| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/5593 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Tropicamide relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ACTBL2 | actin, beta-like 2 | 5.85 |
| TCF12 | transcription factor 12 | 0.67 |
| PKP2 | plakophilin 2 | 0.67 |
| GDPGP1 | GDP-D-glucose phosphorylase 1 | 0.65 |
| CHDH | choline dehydrogenase | 0.53 |
| AGAP2 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 | 0.51 |
| CYBA | cytochrome b-245, alpha polypeptide | 0.48 |
| C2CD4C | C2 calcium-dependent domain containing 4C | 0.46 |
| KLHL20 | kelch-like family member 20 | 0.45 |
| WDR89 | WD repeat domain 89 | 0.44 |
| RBAK | RB-associated KRAB zinc finger | 0.39 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.39 |
| XBP1 | X-box binding protein 1 | 0.39 |
| MAP2K5 | mitogen-activated protein kinase kinase 5 | 0.38 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.37 |
| ZNF566 | zinc finger protein 566 | 0.36 |
| MEX3C | mex-3 RNA binding family member C | 0.36 |
| BBS10 | Bardet-Biedl syndrome 10 | 0.35 |
| EID2 | EP300 interacting inhibitor of differentiation 2 | 0.34 |
| RABIF | RAB interacting factor | 0.33 |
| FN1 | fibronectin 1 | 0.32 |
| SIKE1 | suppressor of IKBKE 1 | 0.32 |
| UBE2B | ubiquitin-conjugating enzyme E2B | 0.32 |
| REV1 | REV1, polymerase (DNA directed) | 0.3 |
| POLR2K | polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa | 0.3 |
| BOD1 | biorientation of chromosomes in cell division 1 | 0.3 |
| ZNF658 | zinc finger protein 658 | 0.3 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.3 |
| MON1B | MON1 secretory trafficking family member B | 0.29 |
| RAC3 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) | 0.29 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.28 |
| ELMO1 | engulfment and cell motility 1 | 0.28 |
| UBE2G2 | ubiquitin-conjugating enzyme E2G 2 | 0.28 |
| ST6GALNAC4 | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 | 0.28 |
| NAA38 | N(alpha)-acetyltransferase 38, NatC auxiliary subunit | 0.28 |
| TOMM7 | translocase of outer mitochondrial membrane 7 homolog (yeast) | 0.28 |
| PDE5A | phosphodiesterase 5A, cGMP-specific | 0.27 |
| EIF4EBP2 | eukaryotic translation initiation factor 4E binding protein 2 | 0.27 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | 0.26 |
| ANGPTL4 | angiopoietin-like 4 | 0.26 |
| S100A14 | S100 calcium binding protein A14 | 0.26 |
| C9ORF40 | chromosome 9 open reading frame 40 | 0.26 |
| MISO1 | mitochondrial inner membrane subdomain organizer 1 | 0.26 |
| DUSP9 | dual specificity phosphatase 9 | 0.25 |
| ZNRD2 | zinc ribbon domain containing 2 | 0.25 |
| SMIM26 | small integral membrane protein 26 | 0.25 |
| DPY30 | dpy-30 homolog (C. elegans) | 0.25 |
| KIAA1324L | KIAA1324-like | 0.25 |
| TRMT112 | tRNA methyltransferase 11-2 homolog (S. cerevisiae) | 0.24 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.24 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.24 |
| TIMM8A | translocase of inner mitochondrial membrane 8 homolog A (yeast) | 0.24 |
| DENND4B | DENN/MADD domain containing 4B | 0.24 |
| OGG1 | 8-oxoguanine DNA glycosylase | 0.23 |
| PFDN5 | prefoldin subunit 5 | 0.23 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.23 |
| ST3GAL4 | ST3 beta-galactoside alpha-2,3-sialyltransferase 4 | 0.22 |
| RGPD2 | RANBP2-like and GRIP domain containing 2 | 0.22 |
| BET1L | Bet1 golgi vesicular membrane trafficking protein-like | 0.22 |
| LAMA5 | laminin, alpha 5 | 0.21 |
| TMEM189 | transmembrane protein 189 | 0.21 |
| GXYLT1 | glucoside xylosyltransferase 1 | 0.21 |
| PRR5 | proline rich 5 (renal) | 0.21 |
| CSTF2 | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa | 0.21 |
| XTBD1 | XRN2 binding domain containing 1 | 0.21 |
