Trimetrexate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Trimetrexate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Trimetrexate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMNL2 formin-like 2 0.0943369
CD44 CD44 molecule (Indian blood group) 0.0892872
ZSWIM6 zinc finger, SWIM-type containing 6 0.0829829
AKAP12 A kinase (PRKA) anchor protein 12 0.0645782
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0625196
INTS6 integrator complex subunit 6 0.0616746
WWOX WW domain containing oxidoreductase 0.0522731
VMP1 vacuole membrane protein 1 0.0494783
GPHN gephyrin 0.0479493
RERE arginine-glutamic acid dipeptide (RE) repeats 0.044379
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0439116
ZC3H12B zinc finger CCCH-type containing 12B 0.0437986
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0433051
BICD1 bicaudal D homolog 1 (Drosophila) 0.0426817
EXT1 exostosin glycosyltransferase 1 0.0397918
SMAD3 SMAD family member 3 0.0389701
CDK6 cyclin-dependent kinase 6 0.0387069
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0383628
SH3KBP1 SH3-domain kinase binding protein 1 0.0374313
EGFR epidermal growth factor receptor 0.0370838
RPS6 ribosomal protein S6 0.0357191
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.035563
ATXN1 ataxin 1 0.0353984
GLS2 glutaminase 2 (liver, mitochondrial) 0.0341781
ATXN2 ataxin 2 0.033846
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0333503
RPL23 ribosomal protein L23 0.0333433
AEBP2 AE binding protein 2 0.033335
RANBP17 RAN binding protein 17 0.0330704
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0328032
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0323643
TOM1L2 target of myb1-like 2 (chicken) 0.0315194
NLK nemo-like kinase 0.0298703
PIAS1 protein inhibitor of activated STAT, 1 0.0297064
RPS19 ribosomal protein S19 0.0295266
SHTN1 shootin 1 0.0293024
RPLP2 ribosomal protein, large, P2 0.02915
BZW1 basic leucine zipper and W2 domains 1 0.0289437
ARB2A ARB2 cotranscriptional regulator A 0.0278947
KIF1B kinesin family member 1B 0.0278288
SATB2 SATB homeobox 2 0.0276786
RAD51B RAD51 paralog B 0.0276376
FCHO2 FCH domain only 2 0.0275132
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0274573
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 0.0272043
TJP1 tight junction protein 1 0.0271178
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0268799
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.0268391
PTEN phosphatase and tensin homolog 0.0267981
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0267563
SIK3 SIK family kinase 3 0.0266798
GMDS GDP-mannose 4,6-dehydratase 0.026495
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0262719
OGA O-GlcNAcase 0.0260927
RSAD2 radical S-adenosyl methionine domain containing 2 0.0259825
KDM6A lysine (K)-specific demethylase 6A 0.0255216
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0255204
EEF2 eukaryotic translation elongation factor 2 0.0255176
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0254904
EFL1 elongation factor like GTPase 1 0.0254018
KDM2A lysine (K)-specific demethylase 2A 0.0253837
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.025369
DENND1A DENN/MADD domain containing 1A 0.0253539
LPP LIM domain containing preferred translocation partner in lipoma 0.0251728
ITFG1 integrin alpha FG-GAP repeat containing 1 0.0251229
STC1 stanniocalcin 1 0.024934
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0247026
UBAP2 ubiquitin associated protein 2 0.02465
PACS1 phosphofurin acidic cluster sorting protein 1 0.0245343
RASAL2 RAS protein activator like 2 0.0244844
SPIDR scaffolding protein involved in DNA repair 0.024341
MEMO1 mediator of cell motility 1 0.0242352
OXSR1 oxidative stress responsive 1 0.0240722
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0239935
SUMF1 sulfatase modifying factor 1 0.0239721
NBEA neurobeachin 0.0237372
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0235915
CLASP2 cytoplasmic linker associated protein 2 0.023296
ZBTB44 zinc finger and BTB domain containing 44 0.0232612
TSC22D2 TSC22 domain family, member 2 0.0231546
PRSS23 protease, serine, 23 0.0230495
PCNX4 pecanex 4 0.0230173
PTK2 protein tyrosine kinase 2 0.022962
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.022944
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0227037
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0226925
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0225672
DNM1L dynamin 1-like 0.022467
XPO6 exportin 6 0.0223665
STK24 serine/threonine kinase 24 0.0223655
TTC3 tetratricopeptide repeat domain 3 0.022299
NALF1 NALCN channel auxiliary factor 1 0.0222202
TPI1 triosephosphate isomerase 1 0.0222166
RCOR1 REST corepressor 1 0.0221935
PRELID2 PRELI domain containing 2 0.0221616
CCDC91 coiled-coil domain containing 91 0.0221566
GSK3B glycogen synthase kinase 3 beta 0.021974
ZNF254 zinc finger protein 254 0.0219458
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0216688
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 0.0216348

