Tubulin inhibitor 6_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Tubulin inhibitor 6 perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Tubulin inhibitor 6_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.197732
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.188346
ACTG1 actin gamma 1 0.176635
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.172716
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.1484
HMGA2 high mobility group AT-hook 2 0.139169
YAP1 Yes-associated protein 1 0.12094
RRM2 ribonucleotide reductase M2 0.118292
ASPH aspartate beta-hydroxylase 0.107971
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.096101
NLGN1 neuroligin 1 0.0831836
TPM3 tropomyosin 3 0.0831801
VMP1 vacuole membrane protein 1 0.0795881
EHBP1 EH domain binding protein 1 0.0783801
POTEF POTE ankyrin domain family, member F 0.0769977
JMJD1C jumonji domain containing 1C 0.0744095
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0737512
NHSL1 NHS-like 1 0.0668195
PCBP2 poly(rC) binding protein 2 0.0616611
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0615921
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0581726
INTS6 integrator complex subunit 6 0.0580058
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0577763
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0557738
ENO1 enolase 1, (alpha) 0.0540683
MACF1 microtubule-actin crosslinking factor 1 0.053973
SPATS2 spermatogenesis associated, serine-rich 2 0.0539156
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0527882
ANXA1 annexin A1 0.052603
PCDH9 protocadherin 9 0.0519066
ADIPOR2 adiponectin receptor 2 0.050414
RAB7A RAB7A, member RAS oncogene family 0.0497014
IPO7 importin 7 0.0495308
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0491697
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0489276
ZSWIM6 zinc finger, SWIM-type containing 6 0.0487524
DST dystonin 0.047026
DENND5A DENN/MADD domain containing 5A 0.0460431
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.045695
EIF4B eukaryotic translation initiation factor 4B 0.045063
MSRB3 methionine sulfoxide reductase B3 0.0429634
KDM2A lysine (K)-specific demethylase 2A 0.0429364
WWOX WW domain containing oxidoreductase 0.0428575
ANKRD17 ankyrin repeat domain 17 0.0424082
PDGFC platelet derived growth factor C 0.0422416
LPP LIM domain containing preferred translocation partner in lipoma 0.0421703
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0416784
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0410764
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0406255
HSPA8 heat shock 70kDa protein 8 0.0401273
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.0400189
USP34 ubiquitin specific peptidase 34 0.0384442
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0382881
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0381417
TAS2R14 taste receptor, type 2, member 14 0.0381217
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0375023
KDM4C lysine (K)-specific demethylase 4C 0.0372389
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0364415
LDHA lactate dehydrogenase A 0.0362919
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0361962
CUX1 cut-like homeobox 1 0.0360013
NEBL nebulette 0.0348223
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0347355
RAB10 RAB10, member RAS oncogene family 0.0346118
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0345717
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0342774
ASXL2 additional sex combs like transcriptional regulator 2 0.0340396
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0338728
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0337999
RABGAP1L RAB GTPase activating protein 1-like 0.0335341
LRMDA leucine rich melanocyte differentiation associated 0.0334835
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0334128
MBD5 methyl-CpG binding domain protein 5 0.0332976
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0332281
EXOC4 exocyst complex component 4 0.03311
TBC1D5 TBC1 domain family, member 5 0.032152
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0314793
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0314481
CALR calreticulin 0.0313894
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0312378
WNK1 WNK lysine deficient protein kinase 1 0.0310197
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0309725
PRKCE protein kinase C, epsilon 0.0309012
KPNB1 karyopherin (importin) beta 1 0.0309001
ANKRD12 ankyrin repeat domain 12 0.0306116
ANK2 ankyrin 2, neuronal 0.0306105
BPTF bromodomain PHD finger transcription factor 0.0303713
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0299698
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0299248
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0298083
R3HDM2 R3H domain containing 2 0.0294548
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 0.0294358
RPS12 ribosomal protein S12 0.0291381
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 0.0288101
GJA1 gap junction protein, alpha 1, 43kDa 0.0286796
