Trimetrexate_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trimetrexate perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trimetrexate_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.110398
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0978054
VEGFA vascular endothelial growth factor A 0.0815418
RPS6 ribosomal protein S6 0.0807735
MT2A metallothionein 2A 0.0797522
VMP1 vacuole membrane protein 1 0.0771963
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0701639
MYOF myoferlin 0.0629794
BICC1 BicC family RNA binding protein 1 0.0629647
ZSWIM6 zinc finger, SWIM-type containing 6 0.062042
KYNU kynureninase 0.0595792
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0574671
FNDC3B fibronectin type III domain containing 3B 0.0560246
ATXN1 ataxin 1 0.053277
RUNX1 runt-related transcription factor 1 0.0529766
RPS12 ribosomal protein S12 0.0520345
TRIO trio Rho guanine nucleotide exchange factor 0.0519625
SMYD3 SET and MYND domain containing 3 0.0506491
UGCG UDP-glucose ceramide glucosyltransferase 0.0500902
DST dystonin 0.0476368
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0468593
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0460422
PRELID2 PRELI domain containing 2 0.0459919
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0455214
HDAC9 histone deacetylase 9 0.0448393
MBNL1 muscleblind-like splicing regulator 1 0.0443178
SMAD3 SMAD family member 3 0.0440548
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0432438
ZNF292 zinc finger protein 292 0.0428647
JMJD1C jumonji domain containing 1C 0.0427512
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.042344
ZBTB38 zinc finger and BTB domain containing 38 0.0420579
USP9X ubiquitin specific peptidase 9, X-linked 0.0413295
RPS2 ribosomal protein S2 0.0403458
FNIP1 folliculin interacting protein 1 0.0394147
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0390758
COL6A3 collagen, type VI, alpha 3 0.0389537
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0387732
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0387581
NRIP1 nuclear receptor interacting protein 1 0.0381438
EEF1G eukaryotic translation elongation factor 1 gamma 0.0381395
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0369598
SLC35F3 solute carrier family 35, member F3 0.0364059
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0363976
TGM2 transglutaminase 2 0.0363142
ANO6 anoctamin 6 0.0358046
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0347256
NAV2 neuron navigator 2 0.0345009
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.034172
CDK19 cyclin-dependent kinase 19 0.0340595
APLP2 amyloid beta (A4) precursor-like protein 2 0.0338956
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0329779
CD44 CD44 molecule (Indian blood group) 0.0323194
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0318024
ELL2 elongation factor, RNA polymerase II, 2 0.0317204
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0314894
PICALM phosphatidylinositol binding clathrin assembly protein 0.0313375
EXT1 exostosin glycosyltransferase 1 0.0311305
KLF12 Kruppel-like factor 12 0.0311138
WWTR1 WW domain containing transcription regulator 1 0.0310748
AHR aryl hydrocarbon receptor 0.0309726
RPS17 ribosomal protein S17 0.030938
MAML2 mastermind-like 2 (Drosophila) 0.0308387
SEPTIN9 septin 9 0.0305965
EFNA5 ephrin-A5 0.0302912
GLIS3 GLIS family zinc finger 3 0.0302082
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.030075
MBNL2 muscleblind-like splicing regulator 2 0.0297552
ANKRD11 ankyrin repeat domain 11 0.0297541
GOLGA4 golgin A4 0.0292693
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0285287
HMGA2 high mobility group AT-hook 2 0.0277643
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0276289
AKAP13 A kinase (PRKA) anchor protein 13 0.0274307
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0268149
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0267438
SHB Src homology 2 domain containing adaptor protein B 0.0266227
RPS3 ribosomal protein S3 0.0264525
TMEM132D transmembrane protein 132D 0.0263929
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.026215
KMT2E lysine (K)-specific methyltransferase 2E 0.0261418
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0261207
KMT2C lysine (K)-specific methyltransferase 2C 0.0259665
MCTP1 multiple C2 domains, transmembrane 1 0.0255302
SVIL supervillin 0.0254669
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0253213
UBA6 ubiquitin-like modifier activating enzyme 6 0.0253052
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0251794
GOLGB1 golgin B1 0.0251665
PTPRK protein tyrosine phosphatase, receptor type, K 0.0250976
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.024937
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0247255
ESYT2 extended synaptotagmin-like protein 2 0.024499
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0244705
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0244081
PACS1 phosphofurin acidic cluster sorting protein 1 0.0242494
