Tropical Spastic Paraparesis Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A viral infectious disease that results_in inflammation located_in spinal cord, has_material_basis_in Human T-lymphotropic virus 1, which is transmitted_by sexual contact, and transmitted_by breast feeding. The infection has_symptom spastic weakness of both legs, has_symptom muscle stiffness, has_symptom sensory disturbance, and has_symptom spasms. (Human Disease Ontology, DOID_321)
External Link https://www.disgenet.org/browser/0/1/0/C0030481
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Genes

78 genes associated with the disease Tropical Spastic Paraparesis in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACAN aggrecan
AHI1 Abelson helper integration site 1
ATF7IP activating transcription factor 7 interacting protein
CCL1 chemokine (C-C motif) ligand 1
CCR4 chemokine (C-C motif) receptor 4
CD27 CD27 molecule
CD9 CD9 molecule
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CFLAR CASP8 and FADD-like apoptosis regulator
CHP1 calcineurin-like EF-hand protein 1
CNTN2 contactin 2 (axonal)
CTAG1A cancer/testis antigen 1A
CTAG1B cancer/testis antigen 1B
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
ERVW-1 endogenous retrovirus group W, member 1
F9 coagulation factor IX
FLVCR1 feline leukemia virus subgroup C cellular receptor 1
FOXP3 forkhead box P3
GATA3 GATA binding protein 3
GORASP1 golgi reassembly stacking protein 1, 65kDa
HBZ hemoglobin, zeta
HLA-C major histocompatibility complex, class I, C
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HLA-E major histocompatibility complex, class I, E
HLA-G major histocompatibility complex, class I, G
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HPRT1 hypoxanthine phosphoribosyltransferase 1
IFNB1 interferon, beta 1, fibroblast
IFNG interferon, gamma
IFNL3 interferon, lambda 3
IL10 interleukin 10
IL15 interleukin 15
IL17A interleukin 17A
IL2 interleukin 2
IL21 interleukin 21
IL22 interleukin 22
IL23A interleukin 23, alpha subunit p19
IL2RA interleukin 2 receptor, alpha
IL2RB interleukin 2 receptor, beta
IL6 interleukin 6
IL6R interleukin 6 receptor
IRF4 interferon regulatory factor 4
ISG20 interferon stimulated exonuclease gene 20kDa
KIR2DS1 killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2
KLRC1 killer cell lectin-like receptor subfamily C, member 1
KLRC4-KLRK1 KLRC4-KLRK1 readthrough
KLRD1 killer cell lectin-like receptor subfamily D, member 1
KLRK1 killer cell lectin-like receptor subfamily K, member 1
MMP9 matrix metallopeptidase 9
NCKIPSD NCK interacting protein with SH3 domain
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRSN1 neurensin 1
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma
PTHLH parathyroid hormone-like hormone
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
RAB4A RAB4A, member RAS oncogene family
RBM45 RNA binding motif protein 45
REG1A regenerating islet-derived 1 alpha
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
SELL selectin L
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SYT1 synaptotagmin I
TGFB1 transforming growth factor, beta 1
THBS1 thrombospondin 1
TMED2 transmembrane emp24 domain trafficking protein 2
TNF tumor necrosis factor
TPPP tubulin polymerization promoting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WNK1 WNK lysine deficient protein kinase 1
ZEB1 zinc finger E-box binding homeobox 1