| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RUNX1 | runt-related transcription factor 1 | 0.148989 |
| EXT1 | exostosin glycosyltransferase 1 | 0.126798 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.122966 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.112745 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.110645 |
| RPS16 | ribosomal protein S16 | 0.106751 |
| EFNA5 | ephrin-A5 | 0.103533 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.101405 |
| RPS12 | ribosomal protein S12 | 0.0993916 |
| PTK2 | protein tyrosine kinase 2 | 0.0984159 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0905629 |
| TPI1 | triosephosphate isomerase 1 | 0.0890037 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0876059 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0855934 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0846233 |
| VCL | vinculin | 0.0812142 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0789137 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0784212 |
| SMAD3 | SMAD family member 3 | 0.0771503 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0769739 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0764755 |
| LMO7 | LIM domain 7 | 0.0756044 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0749033 |
| PRKCA | protein kinase C, alpha | 0.0735186 |
| RPL5 | ribosomal protein L5 | 0.0712024 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0688815 |
| RPL37 | ribosomal protein L37 | 0.0667641 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0646537 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0639622 |
| SQSTM1 | sequestosome 1 | 0.059628 |
| TXNRD1 | thioredoxin reductase 1 | 0.0589578 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0585185 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.057583 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0556485 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0538296 |
| DSPP | dentin sialophosphoprotein | 0.0534908 |
| MT2A | metallothionein 2A | 0.0534648 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0531576 |
| IGF2 | insulin-like growth factor 2 | 0.0525956 |
| INHBA | inhibin, beta A | 0.051856 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0517482 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0510316 |
| GPHN | gephyrin | 0.0492928 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0482088 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0481947 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.048064 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.047873 |
| RAB6A | RAB6A, member RAS oncogene family | 0.0470867 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0465043 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0456771 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0451174 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0449654 |
| RPLP1 | ribosomal protein, large, P1 | 0.0446904 |
| RPL37A | ribosomal protein L37a | 0.0444739 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0442831 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0441768 |
| RPL12 | ribosomal protein L12 | 0.0421732 |
| RAD51B | RAD51 paralog B | 0.041085 |
| SBF2 | SET binding factor 2 | 0.0409443 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0402105 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.039697 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.038075 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0377052 |
| JMJD1C | jumonji domain containing 1C | 0.0372262 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0370033 |
| ATXN1 | ataxin 1 | 0.0359664 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0357944 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.034148 |
| GPC6 | glypican 6 | 0.0337272 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0335004 |
| RPL35A | ribosomal protein L35a | 0.033409 |
| RPS25 | ribosomal protein S25 | 0.0331633 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0326986 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0322534 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0317921 |
| EGFR | epidermal growth factor receptor | 0.031331 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0304133 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.030371 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0284179 |
| RASA3 | RAS p21 protein activator 3 | 0.0272944 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0259604 |
| RPS6 | ribosomal protein S6 | 0.0257236 |
| PDLIM5 | PDZ and LIM domain 5 | 0.024729 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0246621 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | 0.024431 |
| CNOT4 | CCR4-NOT transcription complex, subunit 4 | 0.0243243 |
| PARD3 | par-3 family cell polarity regulator | 0.0232446 |
| MED13L | mediator complex subunit 13-like | 0.0230762 |
| PTPN1 | protein tyrosine phosphatase, non-receptor type 1 | 0.0228724 |
| ZNF292 | zinc finger protein 292 | 0.022289 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0222824 |
| DST | dystonin | 0.0220678 |
| EHBP1 | EH domain binding protein 1 | 0.0218351 |
| RPS3 | ribosomal protein S3 | 0.021787 |
| FMNL2 | formin-like 2 | 0.0215329 |
| RLF | rearranged L-myc fusion | 0.0197247 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0192148 |
