| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL11A1 | collagen, type XI, alpha 1 | 0.175314 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | 0.0980025 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.09178 |
| CDH6 | cadherin 6, type 2, K-cadherin (fetal kidney) | 0.0898847 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | 0.0647586 |
| CDH10 | cadherin 10, type 2 (T2-cadherin) | 0.0637148 |
| MEIS2 | Meis homeobox 2 | 0.0621925 |
| TENM3 | teneurin transmembrane protein 3 | 0.0586108 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0584259 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0549422 |
| TMSB10 | thymosin beta 10 | 0.0514409 |
| HS3ST5 | heparan sulfate (glucosamine) 3-O-sulfotransferase 5 | 0.0482154 |
| COL3A1 | collagen, type III, alpha 1 | 0.0479536 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0467699 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0466117 |
| NTM | neurotrimin | 0.0459171 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0440411 |
| PARD3B | par-3 family cell polarity regulator beta | 0.0436455 |
| MT2A | metallothionein 2A | 0.0431381 |
| IGF2 | insulin-like growth factor 2 | 0.0428246 |
| USP25 | ubiquitin specific peptidase 25 | 0.0412529 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0408449 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0407356 |
| CADM2 | cell adhesion molecule 2 | 0.0395182 |
| SYT1 | synaptotagmin I | 0.0390887 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0384019 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.037782 |
| CLU | clusterin | 0.0366833 |
| FTL | ferritin, light polypeptide | 0.0363495 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0361622 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0355303 |
| CRISPLD1 | cysteine-rich secretory protein LCCL domain containing 1 | 0.0354298 |
| TOX | thymocyte selection-associated high mobility group box | 0.0352266 |
| PLPP1 | phospholipid phosphatase 1 | 0.0347462 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0347428 |
| RASAL2 | RAS protein activator like 2 | 0.0342662 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0342022 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0341241 |
| SHROOM3 | shroom family member 3 | 0.033891 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0333484 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0331997 |
| COL1A2 | collagen, type I, alpha 2 | 0.0330644 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0325431 |
| PCDH7 | protocadherin 7 | 0.0321016 |
| TMEM165 | transmembrane protein 165 | 0.0319787 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0316499 |
| SRP54 | signal recognition particle 54kDa | 0.0315259 |
| SPAG9 | sperm associated antigen 9 | 0.0312448 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0310101 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0307283 |
| JMJD1C | jumonji domain containing 1C | 0.0303205 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0302834 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0301173 |
| NF1 | neurofibromin 1 | 0.0298175 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0293159 |
| TNPO1 | transportin 1 | 0.0288566 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0281809 |
| SLC44A5 | solute carrier family 44, member 5 | 0.0276928 |
| LPIN2 | lipin 2 | 0.0276325 |
| SOX5 | SRY (sex determining region Y)-box 5 | 0.0274136 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0272833 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0271953 |
| NRG1 | neuregulin 1 | 0.0270942 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0270847 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0269504 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0264135 |
| EHBP1 | EH domain binding protein 1 | 0.0260451 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0260208 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0259746 |
| CREBBP | CREB binding protein | 0.0254494 |
| GALNTL6 | polypeptide N-acetylgalactosaminyltransferase-like 6 | 0.0254332 |
| ZNF217 | zinc finger protein 217 | 0.025282 |
| HS2ST1 | heparan sulfate 2-O-sulfotransferase 1 | 0.0252644 |
| SEMA3E | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E | 0.0250522 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0250432 |
| NHSL1 | NHS-like 1 | 0.0248155 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0245536 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0243298 |
| CCNYL1 | cyclin Y-like 1 | 0.0242073 |
| RCOR1 | REST corepressor 1 | 0.0241726 |
| AAK1 | AP2 associated kinase 1 | 0.024165 |
| DST | dystonin | 0.0240678 |
| ZNF146 | zinc finger protein 146 | 0.0239574 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | 0.0236894 |
| GOLPH3 | golgi phosphoprotein 3 (coat-protein) | 0.0235916 |
| UBAP2 | ubiquitin associated protein 2 | 0.0235822 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0235243 |
| GOLGA4 | golgin A4 | 0.0232824 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0232379 |
| ARHGAP24 | Rho GTPase activating protein 24 | 0.023118 |
| PTGES2 | prostaglandin E synthase 2 | 0.0231177 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0231112 |
| GLG1 | golgi glycoprotein 1 | 0.0227983 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0225701 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.022445 |
| GAB2 | GRB2-associated binding protein 2 | 0.0223451 |
| SCFD2 | sec1 family domain containing 2 | 0.0223031 |
| TKT | transketolase | 0.0222205 |
| ACBD6 | acyl-CoA binding domain containing 6 | 0.0221239 |