| PPIE | peptidylprolyl isomerase E (cyclophilin E) | 0.21 |
| WDR60 | WD repeat domain 60 | 0.2 |
| GID8 | GID complex subunit 8 | 0.2 |
| AREL1 | apoptosis resistant E3 ubiquitin protein ligase 1 | 0.2 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.2 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.2 |
| HSPA12B | heat shock 70kD protein 12B | 0.2 |
| COQ6 | coenzyme Q6 monooxygenase | 0.2 |
| PRR3 | proline rich 3 | 0.19 |
| C14ORF119 | chromosome 14 open reading frame 119 | 0.19 |
| CYHR1 | cysteine/histidine-rich 1 | 0.19 |
| KATNBL1 | katanin p80 subunit B-like 1 | 0.19 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.19 |
| PCGF2 | polycomb group ring finger 2 | 0.19 |
| AMDHD1 | amidohydrolase domain containing 1 | 0.19 |
| RXRA | retinoid X receptor, alpha | 0.19 |
| ENPP1 | ectonucleotide pyrophosphatase/phosphodiesterase 1 | 0.19 |
| TLE2 | transducin-like enhancer of split 2 | 0.19 |
| PPP4R4 | protein phosphatase 4, regulatory subunit 4 | 0.19 |
| IL17RD | interleukin 17 receptor D | 0.19 |
| PTGS1 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) | 0.19 |
| RPE | ribulose-5-phosphate-3-epimerase | 0.19 |
| LYST | lysosomal trafficking regulator | 0.19 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | 0.18 |
| TIMM8B | translocase of inner mitochondrial membrane 8 homolog B (yeast) | 0.18 |
| KSR2 | kinase suppressor of ras 2 | 0.18 |
| NEDD4 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | 0.18 |
| RAB30 | RAB30, member RAS oncogene family | 0.18 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.18 |
| DIXDC1 | DIX domain containing 1 | 0.18 |
| KRTCAP3 | keratinocyte associated protein 3 | 0.18 |
| MSX2 | msh homeobox 2 | 0.18 |
| SPRTN | SprT-like N-terminal domain | 0.18 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.18 |
| HSBP1 | heat shock factor binding protein 1 | 0.18 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CPLANE1 | ciliogenesis and planar polarity effector complex subunit 1 | -2.27 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | -1.2 |
| ADPRH | ADP-ribosylarginine hydrolase | -1.0 |
| SGSM1 | small G protein signaling modulator 1 | -0.8 |
| ABHD2 | abhydrolase domain containing 2 | -0.8 |
| LYPD3 | LY6/PLAUR domain containing 3 | -0.75 |
| YPEL5 | yippee-like 5 (Drosophila) | -0.69 |
| TGFB1I1 | transforming growth factor beta 1 induced transcript 1 | -0.65 |
| STARD3 | StAR-related lipid transfer (START) domain containing 3 | -0.65 |
| MEST | mesoderm specific transcript | -0.62 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.6 |
| TRIM35 | tripartite motif containing 35 | -0.57 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -0.55 |
| PPARD | peroxisome proliferator-activated receptor delta | -0.48 |
| ZNF692 | zinc finger protein 692 | -0.48 |
| ALOXE3 | arachidonate lipoxygenase 3 | -0.47 |
| SS18L1 | synovial sarcoma translocation gene on chromosome 18-like 1 | -0.45 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.45 |
| TREX1 | three prime repair exonuclease 1 | -0.44 |
| TSR2 | TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) | -0.44 |
| ZNF286A | zinc finger protein 286A | -0.44 |
| MEX3A | mex-3 RNA binding family member A | -0.43 |
| AMACR | alpha-methylacyl-CoA racemase | -0.42 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.42 |
| FZD3 | frizzled class receptor 3 | -0.42 |
| ETV5 | ets variant 5 | -0.41 |
| COMTD1 | catechol-O-methyltransferase domain containing 1 | -0.39 |
| TFAP2A | transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) | -0.39 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.38 |
| PIWIL2 | piwi-like RNA-mediated gene silencing 2 | -0.38 |
| FDXACB1 | ferredoxin-fold anticodon binding domain containing 1 | -0.38 |
