| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Trimetrexate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.224291 |
| SEPTIN7 | septin 7 | 0.0897245 |
| POTEF | POTE ankyrin domain family, member F | 0.0879827 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0874993 |
| KYNU | kynureninase | 0.0802148 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0790578 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0774342 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0772641 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0723254 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0721109 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0622884 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0609796 |
| CDK6 | cyclin-dependent kinase 6 | 0.0539014 |
| WWOX | WW domain containing oxidoreductase | 0.0497779 |
| GLIS3 | GLIS family zinc finger 3 | 0.0474141 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0444526 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0441672 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0436901 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0430143 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0430022 |
| FAM13A | family with sequence similarity 13, member A | 0.0426662 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0421817 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0420655 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.041177 |
| UGGT2 | UDP-glucose glycoprotein glucosyltransferase 2 | 0.0410146 |
| TGFB2 | transforming growth factor, beta 2 | 0.0378821 |
| AHR | aryl hydrocarbon receptor | 0.0371939 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0369073 |
| RAP1B | RAP1B, member of RAS oncogene family | 0.0363097 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0355537 |
| ENO1 | enolase 1, (alpha) | 0.0343785 |
| RPS14 | ribosomal protein S14 | 0.0342012 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0339297 |
| RPS12 | ribosomal protein S12 | 0.033645 |
| CBX3 | chromobox homolog 3 | 0.0334802 |
| FER | fer (fps/fes related) tyrosine kinase | 0.033405 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0333506 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0326899 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0325712 |
| DIAPH1 | diaphanous-related formin 1 | 0.0325057 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0323183 |
| RPS6 | ribosomal protein S6 | 0.0323074 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0322933 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0321916 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0321659 |
| ANXA1 | annexin A1 | 0.0320278 |
| FOXP1 | forkhead box P1 | 0.0319427 |
| UGCG | UDP-glucose ceramide glucosyltransferase | 0.0315315 |
| SLC38A2 | solute carrier family 38, member 2 | 0.031273 |
| TNS3 | tensin 3 | 0.0312686 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0312565 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0310844 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0310425 |
| NF1 | neurofibromin 1 | 0.0309294 |
| SPIDR | scaffolding protein involved in DNA repair | 0.0308599 |
| RBM25 | RNA binding motif protein 25 | 0.0302828 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.0301055 |
| VPS13A | vacuolar protein sorting 13 homolog A (S. cerevisiae) | 0.0300179 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0298697 |
| UBR3 | ubiquitin protein ligase E3 component n-recognin 3 (putative) | 0.0296713 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | 0.0295719 |
| NBEAL1 | neurobeachin-like 1 | 0.0294708 |
| ERBIN | erbb2 interacting protein | 0.0292629 |
| STC2 | stanniocalcin 2 | 0.0291732 |
| TXNIP | thioredoxin interacting protein | 0.0290454 |
| LARS1 | leucyl-tRNA synthetase 1 | 0.029016 |
| UBAP1 | ubiquitin associated protein 1 | 0.0289649 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0288173 |
| RUNX1 | runt-related transcription factor 1 | 0.0285729 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | 0.0285413 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | 0.0284092 |
| FTO | fat mass and obesity associated | 0.0282925 |
| SEPTIN9 | septin 9 | 0.0281356 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0281124 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.0280933 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0279155 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0279053 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0278672 |
| AOPEP | aminopeptidase O (putative) | 0.0278632 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0278102 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | 0.0277194 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0276288 |
| HMMR | hyaluronan-mediated motility receptor (RHAMM) | 0.0274204 |
| MKI67 | marker of proliferation Ki-67 | 0.0273813 |
| CAPZB | capping protein (actin filament) muscle Z-line, beta | 0.0272722 |
| PCBP2 | poly(rC) binding protein 2 | 0.0271922 |
| SEC24B | SEC24 family member B | 0.0270812 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0270587 |
| RPS17 | ribosomal protein S17 | 0.0269326 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0267189 |
| INTS6 | integrator complex subunit 6 | 0.0264947 |
| JMJD1C | jumonji domain containing 1C | 0.0264328 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0262993 |
| VMP1 | vacuole membrane protein 1 | 0.0261752 |
| SPTY2D1 | SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae) | 0.0260167 |