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.116425
IGFBP3 insulin-like growth factor binding protein 3 -0.114546
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.107877
LDHA lactate dehydrogenase A -0.0890257
TPT1 tumor protein, translationally-controlled 1 -0.0889599
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0709934
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0664934
CENPF centromere protein F, 350/400kDa -0.0621959
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0606238
AHNAK AHNAK nucleoprotein -0.060617
RBM39 RNA binding motif protein 39 -0.0596378
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0594182
NUP58 nucleoporin 58 -0.0577154
GOLGA4 golgin A4 -0.05689
NGLY1 N-glycanase 1 -0.0561925
PGK1 phosphoglycerate kinase 1 -0.0543962
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0531003
YBX3 Y box binding protein 3 -0.0512139
TM4SF1 transmembrane 4 L six family member 1 -0.050337
GNAS GNAS complex locus -0.0490674
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0478478
VIM vimentin -0.0476662
TPX2 TPX2, microtubule-associated -0.0467049
CANX calnexin -0.0463694
TOP2A topoisomerase (DNA) II alpha 170kDa -0.045847
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0452999
TAS2R14 taste receptor, type 2, member 14 -0.0450395
DNER delta/notch-like EGF repeat containing -0.0450241
PTMA prothymosin, alpha -0.0442371
TMEM123 transmembrane protein 123 -0.0441978
ATP13A3 ATPase type 13A3 -0.0427363
PYGL phosphorylase, glycogen, liver -0.0426471
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0425086
ERBIN erbb2 interacting protein -0.0424077
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0414268
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0413054
MACF1 microtubule-actin crosslinking factor 1 -0.0406576
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0394364
SQSTM1 sequestosome 1 -0.0388292
CHD1 chromodomain helicase DNA binding protein 1 -0.0387992
TPM4 tropomyosin 4 -0.0386193
HILPDA hypoxia inducible lipid droplet-associated -0.0384665
SDC4 syndecan 4 -0.0378049
ANLN anillin, actin binding protein -0.0377779
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0375486
ANKRD28 ankyrin repeat domain 28 -0.0367321
CAVIN1 caveolae associated protein 1 -0.0364214
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0362697
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0361772
MKI67 marker of proliferation Ki-67 -0.0361396
SPAG9 sperm associated antigen 9 -0.035969
HLA-C major histocompatibility complex, class I, C -0.0355656
ANXA2 annexin A2 -0.0353165
KIF5B kinesin family member 5B -0.0352161
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0351422
NIPBL Nipped-B homolog (Drosophila) -0.0351177
WDR45B WD repeat domain 45B -0.0341768
RPL26 ribosomal protein L26 -0.0339737
RSRC1 arginine/serine-rich coiled-coil 1 -0.0339671
TNIP1 TNFAIP3 interacting protein 1 -0.033221
HOOK2 hook microtubule-tethering protein 2 -0.0328212
LMAN1 lectin, mannose-binding, 1 -0.0323117
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.032173
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0319128
FRYL FRY-like -0.0317888
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0317405
NDRG1 N-myc downstream regulated 1 -0.0315826
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0313976
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0313609
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -0.0310379
LRRC49 leucine rich repeat containing 49 -0.0306373
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0305846
CEP170 centrosomal protein 170kDa -0.0305146
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0303659
SRRM2 serine/arginine repetitive matrix 2 -0.0302239
SETD5 SET domain containing 5 -0.0301499
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.030084
CKAP2 cytoskeleton associated protein 2 -0.0297514
LOC112694756 uncharaterized LOC112694756 -0.0294257
SMC4 structural maintenance of chromosomes 4 -0.0293679
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0293345
COPB1 coatomer protein complex, subunit beta 1 -0.0290734
BOD1L1 biorientation of chromosomes in cell division 1-like 1 -0.0289681
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0288468
RPL31 ribosomal protein L31 -0.0288374
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0287124
SEC13 SEC13 homolog (S. cerevisiae) -0.0285762
UBB ubiquitin B -0.0285649
DOCK4 dedicator of cytokinesis 4 -0.0285066
DSCAM Down syndrome cell adhesion molecule -0.028348
PANX1 pannexin 1 -0.0281807
BASP1 brain abundant, membrane attached signal protein 1 -0.0280374
HLA-E major histocompatibility complex, class I, E -0.027656
RPS25 ribosomal protein S25 -0.0275224
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0271093
SOD2 superoxide dismutase 2, mitochondrial -0.0269383
GPC6 glypican 6 -0.0268926
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.026589
XRN2 5'-3' exoribonuclease 2 -0.0265509
HM13 histocompatibility (minor) 13 -0.0265322