-related transmembrane protein 4 -0.0509286
TGFBI transforming growth factor, beta-induced, 68kDa -0.0495299
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0484044
CANX calnexin -0.047566
SLC39A8 solute carrier family 39 (zinc transporter), member 8 -0.0474916
TM4SF1 transmembrane 4 L six family member 1 -0.0470923
OSMR oncostatin M receptor -0.046378
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0433962
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.0429815
ANXA2 annexin A2 -0.0425621
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0413619
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0409481
PYGL phosphorylase, glycogen, liver -0.03924
VIM vimentin -0.038097
ZMYND8 zinc finger, MYND-type containing 8 -0.0380076
AHNAK AHNAK nucleoprotein -0.0369223
NCOA7 nuclear receptor coactivator 7 -0.0358105
FOXC1 forkhead box C1 -0.0353139
NCKAP5 NCK-associated protein 5 -0.0336733
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0328699
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.032159
RIGI RNA sensor RIG-I -0.0312894
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0308526
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0305754
ELL2 elongation factor, RNA polymerase II, 2 -0.0302752
ADGRD1 adhesion G protein-coupled receptor D1 -0.030066
PRSS23 protease, serine, 23 -0.0300569
GDA guanine deaminase -0.0297161
STC1 stanniocalcin 1 -0.0288904
ZBTB20 zinc finger and BTB domain containing 20 -0.0284434
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0283083
CTSL cathepsin L -0.0281047
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0281015
S100A10 S100 calcium binding protein A10 -0.0279259
KPNB1 karyopherin (importin) beta 1 -0.0275529
PTGR1 prostaglandin reductase 1 -0.0274229
LDHA lactate dehydrogenase A -0.0273897
SLC16A6 solute carrier family 16, member 6 -0.027365
TPM4 tropomyosin 4 -0.0273619
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0270161
ZBTB38 zinc finger and BTB domain containing 38 -0.0261163
PTMA prothymosin, alpha -0.0256378
KIAA0825 KIAA0825 -0.0254884
GNS glucosamine (N-acetyl)-6-sulfatase -0.0253453
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0251822
RAB3B RAB3B, member RAS oncogene family -0.0250564
CCL5 chemokine (C-C motif) ligand 5 -0.0249604
PCDH15 protocadherin-related 15 -0.0248525
NT5E 5'-nucleotidase, ecto (CD73) -0.0245976
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0244744
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.024448
SOD2 superoxide dismutase 2, mitochondrial -0.023807
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0235282
RPH3AL rabphilin 3A-like (without C2 domains) -0.0232782
LMAN1 lectin, mannose-binding, 1 -0.0232398
CRLF2 cytokine receptor-like factor 2 -0.0231932
TXNRD1 thioredoxin reductase 1 -0.0231743
GCC2 GRIP and coiled-coil domain containing 2 -0.0230769
VDAC1 voltage-dependent anion channel 1 -0.0226495
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.022513
WDR45B WD repeat domain 45B -0.0221031
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0219921
AFF4 AF4/FMR2 family, member 4 -0.021942
KDM5B lysine (K)-specific demethylase 5B -0.0216872
TLK1 tousled-like kinase 1 -0.0216746
IL6 interleukin 6 -0.021433
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0214275
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0213762
ESM1 endothelial cell-specific molecule 1 -0.0213503
CHL1 cell adhesion molecule L1-like -0.0207935
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.020499
ADD3 adducin 3 (gamma) -0.0204126
UNC5D unc-5 homolog D (C. elegans) -0.0202814
RPS16 ribosomal protein S16 -0.0202046
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0195556
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0195533
DPYD dihydropyrimidine dehydrogenase -0.0195236
EFNA5 ephrin-A5 -0.0195187
QPCT glutaminyl-peptide cyclotransferase -0.0191421
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.019142
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.0190946
BLTP2 bridge-like lipid transfer protein family member 2 -0.019023
NDRG1 N-myc downstream regulated 1 -0.0186523
CALR calreticulin -0.0185333
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.01843