| SERBP1 | SERPINE1 mRNA binding protein 1 | -0.38 |
| ZNF302 | zinc finger protein 302 | -0.38 |
| CYP4V2 | cytochrome P450, family 4, subfamily V, polypeptide 2 | -0.38 |
| FBXW2 | F-box and WD repeat domain containing 2 | -0.37 |
| CTSC | cathepsin C | -0.37 |
| TTBK2 | tau tubulin kinase 2 | -0.37 |
| AASDH | aminoadipate-semialdehyde dehydrogenase | -0.37 |
| KCTD21 | potassium channel tetramerization domain containing 21 | -0.37 |
| KANK3 | KN motif and ankyrin repeat domains 3 | -0.36 |
| SLC38A7 | solute carrier family 38, member 7 | -0.36 |
| PLEKHH1 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | -0.35 |
| C4ORF33 | chromosome 4 open reading frame 33 | -0.35 |
| TNIP2 | TNFAIP3 interacting protein 2 | -0.35 |
| CEP63 | centrosomal protein 63kDa | -0.35 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.35 |
| F2R | coagulation factor II (thrombin) receptor | -0.35 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.34 |
| RNF126 | ring finger protein 126 | -0.34 |
| MCTP2 | multiple C2 domains, transmembrane 2 | -0.34 |
| TXNDC16 | thioredoxin domain containing 16 | -0.33 |
| ATE1 | arginyltransferase 1 | -0.33 |
| FABP6 | fatty acid binding protein 6, ileal | -0.33 |
| C9ORF72 | chromosome 9 open reading frame 72 | -0.33 |
| FCHSD1 | FCH and double SH3 domains 1 | -0.32 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.32 |
| ZNF14 | zinc finger protein 14 | -0.32 |
| LCP1 | lymphocyte cytosolic protein 1 (L-plastin) | -0.32 |
| ADGRE2 | adhesion G protein-coupled receptor E2 | -0.31 |
| CDA | cytidine deaminase | -0.31 |
| SIGMAR1 | sigma non-opioid intracellular receptor 1 | -0.31 |
| ETNK2 | ethanolamine kinase 2 | -0.31 |
| KCTD12 | potassium channel tetramerization domain containing 12 | -0.31 |
| RCAN3 | RCAN family member 3 | -0.31 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | -0.3 |
| UTP14C | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) | -0.3 |
| TMOD1 | tropomodulin 1 | -0.3 |
| ZNF410 | zinc finger protein 410 | -0.3 |
| FICD | FIC domain containing | -0.3 |
| YAE1 | YAE1 maturation factor of ABCE1 | -0.3 |
| CLGN | calmegin | -0.3 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | -0.3 |
| LRP4 | low density lipoprotein receptor-related protein 4 | -0.3 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -0.29 |
| C1GALT1C1 | C1GALT1-specific chaperone 1 | -0.29 |
| TRIM29 | tripartite motif containing 29 | -0.29 |
| PDP2 | pyruvate dehyrogenase phosphatase catalytic subunit 2 | -0.28 |
| ZNF92 | zinc finger protein 92 | -0.28 |
| ANKS6 | ankyrin repeat and sterile alpha motif domain containing 6 | -0.28 |
| SLC11A2 | solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 | -0.28 |
| RHBDD1 | rhomboid domain containing 1 | -0.28 |
| NHSL1 | NHS-like 1 | -0.28 |
| ZBED8L | ZBED8 like | -0.27 |
| ZNF652 | zinc finger protein 652 | -0.27 |
| MZT2B | mitotic spindle organizing protein 2B | -0.27 |
| CCDC150 | coiled-coil domain containing 150 | -0.27 |
| PGBD2 | piggyBac transposable element derived 2 | -0.26 |
| NUDT18 | nudix (nucleoside diphosphate linked moiety X)-type motif 18 | -0.26 |
| METTL25 | methyltransferase like 25 | -0.26 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.26 |
| STON2 | stonin 2 | -0.26 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | -0.26 |
| TSLIG3C | tRNA splicing ligase complex subunit 3C | -0.26 |
| GPBP1L1 | GC-rich promoter binding protein 1-like 1 | -0.26 |
| CALU | calumenin | -0.26 |
| TAX1BP3 | Tax1 (human T-cell leukemia virus type I) binding protein 3 | -0.26 |
| LTBP4 | latent transforming growth factor beta binding protein 4 | -0.26 |
| MTX2 | metaxin 2 | -0.26 |
| MED31 | mediator complex subunit 31 | -0.26 |
| PDE6D | phosphodiesterase 6D, cGMP-specific, rod, delta | -0.26 |
