| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.17576 |
| TJP1 | tight junction protein 1 | 0.104209 |
| ZNF608 | zinc finger protein 608 | 0.0958541 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0706248 |
| RTN4 | reticulon 4 | 0.0692797 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0633658 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0614897 |
| ECT2 | epithelial cell transforming 2 | 0.0581178 |
| VMP1 | vacuole membrane protein 1 | 0.0540269 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0521925 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0471796 |
| TXNRD1 | thioredoxin reductase 1 | 0.0468447 |
| TCF12 | transcription factor 12 | 0.0460224 |
| SMAD6 | SMAD family member 6 | 0.0429494 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0424997 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0412 |
| CCDC68 | coiled-coil domain containing 68 | 0.0411175 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | 0.0410481 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0407302 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0406453 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0402514 |
| AHCYL2 | adenosylhomocysteinase-like 2 | 0.039633 |
| ARID5B | AT rich interactive domain 5B (MRF1-like) | 0.038469 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.038177 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0371218 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0365356 |
| NCKAP1 | NCK-associated protein 1 | 0.0364792 |
| DGKH | diacylglycerol kinase, eta | 0.0362255 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0361951 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.035854 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0355327 |
| EZR | ezrin | 0.0342554 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0340907 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0340226 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0338314 |
| PDCD6IP | programmed cell death 6 interacting protein | 0.0338192 |
| LRP12 | low density lipoprotein receptor-related protein 12 | 0.0338029 |
| KIAA0232 | KIAA0232 | 0.0335873 |
| PYGB | phosphorylase, glycogen; brain | 0.0333836 |
| THOC2 | THO complex 2 | 0.0333153 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0329773 |
| ANKRD17 | ankyrin repeat domain 17 | 0.0326991 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.032341 |
| TMEM65 | transmembrane protein 65 | 0.0319955 |
| SLC7A1 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 | 0.0317413 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0316738 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0314685 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0310175 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0309961 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | 0.0303718 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0302059 |
| CPNE1 | copine I | 0.0301671 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 0.0299666 |
| PTK2 | protein tyrosine kinase 2 | 0.0294185 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | 0.0292213 |
| NKTR | natural killer cell triggering receptor | 0.0286372 |
| JMJD1C | jumonji domain containing 1C | 0.0286267 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0280877 |
| NUP153 | nucleoporin 153kDa | 0.0280174 |
| BMPR1A | bone morphogenetic protein receptor, type IA | 0.0279313 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.027763 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0276651 |
| KLF3 | Kruppel-like factor 3 (basic) | 0.0276428 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0274243 |
| MNAT1 | MNAT CDK-activating kinase assembly factor 1 | 0.0274241 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0273722 |
| ZNF638 | zinc finger protein 638 | 0.0273637 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0273407 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0271706 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | 0.0269698 |
| ZNF644 | zinc finger protein 644 | 0.026954 |
| SERINC3 | serine incorporator 3 | 0.0269503 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0262776 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0262348 |
| COG5 | component of oligomeric golgi complex 5 | 0.025803 |
| PDZD8 | PDZ domain containing 8 | 0.0256444 |
| SMYD3 | SET and MYND domain containing 3 | 0.0256262 |
| ARID1A | AT rich interactive domain 1A (SWI-like) | 0.0255357 |
| KLF6 | Kruppel-like factor 6 | 0.025467 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.0252295 |
| DDX46 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 | 0.0252195 |
| PHIP | pleckstrin homology domain interacting protein | 0.0252067 |
| NUP58 | nucleoporin 58 | 0.0251328 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0249085 |
| RPAP2 | RNA polymerase II associated protein 2 | 0.0248666 |
| TMCO3 | transmembrane and coiled-coil domains 3 | 0.0246456 |
| FMN1 | formin 1 | 0.024446 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0244293 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0244259 |
| CCNL1 | cyclin L1 | 0.0244241 |
| ABI1 | abl-interactor 1 | 0.0243473 |
| CARD16 | caspase recruitment domain family, member 16 | 0.0243248 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0242994 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.024133 |
| ABHD12 | abhydrolase domain containing 12 | 0.0241291 |
| METTL15 | methyltransferase like 15 | 0.0241289 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0238148 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0236892 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0236127 |