| TMEM14B | transmembrane protein 14B | 0.0259013 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0255207 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0254432 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.025333 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | 0.0251609 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | -0.227405 |
| FN1 | fibronectin 1 | -0.123114 |
| AHNAK | AHNAK nucleoprotein | -0.120964 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.111079 |
| SDC4 | syndecan 4 | -0.110956 |
| HLA-B | major histocompatibility complex, class I, B | -0.10657 |
| MT2A | metallothionein 2A | -0.103109 |
| LOX | lysyl oxidase | -0.0963652 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0797684 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0774039 |
| COL6A2 | collagen, type VI, alpha 2 | -0.0769622 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0661979 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.065202 |
| CALU | calumenin | -0.0637879 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.0620515 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0616675 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0612446 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0598935 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0571103 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0540961 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0512203 |
| MT1X | metallothionein 1X | -0.0510795 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0509642 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0493931 |
| STC1 | stanniocalcin 1 | -0.0476003 |
| NRXN3 | neurexin 3 | -0.0469872 |
| COL5A1 | collagen, type V, alpha 1 | -0.0465128 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0453661 |
| SETD5 | SET domain containing 5 | -0.0448554 |
| COL1A2 | collagen, type I, alpha 2 | -0.0439245 |
| PRSS23 | protease, serine, 23 | -0.0434673 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0421012 |
| HLA-C | major histocompatibility complex, class I, C | -0.0419067 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.041343 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0401213 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0396866 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0395549 |
| HDLBP | high density lipoprotein binding protein | -0.039242 |
| EGFR | epidermal growth factor receptor | -0.0390274 |
| CALR | calreticulin | -0.0387893 |
| CDH13 | cadherin 13 | -0.0385673 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0380142 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0369716 |
| FBXO11 | F-box protein 11 | -0.0369445 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0369332 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0368426 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0367186 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0363775 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.0359308 |
| PYGL | phosphorylase, glycogen, liver | -0.0358635 |
| RAI14 | retinoic acid induced 14 | -0.0355901 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0353004 |
| SEC24D | SEC24 family member D | -0.0351644 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0348616 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0348592 |
| TFG | TRK-fused gene | -0.0340895 |
| HMGA2 | high mobility group AT-hook 2 | -0.0333473 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0329286 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0318045 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0317018 |
| RBM33 | RNA binding motif protein 33 | -0.0310969 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0307053 |
| SEC63 | SEC63 homolog (S. cerevisiae) | -0.03068 |
| LOXL2 | lysyl oxidase-like 2 | -0.0306507 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0302465 |
| PDE10A | phosphodiesterase 10A | -0.0302025 |
| CADM1 | cell adhesion molecule 1 | -0.0298568 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0298077 |
| HPCAL1 | hippocalcin-like 1 | -0.029788 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0295723 |
| GOLGA4 | golgin A4 | -0.0293085 |
| AFF4 | AF4/FMR2 family, member 4 | -0.029127 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0291065 |
| PTMA | prothymosin, alpha | -0.0290552 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0289917 |
| APP | amyloid beta (A4) precursor protein | -0.0288556 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0285967 |
| NUMB | numb homolog (Drosophila) | -0.0285681 |
| CD109 | CD109 molecule | -0.0285364 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | -0.0283995 |
| ARF1 | ADP-ribosylation factor 1 | -0.0282133 |
| CLMP | CXADR-like membrane protein | -0.02818 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0281676 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0279827 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | -0.0276084 |
| SFTPA2 | surfactant protein A2 | -0.0275453 |
| DOCK7 | dedicator of cytokinesis 7 | -0.0275369 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0275264 |
| CLIC4 | chloride intracellular channel 4 | -0.0275029 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | -0.0273965 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0273568 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0271785 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0271759 |
| KAZN | kazrin, periplakin interacting protein | -0.0270376 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0268786 |
| BMERB1 | bMERB domain containing 1 | -0.0267382 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0265129 |
| JAK1 | Janus kinase 1 | -0.0264081 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0263536 |
| H3-3B | H3.3 histone B | -0.0263269 |
