| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Trimetrexate perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Trimetrexate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EXT1 | exostosin glycosyltransferase 1 | 0.108321 |
| TMEM156 | transmembrane protein 156 | 0.103755 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0831454 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0733147 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0710152 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0689672 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0630063 |
| PTK2 | protein tyrosine kinase 2 | 0.060081 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0600355 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0550223 |
| SMAD3 | SMAD family member 3 | 0.0512184 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0510653 |
| NTN4 | netrin 4 | 0.0510599 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0508599 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0488768 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0486635 |
| DST | dystonin | 0.0479878 |
| CENPF | centromere protein F, 350/400kDa | 0.0435557 |
| VEGFC | vascular endothelial growth factor C | 0.0431068 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0430436 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0424597 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0421648 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0421605 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0415597 |
| JMJD1C | jumonji domain containing 1C | 0.0412645 |
| COPA | coatomer protein complex, subunit alpha | 0.0407535 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0404267 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0393872 |
| SMYD3 | SET and MYND domain containing 3 | 0.0389693 |
| NRP1 | neuropilin 1 | 0.0387196 |
| FNDC3A | fibronectin type III domain containing 3A | 0.038148 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.037793 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0365937 |
| SVIL | supervillin | 0.0364458 |
| VCL | vinculin | 0.0361377 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0360908 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | 0.0345176 |
| FAM3C | family with sequence similarity 3, member C | 0.0338488 |
| NEK7 | NIMA-related kinase 7 | 0.0337385 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0332749 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0329317 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0323811 |
| SPAG9 | sperm associated antigen 9 | 0.0316514 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0314504 |
| AREG | amphiregulin | 0.0312537 |
| TXNRD1 | thioredoxin reductase 1 | 0.0308544 |
| ZC3H12C | zinc finger CCCH-type containing 12C | 0.0307853 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0305733 |
| RUNX1 | runt-related transcription factor 1 | 0.030115 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0300634 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0300579 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0293124 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0287916 |
| HELZ | helicase with zinc finger | 0.0285198 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0283324 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0279192 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0278879 |
| RAB10 | RAB10, member RAS oncogene family | 0.0278817 |
| RASAL2 | RAS protein activator like 2 | 0.0278718 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | 0.027385 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0273432 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0271427 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0270101 |
| ASPH | aspartate beta-hydroxylase | 0.0266237 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0265466 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.026533 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0264803 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0263109 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0261677 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0261053 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0260492 |
| RBPMS | RNA binding protein with multiple splicing | 0.0257754 |
| RNF145 | ring finger protein 145 | 0.025724 |
| RAB31 | RAB31, member RAS oncogene family | 0.0257164 |
| SEPTIN7 | septin 7 | 0.025348 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | 0.025288 |
| ADD3 | adducin 3 (gamma) | 0.0252513 |
| FOXP1 | forkhead box P1 | 0.0251122 |
| ETNK1 | ethanolamine kinase 1 | 0.0250784 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.0250192 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | 0.0250104 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | 0.0249842 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | 0.0249403 |
| UBE2K | ubiquitin-conjugating enzyme E2K | 0.0245955 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0245099 |
| NPTN | neuroplastin | 0.0245039 |
| SIK3 | SIK family kinase 3 | 0.0240778 |
| RPS21 | ribosomal protein S21 | 0.023952 |
| DUSP16 | dual specificity phosphatase 16 | 0.0238497 |
| OGA | O-GlcNAcase | 0.0236473 |
| ACTN1 | actinin, alpha 1 | 0.0236077 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0234172 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0229521 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0228133 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0228073 |
| CUL3 | cullin 3 | 0.0226699 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | 0.0224762 |
| NXN | nucleoredoxin | 0.0222302 |