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.024063
CORO1C coronin, actin binding protein, 1C 0.0239778
EGFR epidermal growth factor receptor 0.0239389
PDE10A phosphodiesterase 10A 0.0238665

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.221873
HLA-B major histocompatibility complex, class I, B -0.200816
TPT1 tumor protein, translationally-controlled 1 -0.11552
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0963993
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.087089
ADM adrenomedullin -0.0862258
IER3 immediate early response 3 -0.0858115
FTL ferritin, light polypeptide -0.0827281
LDHA lactate dehydrogenase A -0.0824204
IGFBP3 insulin-like growth factor binding protein 3 -0.075181
PGK1 phosphoglycerate kinase 1 -0.0723334
ZMYND8 zinc finger, MYND-type containing 8 -0.0687879
FN1 fibronectin 1 -0.0672811
RPL35A ribosomal protein L35a -0.0575333
IFI6 interferon, alpha-inducible protein 6 -0.0570085
IFI16 interferon, gamma-inducible protein 16 -0.0568239
HLA-E major histocompatibility complex, class I, E -0.0564967
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0562026
CTSD cathepsin D -0.0558006
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0517362
B2M beta-2-microglobulin -0.0501944
TPM4 tropomyosin 4 -0.0499909
VDAC1 voltage-dependent anion channel 1 -0.0498148
EIF1 eukaryotic translation initiation factor 1 -0.049312
SFRP1 secreted frizzled-related protein 1 -0.0488063
BTG1 B-cell translocation gene 1, anti-proliferative -0.048481
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0484498
RIGI RNA sensor RIG-I -0.048094
KPNB1 karyopherin (importin) beta 1 -0.0479102
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0467651
PNRC1 proline-rich nuclear receptor coactivator 1 -0.045991
HLA-A major histocompatibility complex, class I, A -0.0454361
ACTG1 actin gamma 1 -0.0442491
NDRG1 N-myc downstream regulated 1 -0.0434439
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0426196
IFITM1 interferon induced transmembrane protein 1 -0.042283
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0417611
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0416519
RPS24 ribosomal protein S24 -0.0394618
ANXA2 annexin A2 -0.0391677
PTMA prothymosin, alpha -0.0376879
IFIH1 interferon induced with helicase C domain 1 -0.0372833
SP100 SP100 nuclear antigen -0.0372113
SFTPA2 surfactant protein A2 -0.0364737
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0358129
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0353711
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0351012
LOX lysyl oxidase -0.03412
UBC ubiquitin C -0.033871
COL1A1 collagen, type I, alpha 1 -0.0338184
BASP1 brain abundant, membrane attached signal protein 1 -0.0337103
IFITM3 interferon induced transmembrane protein 3 -0.0336525
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0333939
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0307388
KDM3A lysine (K)-specific demethylase 3A -0.030673
ZNFX1 zinc finger, NFX1-type containing 1 -0.0305402
TGFBI transforming growth factor, beta-induced, 68kDa -0.0303904
WSB1 WD repeat and SOCS box containing 1 -0.0303093
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0302967
RPL11 ribosomal protein L11 -0.0301166
EGR1 early growth response 1 -0.0299698
CD63 CD63 molecule -0.029842
TUBB tubulin, beta class I -0.0291293
ARL4C ADP-ribosylation factor-like 4C -0.028986
HMGA1 high mobility group AT-hook 1 -0.0283064
CD164 CD164 molecule, sialomucin -0.0279982
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0277344
RNF213 ring finger protein 213 -0.0276553
COL1A2 collagen, type I, alpha 2 -0.0275674
KLHL5 kelch-like family member 5 -0.0267873
SEPTIN7 septin 7 -0.0266831
KRT19 keratin 19, type I -0.0259737
BACE2 beta-site APP-cleaving enzyme 2 -0.0255762
LOC102724023 ES1 protein homolog, mitochondrial -0.0254877
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0252584
CTSB cathepsin B -0.0249683
TMSB10 thymosin beta 10 -0.024791
RTN4 reticulon 4 -0.0247211
H3-3B H3.3 histone B -0.0245509
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -0.0244744
MX1 MX dynamin-like GTPase 1 -0.024354
WDFY1 WD repeat and FYVE domain containing 1 -0.0242847
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0239014
ENO2 enolase 2 (gamma, neuronal) -0.023828
SCGB1D1 secretoglobin, family 1D, member 1 -0.0237797
PMP22 peripheral myelin protein 22 -0.0235075
PLIN2 perilipin 2 -0.0234663
CALR calreticulin -0.0234137
ENO1 enolase 1, (alpha) -0.0232285
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0230005
TUBA1C tubulin, alpha 1c -0.0229968
LMNA lamin A/C -0.0228716
ARFGEF3 ARFGEF family member 3 -0.0227853
TRIM22 tripartite motif containing 22 -0.0225952
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0224702
RPL19 ribosomal protein L19 -0.0220996
WDR45B WD repeat domain 45B -0.0219143
RPS13 ribosomal protein S13 -0.0217495
TCEAL9 transcription elongation factor A like 9 -0.0217064
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0214417