| VIM | vimentin | 0.0235068 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.177461 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.170779 |
| AHNAK | AHNAK nucleoprotein | -0.160929 |
| PTMA | prothymosin, alpha | -0.148072 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.147814 |
| BMP10 | bone morphogenetic protein 10 | -0.137573 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.105385 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0810872 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0711785 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -0.0705641 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0699939 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0697498 |
| SLC1A3 | solute carrier family 1 (glial high affinity glutamate transporter), member 3 | -0.0654236 |
| RPLP1 | ribosomal protein, large, P1 | -0.0623943 |
| ENO1 | enolase 1, (alpha) | -0.0621949 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0599609 |
| NAV2 | neuron navigator 2 | -0.0591202 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0582615 |
| TMSB4X | thymosin beta 4, X-linked | -0.0567057 |
| MYOF | myoferlin | -0.0559804 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0551816 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0545785 |
| RPS6 | ribosomal protein S6 | -0.0536655 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0533318 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0519737 |
| CCND1 | cyclin D1 | -0.0514682 |
| RRBP1 | ribosome binding protein 1 | -0.0481367 |
| PKM | pyruvate kinase, muscle | -0.0470861 |
| GPHN | gephyrin | -0.0465741 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0447652 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0442371 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0439879 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0437842 |
| FHIT | fragile histidine triad | -0.0433239 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0431616 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0430228 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0405018 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.0397119 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0395863 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0395592 |
| EVI5 | ecotropic viral integration site 5 | -0.0388847 |
| GSE1 | Gse1 coiled-coil protein | -0.0386715 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0385639 |
| DUSP6 | dual specificity phosphatase 6 | -0.0384138 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0381609 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0378487 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0363675 |
| SMC3 | structural maintenance of chromosomes 3 | -0.0350944 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0350474 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0333908 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0332578 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0328995 |
| RPS27 | ribosomal protein S27 | -0.0328263 |
| CENPE | centromere protein E, 312kDa | -0.0327221 |
| CSE1L | CSE1 chromosome segregation 1-like (yeast) | -0.032652 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | -0.0326006 |
| RPS8 | ribosomal protein S8 | -0.0323306 |
| MKI67 | marker of proliferation Ki-67 | -0.0320172 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0312223 |
| CSDE1 | cold shock domain containing E1, RNA-binding | -0.0308152 |
| FAM13A | family with sequence similarity 13, member A | -0.0307006 |
| APP | amyloid beta (A4) precursor protein | -0.0302277 |
| GNAS | GNAS complex locus | -0.0300834 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0299569 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | -0.0299421 |
| DIPK2A | divergent protein kinase domain 2A | -0.0294277 |
| RPL3 | ribosomal protein L3 | -0.0294143 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.0291714 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0290048 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | -0.0288951 |
| ENOSF1 | enolase superfamily member 1 | -0.0287754 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0287551 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0286069 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0282519 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0282316 |
| NEBL | nebulette | -0.0281188 |
| RPL37A | ribosomal protein L37a | -0.0276647 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0275433 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | -0.0274993 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0272531 |
| LIMD1 | LIM domains containing 1 | -0.0268549 |
| FUS | FUS RNA binding protein | -0.0264987 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0264732 |
| RPL8 | ribosomal protein L8 | -0.0264405 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0261095 |
| RPL34 | ribosomal protein L34 | -0.0259647 |
| FOXN3 | forkhead box N3 | -0.0258864 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0254138 |
| HDAC8 | histone deacetylase 8 | -0.0253941 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.025371 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0250984 |
| TXNIP | thioredoxin interacting protein | -0.0245817 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0245576 |
| RPS25 | ribosomal protein S25 | -0.024487 |
| SH3TC2 | SH3 domain and tetratricopeptide repeats 2 | -0.0244722 |
| RPL7A | ribosomal protein L7a | -0.0240093 |
| CBFB | core-binding factor, beta subunit | -0.0237695 |
| SBF2 | SET binding factor 2 | -0.023671 |
| PFN1 | profilin 1 | -0.0236505 |
| OSBPL1A | oxysterol binding protein-like 1A | -0.0234768 |