| CCDC88A | coiled-coil domain containing 88A | 0.0221446 |
| CORO1C | coronin, actin binding protein, 1C | 0.0220914 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.299164 |
| NRG1 | neuregulin 1 | -0.296978 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.259659 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.234359 |
| SQSTM1 | sequestosome 1 | -0.108631 |
| CANX | calnexin | -0.108454 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.105921 |
| HLA-B | major histocompatibility complex, class I, B | -0.100701 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.081294 |
| PTMA | prothymosin, alpha | -0.0719913 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0700969 |
| STC2 | stanniocalcin 2 | -0.0696375 |
| PLIN2 | perilipin 2 | -0.0692905 |
| HMGA2 | high mobility group AT-hook 2 | -0.0686308 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0686031 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0674865 |
| NDRG1 | N-myc downstream regulated 1 | -0.065083 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0645749 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0610706 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0610381 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0605688 |
| EFNA5 | ephrin-A5 | -0.0602636 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.059883 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0597329 |
| S100A6 | S100 calcium binding protein A6 | -0.0548725 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0522578 |
| TMSB4X | thymosin beta 4, X-linked | -0.0515337 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0499393 |
| GLIS3 | GLIS family zinc finger 3 | -0.0496952 |
| SFTPA2 | surfactant protein A2 | -0.0493997 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0458882 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0447027 |
| CALR | calreticulin | -0.0414244 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0412456 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0407756 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0403624 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0390951 |
| RAI14 | retinoic acid induced 14 | -0.0385184 |
| LOX | lysyl oxidase | -0.0383882 |
| LRRC23 | leucine rich repeat containing 23 | -0.0382447 |
| ENO1 | enolase 1, (alpha) | -0.0379988 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0379369 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.036959 |
| FAM20C | family with sequence similarity 20, member C | -0.0367448 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0361967 |
| TENM4 | teneurin transmembrane protein 4 | -0.0361771 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0358286 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0355598 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0342526 |
| AHNAK | AHNAK nucleoprotein | -0.0336786 |
| ACTG1 | actin gamma 1 | -0.0336131 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0334726 |
| FTL | ferritin, light polypeptide | -0.0331541 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0323098 |
| RPL35A | ribosomal protein L35a | -0.0306999 |
| TMEM165 | transmembrane protein 165 | -0.0299843 |
| OSMR | oncostatin M receptor | -0.0299246 |
| PGK1 | phosphoglycerate kinase 1 | -0.0289758 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0287544 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0286809 |
| CADM1 | cell adhesion molecule 1 | -0.0284036 |
| B2M | beta-2-microglobulin | -0.0281459 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0281186 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0279683 |
| AHR | aryl hydrocarbon receptor | -0.0279141 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0279027 |
| AHI1 | Abelson helper integration site 1 | -0.0278664 |
| DUSP6 | dual specificity phosphatase 6 | -0.0276799 |
| TGFA | transforming growth factor, alpha | -0.0273674 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0272887 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0272054 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0271045 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | -0.0269758 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0268584 |
| HM13 | histocompatibility (minor) 13 | -0.0266571 |
| GLUL | glutamate-ammonia ligase | -0.026125 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0260978 |
| FRY | furry homolog (Drosophila) | -0.0256868 |
| IRAK3 | interleukin-1 receptor-associated kinase 3 | -0.0256248 |
| TPM4 | tropomyosin 4 | -0.0253837 |
| MMP13 | matrix metallopeptidase 13 | -0.0253099 |
| UBC | ubiquitin C | -0.0251256 |
| HDLBP | high density lipoprotein binding protein | -0.025109 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0251043 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0250362 |
| MORF4L2 | mortality factor 4 like 2 | -0.0249828 |
| CALU | calumenin | -0.0249795 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0247665 |
| CTSD | cathepsin D | -0.0244038 |
| TOMM20 | translocase of outer mitochondrial membrane 20 homolog (yeast) | -0.0244009 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0243414 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0241795 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0241288 |
| TNS3 | tensin 3 | -0.024123 |
| ADAR | adenosine deaminase, RNA-specific | -0.0239903 |
| TMED9 | transmembrane emp24 protein transport domain containing 9 | -0.0238926 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | -0.023818 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0230152 |
| ITGA1 | integrin, alpha 1 | -0.0229201 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0228118 |