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0286733
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0285346
CANX calnexin 0.0283194
RCOR1 REST corepressor 1 0.0277904
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0275781

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.200091
VIM vimentin -0.126478
AREG amphiregulin -0.0739285
SLC38A2 solute carrier family 38, member 2 -0.0628822
CELF2 CUGBP, Elav-like family member 2 -0.0590035
RPS27A ribosomal protein S27a -0.0577768
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0507068
RPS24 ribosomal protein S24 -0.0431412
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0409082
FTL ferritin, light polypeptide -0.0403956
EDN1 endothelin 1 -0.0395025
CXADR coxsackie virus and adenovirus receptor -0.0378875
KDM3A lysine (K)-specific demethylase 3A -0.0374906
OXR1 oxidation resistance 1 -0.036788
CLDN1 claudin 1 -0.0342356
ATP5F1B ATP synthase F1 subunit beta -0.033079
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0326834
UBC ubiquitin C -0.0307954
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.030278
NEK7 NIMA-related kinase 7 -0.0288932
ADGRG6 adhesion G protein-coupled receptor G6 -0.0281755
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0277383
RPL23 ribosomal protein L23 -0.0276001
RPLP1 ribosomal protein, large, P1 -0.0273894
RPL6 ribosomal protein L6 -0.0267964
KLHL24 kelch-like family member 24 -0.0267171
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0263453
LMO7 LIM domain 7 -0.0261928
KIF5B kinesin family member 5B -0.0261848
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0258869
RPL34 ribosomal protein L34 -0.0253027
BTG3 BTG family, member 3 -0.0252943
ZNF217 zinc finger protein 217 -0.0251327
PCNP PEST proteolytic signal containing nuclear protein -0.0251231
RPL32 ribosomal protein L32 -0.0246366
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.023706
RAB1A RAB1A, member RAS oncogene family -0.0236905
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0236852
YBX1 Y box binding protein 1 -0.0236813
BIRC2 baculoviral IAP repeat containing 2 -0.0233688
THOC2 THO complex 2 -0.0232542
RPS21 ribosomal protein S21 -0.0229009
ECT2 epithelial cell transforming 2 -0.0228092
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0225972
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0225054
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0224099
NPR2 natriuretic peptide receptor 2 -0.0223755
RPS23 ribosomal protein S23 -0.0223648
SEC62 SEC62 homolog (S. cerevisiae) -0.022361
CNRIP1 cannabinoid receptor interacting protein 1 -0.0223476
BLTP2 bridge-like lipid transfer protein family member 2 -0.0222878
CEP95 centrosomal protein 95kDa -0.0218765
RPL8 ribosomal protein L8 -0.0217764
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0213892
RPL36 ribosomal protein L36 -0.0211367
RAD21 RAD21 homolog (S. pombe) -0.0210134
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0209404
RPS5 ribosomal protein S5 -0.0205968
RBM39 RNA binding motif protein 39 -0.0204356
THOC1 THO complex 1 -0.0203304
RPS19 ribosomal protein S19 -0.0202144
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.020103
RBM27 RNA binding motif protein 27 -0.0194192
MATR3 matrin 3 -0.0193248
FUS FUS RNA binding protein -0.0192675
RPL31 ribosomal protein L31 -0.0192533
MARCHF6 membrane associated ring-CH-type finger 6 -0.0192449
RPL11 ribosomal protein L11 -0.019239
CHD1 chromodomain helicase DNA binding protein 1 -0.0192359
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0192022
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0187986
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0187458
MYL12B myosin, light chain 12B, regulatory -0.0186702
RSRC1 arginine/serine-rich coiled-coil 1 -0.0185751
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0185714
TNPO1 transportin 1 -0.0184769
WDR43 WD repeat domain 43 -0.0183762
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0183464
RPL12 ribosomal protein L12 -0.0182875
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 -0.0182699
RB1CC1 RB1-inducible coiled-coil 1 -0.0182112
IPMK inositol polyphosphate multikinase -0.0182076
ZBTB20 zinc finger and BTB domain containing 20 -0.0181571
TMEM131 transmembrane protein 131 -0.017847
SYT1 synaptotagmin I -0.0176775
PNISR PNN-interacting serine/arginine-rich protein -0.0175674
ARHGAP12 Rho GTPase activating protein 12 -0.0174262
SERINC1 serine incorporator 1 -0.0174049
EIF1 eukaryotic translation initiation factor 1 -0.0173579
WSB1 WD repeat and SOCS box containing 1 -0.0172299
AFG3L2 AFG3-like AAA ATPase 2 -0.0170767
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.016955
NCEH1 neutral cholesterol ester hydrolase 1 -0.0169205
CCND1 cyclin D1 -0.0169006
RPL26 ribosomal protein L26 -0.0168118
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -0.0167892
PRR11 proline rich 11 -0.0166965
MON2 MON2 homolog (S. cerevisiae) -0.0166282
SCAMP1 secretory carrier membrane protein 1 -0.0165866
RPLP2 ribosomal protein, large, P2 -0.016532