| OGA | O-GlcNAcase | 0.0190369 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0189058 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0186904 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.26756 |
| FN1 | fibronectin 1 | -0.264959 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.186195 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.15417 |
| LDHA | lactate dehydrogenase A | -0.146939 |
| STC1 | stanniocalcin 1 | -0.145859 |
| AHNAK | AHNAK nucleoprotein | -0.145239 |
| PGK1 | phosphoglycerate kinase 1 | -0.114389 |
| PKM | pyruvate kinase, muscle | -0.104396 |
| CCNI | cyclin I | -0.0845926 |
| MAP4 | microtubule-associated protein 4 | -0.0835881 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0775964 |
| UBC | ubiquitin C | -0.0746894 |
| VIM | vimentin | -0.074522 |
| B2M | beta-2-microglobulin | -0.0734432 |
| NAV1 | neuron navigator 1 | -0.0718203 |
| SETD5 | SET domain containing 5 | -0.0687879 |
| MMP1 | matrix metallopeptidase 1 | -0.0672724 |
| SMYD3 | SET and MYND domain containing 3 | -0.0660603 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0654187 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0654158 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0653403 |
| HMGA2 | high mobility group AT-hook 2 | -0.0643586 |
| PTMA | prothymosin, alpha | -0.0641475 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0637845 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0606299 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0581053 |
| NF1 | neurofibromin 1 | -0.0576819 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0569964 |
| HLA-B | major histocompatibility complex, class I, B | -0.0561684 |
| LAMB3 | laminin, beta 3 | -0.0543714 |
| TMSB10 | thymosin beta 10 | -0.0528237 |
| RNF213 | ring finger protein 213 | -0.052723 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0517831 |
| RPL11 | ribosomal protein L11 | -0.0516038 |
| LOXL2 | lysyl oxidase-like 2 | -0.0506969 |
| SEC62 | SEC62 homolog (S. cerevisiae) | -0.0487226 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0486218 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0485213 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0475905 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0469795 |
| OSMR | oncostatin M receptor | -0.0466896 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0465777 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0464942 |
| S100A9 | S100 calcium binding protein A9 | -0.0460892 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0452983 |
| SP100 | SP100 nuclear antigen | -0.0449034 |
| TOR1AIP2 | torsin A interacting protein 2 | -0.0443876 |
| TAOK3 | TAO kinase 3 | -0.0442771 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0439338 |
| FTL | ferritin, light polypeptide | -0.0424025 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.042045 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0417405 |
| RSL24D1 | ribosomal L24 domain containing 1 | -0.0413135 |
| LMNA | lamin A/C | -0.0413057 |
| MAP1B | microtubule-associated protein 1B | -0.0407371 |
| CLTC | clathrin, heavy chain (Hc) | -0.0396467 |
| CANX | calnexin | -0.036981 |
| SNX14 | sorting nexin 14 | -0.0362644 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0358783 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0357326 |
| MX2 | MX dynamin-like GTPase 2 | -0.0353408 |
| COL5A2 | collagen, type V, alpha 2 | -0.0353343 |
| ASPH | aspartate beta-hydroxylase | -0.0351936 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | -0.0347675 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0324393 |
| TRIP12 | thyroid hormone receptor interactor 12 | -0.0314465 |
| RTN4 | reticulon 4 | -0.0308743 |
| MYOF | myoferlin | -0.0306042 |
| NDRG1 | N-myc downstream regulated 1 | -0.030546 |
| PRELID2 | PRELI domain containing 2 | -0.0304498 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0300727 |
| VEGFA | vascular endothelial growth factor A | -0.0292549 |
| ANXA2 | annexin A2 | -0.0290459 |
| S100A6 | S100 calcium binding protein A6 | -0.0289568 |
| ANO6 | anoctamin 6 | -0.0286951 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0279815 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.0266563 |
| MDGA2 | MAM domain containing glycosylphosphatidylinositol anchor 2 | -0.0256363 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0249596 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0241405 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0232997 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0232877 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0231051 |
| FRMD4A | FERM domain containing 4A | -0.0229244 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0223592 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0211315 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0210223 |
| FLNB | filamin B, beta | -0.0206482 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.019826 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0193244 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0188798 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0184334 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0178596 |
| ENO1 | enolase 1, (alpha) | -0.0177334 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0169456 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0168691 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0163156 |
| RPL13A | ribosomal protein L13a | -0.0156283 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0148011 |