| NCOA2 | nuclear receptor coactivator 2 | 0.0221085 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.151557 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.111068 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0742021 |
| PTMA | prothymosin, alpha | -0.0676083 |
| RPS8 | ribosomal protein S8 | -0.0669598 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0604813 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0491367 |
| RPS6 | ribosomal protein S6 | -0.0489568 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0442339 |
| CDH19 | cadherin 19, type 2 | -0.0434922 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0426111 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.042326 |
| PEG10 | paternally expressed 10 | -0.0414596 |
| DEK | DEK proto-oncogene | -0.0412169 |
| MKI67 | marker of proliferation Ki-67 | -0.0411913 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0402799 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0379198 |
| RPS16 | ribosomal protein S16 | -0.0376899 |
| ENAH | enabled homolog (Drosophila) | -0.0375308 |
| MRPS30 | mitochondrial ribosomal protein S30 | -0.0369205 |
| HMGB1 | high mobility group box 1 | -0.036771 |
| GPC3 | glypican 3 | -0.0365941 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0360677 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0354011 |
| QKI | QKI, KH domain containing, RNA binding | -0.0352795 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0348575 |
| RPL26 | ribosomal protein L26 | -0.034692 |
| RPL9 | ribosomal protein L9 | -0.0338756 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0338281 |
| FNDC3A | fibronectin type III domain containing 3A | -0.03367 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0330368 |
| EMP1 | epithelial membrane protein 1 | -0.0330044 |
| RPS27A | ribosomal protein S27a | -0.0328743 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0327932 |
| RPLP1 | ribosomal protein, large, P1 | -0.0318947 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0314597 |
| PDCD5 | programmed cell death 5 | -0.0311399 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0308133 |
| RPL12 | ribosomal protein L12 | -0.0307498 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0304635 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0303106 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0302587 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | -0.0300494 |
| CENPF | centromere protein F, 350/400kDa | -0.0295203 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0292333 |
| MTDH | metadherin | -0.0291174 |
| ANXA2 | annexin A2 | -0.0290025 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0288504 |
| KIF4A | kinesin family member 4A | -0.0283463 |
| RPL5 | ribosomal protein L5 | -0.0283405 |
| OGA | O-GlcNAcase | -0.0281769 |
| LYPLA1 | lysophospholipase I | -0.0280072 |
| RAI1 | retinoic acid induced 1 | -0.0278846 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | -0.0276595 |
| RPL19 | ribosomal protein L19 | -0.027427 |
| SMARCC1 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | -0.0274076 |
| PFN1 | profilin 1 | -0.0272148 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0268136 |
| CAPNS1 | calpain, small subunit 1 | -0.0264931 |
| LDHB | lactate dehydrogenase B | -0.0261909 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0258289 |
| TPX2 | TPX2, microtubule-associated | -0.0255796 |
| PGK1 | phosphoglycerate kinase 1 | -0.0252233 |
| HIP1 | huntingtin interacting protein 1 | -0.0251313 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | -0.0249755 |
| HMGA1 | high mobility group AT-hook 1 | -0.0247976 |
| CCNY | cyclin Y | -0.0244717 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0243984 |
| STAG2 | stromal antigen 2 | -0.0243048 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0242042 |
| ATP5F1E | ATP synthase F1 subunit epsilon | -0.0240519 |
| NDC80 | NDC80 kinetochore complex component | -0.0240435 |
| ARHGAP11A | Rho GTPase activating protein 11A | -0.0240016 |
| HMGB2 | high mobility group box 2 | -0.0238981 |
| TM7SF3 | transmembrane 7 superfamily member 3 | -0.02381 |
| RPL11 | ribosomal protein L11 | -0.0237245 |
| IGF2BP1 | insulin-like growth factor 2 mRNA binding protein 1 | -0.0236971 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0236443 |
| POTEF | POTE ankyrin domain family, member F | -0.0235326 |
| RBM39 | RNA binding motif protein 39 | -0.0234241 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0233356 |
| RPS25 | ribosomal protein S25 | -0.0232348 |
| RPS15 | ribosomal protein S15 | -0.0231437 |
| DYNC2H1 | dynein, cytoplasmic 2, heavy chain 1 | -0.023028 |
| CEP128 | centrosomal protein 128kDa | -0.0230236 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0229855 |
| RAB10 | RAB10, member RAS oncogene family | -0.0227746 |
| SYAP1 | synapse associated protein 1 | -0.0227448 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.022722 |
| RPL36A | ribosomal protein L36a | -0.0227122 |
| ATXN2 | ataxin 2 | -0.0226807 |
| CCT6A | chaperonin containing TCP1, subunit 6A (zeta 1) | -0.0224568 |
| KIF18B | kinesin family member 18B | -0.0222781 |
| RAPGEF2 | Rap guanine nucleotide exchange factor (GEF) 2 | -0.0221497 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0221135 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0220139 |
| RPL23 | ribosomal protein L23 | -0.0218898 |
| SMAP1 | small ArfGAP 1 | -0.0218732 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0217974 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | -0.0217371 |
